| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chuan-Xi Mao, Xue Wen, Shan Jin, Yong Q Zhan. Increased acetylation of microtubules rescues human tau-induced microtubule defects and neuromuscular junction abnormalities in Disease models & mechanisms. vol 10. issue 10. 2018-07-18. PMID:28819043. |
increased acetylation of microtubules rescues human tau-induced microtubule defects and neuromuscular junction abnormalities in tau normally associates with and stabilizes microtubules (mts), but is hyperphosphorylated and aggregated into neurofibrillary tangles in alzheimer's disease and related neurodegenerative diseases, which are collectively known as tauopathies. |
2018-07-18 |
2023-08-13 |
human |
| Joyshree Biswas, Sonam Gupta, Dinesh Kumar Verma, Parul Gupta, Abhishek Singh, Shubhangini Tiwari, Poonam Goswami, Sharad Sharma, Sarika Sing. Involvement of glucose related energy crisis and endoplasmic reticulum stress: Insinuation of streptozotocin induced Alzheimer's like pathology. Cellular signalling. vol 42. 2018-07-18. PMID:29126976. |
the alzheimer's related pathological marker like acetylcholinesterase (ache) activity, tau phosphorylation and amyloid aggregation were observed after stz administration. |
2018-07-18 |
2023-08-13 |
rat |
| Jeremy A Elman, Matthew S Panizzon, Donald J Hagler, Lisa T Eyler, Eric L Granholm, Christine Fennema-Notestine, Michael J Lyons, Linda K McEvoy, Carol E Franz, Anders M Dale, William S Kreme. Task-evoked pupil dilation and BOLD variance as indicators of locus coeruleus dysfunction. Cortex; a journal devoted to the study of the nervous system and behavior. vol 97. 2018-07-17. PMID:29096196. |
the lc is an early site of abnormal tau deposition, which may contribute to key aspects of alzheimer's disease (ad) pathophysiology. |
2018-07-17 |
2023-08-13 |
Not clear |
| David T Jones, Jonathan Graff-Radford, Val J Lowe, Heather J Wiste, Jeffrey L Gunter, Matthew L Senjem, Hugo Botha, Kejal Kantarci, Bradley F Boeve, David S Knopman, Ronald C Petersen, Clifford R Jac. Tau, amyloid, and cascading network failure across the Alzheimer's disease spectrum. Cortex; a journal devoted to the study of the nervous system and behavior. vol 97. 2018-07-17. PMID:29102243. |
tau, amyloid, and cascading network failure across the alzheimer's disease spectrum. |
2018-07-17 |
2023-08-13 |
human |
| David T Jones, Jonathan Graff-Radford, Val J Lowe, Heather J Wiste, Jeffrey L Gunter, Matthew L Senjem, Hugo Botha, Kejal Kantarci, Bradley F Boeve, David S Knopman, Ronald C Petersen, Clifford R Jac. Tau, amyloid, and cascading network failure across the Alzheimer's disease spectrum. Cortex; a journal devoted to the study of the nervous system and behavior. vol 97. 2018-07-17. PMID:29102243. |
in a large cohort (n = 218) spanning the alzheimer's disease spectrum from young, amyloid negative, cognitively normal subjects to alzheimer's disease dementia, we found several distinct spatial patterns of tau deposition, including 'braak-like' and 'non-braak-like', across functionally related brain regions. |
2018-07-17 |
2023-08-13 |
human |
| David T Jones, Jonathan Graff-Radford, Val J Lowe, Heather J Wiste, Jeffrey L Gunter, Matthew L Senjem, Hugo Botha, Kejal Kantarci, Bradley F Boeve, David S Knopman, Ronald C Petersen, Clifford R Jac. Tau, amyloid, and cascading network failure across the Alzheimer's disease spectrum. Cortex; a journal devoted to the study of the nervous system and behavior. vol 97. 2018-07-17. PMID:29102243. |
as predicted by the cascading network failure model of alzheimer's disease, we found that amyloid is a partial mediator of the relationship between functional network failure and tau deposition in functionally connected brain regions. |
2018-07-17 |
2023-08-13 |
human |
