| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuying Li, Kan Wang, Kaixiang Zhou, Wentao Guo, Bin Dai, Yi Liang, Jiapei Dai, Mengchao Cu. Novel D-A-D based near-infrared probes for the detection of β-amyloid and Tau fibrils in Alzheimer's disease. Chemical communications (Cambridge, England). vol 54. issue 63. 2018-08-22. PMID:30023996. |
novel d-a-d based near-infrared probes for the detection of β-amyloid and tau fibrils in alzheimer's disease. |
2018-08-22 |
2023-08-13 |
Not clear |
| Gerard Nuovo, Vicky Amann, James Williams, Paige Vandiver, Maria Quinonez, Paolo Fadda, Bernard Paniccia, Louisa Mezache, Adel Mikhai. Increased expression of importin-β, exportin-5 and nuclear transportable proteins in Alzheimer's disease aids anatomic pathologists in its diagnosis. Annals of diagnostic pathology. vol 32. 2018-08-21. PMID:29414391. |
understanding the metabolic profile of neurons with the hyperphosphorylated tau protein characteristic of alzheimer's disease is essential to unraveling new potential therapies and diagnostics for the surgical pathologist. |
2018-08-21 |
2023-08-13 |
Not clear |
| Gerard Nuovo, Vicky Amann, James Williams, Paige Vandiver, Maria Quinonez, Paolo Fadda, Bernard Paniccia, Louisa Mezache, Adel Mikhai. Increased expression of importin-β, exportin-5 and nuclear transportable proteins in Alzheimer's disease aids anatomic pathologists in its diagnosis. Annals of diagnostic pathology. vol 32. 2018-08-21. PMID:29414391. |
we stratified 75 brain tissues from alzheimer's disease into hyperphosphorylated tau positive or negative and did co-expression analyses and qrtpcr for importin-β and exportin-5 plus several bcl2 family members and compared the data to controls, down's dementia and parkinson's disease. |
2018-08-21 |
2023-08-13 |
Not clear |
| Gerard Nuovo, Vicky Amann, James Williams, Paige Vandiver, Maria Quinonez, Paolo Fadda, Bernard Paniccia, Louisa Mezache, Adel Mikhai. Increased expression of importin-β, exportin-5 and nuclear transportable proteins in Alzheimer's disease aids anatomic pathologists in its diagnosis. Annals of diagnostic pathology. vol 32. 2018-08-21. PMID:29414391. |
there was a significant increase in the expression of importin-β and exportin-5 in alzheimer's disease relative to the three other categories (each p value<0.0001) where each protein co-localized with hyperphosphorylated tau. |
2018-08-21 |
2023-08-13 |
Not clear |
| Gerard Nuovo, Vicky Amann, James Williams, Paige Vandiver, Maria Quinonez, Paolo Fadda, Bernard Paniccia, Louisa Mezache, Adel Mikhai. Increased expression of importin-β, exportin-5 and nuclear transportable proteins in Alzheimer's disease aids anatomic pathologists in its diagnosis. Annals of diagnostic pathology. vol 32. 2018-08-21. PMID:29414391. |
neurons with hyperphosphorylated tau in alzheimer's disease have the profile of metabolically active cells including increased exportin-5 and importin-β mrna and proteins which indicates that immunohistochemistry testing of these proteins may aid the surgical pathologist in making a definitive diagnosis. |
2018-08-21 |
2023-08-13 |
Not clear |
| Pedro Piccardo, Declan King, Deborah Brown, Rona M Barro. Variable tau accumulation in murine models with abnormal prion protein deposits. Journal of the neurological sciences. vol 383. 2018-08-20. PMID:29246602. |
while hyperphosphorylated tau (p.tau) is characteristic of alzheimer's disease (ad), p.tau is also observed in human prion diseases. |
2018-08-20 |
2023-08-13 |
mouse |
| Miho Uematsu, Ayako Nakamura, Momoko Ebashi, Katsuiku Hirokawa, Ryosuke Takahashi, Toshiki Uchihar. Brainstem tau pathology in Alzheimer's disease is characterized by increase of three repeat tau and independent of amyloid β. Acta neuropathologica communications. vol 6. issue 1. 2018-08-20. PMID:29298724. |
brainstem tau pathology in alzheimer's disease is characterized by increase of three repeat tau and independent of amyloid β. |
2018-08-20 |
2023-08-13 |
Not clear |
