| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aditi Dey, Shuai Hao, Marlena Wosiski-Kuhn, Alexis M Stranaha. Glucocorticoid-mediated activation of GSK3β promotes tau phosphorylation and impairs memory in type 2 diabetes. Neurobiology of aging. vol 57. 2018-01-03. PMID:28609678. |
intrahippocampal tdzd-8 blocked tau hyperphosphorylation and normalized hippocampus-dependent memory in db/db mice, suggesting that pathological synergy between diabetes and alzheimer's disease may involve glucocorticoid-mediated activation of gsk3β. |
2018-01-03 |
2023-08-13 |
mouse |
| Katharina Stratmann, Helmut Heinsen, Horst-Werner Korf, Domenico Del Turco, Estifanos Ghebremedhin, Kay Seidel, Mohamed Bouzrou, Lea T Grinberg, Jürgen Bohl, Stephen B Wharton, Wilfred den Dunnen, Udo Rü. Precortical Phase of Alzheimer's Disease (AD)-Related Tau Cytoskeletal Pathology. Brain pathology (Zurich, Switzerland). vol 26. issue 3. 2018-01-02. PMID:26193084. |
precortical phase of alzheimer's disease (ad)-related tau cytoskeletal pathology. |
2018-01-02 |
2023-08-13 |
Not clear |
| Ghulam Abbas, Wajahat Mahmood, Nurul Kabi. Recent progress on the role of GABAergic neurotransmission in the pathogenesis of Alzheimer's disease. Reviews in the neurosciences. vol 27. issue 4. 2018-01-02. PMID:26812781. |
despite their possible causative role, targeting amyloidosis, tau phosphorylation, acetylcholine esterase, glutamate, oxidative stress and mitochondrial metabolism have not yet led to the development of drugs to cure alzheimer's disease (ad). |
2018-01-02 |
2023-08-13 |
Not clear |
| Ryan C Turner, Brandon P Lucke-Wold, Matthew J Robson, John M Lee, Julian E Baile. Alzheimer's disease and chronic traumatic encephalopathy: Distinct but possibly overlapping disease entities. Brain injury. vol 30. issue 11. 2018-01-02. PMID:27715315. |
alzheimer's disease (ad) and chronic traumatic encephalopathy (cte) have long been recognized as sharing some similar neuropathological features, mainly the presence of neurofibrilary tangles and hyperphosphorylated tau, but have generally been described as distinct entities. |
2018-01-02 |
2023-08-13 |
Not clear |
| Vega García-Escudero, Ricardo Gargini, Patricia Martín-Maestro, Esther García, Ramón García-Escudero, Jesús Avil. Tau mRNA 3'UTR-to-CDS ratio is increased in Alzheimer disease. Neuroscience letters. vol 655. 2018-01-01. PMID:28689927. |
tau mrna 3'utr-to-cds ratio is increased in alzheimer disease. |
2018-01-01 |
2023-08-13 |
mouse |
| Vega García-Escudero, Ricardo Gargini, Patricia Martín-Maestro, Esther García, Ramón García-Escudero, Jesús Avil. Tau mRNA 3'UTR-to-CDS ratio is increased in Alzheimer disease. Neuroscience letters. vol 655. 2018-01-01. PMID:28689927. |
the tau protein accumulates in alzheimer diseased brain. |
2018-01-01 |
2023-08-13 |
mouse |
| Vega García-Escudero, Ricardo Gargini, Patricia Martín-Maestro, Esther García, Ramón García-Escudero, Jesús Avil. Tau mRNA 3'UTR-to-CDS ratio is increased in Alzheimer disease. Neuroscience letters. vol 655. 2018-01-01. PMID:28689927. |
to explain this apparently contradictory result, we studied mapt mrna stoichiometry in coding and non-coding regions, and found that the 3'utr-to-cds ratio was higher in the hippocampus of alzheimer disease patients, with higher tau protein but lower total mrna levels. |
2018-01-01 |
2023-08-13 |
mouse |
| Vincent Huin, Vincent Deramecourt, Dominique Caparros-Lefebvre, Claude-Alain Maurage, Charles Duyckaerts, Eniko Kovari, Florence Pasquier, Valérie Buée-Scherrer, Julien Labreuche, Hélène Behal, Luc Buée, Claire-Marie Dhaenens, Bernard Sablonnièr. The MAPT gene is differentially methylated in the progressive supranuclear palsy brain. Movement disorders : official journal of the Movement Disorder Society. vol 31. issue 12. 2017-12-29. PMID:27709663. |
