All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Anny Ho, Bidii Ngala, Chiaki Yamada, Christopher Garcia, Carolina Duarte, Juliet Akkaoui, Dumitru Ciolac, Amilia Nusbaum, William Kochen, Daniela Efremova, Stanislav Groppa, Lubov Nathanson, Stephanie Bissel, Adrian Oblak, Melissa A Kacena, Alexandru Movil. IL-34 exacerbates pathogenic features of Alzheimer's disease and calvaria osteolysis in triple transgenic (3x-Tg) female mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 166. 2023-09-04. PMID:37666180. hallmark features of alzheimer's disease (ad) include elevated accumulation of aggregated aβ40 and aβ42 peptides, hyperphosphorylated tau (p-tau), and neuroinflammation. 2023-09-04 2023-09-07 mouse
Jie Ding, Chushu Shen, Zhenguo Wang, Yongfeng Yang, Georges El Fakhri, Jie Lu, Dong Liang, Hairong Zheng, Yun Zhou, Tao Su. Tau-PET abnormality as a biomarker for Alzheimer's disease staging and early detection: a topological perspective. Cerebral cortex (New York, N.Y. : 1991). 2023-09-01. PMID:37653600. alzheimer's disease can be detected early through biomarkers such as tau positron emission tomography (pet) imaging, which shows abnormal protein accumulations in the brain. 2023-09-01 2023-09-07 human
Xiaoyu Tang, Zhipeng Kan, Na Li, Jinbao Huang, Jinsong Zhang, Henry J Thompson, Feng Gao, Yong Shen, Liang Zhang, Zhongwen Xie, Xiaochun Wan, Yijun Wan. Mechanisms underlying large-leaf yellow tea mediated inhibition of cognitive impairment in the 5xFAD model of Alzheimer's disease. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 120. 2023-08-31. PMID:37651754. alzheimer's disease (ad) is the most common cause of dementia and is characterized by amyloid-β (aβ) peptides and hyperphosphorylated tau proteins. 2023-08-31 2023-09-07 Not clear
Hasaeam Cho, Jimin Lee, Hanjoon Nho, Keunmin Lee, Bopil Gim, Juncheol Lee, Jaehee Lee, Kai K Ewert, Youli Li, Stuart C Feinstein, Cyrus R Safinya, Kyeong Sik Jin, Myung Chul Cho. Synchrotron X-ray study of intrinsically disordered and polyampholytic Tau 4RS and 4RL under controlled ionic strength. The European physical journal. E, Soft matter. vol 46. issue 9. 2023-08-31. PMID:37653246. aggregated and hyperphosphorylated tau is one of the pathological hallmarks of alzheimer's disease. 2023-08-31 2023-09-07 Not clear
Meichen Yu, Shannon L Risacher, Kwangsik T Nho, Qiuting Wen, Adrian L Oblak, Frederick W Unverzagt, Liana G Apostolova, Martin R Farlow, Jared R Brosch, David G Clark, Sophia Wang, Rachael Deardorff, Yu-Chien Wu, Sujuan Gao, Olaf Sporns, Andrew J Sayki. Spatial transcriptomic patterns underlying regional vulnerability to amyloid-β and tau pathologies and their relationships to cognitive dysfunction in Alzheimer's disease. medRxiv : the preprint server for health sciences. 2023-08-30. PMID:37645867. spatial transcriptomic patterns underlying regional vulnerability to amyloid-β and tau pathologies and their relationships to cognitive dysfunction in alzheimer's disease. 2023-08-30 2023-09-07 human
Meichen Yu, Shannon L Risacher, Kwangsik T Nho, Qiuting Wen, Adrian L Oblak, Frederick W Unverzagt, Liana G Apostolova, Martin R Farlow, Jared R Brosch, David G Clark, Sophia Wang, Rachael Deardorff, Yu-Chien Wu, Sujuan Gao, Olaf Sporns, Andrew J Sayki. Spatial transcriptomic patterns underlying regional vulnerability to amyloid-β and tau pathologies and their relationships to cognitive dysfunction in Alzheimer's disease. medRxiv : the preprint server for health sciences. 2023-08-30. PMID:37645867. amyloid-β (aβ) and tau proteins accumulate within distinct neuronal systems in alzheimer's disease (ad). 2023-08-30 2023-09-07 human
