| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alexandre Bejanin, Daniel R Schonhaut, Renaud La Joie, Joel H Kramer, Suzanne L Baker, Natasha Sosa, Nagehan Ayakta, Averill Cantwell, Mustafa Janabi, Mariella Lauriola, James P O'Neil, Maria L Gorno-Tempini, Zachary A Miller, Howard J Rosen, Bruce L Miller, William J Jagust, Gil D Rabinovic. Tau pathology and neurodegeneration contribute to cognitive impairment in Alzheimer's disease. Brain : a journal of neurology. vol 140. issue 12. 2017-12-13. PMID:29053874. |
neuropathological and in vivo studies have revealed a tight relationship between tau pathology and cognitive impairment across the alzheimer's disease spectrum. |
2017-12-13 |
2023-08-13 |
human |
| Alexandre Bejanin, Daniel R Schonhaut, Renaud La Joie, Joel H Kramer, Suzanne L Baker, Natasha Sosa, Nagehan Ayakta, Averill Cantwell, Mustafa Janabi, Mariella Lauriola, James P O'Neil, Maria L Gorno-Tempini, Zachary A Miller, Howard J Rosen, Bruce L Miller, William J Jagust, Gil D Rabinovic. Tau pathology and neurodegeneration contribute to cognitive impairment in Alzheimer's disease. Brain : a journal of neurology. vol 140. issue 12. 2017-12-13. PMID:29053874. |
the aim of the present study was therefore to assess whether grey matter atrophy and amyloid pathology contribute to the relationship between tau pathology, as measured with 18f-av-1451-pet imaging, and cognitive deficits in alzheimer's disease. |
2017-12-13 |
2023-08-13 |
human |
| Alexandre Bejanin, Daniel R Schonhaut, Renaud La Joie, Joel H Kramer, Suzanne L Baker, Natasha Sosa, Nagehan Ayakta, Averill Cantwell, Mustafa Janabi, Mariella Lauriola, James P O'Neil, Maria L Gorno-Tempini, Zachary A Miller, Howard J Rosen, Bruce L Miller, William J Jagust, Gil D Rabinovic. Tau pathology and neurodegeneration contribute to cognitive impairment in Alzheimer's disease. Brain : a journal of neurology. vol 140. issue 12. 2017-12-13. PMID:29053874. |
together, these results show that tau pathology is related in a region-specific manner to cognitive impairment in alzheimer's disease. |
2017-12-13 |
2023-08-13 |
human |
| Yaling Yin, Di Gao, Yali Wang, Zhi-Hao Wang, Xin Wang, Jinwang Ye, Dongqin Wu, Lin Fang, Guilin Pi, Ying Yang, Xiao-Chuan Wang, Chengbiao Lu, Keqiang Ye, Jian-Zhi Wan. Tau accumulation induces synaptic impairment and memory deficit by calcineurin-mediated inactivation of nuclear CaMKIV/CREB signaling. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 26. 2017-12-12. PMID:27298345. |
intracellular accumulation of wild-type tau is a hallmark of sporadic alzheimer's disease (ad), but the molecular mechanisms underlying tau-induced synapse impairment and memory deficit are poorly understood. |
2017-12-12 |
2023-08-13 |
human |
| Lara Ordóñez-Gutiérrez, Adrián Posado-Fernández, Davoud Ahmadvand, Barbara Lettiero, Linping Wu, Marta Antón, Orfeu Flores, Seyed Moein Moghimi, Francisco Wandosel. ImmunoPEGliposome-mediated reduction of blood and brain amyloid levels in a mouse model of Alzheimer's disease is restricted to aged animals. Biomaterials. vol 112. 2017-12-12. PMID:27760398. |
the accumulation of extracellular amyloid-beta (aβ) and intracellular neurofibrillary tangles (hyper-phosphorylated tau) in the brain are two major neuropathological hallmarks of alzheimer's disease (ad). |
2017-12-12 |
2023-08-13 |
mouse |
| P Kurian, T O Obisesan, T J A Craddoc. Oxidative species-induced excitonic transport in tubulin aromatic networks: Potential implications for neurodegenerative disease. Journal of photochemistry and photobiology. B, Biology. vol 175. 2017-12-11. PMID:28865316. |
oxidative stress is a pathological hallmark of neurodegenerative tauopathic disorders such as alzheimer's disease and parkinson's disease-related dementia, which are characterized by altered forms of the microtubule-associated protein (map) tau. |
2017-12-11 |
2023-08-13 |
Not clear |
