| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Min Shi, Andrej Kovac, Ane Korff, Travis J Cook, Carmen Ginghina, Kristin M Bullock, Li Yang, Tessandra Stewart, Danfeng Zheng, Patrick Aro, Anzari Atik, Kathleen F Kerr, Cyrus P Zabetian, Elaine R Peskind, Shu-Ching Hu, Joseph F Quinn, Douglas R Galasko, Thomas J Montine, William A Banks, Jing Zhan. CNS tau efflux via exosomes is likely increased in Parkinson's disease but not in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 12. issue 11. 2017-12-01. PMID:27234211. |
alzheimer's disease (ad) and parkinson's disease (pd) involve tau pathology. |
2017-12-01 |
2023-08-13 |
Not clear |
| Gianvincenzo Sparacia, Francesco Agnello, Giuseppe La Tona, Alberto Iaia, Federico Midiri, Benedetta Sparaci. Assessment of cerebral microbleeds by susceptibility-weighted imaging in Alzheimer's disease patients: A neuroimaging biomarker of the disease. The neuroradiology journal. vol 30. issue 4. 2017-12-01. PMID:28463092. |
purpose the objective of this study was to correlate the presence and distribution of cerebral microbleeds in alzheimer's disease patients with cerebrospinal fluid biomarkers (amyloid-beta and phosphorylated tau 181 protein levels) and cognitive decline by using susceptibility-weighted imaging magnetic resonance sequences at 1.5 t. material and methods fifty-four consecutive alzheimer's disease patients underwent brain magnetic resonance imaging at 1.5 t to assess the presence and distribution of cerebral microbleeds on susceptibility-weighted imaging images. |
2017-12-01 |
2023-08-13 |
Not clear |
| Gianvincenzo Sparacia, Francesco Agnello, Giuseppe La Tona, Alberto Iaia, Federico Midiri, Benedetta Sparaci. Assessment of cerebral microbleeds by susceptibility-weighted imaging in Alzheimer's disease patients: A neuroimaging biomarker of the disease. The neuroradiology journal. vol 30. issue 4. 2017-12-01. PMID:28463092. |
cerebrospinal fluid amyloid-beta, phosphorylated tau 181 protein levels, and cognitive decline were correlated with the number of lobar cerebral microbleeds in alzheimer's disease patients ( p < 0.001). |
2017-12-01 |
2023-08-13 |
Not clear |
| Gianvincenzo Sparacia, Francesco Agnello, Giuseppe La Tona, Alberto Iaia, Federico Midiri, Benedetta Sparaci. Assessment of cerebral microbleeds by susceptibility-weighted imaging in Alzheimer's disease patients: A neuroimaging biomarker of the disease. The neuroradiology journal. vol 30. issue 4. 2017-12-01. PMID:28463092. |
conclusion lobar distribution of cerebral microbleeds is associated with alzheimer's disease and the number of lobar cerebral microbleeds directly correlates with cerebrospinal fluid amyloid-beta and phosphorylated tau 181 protein levels and with the cognitive decline of alzheimer's disease patients. |
2017-12-01 |
2023-08-13 |
Not clear |
| Taisuke Tomit. Aberrant proteolytic processing and therapeutic strategies in Alzheimer disease. Advances in biological regulation. vol 64. 2017-11-30. PMID:28082052. |
amyloid-β peptide (aβ) and tau are major components of senile plaques and neurofibrillary tangles, respectively, deposited in the brains of alzheimer disease (ad) patients. |
2017-11-30 |
2023-08-13 |
Not clear |
| Antonella Marino Gammazza, Celeste Caruso Bavisotto, Rosario Barone, Everly Conway de Macario, Alberto J L Macari. Alzheimer's Disease and Molecular Chaperones: Current Knowledge and the Future of Chaperonotherapy. Current pharmaceutical design. vol 22. issue 26. 2017-11-29. PMID:27189602. |
alzheimer's disease (ad) is a dementia, a neurodegenerative condition, and a protein-misfolding disease or proteinopathy, characterized by protein deposits, extracellular plaques and intracellular neurofibrillary tangles, which contain the ad's typical pathological proteins, abnormal β-amyloid and hyperphosphorylated tau, respectively, and are located predominantly in the cortex of the frontal, parietal, and temporal brain lobes. |
2017-11-29 |
