| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jitendra Subhash Rane, Prasenjit Bhaumik, Dulal Pand. Curcumin Inhibits Tau Aggregation and Disintegrates Preformed Tau Filaments in vitro. Journal of Alzheimer's disease : JAD. vol 60. issue 3. 2018-05-30. PMID:28984591. |
the pathological aggregation of tau is a common feature of most of the neuronal disorders including frontotemporal dementia, parkinson's disease, and alzheimer's disease. |
2018-05-30 |
2023-08-13 |
Not clear |
| Mohammad Ejaz Ahmed, Shankar Iyer, Ramasamy Thangavel, Duraisamy Kempuraj, Govindhasamy Pushpavathi Selvakumar, Sudhanshu P Raikwar, Smita Zaheer, Asgar Zahee. Co-Localization of Glia Maturation Factor with NLRP3 Inflammasome and Autophagosome Markers in Human Alzheimer's Disease Brain. Journal of Alzheimer's disease : JAD. vol 60. issue 3. 2018-05-30. PMID:28984607. |
alzheimer's disease (ad) is a progressive neurodegenerative disease characterized by the presence of intracellular neurofibrillary tangles (nfts) containing hyperphosphorylated tau, and the extracellular deposition of amyloid plaques (aps) with misfolded amyloid-β (aβ) peptide. |
2018-05-30 |
2023-08-13 |
human |
| Esmat Fathi, Fatemeh Hedayati Katouli, Gholam Hossein Riazi, Marzieh Dehghan Shasaltaneh, Elham Parandavar, Samaneh Bayati, Ali Afrasiabi, Reza Nazar. The Effects of Alpha Boswellic Acid on Reelin Expression and Tau Phosphorylation in Human Astrocytes. Neuromolecular medicine. vol 19. issue 1. 2018-05-28. PMID:27567921. |
for this aim, we used streptozotocin (stz), in which from an outlook generates alzheimer's hallmarks in astrocytes, and assayed reelin expression, tau and akt phosphorylation as well as reactive oxygen species (ros) generation and apoptosis in the presences of aba. |
2018-05-28 |
2023-08-13 |
human |
| Anne Maass, Susan Landau, Suzanne L Baker, Andy Horng, Samuel N Lockhart, Renaud La Joie, Gil D Rabinovici, William J Jagus. Comparison of multiple tau-PET measures as biomarkers in aging and Alzheimer's disease. NeuroImage. vol 157. 2018-05-28. PMID:28587897. |
the recent development of tau-specific positron emission tomography (pet) tracers enables in vivo quantification of regional tau pathology, one of the key lesions in alzheimer's disease (ad). |
2018-05-28 |
2023-08-13 |
Not clear |
| Di Xia, Julia M Gutmann, Jürgen Göt. Mobility and subcellular localization of endogenous, gene-edited Tau differs from that of over-expressed human wild-type and P301L mutant Tau. Scientific reports. vol 6. 2018-05-25. PMID:27378256. |
alzheimer's disease (ad) and a subset of frontotemporal dementia termed ftld-tau are characterized by a massive, yet incompletely characterized and understood redistribution of tau. |
2018-05-25 |
2023-08-13 |
mouse |
| Zeyni Mansuroglu, Houda Benhelli-Mokrani, Vasco Marcato, Audrey Sultan, Marie Violet, Alban Chauderlier, Lucie Delattre, Anne Loyens, Smail Talahari, Séverine Bégard, Fabrice Nesslany, Morvane Colin, Sylvie Souès, Bruno Lefebvre, Luc Buée, Marie-Christine Galas, Eliette Bonnefo. Loss of Tau protein affects the structure, transcription and repair of neuronal pericentromeric heterochromatin. Scientific reports. vol 6. 2018-05-24. PMID:27605042. |
we demonstrate that tau, a protein involved in a number of neurodegenerative diseases including alzheimer's disease (ad), binds to and localizes within or next to neuronal pch in primary neuronal cultures from wild-type mice. |
2018-05-24 |
2023-08-13 |
mouse |
| Chao Wang, Michael E Ward, Robert Chen, Kai Liu, Tara E Tracy, Xu Chen, Min Xie, Peter Dongmin Sohn, Connor Ludwig, Anke Meyer-Franke, Celeste M Karch, Sheng Ding, Li Ga. Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening. Stem cell reports. vol 9. issue 4. 2018-05-24. PMID:28966121. |
lowering total tau levels is an attractive therapeutic strategy for alzheimer's disease and other tauopathies. |
