| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Biyue Zhu, Ting Zhang, Qian Jiang, Ying Li, Yu Fu, Jiapei Dai, Ge Li, Qingrong Qi, Yan Chen. Synthesis and evaluation of pyrazine and quinoxaline fluorophores for in vivo detection of cerebral tau tangles in Alzheimer's models. Chemical communications (Cambridge, England). vol 54. issue 82. 2018-10-17. PMID:30204164. |
synthesis and evaluation of pyrazine and quinoxaline fluorophores for in vivo detection of cerebral tau tangles in alzheimer's models. |
2018-10-17 |
2023-08-13 |
mouse |
| Hanna Cho, Hye Sun Lee, Jae Yong Choi, Jae Hoon Lee, Young Hoon Ryu, Myung Sik Lee, Chul Hyoung Lyo. Predicted sequence of cortical tau and amyloid-β deposition in Alzheimer disease spectrum. Neurobiology of aging. vol 68. 2018-10-16. PMID:29751288. |
predicted sequence of cortical tau and amyloid-β deposition in alzheimer disease spectrum. |
2018-10-16 |
2023-08-13 |
human |
| Hanna Cho, Hye Sun Lee, Jae Yong Choi, Jae Hoon Lee, Young Hoon Ryu, Myung Sik Lee, Chul Hyoung Lyo. Predicted sequence of cortical tau and amyloid-β deposition in Alzheimer disease spectrum. Neurobiology of aging. vol 68. 2018-10-16. PMID:29751288. |
we investigated sequential order between tau and amyloid-β (aβ) deposition in alzheimer disease spectrum using a conditional probability method. |
2018-10-16 |
2023-08-13 |
human |
| Faten A Sayed, Maria Telpoukhovskaia, Lay Kodama, Yaqiao Li, Yungui Zhou, David Le, Axel Hauduc, Connor Ludwig, Fuying Gao, Claire Clelland, Lihong Zhan, Yonatan A Cooper, Dimitrios Davalos, Katerina Akassoglou, Giovanni Coppola, Li Ga. Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy. Proceedings of the National Academy of Sciences of the United States of America. vol 115. issue 40. 2018-10-16. PMID:30232263. |
alzheimer's disease (ad), the most common form of dementia, is characterized by the abnormal accumulation of amyloid plaques and hyperphosphorylated tau aggregates, as well as microgliosis. |
2018-10-16 |
2023-08-13 |
Not clear |
| T West, Y Hu, P B Verghese, R J Bateman, J B Braunstein, I Fogelman, K Budur, H Florian, N Mendonca, D M Holtzma. Preclinical and Clinical Development of ABBV-8E12, a Humanized Anti-Tau Antibody, for Treatment of Alzheimer's Disease and Other Tauopathies. The journal of prevention of Alzheimer's disease. vol 4. issue 4. 2018-10-11. PMID:29181488. |
tau neurofibrillary tangles are found in the brains of patients suffering from alzheimer's disease and other tauopathies. |
2018-10-11 |
2023-08-13 |
human |
| Young Kyoung Jang, Chul Hyoung Lyoo, Seongbeom Park, Seung Jun Oh, Hanna Cho, Minyoung Oh, Young Hoon Ryu, Jae Yong Choi, Gil D Rabinovici, Hee Jin Kim, Seung Hwan Moon, Hyemin Jang, Jin San Lee, William J Jagust, Duk L Na, Jae Seung Kim, Sang Won Se. Head to head comparison of [ European journal of nuclear medicine and molecular imaging. vol 45. issue 3. 2018-10-09. PMID:29143870. |
head to head comparison of [ tau accumulation is a core pathologic change in various neurodegenerative diseases including alzheimer's disease and frontotemporal lobar degeneration-tau. |
2018-10-09 |
2023-08-13 |
Not clear |
| Tina Bilousova, Chris Elias, Emily Miyoshi, Mohammad Parvez Alam, Chunni Zhu, Jesus Campagna, Kanagasabai Vadivel, Barbara Jagodzinska, Karen Hoppens Gylys, Varghese Joh. Suppression of tau propagation using an inhibitor that targets the DK-switch of nSMase2. Biochemical and biophysical research communications. vol 499. issue 4. 2018-10-09. PMID:29604274. |
targeting of molecular pathways involved in the cell-to-cell propagation of pathological tau species is a novel approach for development of disease-modifying therapies that could block tau pathology and attenuate cognitive decline in patients with alzheimer's disease and other tauopathies. |
2018-10-09 |
2023-08-13 |
Not clear |
| Fong Ping Chong, Khuen Yen Ng, Rhun Yian Koh, Soi Moi Chy. Tau Proteins and Tauopathies in Alzheimer's Disease. Cellular and molecular neurobiology. vol 38. issue 5. 2018-10-05. PMID:29299792. |
tau proteins and tauopathies in alzheimer's disease. |
2018-10-05 |
2023-08-13 |
human |
| Shuquan Rao, Mahdi Ghani, Zhiyun Guo, Yuetiva Deming, Kesheng Wang, Rebecca Sims, Canquan Mao, Yao Yao, Carlos Cruchaga, Dietrich A Stephan, Ekaterina Rogaev. An APOE-independent cis-eSNP on chromosome 19q13.32 influences tau levels and late-onset Alzheimer's disease risk. Neurobiology of aging. vol 66. 2018-10-05. PMID:29395286. |
an apoe-independent cis-esnp on chromosome 19q13.32 influences tau levels and late-onset alzheimer's disease risk. |
2018-10-05 |
2023-08-13 |
Not clear |
| Andrei G Vlassenko, Brian A Gordon, Manu S Goyal, Yi Su, Tyler M Blazey, Tony J Durbin, Lars E Couture, Jon J Christensen, Hussain Jafri, John C Morris, Marcus E Raichle, Tammie L-S Benzinge. Aerobic glycolysis and tau deposition in preclinical Alzheimer's disease. Neurobiology of aging. vol 67. 2018-10-04. PMID:29655050. |
