All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Cecilia A Brunello, Xu Yan, Henri J Huttune. Internalized Tau sensitizes cells to stress by promoting formation and stability of stress granules. Scientific reports. vol 6. 2018-04-16. PMID:27460788. tau is a central pathological protein in alzheimer's disease and other tauopathies, and misfolded, aggregated tau is capable of propagating pathology via cell-to-cell transmission. 2018-04-16 2023-08-13 Not clear
William A McEwan, Benjamin Falcon, Marina Vaysburd, Dean Clift, Adrian L Oblak, Bernardino Ghetti, Michel Goedert, Leo C Jame. Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 3. 2018-04-16. PMID:28049840. alzheimer's disease (ad) and other neurodegenerative disorders are associated with the cytoplasmic aggregation of microtubule-associated protein tau. 2018-04-16 2023-08-13 Not clear
Mathieu Bourdenx, Nikolaos Stavros Koulakiotis, Despina Sanoudou, Erwan Bezard, Benjamin Dehay, Anthony Tsarbopoulo. Protein aggregation and neurodegeneration in prototypical neurodegenerative diseases: Examples of amyloidopathies, tauopathies and synucleinopathies. Progress in neurobiology. vol 155. 2018-04-11. PMID:26209472. in alzheimer's disease, β-amyloid peptide-containing plaques and intraneuronal neurofibrillary tangles composed of hyperphosphorylated microtubule-associated protein tau are the two main neuropathological lesions, while parkinson's disease is defined by the presence of lewy bodies that are intraneuronal proteinaceous cytoplasmic inclusions. 2018-04-11 2023-08-13 Not clear
Mathieu Bourdenx, Nikolaos Stavros Koulakiotis, Despina Sanoudou, Erwan Bezard, Benjamin Dehay, Anthony Tsarbopoulo. Protein aggregation and neurodegeneration in prototypical neurodegenerative diseases: Examples of amyloidopathies, tauopathies and synucleinopathies. Progress in neurobiology. vol 155. 2018-04-11. PMID:26209472. finally, we present the putative direct link between β-amyloid peptide and tau in causing toxicity in alzheimer's disease as well as α-synuclein in parkinson's disease, along with some of the most promising therapeutic strategies currently in development for those incurable neurodegenerative disorders. 2018-04-11 2023-08-13 Not clear
H Zetterber. Review: Tau in biofluids - relation to pathology, imaging and clinical features. Neuropathology and applied neurobiology. vol 43. issue 3. 2018-04-11. PMID:28054371. in alzheimer's disease (ad), neuroaxonal degeneration results in increased release of tau from neurons. 2018-04-11 2023-08-13 Not clear
Catarina Domingues, Odete A B da Cruz E Silva, Ana Gabriela Henrique. Impact of Cytokines and Chemokines on Alzheimer's Disease Neuropathological Hallmarks. Current Alzheimer research. vol 14. issue 8. 2018-04-11. PMID:28317487. alzheimer's disease (ad) is the most common neurodegenerative disorder, neuropathologically characterized by aggregates of β-amyloid peptides, which deposit as senile plaques, and of tau protein, which forms neurofibrillary tangles. 2018-04-11 2023-08-13 Not clear
Peter Verwilst, Hyeong Seok Kim, Soobin Kim, Chulhun Kang, Jong Seung Ki. Shedding light on tau protein aggregation: the progress in developing highly selective fluorophores. Chemical Society reviews. vol 47. issue 7. 2018-04-11. PMID:29484335. importantly, a handful of near-infrared-emissive dyes have been described as well, and some of these have exhibited good pharmacological profiles, with a significant blood-brain-barrier permeability, and a demonstrated ability to label tau tangles in vivo in small-animal models of alzheimer's disease and other tauopathies. 2018-04-11 2023-08-13 Not clear
