All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Marine Tournissac, Milène Vandal, Arnaud François, Emmanuel Planel, Frédéric Calo. Old age potentiates cold-induced tau phosphorylation: linking thermoregulatory deficit with Alzheimer's disease. Neurobiology of aging. vol 50. 2017-10-06. PMID:27838492. old age potentiates cold-induced tau phosphorylation: linking thermoregulatory deficit with alzheimer's disease. 2017-10-06 2023-08-13 mouse
Simon F Eskildsen, Louise Gyldensted, Kartheeban Nagenthiraja, Rune B Nielsen, Mikkel Bo Hansen, Rikke B Dalby, Jesper Frandsen, Anders Rodell, Carsten Gyldensted, Sune N Jespersen, Torben E Lund, Kim Mouridsen, Hans Brændgaard, Leif Østergaar. Increased cortical capillary transit time heterogeneity in Alzheimer's disease: a DSC-MRI perfusion study. Neurobiology of aging. vol 50. 2017-10-06. PMID:27951412. alzheimer's disease (ad) is characterized by the accumulation of hyperphosphorylated tau and neurotoxic aβ in the brain parenchyma. 2017-10-06 2023-08-13 Not clear
V Guru KrishnaKumar, Sharad Gupt. Simplified method to obtain enhanced expression of tau protein from E. coli and one-step purification by direct boiling. Preparative biochemistry & biotechnology. vol 47. issue 5. 2017-10-06. PMID:28045602. however, in certain disease conditions including alzheimer's disease, tau protein may undergo biochemical and structural changes to form intracellular aggregates. 2017-10-06 2023-08-13 Not clear
Yuanyuan Zhou, Chaoyan Li, Deheng Li, Yaping Zheng, Jin Wan. IL-5 blocks apoptosis and tau hyperphosphorylation induced by Aβ Journal of physiology and biochemistry. vol 73. issue 2. 2017-10-04. PMID:28132394. il-5 blocks apoptosis and tau hyperphosphorylation induced by aβ the primary features of alzheimer's disease (ad) are extracellular amyloid plaques consisting mainly of deposits of amyloid β (aβ) peptides and intracellular neurofibrillary tangles (nfts). 2017-10-04 2023-08-13 Not clear
T A Pascoal, S Mathotaarachchi, S Mohades, A L Benedet, C-O Chung, M Shin, S Wang, T Beaudry, M S Kang, J-P Soucy, A Labbe, S Gauthier, P Rosa-Net. Amyloid-β and hyperphosphorylated tau synergy drives metabolic decline in preclinical Alzheimer's disease. Molecular psychiatry. vol 22. issue 2. 2017-10-03. PMID:27021814. amyloid-β and hyperphosphorylated tau synergy drives metabolic decline in preclinical alzheimer's disease. 2017-10-03 2023-08-13 Not clear
T A Pascoal, S Mathotaarachchi, S Mohades, A L Benedet, C-O Chung, M Shin, S Wang, T Beaudry, M S Kang, J-P Soucy, A Labbe, S Gauthier, P Rosa-Net. Amyloid-β and hyperphosphorylated tau synergy drives metabolic decline in preclinical Alzheimer's disease. Molecular psychiatry. vol 22. issue 2. 2017-10-03. PMID:27021814. this study was designed to test the interaction between amyloid-β and tau proteins as a determinant of metabolic decline in preclinical alzheimer's disease (ad). 2017-10-03 2023-08-13 Not clear
Xuemei Zhang, Yanxian Lin, Neil A Eschmann, Hongjun Zhou, Jennifer N Rauch, Israel Hernandez, Elmer Guzman, Kenneth S Kosik, Songi Ha. RNA stores tau reversibly in complex coacervates. PLoS biology. vol 15. issue 7. 2017-10-03. PMID:28683104. here, we report that tau protein, the primary constituent of alzheimer neurofibrillary tangles, can form liquid droplets and therefore has the necessary biophysical properties to undergo liquid-liquid phase separation (llps) in cells. 2017-10-03 2023-08-13 Not clear