aerobic glycolysis and tau deposition in preclinical alzheimer's disease. |
2018-10-04 |
2023-08-13 |
human |
| Alban Chauderlier, Melissa Gilles, Andrea Spolcova, Raphaelle Caillierez, Maggy Chwastyniak, Michel Kress, Herve Drobecq, Eliette Bonnefoy, Florence Pinet, Dominique Weil, Luc Buée, Marie-Christine Galas, Bruno Lefebvr. Tau/DDX6 interaction increases microRNA activity. Biochimica et biophysica acta. Gene regulatory mechanisms. vol 1861. issue 8. 2018-10-04. PMID:29966762. |
tauopathies, such as alzheimer's disease, are characterized by intracellular aggregates of insoluble tau proteins. |
2018-10-04 |
2023-08-13 |
Not clear |
| Nadine Ait-Bouziad, Guohua Lv, Anne-Laure Mahul-Mellier, Shifeng Xiao, Gizem Zorludemir, David Eliezer, Thomas Walz, Hilal A Lashue. Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes. Nature communications. vol 8. issue 1. 2018-10-01. PMID:29162800. |
the microtubule-associated protein tau plays a central role in the pathogenesis of alzheimer's disease. |
2018-10-01 |
2023-08-13 |
Not clear |
| Lary C Walke. Prion-like mechanisms in Alzheimer disease. Handbook of clinical neurology. vol 153. 2018-09-27. PMID:29887142. |
in alzheimer disease, current evidence indicates that the pathogenic cascade follows from the endogenous, sequential corruption of aβ and then tau. |
2018-09-27 |
2023-08-13 |
Not clear |
| Marjolein Bulk, Walid M Abdelmoula, Rob J A Nabuurs, Linda M van der Graaf, Coen W H Mulders, Aat A Mulder, Carolina R Jost, Abraham J Koster, Mark A van Buchem, Remco Natté, Jouke Dijkstra, Louise van der Weer. Postmortem MRI and histology demonstrate differential iron accumulation and cortical myelin organization in early- and late-onset Alzheimer's disease. Neurobiology of aging. vol 62. 2018-09-26. PMID:29195086. |
neuropathologically, subtypes of alzheimer's disease showed different patterns of iron accumulation and cortical myelin changes independent of amyloid and tau that may be detected by high-field susceptibility-based mri. |
2018-09-26 |
2023-08-13 |
Not clear |
| David Berron, Katja Neumann, Anne Maass, Hartmut Schütze, Klaus Fliessbach, Verena Kiven, Frank Jessen, Magdalena Sauvage, Dharshan Kumaran, Emrah Düze. Age-related functional changes in domain-specific medial temporal lobe pathways. Neurobiology of aging. vol 65. 2018-09-26. PMID:29454154. |
future experiments will elucidate whether the 2 pathways are differentially affected in early stages of alzheimer's disease in relation to amyloid or tau pathology. |
2018-09-26 |
2023-08-13 |
human |
| Sandra Pelleieux, Cynthia Picard, Louise Lamarre-Théroux, Doris Dea, Valérie Leduc, Youla S Tsantrizos, Judes Poirie. Isoprenoids and tau pathology in sporadic Alzheimer's disease. Neurobiology of aging. vol 65. 2018-09-26. PMID:29476987. |
isoprenoids and tau pathology in sporadic alzheimer's disease. |
2018-09-26 |
2023-08-13 |
human |
| Josephine C Ferreon, Antrix Jain, Kyoung-Jae Choi, Phoebe S Tsoi, Kevin R MacKenzie, Sung Yun Jung, Allan Chris Ferreo. Acetylation Disfavors Tau Phase Separation. International journal of molecular sciences. vol 19. issue 5. 2018-09-21. PMID:29734651. |
neuropathological aggregates of the intrinsically disordered microtubule-associated protein tau are hallmarks of alzheimer’s disease, with decades of research devoted to studying the protein’s aggregation properties both in vitro and in vivo. |
2018-09-21 |
2023-08-13 |
Not clear |
| Omkar Bihani, Tripti Rai, Debashis Pand. Interaction of proteins with lemon-juice/glutathione-derived carbon nanodot: Interplay of induced-aggregation and co-solubilization. International journal of biological macromolecules. vol 112. 2018-09-20. PMID:29427683. |
the accumulation of protein aggregates (tau) causes alzheimer's disease (ad), parkinson's disease (pd), and a range of neurodegenerative diseases. |
2018-09-20 |
2023-08-13 |
Not clear |
| Yunior Cabrales Fontela, Harindranath Kadavath, Jacek Biernat, Dietmar Riedel, Eckhard Mandelkow, Markus Zweckstette. Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau. Nature communications. vol 8. issue 1. 2018-09-18. PMID:29215007. |
in addition, aberrant interaction of the microtubule-associated protein tau with filamentous actin is connected to synaptic impairment in alzheimer's disease. |
2018-09-18 |
2023-08-13 |
Not clear |
| Juan Carlos Polanco, Chuanzhou Li, Nela Durisic, Robert Sullivan, Jürgen Göt. Exosomes taken up by neurons hijack the endosomal pathway to spread to interconnected neurons. Acta neuropathologica communications. vol 6. issue 1. 2018-09-18. PMID:29448966. |
in alzheimer disease and related disorders, the microtubule-associated protein tau aggregates and forms cytoplasmic lesions that impair neuronal physiology at many levels. |
2018-09-18 |
2023-08-13 |
mouse |