| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Adriana Ferreira, Sana Afree. Methods related to studying tau fragmentation. Methods in cell biology. vol 141. 2018-06-01. PMID:28882305. |
among them, tau fragmentation has been identified not only in brain samples obtained from alzheimer's disease (ad) and related disorder subjects but also in ad culture and animal models. |
2018-06-01 |
2023-08-13 |
human |
| Sneha Narasimhan, Virginia M Y Le. The use of mouse models to study cell-to-cell transmission of pathological tau. Methods in cell biology. vol 141. 2018-06-01. PMID:28882308. |
here, we present our method for developing a sporadic tauopathy model using pathological tau extracted from human alzheimer's disease (ad) brains. |
2018-06-01 |
2023-08-13 |
mouse |
| Susanne Wegmann, Rachel E Bennett, Ana S Amaral, Bradley T Hyma. Studying tau protein propagation and pathology in the mouse brain using adeno-associated viruses. Methods in cell biology. vol 141. 2018-06-01. PMID:28882310. |
the progressive spread of pathological brain lesions containing aggregated tau protein is a hallmark of alzheimer's disease and other neurodegenerative diseases. |
2018-06-01 |
2023-08-13 |
mouse |
| Yann Fichou, Neil A Eschmann, Timothy J Keller, Songi Ha. Conformation-based assay of tau protein aggregation. Methods in cell biology. vol 141. 2018-06-01. PMID:28882313. |
there is a significant interest in the study of tau protein aggregation mechanisms, given the direct correlation between the deposit of β-sheet structured neurofibrillary tangles made of tau and pathology in several neurodegenerative diseases, including alzheimer's disease. |
2018-06-01 |
2023-08-13 |
Not clear |
| W Ted Allison, Michèle G DuVal, Kim Nguyen-Phuoc, Patricia L A Leighto. Reduced Abundance and Subverted Functions of Proteins in Prion-Like Diseases: Gained Functions Fascinate but Lost Functions Affect Aetiology. International journal of molecular sciences. vol 18. issue 10. 2018-06-01. PMID:29064456. |
thus, key proteins in alzheimer disease and amyotrophic lateral sclerosis (als), including amyloid-β precursor protein, tau and superoxide dismutase 1 (sod1), spread to adjacent cells in their misfolded aggregated forms and exhibit template-directed misfolding to induce further misfolding, disruptions to proteostasis and toxicity. |
2018-06-01 |
2023-08-13 |
Not clear |
| Syed Waseem Bihaqi, Aseel Eid, Nasser H Zawi. Lead exposure and tau hyperphosphorylation: An in vitro study. Neurotoxicology. vol 62. 2018-05-30. PMID:28765091. |
the presence of fibrillary lesions, which are mainly composed of the microtubule associated protein tau (mapt) in neurons, has gained immense recognition due to their presence in numerous neurodegenerative diseases, including alzheimer's disease (ad). |
2018-05-30 |
2023-08-13 |
human |
| Jitendra Subhash Rane, Prasenjit Bhaumik, Dulal Pand. Curcumin Inhibits Tau Aggregation and Disintegrates Preformed Tau Filaments in vitro. Journal of Alzheimer's disease : JAD. vol 60. issue 3. 2018-05-30. PMID:28984591. |
the pathological aggregation of tau is a common feature of most of the neuronal disorders including frontotemporal dementia, parkinson's disease, and alzheimer's disease. |
2018-05-30 |
2023-08-13 |
Not clear |
| Mohammad Ejaz Ahmed, Shankar Iyer, Ramasamy Thangavel, Duraisamy Kempuraj, Govindhasamy Pushpavathi Selvakumar, Sudhanshu P Raikwar, Smita Zaheer, Asgar Zahee. Co-Localization of Glia Maturation Factor with NLRP3 Inflammasome and Autophagosome Markers in Human Alzheimer's Disease Brain. Journal of Alzheimer's disease : JAD. vol 60. issue 3. 2018-05-30. PMID:28984607. |