| David T Jones, Jonathan Graff-Radford, Val J Lowe, Heather J Wiste, Jeffrey L Gunter, Matthew L Senjem, Hugo Botha, Kejal Kantarci, Bradley F Boeve, David S Knopman, Ronald C Petersen, Clifford R Jac. Tau, amyloid, and cascading network failure across the Alzheimer's disease spectrum. Cortex; a journal devoted to the study of the nervous system and behavior. vol 97. 2018-07-17. PMID:29102243. |
this study implicates large-scale brain networks in the pathophysiology of tau deposition and offers support to models incorporating large-scale network physiology into disease models linking tau and amyloid, such as the cascading network failure model of alzheimer's disease. |
2018-07-17 |
2023-08-13 |
human |
| Xiu-Yin Shen, Tao Luo, Sheng Li, Ou-Yang Ting, Feng He, Jie Xu, Hua-Qiao Wan. Quercetin inhibits okadaic acid-induced tau protein hyperphosphorylation through the Ca2+‑calpain‑p25‑CDK5 pathway in HT22 cells. International journal of molecular medicine. vol 41. issue 2. 2018-07-17. PMID:29207020. |
alzheimer's disease (ad) is a common neurodegenerative disorder characterized by aberrant tau protein hyperphosphorylation, which eventually leads to the formation of neurofibrillary tangles. |
2018-07-17 |
2023-08-13 |
Not clear |
| Yan-Hui Zhang, Da-Wei Wang, Shuang-Feng Xu, Shuai Zhang, Yong-Gang Fan, Ying-Ying Yang, Shi-Qi Guo, Shan Wang, Tian Guo, Zhan-You Wang, Chuang Gu. α-Lipoic acid improves abnormal behavior by mitigation of oxidative stress, inflammation, ferroptosis, and tauopathy in P301S Tau transgenic mice. Redox biology. vol 14. 2018-07-16. PMID:29126071. |
alzheimer's disease (ad) is the most common neurodegenerative disease and is characterized by neurofibrillary tangles (nfts) composed of tau protein. |
2018-07-16 |
2023-08-13 |
mouse |
| Cara L Croft, Brenda D Moore, Yong Ran, Paramita Chakrabarty, Yona Levites, Todd E Golde, Benoit I Giasso. Novel monoclonal antibodies targeting the microtubule-binding domain of human tau. PloS one. vol 13. issue 4. 2018-07-16. PMID:29608591. |
tauopathies including alzheimer's disease and progressive supranuclear palsy are a diverse group of progressive neurodegenerative disorders pathologically defined by inclusions containing aberrantly aggregated, post-translationally modified tau. |
2018-07-16 |
2023-08-13 |
mouse |
| Cara L Croft, Brenda D Moore, Yong Ran, Paramita Chakrabarty, Yona Levites, Todd E Golde, Benoit I Giasso. Novel monoclonal antibodies targeting the microtubule-binding domain of human tau. PloS one. vol 13. issue 4. 2018-07-16. PMID:29608591. |
these antibodies are highly specific for tau and recognize pathological tau inclusions in human tauopathies including alzheimer's disease and progressive supranuclear palsy and in transgenic mouse models of tauopathies. |
2018-07-16 |
2023-08-13 |
mouse |
| Colin M Huber, Connor Yee, Taylor May, Apoorva Dhanala, Cassie S Mitchel. Cognitive Decline in Preclinical Alzheimer's Disease: Amyloid-Beta versus Tauopathy. Journal of Alzheimer's disease : JAD. vol 61. issue 1. 2018-07-13. PMID:29154274. |
we perform a large-scale meta-analysis of 51 peer-reviewed 3xtg-ad mouse publications to compare alzheimer's disease (ad) quantitative clinical outcome measures, including amyloid-β (aβ), total tau, and phosphorylated tau (ptau), with cognitive performance in morris water maze (mwm) and novel object recognition (nor). |
2018-07-13 |
2023-08-13 |
mouse |
| Aviva M Tolkovsky, Jack Brelstaf. Sensory Neurons from Tau Transgenic Mice and Their Utility in Drug Screening. Methods in molecular biology (Clifton, N.J.). vol 1727. 2018-07-13. PMID:29222775. |
tau misfolding is a major cause of neurodegeneration, tauopathies being a growing group of diseases in which tau forms insoluble aggregates, best known in alzheimer disease as neurofibrillary tangles (nfts). |