Udo Rüb, Katharina Stratmann, Helmut Heinsen, Domenico Del Turco, Kay Seidel, Wilfred den Dunnen, Horst-Werner Kor. The Brainstem Tau Cytoskeletal Pathology of Alzheimer's Disease: A Brief Historical Overview and Description of its Anatomical Distribution Pattern, Evolutional Features, Pathogenetic and Clinical Relevance. Current Alzheimer research. vol 13. issue 10. 2017-10-02. PMID:27264543. the brainstem tau cytoskeletal pathology of alzheimer's disease: a brief historical overview and description of its anatomical distribution pattern, evolutional features, pathogenetic and clinical relevance. 2017-10-02 2023-08-13 human
Udo Rüb, Katharina Stratmann, Helmut Heinsen, Domenico Del Turco, Kay Seidel, Wilfred den Dunnen, Horst-Werner Kor. The Brainstem Tau Cytoskeletal Pathology of Alzheimer's Disease: A Brief Historical Overview and Description of its Anatomical Distribution Pattern, Evolutional Features, Pathogenetic and Clinical Relevance. Current Alzheimer research. vol 13. issue 10. 2017-10-02. PMID:27264543. in contrast to the cerebral cortex the affection of the brainstem in alzheimer's disease (ad) by the neurofibrillary or tau cytoskeletal pathology was recognized only approximately fourty years ago in initial brainstem studies. 2017-10-02 2023-08-13 human
Siddhartha Mondragón-Rodríguez, George Perry, Fernando Pena-Ortega, Sylvain William. Tau, Amyloid Beta and Deep Brain Stimulation: Aiming to Restore Cognitive Deficit in Alzheimer's Disease. Current Alzheimer research. vol 14. issue 1. 2017-10-02. PMID:27539594. tau, amyloid beta and deep brain stimulation: aiming to restore cognitive deficit in alzheimer's disease. 2017-10-02 2023-08-13 Not clear
Siddhartha Mondragón-Rodríguez, George Perry, Fernando Pena-Ortega, Sylvain William. Tau, Amyloid Beta and Deep Brain Stimulation: Aiming to Restore Cognitive Deficit in Alzheimer's Disease. Current Alzheimer research. vol 14. issue 1. 2017-10-02. PMID:27539594. the last two decades have seen a great advance in the data that supports the two current hypotheses in alzheimer`s disease field, the amyloid beta hypothesis and the tau hypothesis. 2017-10-02 2023-08-13 Not clear
Keran Ma, JoAnne McLauri. α-Melanocyte Stimulating Hormone as a Potential Therapy for Alzheimer`s Disease. Current Alzheimer research. vol 14. issue 1. 2017-10-02. PMID:27539595. alzheimer's disease (ad) is characterized by accumulation and aggregation of beta-amyloid peptide, neurofibrillary tangles of hyperphosphorylated tau, neuroinflammation, synaptic degeneration and eventual neuronal cell loss. 2017-10-02 2023-08-13 Not clear
Jianlan Gu, Feng Wu, Wen Xu, Jianhua Shi, Wen Hu, Nana Jin, Wei Qian, Xinglong Wang, Khalid Iqbal, Cheng-Xin Gong, Fei Li. TDP-43 suppresses tau expression via promoting its mRNA instability. Nucleic acids research. vol 45. issue 10. 2017-10-02. PMID:28335005. in the brains of individuals with alzheimer's disease (ad) and chronic traumatic encephalopathy, tau pathology is accompanied usually by intracellular aggregation of transactive response dna-binding protein 43 (tdp-43). 2017-10-02 2023-08-13 mouse
Jeremy D Baker, Lindsey B Shelton, Dali Zheng, Filippo Favretto, Bryce A Nordhues, April Darling, Leia E Sullivan, Zheying Sun, Parth K Solanki, Mackenzie D Martin, Amirthaa Suntharalingam, Jonathan J Sabbagh, Stefan Becker, Eckhard Mandelkow, Vladimir N Uversky, Markus Zweckstetter, Chad A Dickey, John Koren, Laura J Blai. Human cyclophilin 40 unravels neurotoxic amyloids. PLoS biology. vol 15. issue 6. 2017-10-02. PMID:28654636. the aberrant accumulation of the microtubule associating protein tau (mapt, tau) into toxic oligomers and amyloid deposits is a primary pathology in tauopathies, the most common of which is alzheimer's disease (ad). 2017-10-02 2023-08-13 mouse
