| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Willayat Y Wani, John C Chatham, Victor Darley-Usmar, Lori L McMahon, Jianhua Zhan. O-GlcNAcylation and neurodegeneration. Brain research bulletin. vol 133. 2018-03-30. PMID:27497832. |
in mammalian brain, o-glcnac modification of tau decreases its phosphorylation and toxicity, suggesting a neuroprotective role of pharmacological elevation of brain o-glcnac for alzheimer's disease treatment. |
2018-03-30 |
2023-08-13 |
Not clear |
| Cheng-Cheng Zhang, Jun-Xia Zhu, Yu Wan, Lin Tan, Hui-Fu Wang, Jin-Tai Yu, Lan Ta. Meta-analysis of the association between variants in MAPT and neurodegenerative diseases. Oncotarget. vol 8. issue 27. 2018-03-29. PMID:28402959. |
microtubule-associated protein tau (mapt) gene is compelling among the susceptibility genes of neurodegenerative diseases which include alzheimer's disease (ad), parkinson's disease (pd), progressive supranuclear palsy (psp), corticobasal degeneration (cbd), frontotemporal dementia (ftd) and amyotrophic lateral sclerosis (als). |
2018-03-29 |
2023-08-13 |
Not clear |
| Futao Zhou, Danli Wan. The associations between the MAPT polymorphisms and Alzheimer's disease risk: a meta-analysis. Oncotarget. vol 8. issue 26. 2018-03-29. PMID:28415654. |
published studies revealed that the microtubule-associated protein tau (mapt) gene polymorphisms increased alzheimer's disease (ad) risk; the associations of 4 single nucleotide polymorphisms (snps, rs242557g/a, rs2471738c/t, rs3785883g/a and rs1467967a/g) of the mapt gene with ad risk, however, remain inconclusive. |
2018-03-29 |
2023-08-13 |
Not clear |
| Michael J Van Kanegan, Denise E Dunn, Linda S Kaltenbach, Bijal Shah, Dong Ning He, Daniel D McCoy, Peiying Yang, Jiangnan Peng, Li Shen, Lin Du, Robert H Cichewicz, Robert A Newman, Donald C L. Dual activities of the anti-cancer drug candidate PBI-05204 provide neuroprotection in brain slice models for neurodegenerative diseases and stroke. Scientific reports. vol 6. 2018-03-27. PMID:27172999. |
finally, we show that fraction 0-4 provides broad neuroprotection in organotypic brain slice models for neurodegeneration driven by amyloid precursor protein (app) and tau implicated in alzheimer's disease and frontotemporal dementias, respectively, in addition to ischemic injury modeled by ogd. |
2018-03-27 |
2023-08-13 |
Not clear |
| Brendan P Lucey, Anne M Fagan, David M Holtzman, John C Morris, Randall J Batema. Diurnal oscillation of CSF Aβ and other AD biomarkers. Molecular neurodegeneration. vol 12. issue 1. 2018-03-27. PMID:28478762. |
to assess stages of alzheimer's disease (ad) pathogenesis and the efficacy of drugs during clinical trials, there has been immense interest in the field to establish baseline cerebrospinal fluid (csf) concentrations for potential ad biomarkers such as amyloid-β (aβ) and tau. |
2018-03-27 |
2023-08-13 |
Not clear |
| Liliana Lozano, Jorge Guevara, Tony Lefebvre, Ivan Ramos-Martinez, Daniel Limón, Alfonso Díaz, Eduarda Cerón, Edgar Zenten. Effect of amyloid-Β (25-35) in hyperglycemic and hyperinsulinemic rats, effects on phosphorylation and O-GlcNAcylation of tau protein. Neuropeptides. vol 63. 2018-03-26. PMID:28427866. |
aggregation of the amyloid beta (aβ) peptide and hyperphosphorylation of tau protein, which are markers of alzheimer's disease (ad), have been reported also in diabetes mellitus (dm). |
2018-03-26 |
2023-08-13 |
rat |
| Shunsuke Kobayashi, Toru Tanaka, Yoshiyuki Soeda, Osborne F X Almeida, Akihiko Takashim. Local Somatodendritic Translation and Hyperphosphorylation of Tau Protein Triggered by AMPA and NMDA Receptor Stimulation. EBioMedicine. vol 20. 2018-03-26. PMID:28566250. |
