All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Hayk Davtyan, Wesley W Chen, Karen Zagorski, Joy Davis, Irina Petrushina, Konstantin Kazarian, David H Cribbs, Michael G Agadjanyan, Mathew Blurton-Jones, Anahit Ghochikya. MultiTEP platform-based DNA epitope vaccine targeting N-terminus of tau induces strong immune responses and reduces tau pathology in THY-Tau22 mice. Vaccine. vol 35. issue 16. 2017-12-19. PMID:28320590. by the time clinical symptoms of alzheimer's disease (ad) manifest in patients there is already substantial tau pathology in the brain. 2017-12-19 2023-08-13 mouse
Juan Pablo Palavicini, Chunyan Wang, Linyuan Chen, Kristen Hosang, Jianing Wang, Takami Tomiyama, Hiroshi Mori, Xianlin Ha. Oligomeric amyloid-beta induces MAPK-mediated activation of brain cytosolic and calcium-independent phospholipase A Acta neuropathologica communications. vol 5. issue 1. 2017-12-19. PMID:28750656. oligomeric amyloid-beta induces mapk-mediated activation of brain cytosolic and calcium-independent phospholipase a alzheimer's disease (ad) is histopathologically characterized by the build-up of fibrillar amyloid beta (aβ) in the form of amyloid plaques and the development of intraneuronal neurofibrillary tangles consisting of aggregated hyperphosphorylated tau. 2017-12-19 2023-08-13 mouse
Yan-Juan Wang, Qing-Guo Ren, Wei-Gang Gong, Di Wu, Xiang Tang, Xiao-Li Li, Fang-Fang Wu, Feng Bai, Lin Xu, Zhi-Jun Zhan. Escitalopram attenuates β-amyloid-induced tau hyperphosphorylation in primary hippocampal neurons through the 5-HT1A receptor mediated Akt/GSK-3β pathway. Oncotarget. vol 7. issue 12. 2017-12-15. PMID:26950279. tau hyperphosphorylation is an important pathological feature of alzheimer's disease (ad). 2017-12-15 2023-08-13 rat
Zi-Ai Zhao, Ya-Lei Ning, Ping Li, Nan Yang, Yan Peng, Ren-Ping Xiong, Yan Zhao, Dong Liu, Xu-Jia Zeng, Jiang-Fan Chen, Yuan-Guo Zho. Widespread hyperphosphorylated tau in the working memory circuit early after cortical impact injury of brain (Original study). Behavioural brain research. vol 323. 2017-12-13. PMID:28163095. given that tau hyperphosphorylation is an important cause of cognitive impairment in patients of alzheimer's disease, our present study detected the presence of hyperphosphorylated tau (p-tau), mainly at ser404, in multiple brain regions, including the ipsilateral parietal cortex, contralateral hippocampus and prefrontal cortex, immediately after the injury in a mouse tbi model; these changes lasted for at least 4w. 2017-12-13 2023-08-13 mouse
Sarah K Kaufman, Talitha L Thomas, Kelly Del Tredici, Heiko Braak, Marc I Diamon. Characterization of tau prion seeding activity and strains from formaldehyde-fixed tissue. Acta neuropathologica communications. vol 5. issue 1. 2017-12-13. PMID:28587664. tauopathies such as alzheimer's disease (ad) feature progressive intraneuronal deposition of aggregated tau protein. 2017-12-13 2023-08-13 mouse
Alexandre Bejanin, Daniel R Schonhaut, Renaud La Joie, Joel H Kramer, Suzanne L Baker, Natasha Sosa, Nagehan Ayakta, Averill Cantwell, Mustafa Janabi, Mariella Lauriola, James P O'Neil, Maria L Gorno-Tempini, Zachary A Miller, Howard J Rosen, Bruce L Miller, William J Jagust, Gil D Rabinovic. Tau pathology and neurodegeneration contribute to cognitive impairment in Alzheimer's disease. Brain : a journal of neurology. vol 140. issue 12. 2017-12-13. PMID:29053874. tau pathology and neurodegeneration contribute to cognitive impairment in alzheimer's disease. 2017-12-13 2023-08-13 human