alzheimer's disease (ad) is a progressive neurodegenerative disease characterized by the presence of intracellular neurofibrillary tangles (nfts) containing hyperphosphorylated tau, and the extracellular deposition of amyloid plaques (aps) with misfolded amyloid-β (aβ) peptide. |
2018-05-30 |
2023-08-13 |
human |
| Esmat Fathi, Fatemeh Hedayati Katouli, Gholam Hossein Riazi, Marzieh Dehghan Shasaltaneh, Elham Parandavar, Samaneh Bayati, Ali Afrasiabi, Reza Nazar. The Effects of Alpha Boswellic Acid on Reelin Expression and Tau Phosphorylation in Human Astrocytes. Neuromolecular medicine. vol 19. issue 1. 2018-05-28. PMID:27567921. |
for this aim, we used streptozotocin (stz), in which from an outlook generates alzheimer's hallmarks in astrocytes, and assayed reelin expression, tau and akt phosphorylation as well as reactive oxygen species (ros) generation and apoptosis in the presences of aba. |
2018-05-28 |
2023-08-13 |
human |
| Anne Maass, Susan Landau, Suzanne L Baker, Andy Horng, Samuel N Lockhart, Renaud La Joie, Gil D Rabinovici, William J Jagus. Comparison of multiple tau-PET measures as biomarkers in aging and Alzheimer's disease. NeuroImage. vol 157. 2018-05-28. PMID:28587897. |
the recent development of tau-specific positron emission tomography (pet) tracers enables in vivo quantification of regional tau pathology, one of the key lesions in alzheimer's disease (ad). |
2018-05-28 |
2023-08-13 |
Not clear |
| Di Xia, Julia M Gutmann, Jürgen Göt. Mobility and subcellular localization of endogenous, gene-edited Tau differs from that of over-expressed human wild-type and P301L mutant Tau. Scientific reports. vol 6. 2018-05-25. PMID:27378256. |
alzheimer's disease (ad) and a subset of frontotemporal dementia termed ftld-tau are characterized by a massive, yet incompletely characterized and understood redistribution of tau. |
2018-05-25 |
2023-08-13 |
mouse |
| Zeyni Mansuroglu, Houda Benhelli-Mokrani, Vasco Marcato, Audrey Sultan, Marie Violet, Alban Chauderlier, Lucie Delattre, Anne Loyens, Smail Talahari, Séverine Bégard, Fabrice Nesslany, Morvane Colin, Sylvie Souès, Bruno Lefebvre, Luc Buée, Marie-Christine Galas, Eliette Bonnefo. Loss of Tau protein affects the structure, transcription and repair of neuronal pericentromeric heterochromatin. Scientific reports. vol 6. 2018-05-24. PMID:27605042. |
we demonstrate that tau, a protein involved in a number of neurodegenerative diseases including alzheimer's disease (ad), binds to and localizes within or next to neuronal pch in primary neuronal cultures from wild-type mice. |
2018-05-24 |
2023-08-13 |
mouse |
| Chao Wang, Michael E Ward, Robert Chen, Kai Liu, Tara E Tracy, Xu Chen, Min Xie, Peter Dongmin Sohn, Connor Ludwig, Anke Meyer-Franke, Celeste M Karch, Sheng Ding, Li Ga. Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening. Stem cell reports. vol 9. issue 4. 2018-05-24. PMID:28966121. |
lowering total tau levels is an attractive therapeutic strategy for alzheimer's disease and other tauopathies. |
2018-05-24 |
2023-08-13 |
human |
| Rostislav Skrabana, Branislav Kovacech, Peter Filipcik, Norbert Zilka, Santosh Jadhav, Tomas Smolek, Eva Kontsekova, Michal Nova. Neuronal Expression of Truncated Tau Efficiently Promotes Neurodegeneration in Animal Models: Pitfalls of Toxic Oligomer Analysis. Journal of Alzheimer's disease : JAD. vol 58. issue 4. 2018-05-22. PMID:28527208. |