2018-07-13 |
2023-08-13 |
mouse |
| Xiaoli Wu, Jayasankar Kosaraju, Kin Yip Ta. SLM, a novel carbazole-based fluorophore attenuates okadaic acid-induced tau hyperphosphorylation via down-regulating GSK-3β activity in SH-SY5Y cells. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 110. 2018-07-10. PMID:28359686. |
attenuating tau hyperphosphorylation is considered as an effective therapeutic approach for alzheimer's disease (ad). |
2018-07-10 |
2023-08-13 |
mouse |
| Kwang-Su Park, Mi Kyoung Kim, Yujin Seo, Taewoong Ha, Kyeongha Yoo, Seung Jae Hyeon, Yu Jin Hwang, Junghee Lee, Hoon Ryu, Hyunah Choo, Youhoon Chon. A Difluoroboron β-Diketonate Probe Shows "Turn-on" Near-Infrared Fluorescence Specific for Tau Fibrils. ACS chemical neuroscience. vol 8. issue 10. 2018-07-10. PMID:28737890. |
tau aggregation in neuronal cells has recently received significant attention as a robust predictor of the progression of alzheimer's disease (ad) because of its proven correlation with the degree of cognitive impairment in ad patients. |
2018-07-10 |
2023-08-13 |
human |
| Ioannis Sotiropoulos, Marie-Christine Galas, Joana M Silva, Efthimios Skoulakis, Susanne Wegmann, Mahmoud Bukar Maina, David Blum, Carmen Laura Sayas, Eva-Maria Mandelkow, Eckhard Mandelkow, Maria Grazia Spillantini, Nuno Sousa, Jesus Avila, Miguel Medina, Amrit Mudher, Luc Bue. Atypical, non-standard functions of the microtubule associated Tau protein. Acta neuropathologica communications. vol 5. issue 1. 2018-07-10. PMID:29187252. |
since the discovery of the microtubule-associated protein tau (mapt) over 40 years ago, most studies have focused on tau's role in microtubule stability and regulation, as well as on the neuropathological consequences of tau hyperphosphorylation and aggregation in alzheimer's disease (ad) brains. |
2018-07-10 |
2023-08-13 |
Not clear |
| Shruti Mishra, Brian A Gordon, Yi Su, Jon Christensen, Karl Friedrichsen, Kelley Jackson, Russ Hornbeck, David A Balota, Nigel J Cairns, John C Morris, Beau M Ances, Tammie L S Benzinge. AV-1451 PET imaging of tau pathology in preclinical Alzheimer disease: Defining a summary measure. NeuroImage. vol 161. 2018-07-09. PMID:28756238. |
av-1451 pet imaging of tau pathology in preclinical alzheimer disease: defining a summary measure. |
2018-07-09 |
2023-08-13 |
human |
| Shruti Mishra, Brian A Gordon, Yi Su, Jon Christensen, Karl Friedrichsen, Kelley Jackson, Russ Hornbeck, David A Balota, Nigel J Cairns, John C Morris, Beau M Ances, Tammie L S Benzinge. AV-1451 PET imaging of tau pathology in preclinical Alzheimer disease: Defining a summary measure. NeuroImage. vol 161. 2018-07-09. PMID:28756238. |
utilizing [18f]-av-1451 tau positron emission tomography (pet) as an alzheimer disease (ad) biomarker will require identification of brain regions that are most important in detecting elevated tau pathology in preclinical ad. |
2018-07-09 |
2023-08-13 |
human |
| Jonathan A Fauerbach, Thomas M Jovi. Pre-aggregation kinetics and intermediates of α-synuclein monitored by the ESIPT probe 7MFE. European biophysics journal : EBJ. vol 47. issue 4. 2018-07-06. PMID:29255947. |
the time course of amyloid conversion has been studied extensively in vitro with the proteins involved in the neurodegenerative pathology of parkinson's disease (α-synuclein), alzheimer's disease (tau) and huntington's disease (huntingtin). |
2018-07-06 |
2023-08-13 |
Not clear |
| Jean-Jacques Hauw, Stéphane Haik, Jean-Philippe Brande. History of Prions and transmission of protein misfolding. Bulletin de l'Academie nationale de medecine. vol 199. issue 6. 2018-07-03. PMID:29901879. |
in 1991, h. braak showed, in alzheimer's disease brain, the low spreading of neuropathological tau associated lesions along anatomic pathways. |
2018-07-03 |
2023-08-13 |
human |