| Miho Uematsu, Ayako Nakamura, Momoko Ebashi, Katsuiku Hirokawa, Ryosuke Takahashi, Toshiki Uchihar. Brainstem tau pathology in Alzheimer's disease is characterized by increase of three repeat tau and independent of amyloid β. Acta neuropathologica communications. vol 6. issue 1. 2018-08-20. PMID:29298724. |
if this preferential accumulation of 3r tau also occurs in the brainstem, it may be fundamentally related to progression of alzheimer pathology. |
2018-08-20 |
2023-08-13 |
Not clear |
| Elena Pérez-Ruiz, Deborah Decrop, Karen Ven, Lisa Tripodi, Karen Leirs, Joelle Rosseels, Marlies van de Wouwer, Nick Geukens, Ann De Vos, Eugeen Vanmechelen, Joris Winderickx, Jeroen Lammertyn, Dragana Spasi. Digital ELISA for the quantification of attomolar concentrations of Alzheimer's disease biomarker protein Tau in biological samples. Analytica chimica acta. vol 1015. 2018-08-14. PMID:29530254. |
digital elisa for the quantification of attomolar concentrations of alzheimer's disease biomarker protein tau in biological samples. |
2018-08-14 |
2023-08-13 |
Not clear |
| Elena Pérez-Ruiz, Deborah Decrop, Karen Ven, Lisa Tripodi, Karen Leirs, Joelle Rosseels, Marlies van de Wouwer, Nick Geukens, Ann De Vos, Eugeen Vanmechelen, Joris Winderickx, Jeroen Lammertyn, Dragana Spasi. Digital ELISA for the quantification of attomolar concentrations of Alzheimer's disease biomarker protein Tau in biological samples. Analytica chimica acta. vol 1015. 2018-08-14. PMID:29530254. |
the close correlation between tau pathology and alzheimer's disease (ad) progression makes this protein a suitable biomarker for diagnosis and monitoring of the disorder evolution. |
2018-08-14 |
2023-08-13 |
Not clear |
| Esraa Haj, Yelena Losev, V Guru KrishnaKumar, Edward Pichinuk, Hamutal Engel, Avi Raveh, Ehud Gazit, Daniel Sega. Integrating in vitro and in silico approaches to evaluate the "dual functionality" of palmatine chloride in inhibiting and disassembling Tau-derived VQIVYK peptide fibrils. Biochimica et biophysica acta. General subjects. vol 1862. issue 7. 2018-08-14. PMID:29634991. |
alzheimer's disease (ad) is the most common neurodegenerative disorder which is characterized by the deposits of intra-cellular tau protein and extra-cellular amyloid-β (aβ) peptides in the human brain. |
2018-08-14 |
2023-08-13 |
human |
| Petr Novak, Martin Cente, Nina Kosikova, Tomas Augustin, Richard Kvetnansky, Michal Novak, Peter Filipci. Stress-Induced Alterations of Immune Profile in Animals Suffering by Tau Protein-Driven Neurodegeneration. Cellular and molecular neurobiology. vol 38. issue 1. 2018-08-13. PMID:28405903. |
alzheimer's disease (ad) is a multifactorial disorder; neurofibrillary pathology composed of tau protein is found side by side with amyloid-β deposits and extensive neuroinflammation. |
2018-08-13 |
2023-08-13 |
rat |
| Minoru Kouzuki, Tetsuya Suzuki, Masaya Nagano, Syouta Nakamura, Yuto Katsumata, Ayumi Takamura, Katsuya Urakam. Comparison of olfactory and gustatory disorders in Alzheimer's disease. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 39. issue 2. 2018-08-13. PMID:29128987. |
we performed the odor stick identification test for japanese (osit-j), gustatory test by the intraoral dropping method using taste solutions, mini-mental state examination (mmse), alzheimer's disease assessment scale-cognitive subscale japanese version (adas-j cog), touch panel-type dementia assessment scale (tdas), and measurement of amyloid β (aβ) 42 and phosphorylated tau (p-tau) 181 levels in cerebrospinal fluid (csf). |
2018-08-13 |
2023-08-13 |
Not clear |
| Xiao-Meng Shi, Hua Zhang, Zhang-Jiuzhi Zhou, Ying-Ying Ruan, Jie Pang, Lu Zhang, Wei Zhai, Yan-Li H. Effects of safflower yellow on beta-amyloid deposition and activation of astrocytes in the brain of APP/PS1 transgenic mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 98. 2018-08-13. PMID:29288971. |