our results underline the necessity of thiol-protecting conditions during the analysis of tau oligomers involved in the etiopathogenesis of various tauopathies including alzheimer's disease. |
2018-05-22 |
2023-08-13 |
mouse |
| Kacie D Deters, Shannon L Risacher, Sungeun Kim, Kwangsik Nho, John D West, Kaj Blennow, Henrik Zetterberg, Leslie M Shaw, John Q Trojanowski, Michael W Weiner, Andrew J Sayki. Plasma Tau Association with Brain Atrophy in Mild Cognitive Impairment and Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 58. issue 4. 2018-05-22. PMID:28550246. |
plasma tau association with brain atrophy in mild cognitive impairment and alzheimer's disease. |
2018-05-22 |
2023-08-13 |
Not clear |
| Kacie D Deters, Shannon L Risacher, Sungeun Kim, Kwangsik Nho, John D West, Kaj Blennow, Henrik Zetterberg, Leslie M Shaw, John Q Trojanowski, Michael W Weiner, Andrew J Sayki. Plasma Tau Association with Brain Atrophy in Mild Cognitive Impairment and Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 58. issue 4. 2018-05-22. PMID:28550246. |
peripheral (plasma) and central (cerebrospinal fluid, csf) measures of tau are higher in alzheimer's disease (ad) relative to prodromal stages and controls. |
2018-05-22 |
2023-08-13 |
Not clear |
| Rubén Corpas, Susana Revilla, Suzanna Ursulet, Marco Castro-Freire, Perla Kaliman, Valérie Petegnief, Lydia Giménez-Llort, Chamsy Sarkis, Mercè Pallàs, Coral Sanfeli. SIRT1 Overexpression in Mouse Hippocampus Induces Cognitive Enhancement Through Proteostatic and Neurotrophic Mechanisms. Molecular neurobiology. vol 54. issue 7. 2018-05-18. PMID:27614878. |
sirt1 induces cell survival and has shown neuroprotection against amyloid and tau pathologies in alzheimer's disease (ad). |
2018-05-18 |
2023-08-13 |
mouse |
| Jennifer N Perusini, Stephanie A Cajigas, Omid Cohensedgh, Sean C Lim, Ina P Pavlova, Zoe R Donaldson, Christine A Denn. Optogenetic stimulation of dentate gyrus engrams restores memory in Alzheimer's disease mice. Hippocampus. vol 27. issue 10. 2018-05-18. PMID:28667669. |
alzheimer's disease (ad) is a prevalent neurodegenerative disorder characterized by amyloid-beta (aβ) plaques and tau neurofibrillary tangles. |
2018-05-18 |
2023-08-13 |
mouse |
| Hayk Davtyan, Karen Zagorski, Harinda Rajapaksha, Armine Hovakimyan, Arpine Davtyan, Irina Petrushina, Konstantin Kazarian, David H Cribbs, Nikolai Petrovsky, Michael G Agadjanyan, Anahit Ghochikya. Alzheimer's disease Advax(CpG)- adjuvanted MultiTEP-based dual and single vaccines induce high-titer antibodies against various forms of tau and Aβ pathological molecules. Scientific reports. vol 6. 2018-05-15. PMID:27363809. |
alzheimer's disease advax(cpg)- adjuvanted multitep-based dual and single vaccines induce high-titer antibodies against various forms of tau and aβ pathological molecules. |
2018-05-15 |
2023-08-13 |
mouse |
| Hayk Davtyan, Karen Zagorski, Harinda Rajapaksha, Armine Hovakimyan, Arpine Davtyan, Irina Petrushina, Konstantin Kazarian, David H Cribbs, Nikolai Petrovsky, Michael G Agadjanyan, Anahit Ghochikya. Alzheimer's disease Advax(CpG)- adjuvanted MultiTEP-based dual and single vaccines induce high-titer antibodies against various forms of tau and Aβ pathological molecules. Scientific reports. vol 6. 2018-05-15. PMID:27363809. |
although β-amyloid (aβ) may be the primary driver of alzheimer's disease (ad) pathology, accumulation of pathological tau correlates with dementia in ad patients. |
2018-05-15 |
2023-08-13 |
mouse |