| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Val J Lowe, Geoffry Curran, Ping Fang, Amanda M Liesinger, Keith A Josephs, Joseph E Parisi, Kejal Kantarci, Bradley F Boeve, Mukesh K Pandey, Tyler Bruinsma, David S Knopman, David T Jones, Leonard Petrucelli, Casey N Cook, Neill R Graff-Radford, Dennis W Dickson, Ronald C Petersen, Clifford R Jack, Melissa E Murra. An autoradiographic evaluation of AV-1451 Tau PET in dementia. Acta neuropathologica communications. vol 4. issue 1. 2017-10-25. PMID:27296779. |
we performed autoradiography in autopsy-confirmed alzheimer disease and other neurodegenerative disorders to evaluate the specificity of av-1451 binding for tau aggregates. |
2017-10-25 |
2023-08-13 |
Not clear |
| Amit K Chouhan, Caiwei Guo, Yi-Chen Hsieh, Hui Ye, Mumine Senturk, Zhongyuan Zuo, Yarong Li, Shreyasi Chatterjee, Juan Botas, George R Jackson, Hugo J Bellen, Joshua M Shulma. Uncoupling neuronal death and dysfunction in Drosophila models of neurodegenerative disease. Acta neuropathologica communications. vol 4. issue 1. 2017-10-25. PMID:27338814. |
common neurodegenerative proteinopathies, such as alzheimer's disease (ad) and parkinson's disease (pd), are characterized by the misfolding and aggregation of toxic protein species, including the amyloid beta (aß) peptide, microtubule-associated protein tau (tau), and alpha-synuclein (αsyn) protein. |
2017-10-25 |
2023-08-13 |
human |
| Luke W Bonham, Rahul S Desikan, Jennifer S Yokoyam. The relationship between complement factor C3, APOE ε4, amyloid and tau in Alzheimer's disease. Acta neuropathologica communications. vol 4. issue 1. 2017-10-25. PMID:27357286. |
the relationship between complement factor c3, apoe ε4, amyloid and tau in alzheimer's disease. |
2017-10-25 |
2023-08-13 |
Not clear |
| Luke W Bonham, Rahul S Desikan, Jennifer S Yokoyam. The relationship between complement factor C3, APOE ε4, amyloid and tau in Alzheimer's disease. Acta neuropathologica communications. vol 4. issue 1. 2017-10-25. PMID:27357286. |
as a part of the innate immune system, the complement cascade enhances the body's ability to destroy and remove pathogens and has recently been shown to influence alzheimer's associated amyloid and tau pathology. |
2017-10-25 |
2023-08-13 |
Not clear |
| Luke W Bonham, Rahul S Desikan, Jennifer S Yokoyam. The relationship between complement factor C3, APOE ε4, amyloid and tau in Alzheimer's disease. Acta neuropathologica communications. vol 4. issue 1. 2017-10-25. PMID:27357286. |
our results support a conceptual model of the ad pathogenic cascade where a synergistic relationship between the complement cascade (c3) and apoe ε4 results in elevated alzheimer's neurodegeneration and in turn, amyloid further regulates the effect of the complement cascade on downstream tau pathology. |
2017-10-25 |
2023-08-13 |
Not clear |
| Anthony Papegaey, Sabiha Eddarkaoui, Vincent Deramecourt, Francisco-Jose Fernandez-Gomez, Pierre Pantano, Hélène Obriot, Camille Machala, Vincent Anquetil, Agnès Camuzat, Alexis Brice, Claude-Alain Maurage, Isabelle Le Ber, Charles Duyckaerts, Luc Buée, Nicolas Sergeant, Valérie Buée-Scherre. Reduced Tau protein expression is associated with frontotemporal degeneration with progranulin mutation. Acta neuropathologica communications. vol 4. issue 1. 2017-10-25. PMID:27435172. |
to address this question, we have analyzed tau expression in the frontal brain areas from control, alzheimer's disease and ftld cases, including ftld- tau (mapt), ftld-tdp (sporadic, ftld-tdp-grn, ftld-tdp-c9orf72) and sporadic ftld-fus, using western blot and 2d-dige (two-dimensional fluorescence difference gel electrophoresis) approaches. |
2017-10-25 |
2023-08-13 |
Not clear |
| Johannes Steffen, Markus Krohn, Kristin Paarmann, Christina Schwitlick, Thomas Brüning, Rita Marreiros, Andreas Müller-Schiffmann, Carsten Korth, Katharina Braun, Jens Pahnk. Revisiting rodent models: Octodon degus as Alzheimer's disease model? Acta neuropathologica communications. vol 4. issue 1. 2017-10-25. PMID:27566602. |
