| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ann-Charlotte Granholm, Eric D Hamlet. The Role of Tau Pathology in Alzheimer's Disease and Down Syndrome. Journal of clinical medicine. vol 13. issue 5. 2024-04-09. PMID:38592182. |
the role of tau pathology in alzheimer's disease and down syndrome. |
2024-04-09 |
2024-04-11 |
Not clear |
| Tim Bathe, Gabriela P Hery, Jonathan A B Villareal, Jennifer L Phillips, Eric M Cohen, Rohan V Sharma, Wangchen Tsering, Stefan Proko. Disease and brain region specific immune response profiles in neurodegenerative diseases with pure and mixed protein pathologies. Acta neuropathologica communications. vol 12. issue 1. 2024-04-08. PMID:38581050. |
to better characterize the interplay between different extracellular and intracellular protein pathologies and the brain's intrinsic immune system in nd, we set out to comprehensively profile the local immune response in postmortem brain samples of individuals with "pure" beta-amyloid and tau pathology (ad), "pure" α-synuclein pathology in lewy body diseases (lbd), as well as cases with alzheimer's disease neuropathological changes (adnc) and lewy body pathology (mix). |
2024-04-08 |
2024-04-10 |
human |
| Ke Hou, Peng Ge, Michael R Sawaya, Joshua L Dolinsky, Yuan Yang, Yi Xiao Jiang, Liisa Lutter, David R Boyer, Xinyi Cheng, Justin Pi, Jeffrey Zhang, Jiahui Lu, Shixin Yang, Zhiheng Yu, Juli Feigon, David S Eisenber. How short peptides can disassemble ultra-stable tau fibrils extracted from Alzheimer's disease brain by a strain-relief mechanism. bioRxiv : the preprint server for biology. 2024-04-08. PMID:38585812. |
how short peptides can disassemble ultra-stable tau fibrils extracted from alzheimer's disease brain by a strain-relief mechanism. |
2024-04-08 |
2024-04-10 |
Not clear |
| Ke Hou, Peng Ge, Michael R Sawaya, Joshua L Dolinsky, Yuan Yang, Yi Xiao Jiang, Liisa Lutter, David R Boyer, Xinyi Cheng, Justin Pi, Jeffrey Zhang, Jiahui Lu, Shixin Yang, Zhiheng Yu, Juli Feigon, David S Eisenber. How short peptides can disassemble ultra-stable tau fibrils extracted from Alzheimer's disease brain by a strain-relief mechanism. bioRxiv : the preprint server for biology. 2024-04-08. PMID:38585812. |
reducing fibrous aggregates of protein tau is a possible strategy for halting progression of alzheimer's disease (ad). |
2024-04-08 |
2024-04-10 |
Not clear |
| Dmytro Morderer, Melissa C Wren, Feilin Liu, Naomi Kouri, Anastasiia Maistrenko, Bilal Khalil, Nora Pobitzer, Michelle Salemi, Brett S Phinney, Dennis W Dickson, Melissa E Murray, Wilfried Rossol. Probe-dependent Proximity Profiling (ProPPr) Uncovers Similarities and Differences in Phospho-Tau-Associated Proteomes Between Tauopathies. bioRxiv : the preprint server for biology. 2024-04-08. PMID:38585836. |
to comprehensively investigate the common and unique protein interactors associated with the variety of tau lesions present across different human tauopathies, alzheimer's disease (ad), corticobasal degeneration (cbd), pick's disease (pid), and progressive supranuclear palsy (psp), were selected to represent the major tauopathy diseases. |
2024-04-08 |
2024-04-10 |
human |
| Kira Breunig, Xiufen Lei, Mauro Montalbano, Gabriela D A Guardia, Shiva Ostadrahimi, Victoria Alers, Adam Kosti, Jennifer Chiou, Nicole Klein, Corina Vinarov, Lily Wang, Mujia Li, Weidan Song, W Lee Kraus, David S Libich, Stefano Tiziani, Susan T Weintraub, Pedro A F Galante, Luiz O F Penalv. SERBP1 interacts with PARP1 and is present in PARylation-dependent protein complexes regulating splicing, cell division, and ribosome biogenesis. bioRxiv : the preprint server for biology. 2024-04-08. PMID:38585848. |
we uncovered novel serbp1 roles in splicing, cell division, and ribosomal biogenesis and showed its participation in pathological stress granules and tau aggregates in alzheimer's disease brains. |
2024-04-08 |
2024-04-10 |
Not clear |