Cory M Nadel, Kristin Wucherer, Abby Oehler, Aye C Thwin, Koli Basu, Matthew D Callahan, Daniel R Southworth, Daniel A Mordes, Charles S Craik, Jason E Gestwick. Phosphorylation of a Cleaved Tau Proteoform at a Single Residue Inhibits Binding to the E3 Ubiquitin Ligase, CHIP. bioRxiv : the preprint server for biology. 2023-08-30. PMID:37645969. microtubule-associated protein tau (mapt/tau) accumulates in a family of neurodegenerative diseases, including alzheimer's disease (ad). 2023-08-30 2023-09-07 Not clear
Michiel Bertsch, Bruno Franchi, Maria Carla Tesi, Veronica Tor. The role of A[Formula: see text] and Tau proteins in Alzheimer's disease: a mathematical model on graphs. Journal of mathematical biology. vol 87. issue 3. 2023-08-30. PMID:37646953. the role of a[formula: see text] and tau proteins in alzheimer's disease: a mathematical model on graphs. 2023-08-30 2023-09-07 human
Michiel Bertsch, Bruno Franchi, Maria Carla Tesi, Veronica Tor. The role of A[Formula: see text] and Tau proteins in Alzheimer's disease: a mathematical model on graphs. Journal of mathematical biology. vol 87. issue 3. 2023-08-30. PMID:37646953. toxic proteins such as [formula: see text] amyloid and tau play in fact a crucial role in the development of alzheimer's disease and, separately, have been targets of medical treatments. 2023-08-30 2023-09-07 human
Xin Wang, Erin E Sundermann, Rachel F Buckley, Sarah J Bank. Sex differences in the association between tau PET and cognitive performance in a non-Hispanic White cohort with preclinical AD. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-08-29. PMID:37641484. we investigated how the associations between tau and cognitive measures differ by sex in the preclinical alzheimer's disease (ad) stage. 2023-08-29 2023-09-07 Not clear
Camilla A Molobekova, Elena M Kondaurova, Tatiana V Ilchibaeva, Alexander Ya Rodnyy, Natalia A Stefanova, Nataliya G Kolosova, Vladimir S Naumenk. Amisulpride decreases tau protein hyperphosphorylation in the brain of OXYS rats. Current Alzheimer research. 2023-08-29. PMID:37641989. in this study, oxys rats of three ages (1, 3, and 6 months), a proven model of alzheimer's disease (ad), at various stages of disease progression were used to thoroughly study the effects of amisulpride on behavior and tau protein phosphorylation. 2023-08-29 2023-09-07 rat
Cecilia Monteiro, Balazs Toth, Flavia Brunstein, Ashwini Bobbala, Seema Datta, Ryan Ceniceros, Sandra Sanabria Bohorquez, Veronica Anania, Kristin Wildsmith, Stephen Schauer, Julie Lee, Michael Dolton, Vidya Ramakrishnan, Daniel Abramzon, Edmond Ten. A Randomized Phase II Study of the Safety and Efficacy of Semorinemab in Participants with Mild-to-Moderate Alzheimer's Disease (Lauriet). Neurology. 2023-08-29. PMID:37643887. accumulation of tau pathology in alzheimer's disease (ad) correlates with cognitive decline. 2023-08-29 2023-09-07 human
William P Flavin, Helia Hosseini, Jeffrey W Ruberti, H Pirouz Kavehpour, Christopher C Giza, Mayumi L Prin. Traumatic brain injury and the pathways to cerebral tau accumulation. Frontiers in neurology. vol 14. 2023-08-28. PMID:37638180. there are many pathways involved in phosphorylating tau including diabetes, stroke, alzheimer's disease (ad), brain injury, aging, and drug use. 2023-08-28 2023-09-07 Not clear