Yen Ying Lim, Jason Hassenstab, Carlos Cruchaga, Alison Goate, Anne M Fagan, Tammie L S Benzinger, Paul Maruff, Peter J Snyder, Colin L Masters, Ricardo Allegri, Jasmeer Chhatwal, Martin R Farlow, Neill R Graff-Radford, Christoph Laske, Johannes Levin, Eric McDade, John M Ringman, Martin Rossor, Stephen Salloway, Peter R Schofield, David M Holtzman, John C Morris, Randall J Batema. BDNF Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer's disease. Brain : a journal of neurology. vol 139. issue Pt 10. 2018-04-10. PMID:27521573. bdnf val66met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant alzheimer's disease. 2018-04-10 2023-08-13 Not clear
Yen Ying Lim, Jason Hassenstab, Carlos Cruchaga, Alison Goate, Anne M Fagan, Tammie L S Benzinger, Paul Maruff, Peter J Snyder, Colin L Masters, Ricardo Allegri, Jasmeer Chhatwal, Martin R Farlow, Neill R Graff-Radford, Christoph Laske, Johannes Levin, Eric McDade, John M Ringman, Martin Rossor, Stephen Salloway, Peter R Schofield, David M Holtzman, John C Morris, Randall J Batema. BDNF Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer's disease. Brain : a journal of neurology. vol 139. issue Pt 10. 2018-04-10. PMID:27521573. we aimed to determine the effect of bdnf val66met on cognitive function, hippocampal function, tau and amyloid-β in preclinical autosomal dominant alzheimer's disease. 2018-04-10 2023-08-13 Not clear
Jennifer R Gatchel, Nancy J Donovan, Joseph J Locascio, Aaron P Schultz, J Alex Becker, Jasmeer Chhatwal, Kathryn V Papp, Rebecca E Amariglio, Dorene M Rentz, Deborah Blacker, Reisa A Sperling, Keith A Johnson, Gad A Marshal. Depressive Symptoms and Tau Accumulation in the Inferior Temporal Lobe and Entorhinal Cortex in Cognitively Normal Older Adults: A Pilot Study. Journal of Alzheimer's disease : JAD. vol 59. issue 3. 2018-04-10. PMID:28697559. these symptoms occur during preclinical and prodromal stages of alzheimer's disease (ad), but their relationship to tau, one of the main ad proteinopathies, is poorly understood. 2018-04-10 2023-08-13 Not clear
Gisela Esquerda-Canals, Joaquim Martí-Clúa, Alejandro R Roda, Sandra Villega. An Intracellular Amyloid-β/AβPP Epitope Correlates with Neurodegeneration in those Neuronal Populations Early Involved in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 59. issue 3. 2018-04-10. PMID:28697564. the main histopathological hallmarks of alzheimer's disease (ad) are the extracellular deposition of neuritic amyloid plaques, composed of amyloid-β (aβ) peptide, and the intracellular accumulation of neurofibrillary tangles, composed of hyperphosphorylated tau. 2018-04-10 2023-08-13 mouse
Anne-Brita Knapskog, Rannveig Sakshaug Eldholm, Anne Braekhus, Knut Engedal, Ingvild Saltved. Factors that influence the levels of cerebrospinal fluid biomarkers in memory clinic patients. BMC geriatrics. vol 17. issue 1. 2018-04-10. PMID:28893185. the cerebrospinal fluid (csf) biomarkers amyloid β (aβ), phospho tau (p-tau) and total tau (t-tau) are used increasingly to support a clinical diagnosis of alzheimer's disease. 2018-04-10 2023-08-13 Not clear
Keerthi Nadimidla, Tania Ismail, Mathumai Kanapathipilla. Tau peptides and tau mutant protein aggregation inhibition by cationic polyethyleneimine and polyarginine. Biopolymers. vol 107. issue 9. 2018-04-09. PMID:28456996. tau protein plays a major role in alzheimer's disease. 2018-04-09 2023-08-13 Not clear
Panagiota Mavroeidi, Olga Mavrofrydi, Elpiniki Pappa, Myrto Panopoulou, Panagiota Papazafiri, Sylva Haralambous, Spiros Efthimiopoulo. Oxygen and Glucose Deprivation Alter Synaptic Distribution of Tau Protein: The Role of Phosphorylation. Journal of Alzheimer's disease : JAD. vol 60. issue 2. 2018-04-09. PMID:28869464. alterations in tau synaptic distribution are considered to underlie synaptic dysfunction observed in alzheimer's disease (ad). 2018-04-09 2023-08-13 mouse