phosphoepitope-specific antibodies against tau species displayed similar intraneuronal reactivity in both, young and aged octodon degus.in contrast to previous results, our study suggests that octodon degus born and bred in captivity do not inevitably develop cortical amyloidosis, tangle formation or neuronal loss as seen in alzheimer's disease patients or transgenic disease models. |
2017-10-25 |
2023-08-13 |
mouse |
| Masaki Takao, Nobuyoshi Hirose, Yasumichi Arai, Ban Mihara, Masaru Mimur. Neuropathology of supercentenarians - four autopsy case studies. Acta neuropathologica communications. vol 4. issue 1. 2017-10-25. PMID:27590044. |
in particular, we focused on the pathology of alzheimer's disease and lewy body disease, as well as the status of hippocampal sclerosis, tdp-43 pathology, aging-related tau astrogliopathy, and cerebrovascular diseases. |
2017-10-25 |
2023-08-13 |
human |
| Vera I Wiersma, Wim van Hecke, Wiep Scheper, Martijn A J van Osch, Will J M Hermsen, Annemieke J M Rozemuller, Jeroen J M Hoozeman. Activation of the unfolded protein response and granulovacuolar degeneration are not common features of human prion pathology. Acta neuropathologica communications. vol 4. issue 1. 2017-10-25. PMID:27793194. |
in post-mortem brain tissue from patients with other neurodegenerative diseases characterized by protein misfolding, including alzheimer's disease (ad) and frontotemporal lobar degeneration with tau pathology (ftld-tau), increased activation of the unfolded protein response (upr) has been observed. |
2017-10-25 |
2023-08-13 |
human |
| Benedicte Foveau, Steffen Albrecht, David A Bennett, José A Correa, Andrea C LeBlan. Increased Caspase-6 activity in the human anterior olfactory nuclei of the olfactory bulb is associated with cognitive impairment. Acta neuropathologica communications. vol 4. issue 1. 2017-10-25. PMID:27931265. |
to examine this possibility, we examined the presence of casp6 activity, neurofibrillary tangle formation and amyloid deposition by immunohistochemistry with neoepitope antisera against the p20 subunit of active casp6 and tau cleaved by casp6 (tau∆casp6), phosphorylated tau paired helical filament (phf-1) antibodies and anti-β-amyloid antiserum, respectively, in brains from individuals with no or mild cognitive impairment and alzheimer disease (ad) dementia. |
2017-10-25 |
2023-08-13 |
mouse |
| Wei Wang, Lu Lu, Qiao-Qi Wu, Jian-Ping Ji. Brain Amyloid-β Plays an Initiating Role in the Pathophysiological Process of the PS1V97L-Tg Mouse Model of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 52. issue 3. 2017-10-24. PMID:27079718. |
amyloid-β (aβ) aggregation, tau hyperphosphorylation, oxidative stress, and neuroinflammation are major pathophysiological events in alzheimer's disease (ad). |
2017-10-24 |
2023-08-13 |
mouse |
| Dawn H W Lau, Marte Hogseth, Emma C Phillips, Michael J O'Neill, Amy M Pooler, Wendy Noble, Diane P Hange. Critical residues involved in tau binding to fyn: implications for tau phosphorylation in Alzheimer's disease. Acta neuropathologica communications. vol 4. issue 1. 2017-10-24. PMID:27193083. |
critical residues involved in tau binding to fyn: implications for tau phosphorylation in alzheimer's disease. |
2017-10-24 |
2023-08-13 |
human |
| Dawn H W Lau, Marte Hogseth, Emma C Phillips, Michael J O'Neill, Amy M Pooler, Wendy Noble, Diane P Hange. Critical residues involved in tau binding to fyn: implications for tau phosphorylation in Alzheimer's disease. Acta neuropathologica communications. vol 4. issue 1. 2017-10-24. PMID:27193083. |
alzheimer's disease (ad) is a progressive neurodegenerative disorder characterised by neuropathological deposits of amyloid plaques and neurofibrillary tangles comprised of β-amyloid and tau protein, respectively. |
2017-10-24 |
2023-08-13 |
human |
| Toshiki Uchihara, Kentaro Endo, Hiromi Kondo, Sachi Okabayashi, Nobuhiro Shimozawa, Yasuhiro Yasutomi, Eijiro Adachi, Nobuyuki Kimur. Tau pathology in aged cynomolgus monkeys is progressive supranuclear palsy/corticobasal degeneration- but not Alzheimer disease-like -Ultrastructural mapping of tau by EDX. Acta neuropathologica communications. vol 4. issue 1. 2017-10-24. PMID:27842611. |