Nathalie Moussa, Ninar Dayou. Exploring the role of COX-2 in Alzheimer's disease: Potential therapeutic implications of COX-2 inhibitors. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society. vol 31. issue 9. 2023-08-28. PMID:37638222. in addition to cox-2 enzymes role in inflammation, the formation of amyloid plaques and neurofibrillary tangles in the brain, the review emphasizes that coxs-2 have a crucial role in normal synaptic activity and plasticity, and have a relationship with acetylcholine, tau protein, and beta-amyloid (aβ) which are the main causes of alzheimer's disease. 2023-08-28 2023-09-07 Not clear
Nathalie Moussa, Ninar Dayou. Exploring the role of COX-2 in Alzheimer's disease: Potential therapeutic implications of COX-2 inhibitors. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society. vol 31. issue 9. 2023-08-28. PMID:37638222. furthermore, the review points out that cox-2 enzymes have a relationship with kinase enzymes, including cyclin dependent kinase 5 (cdk5) and glycogen synthase kinase 3β (gsk3β), which are known to play a role in tau phosphorylation and are strongly associated with alzheimer's disease. 2023-08-28 2023-09-07 Not clear
Ruizhi Wang, Kun Ping Lu, Xiao Zhen Zho. Function and regulation of cis P-tau in the pathogenesis and treatment of conventional and nonconventional tauopathies. Journal of neurochemistry. 2023-08-28. PMID:37638382. conventional tauopathies are a group of disease characterized by tau inclusions in the brains, including alzheimer's disease (ad), pick's disease (pid), progressive supranuclear palsy (psp), corticobasal degeneration (cbd), and certain types of frontotemporal dementia (ftd), among which ad is the most prevalent. 2023-08-28 2023-09-07 Not clear
George S Bloom, Andrés Norambuen. Dysregulation of mTOR by tau in Alzheimer's disease. Cytoskeleton (Hoboken, N.J.). 2023-08-28. PMID:37638691. dysregulation of mtor by tau in alzheimer's disease. 2023-08-28 2023-09-07 Not clear
George S Bloom, Andrés Norambuen. Dysregulation of mTOR by tau in Alzheimer's disease. Cytoskeleton (Hoboken, N.J.). 2023-08-28. PMID:37638691. interest in tau rose by the late 1980's, when it was shown to be the principal subunit of the neurofibrillary tangles (nfts) that accumulate in alzheimer's disease (ad) brain, and achieved new heights by the late 1990's, when numerous tau mutations were found to be highly penetrant for ad-related disorders that also are associated with nfts and came to be known as non-alzheimer's tauopathies. 2023-08-28 2023-09-07 Not clear
Junhao Li, Amit Kumar, Bengt Långström, Agneta Nordberg, Hans Ågre. Insight into the Binding of First- and Second-Generation PET Tracers to 4R and 3R/4R Tau Protofibrils. ACS chemical neuroscience. 2023-08-28. PMID:37639522. similar to alzheimer's disease (ad), the abnormal aggregation of tau fibrils in the central neuronal and glial cells is a major hallmark of psp disease. 2023-08-28 2023-09-07 Not clear
Giulia Arenare, Riccardo Manca, Paolo Caffarra, Annalena Venneri, On Behalf Of The Alzheimer's Disease Neuroimaging Initiativ. Associations between Neuropsychiatric Symptoms and Alzheimer's Disease Biomarkers in People with Mild Cognitive Impairment. Brain sciences. vol 13. issue 8. 2023-08-26. PMID:37626552. this study aimed to investigate the association between nps severity and alzheimer's disease (ad) biomarkers, i.e., amyloid-β (aβ), phosphorylated tau protein (p-tau) and hippocampal volume ratio (hr), to characterise in more detail mci patients with a poor prognosis. 2023-08-26 2023-09-07 Not clear