Asokan Prema, Arokiasamy Justin Thenmozhi, Thamilarasan Manivasagam, Musthafa Mohamed Essa, Gilles J Guillemi. Fenugreek Seed Powder Attenuated Aluminum Chloride-Induced Tau Pathology, Oxidative Stress, and Inflammation in a Rat Model of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 60. issue s1. 2018-04-06. PMID:28269780. fenugreek seed powder attenuated aluminum chloride-induced tau pathology, oxidative stress, and inflammation in a rat model of alzheimer's disease. 2018-04-06 2023-08-13 rat
Weiqi Bao, Hongmei Jia, Sjoerd Finnema, Zhengxin Cai, Richard E Carson, Yiyun Henry Huan. PET Imaging for Early Detection of Alzheimer's Disease: From Pathologic to Physiologic Biomarkers. PET clinics. vol 12. issue 3. 2018-04-06. PMID:28576171. this article describes the application of various pet imaging agents in the investigation and diagnosis of alzheimer's disease (ad), including radiotracers for pathologic biomarkers of ad such as β-amyloid deposits and tau protein aggregates, and the neuroinflammation biomarker 18 kda translocator protein, as well as physiologic biomarkers, such as cholinergic receptors, glucose metabolism, and the synaptic density biomarker synaptic vesicle glycoprotein 2a. 2018-04-06 2023-08-13 Not clear
Chenjie Xia, Bradford C Dickerso. Multimodal PET Imaging of Amyloid and Tau Pathology in Alzheimer Disease and Non-Alzheimer Disease Dementias. PET clinics. vol 12. issue 3. 2018-04-06. PMID:28576172. multimodal pet imaging of amyloid and tau pathology in alzheimer disease and non-alzheimer disease dementias. 2018-04-06 2023-08-13 Not clear
Michiaki Okuda, Yuki Fujita, Ichiro Hijikuro, Mei Wada, Takuya Uemura, Yukako Kobayashi, Tomonori Waku, Naoki Tanaka, Takaaki Nishimoto, Yasuhiko Izumi, Toshiaki Kume, Akinori Akaike, Takashi Takahashi, Hachiro Sugimot. PE859, A Novel Curcumin Derivative, Inhibits Amyloid-β and Tau Aggregation, and Ameliorates Cognitive Dysfunction in Senescence-Accelerated Mouse Prone 8. Journal of Alzheimer's disease : JAD. vol 59. issue 1. 2018-04-06. PMID:28598836. aggregation of amyloid-β (aβ) and tau plays a crucial role in the onset and progression of alzheimer's disease (ad). 2018-04-06 2023-08-13 mouse
Gerard Nuovo, Bernard Paniccia, Louisa Mezache, Maria Quiñónez, James Williams, Paige Vandiver, Paolo Fadda, Vicky Aman. Diagnostic pathology of Alzheimer's disease from routine microscopy to immunohistochemistry and experimental correlations. Annals of diagnostic pathology. vol 28. 2018-04-05. PMID:28648936. experimental evidence using neuronal cell cultures suggests that the affected neurons in alzheimer's disease may have undergone molecular changes that include accumulation of anti-apopotic proteins mcl1 and cflip that do not allow the cell to undergo programmed cell death but, rather, to "immortalize" and thus accumulate hyperphosphorylated tau protein in the neuronal cell body and beta amyloid in downstream dendrites. 2018-04-05 2023-08-13 Not clear
WeiYue Chen, Laurence J Young, Meng Lu, Alessio Zaccone, Florian Ströhl, Na Yu, Gabriele S Kaminski Schierle, Clemens F Kaminsk. Fluorescence Self-Quenching from Reporter Dyes Informs on the Structural Properties of Amyloid Clusters Formed in Vitro and in Cells. Nano letters. vol 17. issue 1. 2018-04-04. PMID:28073262. we investigate the mechanism and advantages of the lifetime sensor in studies of the k18 protein fragment of the alzheimer's disease related protein tau and its amyloid aggregates formed in vitro. 2018-04-04 2023-08-13 Not clear