2018-05-24 |
2023-08-13 |
human |
| Rostislav Skrabana, Branislav Kovacech, Peter Filipcik, Norbert Zilka, Santosh Jadhav, Tomas Smolek, Eva Kontsekova, Michal Nova. Neuronal Expression of Truncated Tau Efficiently Promotes Neurodegeneration in Animal Models: Pitfalls of Toxic Oligomer Analysis. Journal of Alzheimer's disease : JAD. vol 58. issue 4. 2018-05-22. PMID:28527208. |
our results underline the necessity of thiol-protecting conditions during the analysis of tau oligomers involved in the etiopathogenesis of various tauopathies including alzheimer's disease. |
2018-05-22 |
2023-08-13 |
mouse |
| Kacie D Deters, Shannon L Risacher, Sungeun Kim, Kwangsik Nho, John D West, Kaj Blennow, Henrik Zetterberg, Leslie M Shaw, John Q Trojanowski, Michael W Weiner, Andrew J Sayki. Plasma Tau Association with Brain Atrophy in Mild Cognitive Impairment and Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 58. issue 4. 2018-05-22. PMID:28550246. |
plasma tau association with brain atrophy in mild cognitive impairment and alzheimer's disease. |
2018-05-22 |
2023-08-13 |
Not clear |
| Kacie D Deters, Shannon L Risacher, Sungeun Kim, Kwangsik Nho, John D West, Kaj Blennow, Henrik Zetterberg, Leslie M Shaw, John Q Trojanowski, Michael W Weiner, Andrew J Sayki. Plasma Tau Association with Brain Atrophy in Mild Cognitive Impairment and Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 58. issue 4. 2018-05-22. PMID:28550246. |
peripheral (plasma) and central (cerebrospinal fluid, csf) measures of tau are higher in alzheimer's disease (ad) relative to prodromal stages and controls. |
2018-05-22 |
2023-08-13 |
Not clear |
| Rubén Corpas, Susana Revilla, Suzanna Ursulet, Marco Castro-Freire, Perla Kaliman, Valérie Petegnief, Lydia Giménez-Llort, Chamsy Sarkis, Mercè Pallàs, Coral Sanfeli. SIRT1 Overexpression in Mouse Hippocampus Induces Cognitive Enhancement Through Proteostatic and Neurotrophic Mechanisms. Molecular neurobiology. vol 54. issue 7. 2018-05-18. PMID:27614878. |
sirt1 induces cell survival and has shown neuroprotection against amyloid and tau pathologies in alzheimer's disease (ad). |
2018-05-18 |
2023-08-13 |
mouse |
| Jennifer N Perusini, Stephanie A Cajigas, Omid Cohensedgh, Sean C Lim, Ina P Pavlova, Zoe R Donaldson, Christine A Denn. Optogenetic stimulation of dentate gyrus engrams restores memory in Alzheimer's disease mice. Hippocampus. vol 27. issue 10. 2018-05-18. PMID:28667669. |
alzheimer's disease (ad) is a prevalent neurodegenerative disorder characterized by amyloid-beta (aβ) plaques and tau neurofibrillary tangles. |
2018-05-18 |
2023-08-13 |
mouse |
| Hayk Davtyan, Karen Zagorski, Harinda Rajapaksha, Armine Hovakimyan, Arpine Davtyan, Irina Petrushina, Konstantin Kazarian, David H Cribbs, Nikolai Petrovsky, Michael G Agadjanyan, Anahit Ghochikya. Alzheimer's disease Advax(CpG)- adjuvanted MultiTEP-based dual and single vaccines induce high-titer antibodies against various forms of tau and Aβ pathological molecules. Scientific reports. vol 6. 2018-05-15. PMID:27363809. |
alzheimer's disease advax(cpg)- adjuvanted multitep-based dual and single vaccines induce high-titer antibodies against various forms of tau and aβ pathological molecules. |
2018-05-15 |
2023-08-13 |
mouse |
| Hayk Davtyan, Karen Zagorski, Harinda Rajapaksha, Armine Hovakimyan, Arpine Davtyan, Irina Petrushina, Konstantin Kazarian, David H Cribbs, Nikolai Petrovsky, Michael G Agadjanyan, Anahit Ghochikya. Alzheimer's disease Advax(CpG)- adjuvanted MultiTEP-based dual and single vaccines induce high-titer antibodies against various forms of tau and Aβ pathological molecules. Scientific reports. vol 6. 2018-05-15. PMID:27363809. |
although β-amyloid (aβ) may be the primary driver of alzheimer's disease (ad) pathology, accumulation of pathological tau correlates with dementia in ad patients. |