altered dna methylation of the microtubule-associated protein tau gene correlates with the expression changes in alzheimer's disease and parkinson's disease brains. |
2017-12-29 |
2023-08-13 |
Not clear |
| Tengfei Li, Matthias Vandesquille, Fani Koukouli, Clémence Dudeffant, Ihsen Youssef, Pascal Lenormand, Christelle Ganneau, Uwe Maskos, Christian Czech, Fiona Grueninger, Charles Duyckaerts, Marc Dhenain, Sylvie Bay, Benoît Delatour, Pierre Lafay. Camelid single-domain antibodies: A versatile tool for in vivo imaging of extracellular and intracellular brain targets. Journal of controlled release : official journal of the Controlled Release Society. vol 243. 2017-12-27. PMID:27671875. |
the present work describes two novel single-domain antibodies (vhhs or nanobodies) that specifically recognize extracellular amyloid deposits and intracellular tau neurofibrillary tangles, the two core lesions of alzheimer's disease (ad). |
2017-12-27 |
2023-08-13 |
mouse |
| Aleš Benda, Hayden Aitken, Danielle S Davies, Renee Whan, Claire Goldsbur. STED imaging of tau filaments in Alzheimer's disease cortical grey matter. Journal of structural biology. vol 195. issue 3. 2017-12-26. PMID:27402534. |
sted imaging of tau filaments in alzheimer's disease cortical grey matter. |
2017-12-26 |
2023-08-13 |
human |
| Aleš Benda, Hayden Aitken, Danielle S Davies, Renee Whan, Claire Goldsbur. STED imaging of tau filaments in Alzheimer's disease cortical grey matter. Journal of structural biology. vol 195. issue 3. 2017-12-26. PMID:27402534. |
alzheimer's disease (ad) involves the propagation of filaments of tau protein throughout the cerebral cortex. |
2017-12-26 |
2023-08-13 |
human |
| Rachel F Buckley, Bernard Hanseeuw, Aaron P Schultz, Patrizia Vannini, Sarah L Aghjayan, Michael J Properzi, Jonathan D Jackson, Elizabeth C Mormino, Dorene M Rentz, Reisa A Sperling, Keith A Johnson, Rebecca E Amarigli. Region-Specific Association of Subjective Cognitive Decline With Tauopathy Independent of Global β-Amyloid Burden. JAMA neurology. vol 74. issue 12. 2017-12-26. PMID:28973551. |
the ability to explore associations between reports of subjective cognitive decline (scd) and biomarkers of early alzheimer disease (ad) pathophysiologic processes (accumulation of neocortical β-amyloid [aβ] and tau) provides an important opportunity to understand the basis of scd and ad risk. |
2017-12-26 |
2023-08-13 |
Not clear |
| Patrícia Silva Guerreiro, Ellen Gerhardt, Tomás Lopes da Fonseca, Mathias Bähr, Tiago Fleming Outeiro, Katrin Eckerman. LRRK2 Promotes Tau Accumulation, Aggregation and Release. Molecular neurobiology. vol 53. issue 5. 2017-12-25. PMID:26014385. |
hyperphosphorylated tau protein accumulates in neurofibrillary tangles, a typical pathological hallmark in alzheimer's disease and frontotemporal dementia. |
2017-12-25 |
2023-08-13 |
Not clear |
| Denglei Ma, Yanqiu Zhu, Yanzheng Li, Cuicui Yang, Li Zhang, Yali Li, Lin Li, Lan Zhan. Beneficial effects of cornel iridoid glycoside on behavioral impairment and senescence status in SAMP8 mice at different ages. Behavioural brain research. vol 312. 2017-12-19. PMID:27283974. |
together, these results indicate that cig represent a potentially useful treatment for ameliorating the impaired cognitive ability, the motor dysfunction, aging conditions and hyperphosphorylation of tau in aging and age-related neurodegenerative diseases, such as alzheimer's disease. |