safflower yellow (sy), one of traditional chinese medicine extracted from safflower, has been shown to have neuroprotective effects on animal models of vascular dementia and alzheimer's diseases (ad), by inhibiting oxidative injury, neuronal apoptosis and tau hyperphosphorylation. |
2018-08-13 |
2023-08-13 |
mouse |
| Abolfazl Jangholi, Mohammad Reza Ashrafi-Kooshk, Seyed Shahriar Arab, Saeed Karima, Mansour Poorebrahim, Seyyed Abolghasem Ghadami, Ali Akbar Moosavi-Movahedi, Reza Khodarahm. Can any "non-specific charge modification within microtubule binding domains of Tau" be a prerequisite of the protein amyloid aggregation? An in vitro study on the 1N4R isoform. International journal of biological macromolecules. vol 109. 2018-08-10. PMID:29248553. |
the aggregation of tau into amyloid fibrils is a hallmark of neurodegenerative diseases such as alzheimer's disease (ad). |
2018-08-10 |
2023-08-13 |
Not clear |
| Suhee Kim, Alastair W Wark, Hye Jin Le. Femtomolar Detection of Tau Proteins in Undiluted Plasma Using Surface Plasmon Resonance. Analytical chemistry. vol 88. issue 15. 2018-08-09. PMID:27399254. |
the ability to directly detect tau protein and other neurodegenerative biomarkers in human plasma at clinically relevant concentrations continues to be a significant hurdle for the establishment of diagnostic tests for alzheimer's disease (ad). |
2018-08-09 |
2023-08-13 |
human |
| Jun Zhang, Alexander Sandberg, Audun Konsmo, Xiongyu Wu, Sofie Nyström, K Peter R Nilsson, Peter Konradsson, Harry LeVine, Mikael Lindgren, Per Hammarströ. Detection and Imaging of Aβ1-42 and Tau Fibrils by Redesigned Fluorescent X-34 Analogues. Chemistry (Weinheim an der Bergstrasse, Germany). vol 24. issue 28. 2018-08-08. PMID:29543355. |
we revisited the congo red analogue 2,5-bis(4'-hydroxy-3'-carboxy-styryl)benzene (x-34) to develop this highly fluorescent amyloid dye for imaging alzheimer's disease (ad) pathology comprising aβ and tau fibrils. |
2018-08-08 |
2023-08-13 |
Not clear |
| Alice Kunzler, Eduardo Antônio Kolling, Jeferson Delgado da Silva, Juciano Gasparotto, Matheus Augusto de Bittencourt Pasquali, José Cláudio Fonseca Moreira, Daniel Pens Gelai. Retinol (Vitamin A) Increases α-Synuclein, β-Amyloid Peptide, Tau Phosphorylation and RAGE Content in Human SH-SY5Y Neuronal Cell Line. Neurochemical research. vol 42. issue 10. 2018-08-07. PMID:28497345. |
here we investigate the role of retinol supplementation to human neuron-derived sh-sy5y cells over rs production and biochemical markers associated to neurodegenerative diseases expressed at neuronal level in parkinson's disease and alzheimer's disease: α-synuclein, β-amyloid peptide, tau phosphorylation and rage. |
2018-08-07 |
2023-08-13 |
human |
| Francesca Rossi, Philippine C Geiszler, Weina Meng, Matthew R Barron, Malcolm Prior, Anna Herd-Smith, Andrea Loreto, Maria Yanez Lopez, Henryk Faas, Marie-Christine Pardon, Laura Confort. NAD-biosynthetic enzyme NMNAT1 reduces early behavioral impairment in the htau mouse model of tauopathy. Behavioural brain research. vol 339. 2018-08-07. PMID:29175372. |
here, we investigated whether modulating the expression of the nmnat nuclear isoform nmnat1, which is important for neuronal maintenance, influences the development of behavioral and neuropathological abnormalities in htau mice, which express non-mutant human tau isoforms and represent a model of tauopathy relevant to alzheimer's disease. |
2018-08-07 |
2023-08-13 |
mouse |
| Francesca Rossi, Philippine C Geiszler, Weina Meng, Matthew R Barron, Malcolm Prior, Anna Herd-Smith, Andrea Loreto, Maria Yanez Lopez, Henryk Faas, Marie-Christine Pardon, Laura Confort. NAD-biosynthetic enzyme NMNAT1 reduces early behavioral impairment in the htau mouse model of tauopathy. Behavioural brain research. vol 339. 2018-08-07. PMID:29175372. |
prior to the development of cognitive symptoms, htau mice exhibit tau hyperphosphorylation associated with a selective deficit in food burrowing, a behavior reminiscent to activities of daily living which are impaired early in alzheimer's disease. |
2018-08-07 |
2023-08-13 |
mouse |