All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Rachel H L H Rueli, Daniel J Torres, Andrea S T Dewing, Arlene C Kiyohara, Stephanie M Barayuga, Miyoko T Bellinger, Jane H Uyehara-Lock, Lon R White, Paula I Moreira, Marla J Berry, George Perry, Frederick P Bellinge. Selenoprotein S Reduces Endoplasmic Reticulum Stress-Induced Phosphorylation of Tau: Potential Role in Selenate Mitigation of Tau Pathology. Journal of Alzheimer's disease : JAD. vol 55. issue 2. 2018-02-22. PMID:27802219. these results indicate that selenate can alter phosphorylation of tau by increasing expression of sels in alzheimer's disease and potentially other neurodegenerative disorders. 2018-02-22 2023-08-13 human
Julian Dronse, Klaus Fliessbach, Gérard N Bischof, Boris von Reutern, Jennifer Faber, Jochen Hammes, Georg Kuhnert, Bernd Neumaier, Oezguer A Onur, Juraj Kukolja, Thilo van Eimeren, Frank Jessen, Gereon R Fink, Thomas Klockgether, Alexander Drzezg. In vivo Patterns of Tau Pathology, Amyloid-β Burden, and Neuronal Dysfunction in Clinical Variants of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 55. issue 2. 2018-02-22. PMID:27802224. in vivo patterns of tau pathology, amyloid-β burden, and neuronal dysfunction in clinical variants of alzheimer's disease. 2018-02-22 2023-08-13 Not clear
Julian Dronse, Klaus Fliessbach, Gérard N Bischof, Boris von Reutern, Jennifer Faber, Jochen Hammes, Georg Kuhnert, Bernd Neumaier, Oezguer A Onur, Juraj Kukolja, Thilo van Eimeren, Frank Jessen, Gereon R Fink, Thomas Klockgether, Alexander Drzezg. In vivo Patterns of Tau Pathology, Amyloid-β Burden, and Neuronal Dysfunction in Clinical Variants of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 55. issue 2. 2018-02-22. PMID:27802224. we assessed the relationship between clinical symptoms, in vivo tau pathology, amyloid distribution, and hypometabolism in variants of alzheimer's disease using novel multimodal pet imaging techniques. 2018-02-22 2023-08-13 Not clear
Julian Dronse, Klaus Fliessbach, Gérard N Bischof, Boris von Reutern, Jennifer Faber, Jochen Hammes, Georg Kuhnert, Bernd Neumaier, Oezguer A Onur, Juraj Kukolja, Thilo van Eimeren, Frank Jessen, Gereon R Fink, Thomas Klockgether, Alexander Drzezg. In vivo Patterns of Tau Pathology, Amyloid-β Burden, and Neuronal Dysfunction in Clinical Variants of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 55. issue 2. 2018-02-22. PMID:27802224. tau pet imaging may thus serve as a valuable biomarker for the localization of neuronal injury in vivo and may help to validate atypical subtypes of alzheimer's disease. 2018-02-22 2023-08-13 Not clear
Jennifer M Walker, Shilpy Dixit, Anjelica C Saulsberry, James M May, Fiona E Harriso. Reversal of high fat diet-induced obesity improves glucose tolerance, inflammatory response, β-amyloid accumulation and cognitive decline in the APP/PSEN1 mouse model of Alzheimer's disease. Neurobiology of disease. vol 100. 2018-02-22. PMID:28108292. insoluble β-amyloid levels, and extent of tau phosphorylation were also lower following dietary reversal in app/psen1 mice compared to high fat-fed animals, indicating that the inflammatory response may have contributed to key pathogenic pathways in the alzheimer's disease model. 2018-02-22 2023-08-13 mouse
Yuxue Chen, Lu Liu, Mengzhu Li, Ensheng Yao, Jiahuan Hao, Yuanji Dong, Xiaolong Zheng, Xinghua Li. Expression of human Tau40 in the medial entorhinal cortex impairs synaptic plasticity and associated cognitive functions in mice. Biochemical and biophysical research communications. vol 496. issue 3. 2018-02-22. PMID:28472625. entorhinal cortex (ec) is the initial brain region that suffers abnormal tau in alzheimer's disease (ad). 2018-02-22 2023-08-13 mouse