2023-08-13 |
Not clear |
| Roland Brandt, Lidia Bakot. Microtubule dynamics and the neurodegenerative triad of Alzheimer's disease: The hidden connection. Journal of neurochemistry. vol 143. issue 4. 2017-11-28. PMID:28267200. |
alzheimer's disease (ad) is the most common neurodegenerative disorder and is, on a histopathological level, characterized by the presence of extracellular amyloid plaques composed of the protein fragment aβ, and intracellular neurofibrillary tangles, which contain the microtubule-associated protein tau in a hyperphosphorylated state. |
2017-11-28 |
2023-08-13 |
Not clear |
| Virginie Vanden Dries, Virginie Stygelbout, Nathalie Pierrot, Zehra Yilmaz, Valérie Suain, Robert De Decker, Luc Buée, Jean-Noël Octave, Jean-Pierre Brion, Karelle Lero. Amyloid precursor protein reduction enhances the formation of neurofibrillary tangles in a mutant tau transgenic mouse model. Neurobiology of aging. vol 55. 2017-11-28. PMID:28464981. |
alzheimer's disease is characterized by the presence of 2 neuropathological lesions: neurofibrillary tangles, composed of tau proteins which are highly phosphorylated and phosphorylated on uncommon sites, and amyloid plaques, containing the aß peptides generated from the amyloid precursor protein (app). |
2017-11-28 |
2023-08-13 |
mouse |
| Virginie Vanden Dries, Virginie Stygelbout, Nathalie Pierrot, Zehra Yilmaz, Valérie Suain, Robert De Decker, Luc Buée, Jean-Noël Octave, Jean-Pierre Brion, Karelle Lero. Amyloid precursor protein reduction enhances the formation of neurofibrillary tangles in a mutant tau transgenic mouse model. Neurobiology of aging. vol 55. 2017-11-28. PMID:28464981. |
reduction of some app proteolytic derivatives in alzheimer's disease such as sappα fragment has been reported and sappα has been shown to affect tau phosphorylation. |
2017-11-28 |
2023-08-13 |
mouse |
| Youssra K Al-Hilaly, Saskia J Pollack, Devkee M Vadukul, Francesca Citossi, Janet E Rickard, Michael Simpson, John M D Storey, Charles R Harrington, Claude M Wischik, Louise C Serpel. Alzheimer's Disease-like Paired Helical Filament Assembly from Truncated Tau Protein Is Independent of Disulfide Crosslinking. Journal of molecular biology. vol 429. issue 23. 2017-11-28. PMID:28919235. |
alzheimer's disease-like paired helical filament assembly from truncated tau protein is independent of disulfide crosslinking. |
2017-11-28 |
2023-08-13 |
Not clear |
| Youssra K Al-Hilaly, Saskia J Pollack, Devkee M Vadukul, Francesca Citossi, Janet E Rickard, Michael Simpson, John M D Storey, Charles R Harrington, Claude M Wischik, Louise C Serpel. Alzheimer's Disease-like Paired Helical Filament Assembly from Truncated Tau Protein Is Independent of Disulfide Crosslinking. Journal of molecular biology. vol 429. issue 23. 2017-11-28. PMID:28919235. |
alzheimer's disease is characterized by the self-assembly of tau and amyloid β proteins into oligomers and fibrils. |
2017-11-28 |
2023-08-13 |
Not clear |
| Youssra K Al-Hilaly, Saskia J Pollack, Devkee M Vadukul, Francesca Citossi, Janet E Rickard, Michael Simpson, John M D Storey, Charles R Harrington, Claude M Wischik, Louise C Serpel. Alzheimer's Disease-like Paired Helical Filament Assembly from Truncated Tau Protein Is Independent of Disulfide Crosslinking. Journal of molecular biology. vol 429. issue 23. 2017-11-28. PMID:28919235. |
tau protein assembles into paired helical filaments (phfs) that constitute the neurofibrillary tangles observed in neuronal cell bodies in individuals with alzheimer's disease. |
2017-11-28 |
2023-08-13 |
Not clear |
| Yi He, Heng Li, Feng Zhang, Guitao Zhang, Xiaosan Tang, Tianrui Zhu, Nana Huang, Xiaohong L. Immunotherapeutic effects of lymphocytes co-cultured with human cord blood-derived multipotent stem cells transplantation on APP/PS1 mice. Behavioural brain research. vol 315. 2017-11-24. PMID:27528555. |