Alexandre Bejanin, Daniel R Schonhaut, Renaud La Joie, Joel H Kramer, Suzanne L Baker, Natasha Sosa, Nagehan Ayakta, Averill Cantwell, Mustafa Janabi, Mariella Lauriola, James P O'Neil, Maria L Gorno-Tempini, Zachary A Miller, Howard J Rosen, Bruce L Miller, William J Jagust, Gil D Rabinovic. Tau pathology and neurodegeneration contribute to cognitive impairment in Alzheimer's disease. Brain : a journal of neurology. vol 140. issue 12. 2017-12-13. PMID:29053874. neuropathological and in vivo studies have revealed a tight relationship between tau pathology and cognitive impairment across the alzheimer's disease spectrum. 2017-12-13 2023-08-13 human
Alexandre Bejanin, Daniel R Schonhaut, Renaud La Joie, Joel H Kramer, Suzanne L Baker, Natasha Sosa, Nagehan Ayakta, Averill Cantwell, Mustafa Janabi, Mariella Lauriola, James P O'Neil, Maria L Gorno-Tempini, Zachary A Miller, Howard J Rosen, Bruce L Miller, William J Jagust, Gil D Rabinovic. Tau pathology and neurodegeneration contribute to cognitive impairment in Alzheimer's disease. Brain : a journal of neurology. vol 140. issue 12. 2017-12-13. PMID:29053874. the aim of the present study was therefore to assess whether grey matter atrophy and amyloid pathology contribute to the relationship between tau pathology, as measured with 18f-av-1451-pet imaging, and cognitive deficits in alzheimer's disease. 2017-12-13 2023-08-13 human
Alexandre Bejanin, Daniel R Schonhaut, Renaud La Joie, Joel H Kramer, Suzanne L Baker, Natasha Sosa, Nagehan Ayakta, Averill Cantwell, Mustafa Janabi, Mariella Lauriola, James P O'Neil, Maria L Gorno-Tempini, Zachary A Miller, Howard J Rosen, Bruce L Miller, William J Jagust, Gil D Rabinovic. Tau pathology and neurodegeneration contribute to cognitive impairment in Alzheimer's disease. Brain : a journal of neurology. vol 140. issue 12. 2017-12-13. PMID:29053874. together, these results show that tau pathology is related in a region-specific manner to cognitive impairment in alzheimer's disease. 2017-12-13 2023-08-13 human
Yaling Yin, Di Gao, Yali Wang, Zhi-Hao Wang, Xin Wang, Jinwang Ye, Dongqin Wu, Lin Fang, Guilin Pi, Ying Yang, Xiao-Chuan Wang, Chengbiao Lu, Keqiang Ye, Jian-Zhi Wan. Tau accumulation induces synaptic impairment and memory deficit by calcineurin-mediated inactivation of nuclear CaMKIV/CREB signaling. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 26. 2017-12-12. PMID:27298345. intracellular accumulation of wild-type tau is a hallmark of sporadic alzheimer's disease (ad), but the molecular mechanisms underlying tau-induced synapse impairment and memory deficit are poorly understood. 2017-12-12 2023-08-13 human
Lara Ordóñez-Gutiérrez, Adrián Posado-Fernández, Davoud Ahmadvand, Barbara Lettiero, Linping Wu, Marta Antón, Orfeu Flores, Seyed Moein Moghimi, Francisco Wandosel. ImmunoPEGliposome-mediated reduction of blood and brain amyloid levels in a mouse model of Alzheimer's disease is restricted to aged animals. Biomaterials. vol 112. 2017-12-12. PMID:27760398. the accumulation of extracellular amyloid-beta (aβ) and intracellular neurofibrillary tangles (hyper-phosphorylated tau) in the brain are two major neuropathological hallmarks of alzheimer's disease (ad). 2017-12-12 2023-08-13 mouse
P Kurian, T O Obisesan, T J A Craddoc. Oxidative species-induced excitonic transport in tubulin aromatic networks: Potential implications for neurodegenerative disease. Journal of photochemistry and photobiology. B, Biology. vol 175. 2017-12-11. PMID:28865316. oxidative stress is a pathological hallmark of neurodegenerative tauopathic disorders such as alzheimer's disease and parkinson's disease-related dementia, which are characterized by altered forms of the microtubule-associated protein (map) tau. 2017-12-11 2023-08-13 Not clear