Alejandro Antón-Fernández, Guillermo Aparicio-Torres, Silvia Tapia, Javier DeFelipe, Alberto Muño. Morphometric alterations of Golgi apparatus in Alzheimer's disease are related to tau hyperphosphorylation. Neurobiology of disease. vol 97. issue Pt A. 2018-02-21. PMID:27793637. morphometric alterations of golgi apparatus in alzheimer's disease are related to tau hyperphosphorylation. 2018-02-21 2023-08-13 Not clear
Tian-Syuan Lin, Han-Jung Tsai, Chih-Han Lee, Yan-Qing Song, Rih-Sheng Huang, Hsiu-Mei Hsieh-Li, Mei-Chih Liang, Yenshou Li. An Improved Drugs Screening System Reveals that Baicalein Ameliorates the Aβ/AMPA/NMDA-Induced Depolarization of Neurons. Journal of Alzheimer's disease : JAD. vol 56. issue 3. 2018-02-21. PMID:28106556. the presence of amyloid-β (aβ) plaque and tau protein hyperphosphorylation in brain tissue is the pathological hallmark of alzheimer's disease (ad). 2018-02-21 2023-08-13 mouse
Dorene M Rentz, Elizabeth C Mormino, Kathryn V Papp, Rebecca A Betensky, Reisa A Sperling, Keith A Johnso. Cognitive resilience in clinical and preclinical Alzheimer's disease: the Association of Amyloid and Tau Burden on cognitive performance. Brain imaging and behavior. vol 11. issue 2. 2018-02-20. PMID:27738998. cognitive resilience in clinical and preclinical alzheimer's disease: the association of amyloid and tau burden on cognitive performance. 2018-02-20 2023-08-13 human
Jesus Mendiola-Precoma, Karla Padilla, Alfredo Rodríguez-Cruz, Laura C Berumen, Ricardo Miledi, Guadalupe García-Alcoce. Theobromine-Induced Changes in A1 Purinergic Receptor Gene Expression and Distribution in a Rat Brain Alzheimer's Disease Model. Journal of Alzheimer's disease : JAD. vol 55. issue 3. 2018-02-20. PMID:27792010. dementia caused by alzheimer's disease (ad) is mainly characterized by accumulation in the brain of extra- and intraneuronal amyloid-β (aβ) and tau proteins, respectively, which selectively affect specific regions, particularly the neocortex and the hippocampus. 2018-02-20 2023-08-13 rat
Tiina Laiterä, Jussi Paananen, Seppo Helisalmi, Timo Sarajärvi, Joel Huovinen, Marjo Laitinen, Tuomas Rauramaa, Irina Alafuzoff, Anne M Remes, Hilkka Soininen, Annakaisa Haapasalo, Juha E Jääskeläinen, Ville Leinonen, Mikko Hiltune. Effects of Alzheimer's Disease-Associated Risk Loci on Amyloid-β Accumulation in the Brain of Idiopathic Normal Pressure Hydrocephalus Patients. Journal of Alzheimer's disease : JAD. vol 55. issue 3. 2018-02-20. PMID:27802227. in alzheimer's disease (ad) patients, diffuse aggregates of amyloid-β (aβ) and neurofibrillary hyperphosphorylated tau are detected in the neocortex of the brain, while similar accumulation of aβ is also detected in inph. 2018-02-20 2023-08-13 Not clear
Nicola Voyle, Hamel Patel, Amos Folarin, Stephen Newhouse, Caroline Johnston, Pieter Jelle Visser, Richard J B Dobson, Steven J Kiddl. Genetic Risk as a Marker of Amyloid-β and Tau Burden in Cerebrospinal Fluid. Journal of Alzheimer's disease : JAD. vol 55. issue 4. 2018-02-20. PMID:27834776. the search for a biomarker of alzheimer's disease (ad) pathology (amyloid-β (aβ) and tau) is ongoing, with the best markers currently being measurements of aβ and tau in cerebrospinal fluid (csf) and via positron emission tomography (pet) scanning. 2018-02-20 2023-08-13 Not clear
Samir Abu Rumeileh, Francesca Lattanzio, Michelangelo Stanzani Maserati, Romana Rizzi, Sabina Capellari, Piero Parch. Diagnostic Accuracy of a Combined Analysis of Cerebrospinal Fluid t-PrP, t-tau, p-tau, and Aβ42 in the Differential Diagnosis of Creutzfeldt-Jakob Disease from Alzheimer's Disease with Emphasis on Atypical Disease Variants. Journal of Alzheimer's disease : JAD. vol 55. issue 4. 2018-02-20. PMID:27886009. according to recent studies, the determination of cerebrospinal fluid (csf) total tau (t-tau)/phosphorylated tau (p-tau) ratio and total prion protein (t-prp) levels significantly improves the accuracy of the diagnosis of alzheimer's disease (ad) in atypical cases with clinical or laboratory features mimicking creutzfeldt-jakob disease (cjd). 2018-02-20 2023-08-13 Not clear