| Ghulam Jeelani Pir, Bikash Choudhary, Eckhard Mandelko. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 31. issue 12. 2017-12-11. PMID:29191965. |
one of the hallmarks of the tauopathies, which include the neurodegenerative disorders, such as alzheimer disease (ad), corticobasal degeneration, frontotemporal dementia, and progressive supranuclear palsy (psp), is the abnormal accumulation of post-translationally modified, insoluble tau. |
2017-12-11 |
2023-08-13 |
Not clear |
| Makoto Higuch. [Tau Positron Emission Tomography]. Brain and nerve = Shinkei kenkyu no shinpo. vol 69. issue 7. 2017-12-08. PMID:28739996. |
accumulation of fibrillar tau protein aggregates is a neuropathological hallmark of alzheimer's disease (ad) and related neurodegenerative dementias, including a subgroup of frontotemporal lobar degeneration (ftld). |
2017-12-08 |
2023-08-13 |
human |
| Matthew R Brier, Brian Gordon, Karl Friedrichsen, John McCarthy, Ari Stern, Jon Christensen, Christopher Owen, Patricia Aldea, Yi Su, Jason Hassenstab, Nigel J Cairns, David M Holtzman, Anne M Fagan, John C Morris, Tammie L S Benzinger, Beau M Ance. Tau and Aβ imaging, CSF measures, and cognition in Alzheimer's disease. Science translational medicine. vol 8. issue 338. 2017-12-07. PMID:27169802. |
tau and aβ imaging, csf measures, and cognition in alzheimer's disease. |
2017-12-07 |
2023-08-13 |
Not clear |
| Chuanzhou Li, Jürgen Göt. Tau-based therapies in neurodegeneration: opportunities and challenges. Nature reviews. Drug discovery. vol 16. issue 12. 2017-12-07. PMID:28983098. |
aggregates of the microtubule-associated protein tau are a defining feature of several neurodegenerative diseases that are collectively known as tauopathies, and constitute one of the hallmark lesions of alzheimer disease (ad). |
2017-12-07 |
2023-08-13 |
Not clear |
| Marta Olivera Santa-Catalina, Montaña Caballero Bermejo, Ricardo Argent, Juan C Alonso, Francisco Centeno, María J Lorenz. JNK signaling pathway regulates sorbitol-induced Tau proteolysis and apoptosis in SH-SY5Y cells by targeting caspase-3. Archives of biochemistry and biophysics. vol 636. 2017-12-06. PMID:29126968. |
interestingly, abnormal hyperphosphorylation and cleavage of tau have been proven to lead to the genesis of filamentous structures referred to as neurofibrillary tangles, the main pathological hallmark of alzheimer's disease. |
2017-12-06 |
2023-08-13 |
Not clear |
| Elliott J Mufson, Milos D Ikonomovic, Scott E Counts, Sylvia E Perez, Michael Malek-Ahmadi, Stephen W Scheff, Stephen D Ginsber. Molecular and cellular pathophysiology of preclinical Alzheimer's disease. Behavioural brain research. vol 311. 2017-12-05. PMID:27185734. |
although the two pathological hallmarks of alzheimer's disease (ad), senile plaques composed of amyloid-β (aβ) peptides and neurofibrillary tangles (nfts) consisting of hyperphosphorylated tau, have been studied extensively in postmortem ad and relevant animal and cellular models, the pathogenesis of ad remains unknown, particularly in the early stages of the disease where therapies presumably would be most effective. |
2017-12-05 |
2023-08-13 |
Not clear |
| Anthony W P Fitzpatrick, Benjamin Falcon, Shaoda He, Alexey G Murzin, Garib Murshudov, Holly J Garringer, R Anthony Crowther, Bernardino Ghetti, Michel Goedert, Sjors H W Schere. Cryo-EM structures of tau filaments from Alzheimer's disease. Nature. vol 547. issue 7662. 2017-12-05. PMID:28678775. |
cryo-em structures of tau filaments from alzheimer's disease. |
2017-12-05 |
2023-08-13 |
Not clear |
| Jean-Baptiste Oudart, Laure Zucchini, François-Xavier Maquart, Xavier Dubernard, Marc Labrousse, Géraldine Fiabane, Alexandra Quedreux, Fabien Litre, Laurent Ramon. Tau protein as a possible marker of cerebrospinal fluid leakage in cerebrospinal fluid rhinorrhoea: A pilot study. Biochemia medica. vol 27. issue 3. 2017-12-05. PMID:28900366. |