Ghulam Jeelani Pir, Bikash Choudhary, Eckhard Mandelko. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 31. issue 12. 2017-12-11. PMID:29191965. one of the hallmarks of the tauopathies, which include the neurodegenerative disorders, such as alzheimer disease (ad), corticobasal degeneration, frontotemporal dementia, and progressive supranuclear palsy (psp), is the abnormal accumulation of post-translationally modified, insoluble tau. 2017-12-11 2023-08-13 Not clear
Makoto Higuch. [Tau Positron Emission Tomography]. Brain and nerve = Shinkei kenkyu no shinpo. vol 69. issue 7. 2017-12-08. PMID:28739996. accumulation of fibrillar tau protein aggregates is a neuropathological hallmark of alzheimer's disease (ad) and related neurodegenerative dementias, including a subgroup of frontotemporal lobar degeneration (ftld). 2017-12-08 2023-08-13 human
Matthew R Brier, Brian Gordon, Karl Friedrichsen, John McCarthy, Ari Stern, Jon Christensen, Christopher Owen, Patricia Aldea, Yi Su, Jason Hassenstab, Nigel J Cairns, David M Holtzman, Anne M Fagan, John C Morris, Tammie L S Benzinger, Beau M Ance. Tau and Aβ imaging, CSF measures, and cognition in Alzheimer's disease. Science translational medicine. vol 8. issue 338. 2017-12-07. PMID:27169802. tau and aβ imaging, csf measures, and cognition in alzheimer's disease. 2017-12-07 2023-08-13 Not clear
Chuanzhou Li, Jürgen Göt. Tau-based therapies in neurodegeneration: opportunities and challenges. Nature reviews. Drug discovery. vol 16. issue 12. 2017-12-07. PMID:28983098. aggregates of the microtubule-associated protein tau are a defining feature of several neurodegenerative diseases that are collectively known as tauopathies, and constitute one of the hallmark lesions of alzheimer disease (ad). 2017-12-07 2023-08-13 Not clear
Marta Olivera Santa-Catalina, Montaña Caballero Bermejo, Ricardo Argent, Juan C Alonso, Francisco Centeno, María J Lorenz. JNK signaling pathway regulates sorbitol-induced Tau proteolysis and apoptosis in SH-SY5Y cells by targeting caspase-3. Archives of biochemistry and biophysics. vol 636. 2017-12-06. PMID:29126968. interestingly, abnormal hyperphosphorylation and cleavage of tau have been proven to lead to the genesis of filamentous structures referred to as neurofibrillary tangles, the main pathological hallmark of alzheimer's disease. 2017-12-06 2023-08-13 Not clear
Elliott J Mufson, Milos D Ikonomovic, Scott E Counts, Sylvia E Perez, Michael Malek-Ahmadi, Stephen W Scheff, Stephen D Ginsber. Molecular and cellular pathophysiology of preclinical Alzheimer's disease. Behavioural brain research. vol 311. 2017-12-05. PMID:27185734. although the two pathological hallmarks of alzheimer's disease (ad), senile plaques composed of amyloid-β (aβ) peptides and neurofibrillary tangles (nfts) consisting of hyperphosphorylated tau, have been studied extensively in postmortem ad and relevant animal and cellular models, the pathogenesis of ad remains unknown, particularly in the early stages of the disease where therapies presumably would be most effective. 2017-12-05 2023-08-13 Not clear
Anthony W P Fitzpatrick, Benjamin Falcon, Shaoda He, Alexey G Murzin, Garib Murshudov, Holly J Garringer, R Anthony Crowther, Bernardino Ghetti, Michel Goedert, Sjors H W Schere. Cryo-EM structures of tau filaments from Alzheimer's disease. Nature. vol 547. issue 7662. 2017-12-05. PMID:28678775. cryo-em structures of tau filaments from alzheimer's disease. 2017-12-05 2023-08-13 Not clear
Jean-Baptiste Oudart, Laure Zucchini, François-Xavier Maquart, Xavier Dubernard, Marc Labrousse, Géraldine Fiabane, Alexandra Quedreux, Fabien Litre, Laurent Ramon. Tau protein as a possible marker of cerebrospinal fluid leakage in cerebrospinal fluid rhinorrhoea: A pilot study. Biochemia medica. vol 27. issue 3. 2017-12-05. PMID:28900366. csf tau protein is a neuronal protein, commonly assessed for diagnosis of alzheimer disease (ad). 2017-12-05 2023-08-13 Not clear