Chin Hong Tan, Bradley T Hyman, Jacinth J X Tan, Christopher P Hess, William P Dillon, Gerard D Schellenberg, Lilah M Besser, Walter A Kukull, Karolina Kauppi, Linda K McEvoy, Ole A Andreassen, Anders M Dale, Chun Chieh Fan, Rahul S Desika. Polygenic hazard scores in preclinical Alzheimer disease. Annals of neurology. vol 82. issue 3. 2017-10-02. PMID:28940650. phs predicted longitudinal clinical decline among older individuals with moderate to high consortium to establish a registry for alzheimer's disease (amyloid) and braak (tau) scores at autopsy, even among apoe ɛ4 noncarriers. 2017-10-02 2023-08-13 Not clear
Aurélie Joly-Amado, Karisa S Serraneau, Milene Brownlow, Caralina Marín de Evsikova, John R Speakman, Marcia N Gordon, Dave Morga. Metabolic changes over the course of aging in a mouse model of tau deposition. Neurobiology of aging. vol 44. 2017-09-28. PMID:27318134. these diverse changes in metabolism in a mouse model of tau deposition are discussed in the context of known changes in energy metabolism in alzheimer's disease. 2017-09-28 2023-08-13 mouse
Emilie Dorard, Lucie Gorisse-Hussonnois, Chantal Guihenneuc-Jouyaux, Christelle Albac, Marie-Claude Potier, Bernadette Allinquan. Increases of SET level and translocation are correlated with tau hyperphosphorylation at ser202/thr205 in CA1 of Ts65Dn mice. Neurobiology of aging. vol 46. 2017-09-28. PMID:27460148. here, we show that in ca1 of 3-month-old ts65dn mice modeling ds, set level is increased, and set is translocated to the cytoplasm and associated with tau hyperphosphorylations at ser202/thr205 and with amyloid precursor protein caspase cleaved as observed in alzheimer disease brains. 2017-09-28 2023-08-13 mouse
Geri Meduri, Kevin Guillemeau, Omar Dounane, Véronique Sazdovitch, Charles Duyckaerts, Béatrice Chambraud, Etienne Emile Baulieu, Julien Giustinian. Caspase-cleaved Tau-D(421) is colocalized with the immunophilin FKBP52 in the autophagy-endolysosomal system of Alzheimer's disease neurons. Neurobiology of aging. vol 46. 2017-09-28. PMID:27479154. pathologic modifications of the tau protein leading to neurofibrillary tangle (nft) formation are a common feature of a wide range of neurodegenerative diseases known as tauopathies, which include alzheimer's disease (ad). 2017-09-28 2023-08-13 Not clear
E Magnin, J Dumurgier, E Bouaziz-Amar, S Bombois, D Wallon, A Gabelle, S Lehmann, F Blanc, O Bousiges, D Hannequin, B Jung, C Miguet-Alfonsi, M Quillard, F Pasquier, K Peoc'h, J-L Laplanche, J Hugon, C Paque. [Alzheimer's disease cerebro-spinal fluid biomarkers: A clinical research tool sometimes useful in daily clinical practice of memory clinics for the diagnosis of complex cases]. La Revue de medecine interne. vol 38. issue 4. 2017-09-28. PMID:27890382. cerebro-spinal fluid (csf) biomarkers (total tau protein, threonine 181 phosphorylated tau protein and amyloid aβ1-42 peptide) are associated with cerebral neuropathological lesions observed in alzheimer's disease (neuronal death, neurofibrillary tangle with abnormal tau deposits and amyloid plaque). 2017-09-28 2023-08-13 human
Jeffrey A Zahratka, Yvonne Shao, McKenzie Shaw, Kaitlin Todd, Shane V Formica, Maria Khrestian, Thomas Montine, James B Leverenz, Lynn M Bekri. Regulatory region genetic variation is associated with FYN expression in Alzheimer's disease. Neurobiology of aging. vol 51. 2017-09-28. PMID:28033507. neurofibrillary tangles (nfts), composed of hyperphosphorylated tau, are a key pathologic feature of alzheimer's disease (ad). 2017-09-28 2023-08-13 Not clear