csf tau protein is a neuronal protein, commonly assessed for diagnosis of alzheimer disease (ad). |
2017-12-05 |
2023-08-13 |
Not clear |
| S-S Jiao, L-L Shen, C Zhu, X-L Bu, Y-H Liu, C-H Liu, X-Q Yao, L-L Zhang, H-D Zhou, D G Walker, J Tan, J Götz, X-F Zhou, Y-J Wan. Brain-derived neurotrophic factor protects against tau-related neurodegeneration of Alzheimer's disease. Translational psychiatry. vol 6. issue 10. 2017-12-04. PMID:27701410. |
reduced expression of brain-derived neurotrophic factor (bdnf) has a crucial role in the pathogenesis of alzheimer's disease (ad), which is characterized with the formation of neuritic plaques consisting of amyloid-beta (aβ) and neurofibrillary tangles composed of hyperphosphorylated tau protein. |
2017-12-04 |
2023-08-13 |
mouse |
| Gregory S Day, Brian A Gordon, Kelley Jackson, Jon J Christensen, Maria Rosana Ponisio, Yi Su, Beau M Ances, Tammie L S Benzinger, John C Morri. Tau-PET Binding Distinguishes Patients With Early-stage Posterior Cortical Atrophy From Amnestic Alzheimer Disease Dementia. Alzheimer disease and associated disorders. vol 31. issue 2. 2017-12-04. PMID:28394771. |
flortaucipir (tau) positron emission tomography (pet) binding distinguishes individuals with clinically well-established posterior cortical atrophy (pca) due to alzheimer disease (ad) from cognitively normal (cn) controls. |
2017-12-04 |
2023-08-13 |
Not clear |
| Garrett S Gibbons, Rachel A Banks, Bumjin Kim, Hong Xu, Lakshmi Changolkar, Susan N Leight, Dawn M Riddle, Chi Li, Ronald J Gathagan, Hannah J Brown, Bin Zhang, John Q Trojanowski, Virginia M-Y Le. GFP-Mutant Human Tau Transgenic Mice Develop Tauopathy Following CNS Injections of Alzheimer's Brain-Derived Pathological Tau or Synthetic Mutant Human Tau Fibrils. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 47. 2017-12-04. PMID:28986461. |
gfp-mutant human tau transgenic mice develop tauopathy following cns injections of alzheimer's brain-derived pathological tau or synthetic mutant human tau fibrils. |
2017-12-04 |
2023-08-13 |
mouse |
| Garrett S Gibbons, Rachel A Banks, Bumjin Kim, Hong Xu, Lakshmi Changolkar, Susan N Leight, Dawn M Riddle, Chi Li, Ronald J Gathagan, Hannah J Brown, Bin Zhang, John Q Trojanowski, Virginia M-Y Le. GFP-Mutant Human Tau Transgenic Mice Develop Tauopathy Following CNS Injections of Alzheimer's Brain-Derived Pathological Tau or Synthetic Mutant Human Tau Fibrils. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 47. 2017-12-04. PMID:28986461. |
neurodegenerative proteinopathies characterized by intracellular aggregates of tau proteins, termed tauopathies, include alzheimer's disease (ad), frontotemporal lobar degeneration (ftld) with tau pathology (ftld-tau), and related disorders. |
2017-12-04 |
2023-08-13 |
mouse |
| Sneha Narasimhan, Jing L Guo, Lakshmi Changolkar, Anna Stieber, Jennifer D McBride, Luisa V Silva, Zhuohao He, Bin Zhang, Ronald J Gathagan, John Q Trojanowski, Virginia M Y Le. Pathological Tau Strains from Human Brains Recapitulate the Diversity of Tauopathies in Nontransgenic Mouse Brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 47. 2017-12-04. PMID:29054878. |
pathological tau aggregates occur in alzheimer's disease (ad) and other neurodegenerative tauopathies. |
2017-12-04 |
2023-08-13 |
mouse |
| Min Shi, Andrej Kovac, Ane Korff, Travis J Cook, Carmen Ginghina, Kristin M Bullock, Li Yang, Tessandra Stewart, Danfeng Zheng, Patrick Aro, Anzari Atik, Kathleen F Kerr, Cyrus P Zabetian, Elaine R Peskind, Shu-Ching Hu, Joseph F Quinn, Douglas R Galasko, Thomas J Montine, William A Banks, Jing Zhan. CNS tau efflux via exosomes is likely increased in Parkinson's disease but not in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 12. issue 11. 2017-12-01. PMID:27234211. |
cns tau efflux via exosomes is likely increased in parkinson's disease but not in alzheimer's disease. |
2017-12-01 |
2023-08-13 |
Not clear |