2017-12-19 |
2023-08-13 |
mouse |
| Hayk Davtyan, Wesley W Chen, Karen Zagorski, Joy Davis, Irina Petrushina, Konstantin Kazarian, David H Cribbs, Michael G Agadjanyan, Mathew Blurton-Jones, Anahit Ghochikya. MultiTEP platform-based DNA epitope vaccine targeting N-terminus of tau induces strong immune responses and reduces tau pathology in THY-Tau22 mice. Vaccine. vol 35. issue 16. 2017-12-19. PMID:28320590. |
by the time clinical symptoms of alzheimer's disease (ad) manifest in patients there is already substantial tau pathology in the brain. |
2017-12-19 |
2023-08-13 |
mouse |
| Juan Pablo Palavicini, Chunyan Wang, Linyuan Chen, Kristen Hosang, Jianing Wang, Takami Tomiyama, Hiroshi Mori, Xianlin Ha. Oligomeric amyloid-beta induces MAPK-mediated activation of brain cytosolic and calcium-independent phospholipase A Acta neuropathologica communications. vol 5. issue 1. 2017-12-19. PMID:28750656. |
oligomeric amyloid-beta induces mapk-mediated activation of brain cytosolic and calcium-independent phospholipase a alzheimer's disease (ad) is histopathologically characterized by the build-up of fibrillar amyloid beta (aβ) in the form of amyloid plaques and the development of intraneuronal neurofibrillary tangles consisting of aggregated hyperphosphorylated tau. |
2017-12-19 |
2023-08-13 |
mouse |
| Yan-Juan Wang, Qing-Guo Ren, Wei-Gang Gong, Di Wu, Xiang Tang, Xiao-Li Li, Fang-Fang Wu, Feng Bai, Lin Xu, Zhi-Jun Zhan. Escitalopram attenuates β-amyloid-induced tau hyperphosphorylation in primary hippocampal neurons through the 5-HT1A receptor mediated Akt/GSK-3β pathway. Oncotarget. vol 7. issue 12. 2017-12-15. PMID:26950279. |
tau hyperphosphorylation is an important pathological feature of alzheimer's disease (ad). |
2017-12-15 |
2023-08-13 |
rat |
| Zi-Ai Zhao, Ya-Lei Ning, Ping Li, Nan Yang, Yan Peng, Ren-Ping Xiong, Yan Zhao, Dong Liu, Xu-Jia Zeng, Jiang-Fan Chen, Yuan-Guo Zho. Widespread hyperphosphorylated tau in the working memory circuit early after cortical impact injury of brain (Original study). Behavioural brain research. vol 323. 2017-12-13. PMID:28163095. |
given that tau hyperphosphorylation is an important cause of cognitive impairment in patients of alzheimer's disease, our present study detected the presence of hyperphosphorylated tau (p-tau), mainly at ser404, in multiple brain regions, including the ipsilateral parietal cortex, contralateral hippocampus and prefrontal cortex, immediately after the injury in a mouse tbi model; these changes lasted for at least 4w. |
2017-12-13 |
2023-08-13 |
mouse |
| Sarah K Kaufman, Talitha L Thomas, Kelly Del Tredici, Heiko Braak, Marc I Diamon. Characterization of tau prion seeding activity and strains from formaldehyde-fixed tissue. Acta neuropathologica communications. vol 5. issue 1. 2017-12-13. PMID:28587664. |
tauopathies such as alzheimer's disease (ad) feature progressive intraneuronal deposition of aggregated tau protein. |
2017-12-13 |
2023-08-13 |
mouse |
| Alexandre Bejanin, Daniel R Schonhaut, Renaud La Joie, Joel H Kramer, Suzanne L Baker, Natasha Sosa, Nagehan Ayakta, Averill Cantwell, Mustafa Janabi, Mariella Lauriola, James P O'Neil, Maria L Gorno-Tempini, Zachary A Miller, Howard J Rosen, Bruce L Miller, William J Jagust, Gil D Rabinovic. Tau pathology and neurodegeneration contribute to cognitive impairment in Alzheimer's disease. Brain : a journal of neurology. vol 140. issue 12. 2017-12-13. PMID:29053874. |
tau pathology and neurodegeneration contribute to cognitive impairment in alzheimer's disease. |
2017-12-13 |
2023-08-13 |
human |