tau is a major component of the neurofibrillary tangles (nft) that represent a pathological hallmark of alzheimer's disease (ad). |
2018-03-26 |
2023-08-13 |
Not clear |
| Daniela Puzzo, Roberto Piacentini, Mauro Fá, Walter Gulisano, Domenica D Li Puma, Agnes Staniszewski, Hong Zhang, Maria Rosaria Tropea, Sara Cocco, Agostino Palmeri, Paul Fraser, Luciano D'Adamio, Claudio Grassi, Ottavio Aranci. LTP and memory impairment caused by extracellular Aβ and Tau oligomers is APP-dependent. eLife. vol 6. 2018-03-26. PMID:28696204. |
thus, app might serve as a common therapeutic target against alzheimer's disease (ad) and a host of other neurodegenerative diseases characterized by abnormal levels of aβ and/or tau. |
2018-03-26 |
2023-08-13 |
mouse |
| Dujuan Li, Simona Scarano, Samuele Lisi, Pasquale Palladino, Maria Minunn. Real-Time Tau Protein Detection by Sandwich-Based Piezoelectric Biosensing: Exploring Tubulin as a Mass Enhancer. Sensors (Basel, Switzerland). vol 18. issue 4. 2018-03-26. PMID:29565824. |
our results open up new and encouraging perspectives for the use of tubulin as an alternative receptor for tau protein with interesting features due to the possibility of taking advantage of its polymerization and reversible binding to this key hallmark of alzheimer's disease. |
2018-03-26 |
2023-08-13 |
human |
| Qingmei Kang, Yue Xiang, Dan Li, Jie Liang, Xiong Zhang, Fanlin Zhou, Mengyuan Qiao, Yingling Nie, Yurong He, Jingyi Cheng, Yubing Dai, Yu L. MiR-124-3p attenuates hyperphosphorylation of Tau protein-induced apoptosis via caveolin-1-PI3K/Akt/GSK3β pathway in N2a/APP695swe cells. Oncotarget. vol 8. issue 15. 2018-03-22. PMID:28186985. |
hyperphosphorylation of tau forming neurofibrillary tangles has been considered as a crucial event in the pathogenesis of alzheimer's disease (ad). |
2018-03-22 |
2023-08-13 |
Not clear |
| Lone Helboe, Jan Egebjerg, Pernille Barkholt, Christiane Volbrach. Early depletion of CA1 neurons and late neurodegeneration in a mouse tauopathy model. Brain research. vol 1665. 2018-03-22. PMID:28411086. |
alzheimer's disease (ad) and tauopathies, such as frontotemporal dementia (ftd), are characterized by formation of neurofibrillary tangles consisting of hyperphosphorylated tau. |
2018-03-22 |
2023-08-13 |
mouse |
| Rita Khoury, Kush Patel, Jake Gold, Stephanie Hinds, George T Grossber. Recent Progress in the Pharmacotherapy of Alzheimer's Disease. Drugs & aging. vol 34. issue 11. 2018-03-22. PMID:29116600. |
the latter have yielded disappointing results by focusing mainly on the two pathophysiological hallmarks of alzheimer's disease: aβ amyloid deposits and tau protein aggregates forming neurofibrillary tangles. |
2018-03-22 |
2023-08-13 |
Not clear |
| Ganesh M Babulal, Sarah H Stout, Denise Head, David M Holtzman, Anne M Fagan, John C Morris, Catherine M Ro. Neuropsychiatric Symptoms and Alzheimer's Disease Biomarkers Predict Driving Decline: Brief Report. Journal of Alzheimer's disease : JAD. vol 58. issue 3. 2018-03-21. PMID:28453487. |
we examined whether neuropsychiatric symptoms (nps) interact with cerebrospinal fluid (csf) biomarkers (amyloid-β42 [aβ42], tau, phosphorylated tau181 [ptau181], tau/aβ42, and ptau181/aβ42) of alzheimer's disease pathology to predict driving decline among cognitively-normal older adults (n = 116) aged ≥65. |
2018-03-21 |
2023-08-13 |
human |
| Eric Swanson, Leigham Breckenridge, Lloyd McMahon, Sreemoyee Som, Ian McConnell, George S Bloo. Extracellular Tau Oligomers Induce Invasion of Endogenous Tau into the Somatodendritic Compartment and Axonal Transport Dysfunction. Journal of Alzheimer's disease : JAD. vol 58. issue 3. 2018-03-21. PMID:28482642. |