tau pathology in aged cynomolgus monkeys is progressive supranuclear palsy/corticobasal degeneration- but not alzheimer disease-like -ultrastructural mapping of tau by edx. |
2017-10-24 |
2023-08-13 |
human |
| Toshiki Uchihara, Kentaro Endo, Hiromi Kondo, Sachi Okabayashi, Nobuhiro Shimozawa, Yasuhiro Yasutomi, Eijiro Adachi, Nobuyuki Kimur. Tau pathology in aged cynomolgus monkeys is progressive supranuclear palsy/corticobasal degeneration- but not Alzheimer disease-like -Ultrastructural mapping of tau by EDX. Acta neuropathologica communications. vol 4. issue 1. 2017-10-24. PMID:27842611. |
concomitant deposition of amyloid -beta protein (aβ) and neuronal tau as neurofibrillary tangles in the human brain is a hallmark of alzheimer disease (ad). |
2017-10-24 |
2023-08-13 |
human |
| Ibrahim Kaya, Dimitri Brinet, Wojciech Michno, Stina Syvänen, Dag Sehlin, Henrik Zetterberg, Kaj Blennow, Jörg Hanriede. Delineating Amyloid Plaque Associated Neuronal Sphingolipids in Transgenic Alzheimer's Disease Mice (tgArcSwe) Using MALDI Imaging Mass Spectrometry. ACS chemical neuroscience. vol 8. issue 2. 2017-10-24. PMID:27984697. |
the major pathological hallmarks of alzheimer's disease (ad) are the progressive aggregation and accumulation of beta-amyloid (aβ) and hyperphosphorylated tau protein into neurotoxic deposits. |
2017-10-24 |
2023-08-13 |
mouse |
| Sarah Westwood, Emanuela Leoni, Abdul Hye, Steven Lynham, Mizanur R Khondoker, Nicholas J Ashton, Steven J Kiddle, Alison L Baird, Ricardo Sainz-Fuertes, Rufina Leung, John Graf, Cristina Tan Hehir, David Baker, Cristina Cereda, Chantal Bazenet, Malcolm Ward, Madhav Thambisetty, Simon Loveston. Blood-Based Biomarker Candidates of Cerebral Amyloid Using PiB PET in Non-Demented Elderly. Journal of Alzheimer's disease : JAD. vol 52. issue 2. 2017-10-23. PMID:27031486. |
increasingly, clinical trials for alzheimer's disease (ad) are being conducted earlier in the disease phase and with biomarker confirmation using in vivo amyloid pet imaging or csf tau and aβ measures to quantify pathology. |
2017-10-23 |
2023-08-13 |
human |
| Jeffrey L Dage, Alexandra M V Wennberg, David C Airey, Clinton E Hagen, David S Knopman, Mary M Machulda, Rosebud O Roberts, Clifford R Jack, Ronald C Petersen, Michelle M Mielk. Levels of tau protein in plasma are associated with neurodegeneration and cognitive function in a population-based elderly cohort. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 12. issue 12. 2017-10-23. PMID:27436677. |
we examined associations between plasma tau levels and alzheimer's disease (ad)-related magnetic resonance imaging (mri) and positron emission tomography (pet) neuroimaging measures among nondemented individuals. |
2017-10-23 |
2023-08-13 |
Not clear |
| Idir Malki, François-Xavier Cantrelle, Yoann Sottejeau, Guy Lippens, Jean-Charles Lambert, Isabelle Landrie. Regulation of the interaction between the neuronal BIN1 isoform 1 and Tau proteins - role of the SH3 domain. The FEBS journal. vol 284. issue 19. 2017-10-20. PMID:28755476. |
bridging integrator 1 (bin1) gene is a genetic determinant of alzheimer's disease (ad) and has been reported to modulate alzheimer's pathogenesis through pathway(s) involving tau. |
2017-10-20 |
2023-08-13 |
Not clear |
| Keith A Josephs, Dennis W Dickson, Nirubol Tosakulwong, Stephen D Weigand, Melissa E Murray, Leonard Petrucelli, Amanda M Liesinger, Matthew L Senjem, Anthony J Spychalla, David S Knopman, Joseph E Parisi, Ronald C Petersen, Clifford R Jack, Jennifer L Whitwel. Rates of hippocampal atrophy and presence of post-mortem TDP-43 in patients with Alzheimer's disease: a longitudinal retrospective study. The Lancet. Neurology. vol 16. issue 11. 2017-10-20. PMID:28919059. |
post-mortem studies have not identified an association between β-amyloid or tau and rates of hippocampal atrophy in patients with alzheimer's disease. |
2017-10-20 |
2023-08-13 |
Not clear |