2018-05-15 |
2023-08-13 |
mouse |
| Jie-Zhong Yu, Yan-Hua Li, Chun-Yun Liu, Qing Wang, Qing-Fang Gu, Hui-Qing Wang, Guang-Xian Zhang, Bao-Guo Xiao, Cun-Gen M. Multitarget Therapeutic Effect of Fasudil in APP/PS1transgenic Mice. CNS & neurological disorders drug targets. vol 16. issue 2. 2018-05-15. PMID:27401064. |
therapeutic strategies targeting alzheimer's disease-related molecule β- amyloid (aβ), tau protein and β-site amyloid precursor protein cleaving enzyme (bace) have been recently explored. |
2018-05-15 |
2023-08-13 |
mouse |
| Patrick Reilly, Charisse N Winston, Kelsey R Baron, Margarita Trejo, Edward M Rockenstein, Johnny C Akers, Najla Kfoury, Marc Diamond, Eliezer Masliah, Robert A Rissman, Shauna H Yua. Novel human neuronal tau model exhibiting neurofibrillary tangles and transcellular propagation. Neurobiology of disease. vol 106. 2018-05-15. PMID:28610892. |
tauopathies are a class of neurodegenerative diseases, including alzheimer's disease, frontotemporal dementia and progressive supranuclear palsy, which are associated with the pathological aggregation of tau protein into neurofibrillary tangles (nft). |
2018-05-15 |
2023-08-13 |
mouse |
| Joery Goossens, Maria Bjerke, Hanne Struyfs, Ellis Niemantsverdriet, Charisse Somers, Tobi Van den Bossche, Sara Van Mossevelde, Bart De Vil, Anne Sieben, Jean-Jacques Martin, Patrick Cras, Johan Goeman, Peter Paul De Deyn, Christine Van Broeckhoven, Julie van der Zee, Sebastiaan Engelborgh. No added diagnostic value of non-phosphorylated tau fraction (p-tau Alzheimer's research & therapy. vol 9. issue 1. 2018-05-15. PMID:28709448. |
no added diagnostic value of non-phosphorylated tau fraction (p-tau the alzheimer's disease (ad) cerebrospinal fluid (csf) biomarkers aβ |
2018-05-15 |
2023-08-13 |
Not clear |
| Mu-Han Li, Jing Zhang, Run-Qing Zhao, Xian-Zhe Dong, Yuan Hu, Ting Chen, Jie Li, Li Liu, Ping Li. [Effect of six class of Kaixin San formulas on pharmacological and preliminary mechanism of Alzheimer's disease mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 41. issue 7. 2018-05-15. PMID:28879742. |
kunming mice were selected and established a mouse model of alzheimer's by intraperitoneal injection of d-galactose and sodium nitrite, continued intragastric 4 weeks, using the ability of learning and memory in morris water maze test to evaluate the animals in each group; the content of bdnf in the hippocampus of mice with western blotting detected; elisa method for the detection of each group of mice hippocampal tau protein,p-tau protein, aβ,ach,ache and serum nt-probnp levels. |
2018-05-15 |
2023-08-13 |
mouse |
| Christian Humpe. Platelets: Their Potential Contribution to the Generation of Beta-amyloid Plaques in Alzheimer's Disease. Current neurovascular research. vol 14. issue 3. 2018-05-14. PMID:28677497. |
alzheimer's disease is a severe neurodegenerative brain disorder, showing severe beta-amyloid depositions in the brain (plaques) and in vessels (cerebral amyloid angiopathy, caa), tau pathology, neurodegeneration (and loss of acetylcholine), inflammation with reactive astrocytes and microglia and cerebrovascular damage, all resulting in memory loss. |
2018-05-14 |
2023-08-13 |
Not clear |
| Stephen D Skaper, Laura Facci, Morena Zusso, Pietro Giust. Synaptic Plasticity, Dementia and Alzheimer Disease. CNS & neurological disorders drug targets. vol 16. issue 3. 2018-05-11. PMID:28088900. |
consider the aging-dependent neurodegenerative disorder alzheimer's disease (ad) which is characterised at the neuropathological level by deposits of insoluble amyloid β-peptide (aβ) in extracellular plaques and aggregated tau protein, which is found largely in the intracellular neurofibrillary tangles. |
2018-05-11 |
2023-08-13 |
human |