aggregates composed of the microtubule associated protein, tau, are a hallmark of alzheimer's disease and non-alzheimer's tauopathies. |
2018-03-21 |
2023-08-13 |
Not clear |
| Mikael Edsbagge, Ulf Andreasson, Khalid Ambarki, Carsten Wikkelsø, Anders Eklund, Kaj Blennow, Henrik Zetterberg, Mats Tullber. Alzheimer's Disease-Associated Cerebrospinal Fluid (CSF) Biomarkers do not Correlate with CSF Volumes or CSF Production Rate. Journal of Alzheimer's disease : JAD. vol 58. issue 3. 2018-03-21. PMID:28505972. |
neuropathologically, alzheimer's disease (ad) is characterized by accumulation of a 42 amino acid peptide called amyloid-β (aβ42) in extracellular senile plaques together with intraneuronal inclusions of hyperphosphorylated tau protein in neurofibrillary tangles and neuronal degeneration. |
2018-03-21 |
2023-08-13 |
Not clear |
| Manon Thierry, Serge Marty, Susana Boluda, Charles Duyckaert. Alzheimer's senile plaque as shown by microcryodissection, a new technique for dissociating tissue structures. Journal of neural transmission (Vienna, Austria : 1996). vol 124. issue 6. 2018-03-20. PMID:28386671. |
extracellular accumulation of aβ peptides and intracellular aggregation of hyperphosphorylated tau proteins are the two hallmark lesions of alzheimer disease (ad). |
2018-03-20 |
2023-08-13 |
Not clear |
| Lihong Chen, Junshan Huang, Lanfang Yang, Xue-Ai Zeng, Ya Zhang, Xiufeng Wang, Mingqi Chen, Xing Li, Yifan Zhang, Min Zhan. Sleep deprivation accelerates the progression of alzheimer's disease by influencing Aβ-related metabolism. Neuroscience letters. vol 650. 2018-03-19. PMID:28455102. |
sleep disorders have previously been connected with the neurodegenerative pathology of alzheimer's disease (ad) due to the aggregation of β-amyloid(aβ)peptides and tau proteinsinduced by sleep deprivation (sd). |
2018-03-19 |
2023-08-13 |
rat |
| Jieun Kim, In-Young Choi, Karen E Duff, Phil Le. Progressive Pathological Changes in Neurochemical Profile of the Hippocampus and Early Changes in the Olfactory Bulbs of Tau Transgenic Mice (rTg4510). Neurochemical research. vol 42. issue 6. 2018-03-19. PMID:28523532. |
tauopathies such as alzheimer's disease and frontotemporal lobe degeneration (ftld-tau) dementia, characterized by pathologic aggregation of the microtubule-associated tau protein and formation of neurofibrillary tangles, have been linked to neurodegeneration and cognitive decline. |
2018-03-19 |
2023-08-13 |
mouse |
| Mony J de Leon, Elizabeth Pirraglia, Ricardo S Osorio, Lidia Glodzik, Les Saint-Louis, Hee-Jin Kim, Juan Fortea, Silvia Fossati, Eugene Laska, Carole Siegel, Tracy Butler, Yi Li, Henry Rusinek, Henrik Zetterberg, Kaj Blenno. The nonlinear relationship between cerebrospinal fluid Aβ42 and tau in preclinical Alzheimer's disease. PloS one. vol 13. issue 2. 2018-03-19. PMID:29415068. |
the nonlinear relationship between cerebrospinal fluid aβ42 and tau in preclinical alzheimer's disease. |
2018-03-19 |
2023-08-13 |
Not clear |
| Mony J de Leon, Elizabeth Pirraglia, Ricardo S Osorio, Lidia Glodzik, Les Saint-Louis, Hee-Jin Kim, Juan Fortea, Silvia Fossati, Eugene Laska, Carole Siegel, Tracy Butler, Yi Li, Henry Rusinek, Henrik Zetterberg, Kaj Blenno. The nonlinear relationship between cerebrospinal fluid Aβ42 and tau in preclinical Alzheimer's disease. PloS one. vol 13. issue 2. 2018-03-19. PMID:29415068. |
cerebrospinal fluid (csf) studies consistently show that csf levels of amyloid-beta 1-42 (aβ42) are reduced and tau levels increased prior to the onset of cognitive decline related to alzheimer's disease (ad). |
2018-03-19 |
2023-08-13 |
Not clear |