Andrea Slachevsky, Leonardo Guzmán-Martínez, Carolina Delgado, Pablo Reyes, Gonzalo A Farías, Carlos Muñoz-Neira, Eduardo Bravo, Mauricio Farías, Patricia Flores, Cristian Garrido, James T Becker, Oscar L López, Ricardo B Maccion. Tau Platelets Correlate with Regional Brain Atrophy in Patients with Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 55. issue 4. 2018-02-20. PMID:27911301. intracellular neurofibrillary tangles are part of the core pathology of alzheimer's disease (ad), which are mainly composed of hyperphosphorylated tau protein. 2018-02-20 2023-08-13 Not clear
İrem Lütfiye Atasoy, Erdinç Dursun, Duygu Gezen-Ak, Derya Metin-Armağan, Melek Öztürk, Selma Yılmaze. Both secreted and the cellular levels of BDNF attenuated due to tau hyperphosphorylation in primary cultures of cortical neurons. Journal of chemical neuroanatomy. vol 80. 2018-02-20. PMID:27914953. intracellular aggregation of hyperphosphorylated tau in neurofibrillary tangles (nfts) is a major neuropathological hallmark of taupathies such as alzheimer's disease. 2018-02-20 2023-08-13 Not clear
Jingdun Xie, Haitao Wang, Ting Lin, Bingtian B. Microglia-Synapse Pathways: Promising Therapeutic Strategy for Alzheimer's Disease. BioMed research international. vol 2017. 2018-02-16. PMID:28473983. the main hallmarks of alzheimer's disease (ad) are extracellular deposits of amyloid plaques and intracellular accumulation of hyperphosphorylated neurofibrillary tangles (tau). 2018-02-16 2023-08-13 Not clear
Claire L Russell, Vikram Mitra, Karl Hansson, Kaj Blennow, Johan Gobom, Henrik Zetterberg, Mikko Hiltunen, Malcolm Ward, Ian Pik. Comprehensive Quantitative Profiling of Tau and Phosphorylated Tau Peptides in Cerebrospinal Fluid by Mass Spectrometry Provides New Biomarker Candidates. Journal of Alzheimer's disease : JAD. vol 55. issue 1. 2018-02-15. PMID:27636850. aberrant tau phosphorylation is a hallmark in alzheimer's disease (ad), believed to promote formation of paired helical filaments, the main constituent of neurofibrillary tangles in the brain. 2018-02-15 2023-08-13 human
Piotr Lewczuk, Natalia Lelental, Ingolf Lachmann, Max Holzer, Katharina Flach, Sebastian Brandner, Sebastiaan Engelborghs, Charlotte E Teunissen, Henrik Zetterberg, José Luis Molinuevo, Barbara Mroczko, Kaj Blennow, Julius Popp, Lucilla Parnetti, Davide Chiasserini, Armand Perret-Liaudet, Philipp Spitzer, Juan Manuel Maler, Johannes Kornhube. Non-Phosphorylated Tau as a Potential Biomarker of Alzheimer's Disease: Analytical and Diagnostic Characterization. Journal of Alzheimer's disease : JAD. vol 55. issue 1. 2018-02-15. PMID:27662295. non-phosphorylated tau as a potential biomarker of alzheimer's disease: analytical and diagnostic characterization. 2018-02-15 2023-08-13 Not clear
Bettina Maria Foidl, Patricia Do-Dinh, Bianca Hutter-Schmid, Harald R Bliem, Christian Humpe. Cholinergic neurodegeneration in an Alzheimer mouse model overexpressing amyloid-precursor protein with the Swedish-Dutch-Iowa mutations. Neurobiology of learning and memory. vol 136. 2018-02-15. PMID:27670619. alzheimer's disease (ad) is a chronic neurodegenerative disorder that is mainly characterized by beta-amyloid (aβ) plaque deposition, tau pathology and dysfunction of the cholinergic system causing memory impairment. 2018-02-15 2023-08-13 mouse
Chandra Sekhar Kuruva, P Hemachandra Redd. Amyloid beta modulators and neuroprotection in Alzheimer's disease: a critical appraisal. Drug discovery today. vol 22. issue 2. 2018-02-15. PMID:27794478. multiple cellular changes have been identified as being involved in alzheimer's disease (ad) pathogenesis, including mitochondrial damage, synaptic loss, amyloid beta (aβ) production and/or accumulation, inflammatory responses, and phosphorylated tau formation and/or accumulation. 2018-02-15 2023-08-13 Not clear