alzheimer's disease (ad) is an inexorable neurodegenerative disease that involves neuroinflammation in the brain, in addition to abnormal accumulation of amyloid-β (aβ) and hyperphosphorylated tau. |
2017-11-24 |
2023-08-13 |
mouse |
| Luka Rejc, Lojze Šmid, Vladimir Kepe, Črtomir Podlipnik, Amalija Golobič, Mara Bresjanac, Jorge R Barrio, Andrej Petrič, Janez Košmrl. Design, Syntheses, and in Vitro Evaluation of New Fluorine-18 Radiolabeled Tau-Labeling Molecular Probes. Journal of medicinal chemistry. vol 60. issue 21. 2017-11-22. PMID:28921979. |
deposition of aggregates of hyperphosphorylated tau protein is a hallmark of tauopathies like alzheimer and many other neurodegenerative diseases. |
2017-11-22 |
2023-08-13 |
Not clear |
| Maxime Wc Rousseaux, Maria de Haro, Cristian A Lasagna-Reeves, Antonia De Maio, Jeehye Park, Paymaan Jafar-Nejad, Ismael Al-Ramahi, Ajay Sharma, Lauren See, Nan Lu, Luis Vilanova-Velez, Tiemo J Klisch, Thomas F Westbrook, Juan C Troncoso, Juan Botas, Huda Y Zoghb. TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau. eLife. vol 5. 2017-11-20. PMID:27779468. |
elevated levels of alpha-synuclein (α-syn) appear to drive neurotoxicity in parkinson's disease (pd); neuronal accumulation of tau is a hallmark of alzheimer's disease (ad); and their increased levels cause neurodegeneration in humans and model organisms. |
2017-11-20 |
2023-08-13 |
Not clear |
| Susmitha Ambadipudi, Jacek Biernat, Dietmar Riedel, Eckhard Mandelkow, Markus Zweckstette. Liquid-liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau. Nature communications. vol 8. issue 1. 2017-11-20. PMID:28819146. |
the protein tau aggregates into tangles in the brain of patients with alzheimer's disease. |
2017-11-20 |
2023-08-13 |
Not clear |
| Susmitha Ambadipudi, Jacek Biernat, Dietmar Riedel, Eckhard Mandelkow, Markus Zweckstette. Liquid-liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau. Nature communications. vol 8. issue 1. 2017-11-20. PMID:28819146. |
the combined data propose a mechanism in which liquid droplets formed by the positively charged microtubule-binding domain of tau undergo coacervation with negatively charged molecules to promote amyloid formation.tau forms aggregates in the brains of alzheimer patients. |
2017-11-20 |
2023-08-13 |
Not clear |
| Mikiko Oka, Naoki Fujisaki, Akiko Maruko-Otake, Yosuke Ohtake, Sawako Shimizu, Taro Saito, Shin-Ichi Hisanaga, Koichi M Iijima, Kanae And. Ca2+/calmodulin-dependent protein kinase II promotes neurodegeneration caused by tau phosphorylated at Ser262/356 in a transgenic Drosophila model of tauopathy. Journal of biochemistry. vol 162. issue 5. 2017-11-20. PMID:28992057. |
abnormal deposition of the microtubule-associated protein tau is a common pathological feature of multiple neurodegenerative diseases, including alzheimer's disease (ad), and plays critical roles in their pathogenesis. |
2017-11-20 |
2023-08-13 |
drosophila_melanogaster |
| M Dash, A Eid, G Subaiea, J Chang, R Deeb, A Masoud, W E Renehan, A Adem, N H Zawi. Developmental exposure to lead (Pb) alters the expression of the human tau gene and its products in a transgenic animal model. Neurotoxicology. vol 55. 2017-11-17. PMID:27293183. |
the best known of these illnesses is alzheimer's disease (ad); a disease where the microtubule associated protein tau (mapt) becomes hyperphosphorylated (lowering its binding affinity to microtubules) and aggregates within neurons in the form of neurofibrillary tangles (nfts). |
2017-11-17 |
2023-08-13 |
mouse |
| Yukari Murata-Shinozaki, Tetsuya Takahashi, Tomoyasu Matsubara, Hirofumi Maruyama, Yuishin Izumi, Masayasu Matsumot. The origins of rimmed vacuoles and granulovacuolar degeneration bodies are associated with the Wnt signaling pathway. Neuroscience letters. vol 638. 2017-11-17. PMID:27939356. |
inclusion-body myositis (ibm) and alzheimer's disease (ad) are biochemically characterized by the presence of aggregated β-amyloid protein and tau protein. |
2017-11-17 |
2023-08-13 |
Not clear |