| Gustavo A Patow, Anira Escrichs, Petra Ritter, Gustavo Dec. Whole-Brain Dynamics Disruptions in the Progression of Alzheimer's Disease: Understanding the Influence of Amyloid-Beta and Tau. bioRxiv : the preprint server for biology. 2024-04-08. PMID:38585882. |
whole-brain dynamics disruptions in the progression of alzheimer's disease: understanding the influence of amyloid-beta and tau. |
2024-04-08 |
2024-04-10 |
Not clear |
| Jie Wang, Qi Huang, Xing Chen, Zhiwen You, Kun He, Qihao Guo, Yiyun Huang, Yang Yang, Zengping Lin, Tengfei Guo, Jun Zhao, Yihui Guan, Binyin Li, Fang Xi. Tau pathology is associated with synaptic density and longitudinal synaptic loss in Alzheimer's disease. Molecular psychiatry. 2024-04-08. PMID:38589563. |
tau pathology is associated with synaptic density and longitudinal synaptic loss in alzheimer's disease. |
2024-04-08 |
2024-04-11 |
human |
| Jie Wang, Qi Huang, Xing Chen, Zhiwen You, Kun He, Qihao Guo, Yiyun Huang, Yang Yang, Zengping Lin, Tengfei Guo, Jun Zhao, Yihui Guan, Binyin Li, Fang Xi. Tau pathology is associated with synaptic density and longitudinal synaptic loss in Alzheimer's disease. Molecular psychiatry. 2024-04-08. PMID:38589563. |
the associations of synaptic loss with amyloid-β (aβ) and tau pathology measured by positron emission tomography (pet) and plasma analysis in alzheimer's disease (ad) patients are unknown. |
2024-04-08 |
2024-04-11 |
human |
| Michael Anekson Widjaya, Shin-Da Lee, Wei-Chung Cheng, Bor-Tsang W. Effects of Exercise Training on Immune-Related Genes and Pathways in the Cortex of Animal Models of Alzheimer's Disease: A Systematic Review. Journal of Alzheimer's disease : JAD. 2024-04-05. PMID:38578886. |
alzheimer's disease (ad) is a chronic neurodegenerative disease that affects the immune system due to the accumulation of amyloid-β (aβ) and tau associated molecular pathology and other pathogenic processes. |
2024-04-05 |
2024-04-10 |
Not clear |
| Estela Area-Gomez, Eric A Scho. Towards a Unitary Hypothesis of Alzheimer's Disease Pathogenesis. Journal of Alzheimer's disease : JAD. 2024-04-05. PMID:38578892. |
the "amyloid cascade" hypothesis of alzheimer's disease (ad) pathogenesis invokes the accumulation in the brain of plaques (containing the amyloid-β protein precursor [aβpp] cleavage product amyloid-β [aβ]) and tangles (containing hyperphosphorylated tau) as drivers of pathogenesis. |
2024-04-05 |
2024-04-10 |
Not clear |
| Erica Acquarone, Elentina K Argyrousi, Ottavio Arancio, D Martin Watterson, Saktimayee M Ro. The 5HT2b Receptor in Alzheimer's Disease: Increased Levels in Patient Brains and Antagonist Attenuation of Amyloid and Tau Induced Dysfunction. Journal of Alzheimer's disease : JAD. 2024-04-05. PMID:38578894. |
the 5ht2b receptor in alzheimer's disease: increased levels in patient brains and antagonist attenuation of amyloid and tau induced dysfunction. |
2024-04-05 |
2024-04-10 |
Not clear |
| Umberto Nencha, Isotta Rigoni, Federica Ribaldi, Daniele Altomare, Margitta Seeck, Valentina Garibotto, Serge Vulliémoz, Giovanni B Frison. Alterations in gamma frequency oscillations correlate with cortical tau deposition in Alzheimer's disease. Neurobiology of aging. vol 139. 2024-04-04. PMID:38574424. |
alterations in gamma frequency oscillations correlate with cortical tau deposition in alzheimer's disease. |
2024-04-04 |
2024-04-07 |
Not clear |
| Umberto Nencha, Isotta Rigoni, Federica Ribaldi, Daniele Altomare, Margitta Seeck, Valentina Garibotto, Serge Vulliémoz, Giovanni B Frison. Alterations in gamma frequency oscillations correlate with cortical tau deposition in Alzheimer's disease. Neurobiology of aging. vol 139. 2024-04-04. PMID:38574424. |
we assessed the relationship of gamma oscillations with tau deposition in alzheimer's disease (ad) and other cognitive diseases, as both are altered during the disease course and relate to neurodegeneration. |
2024-04-04 |
2024-04-07 |
Not clear |
| Lulu Jiang, Rebecca Roberts, Melissa Wong, Lushuang Zhang, Chelsea Joy Webber, Jenna Libera, Zihan Wang, Alper Kilci, Matthew Jenkins, Alejandro Rondón Ortiz, Luke Dorrian, Jingjing Sun, Guangxin Sun, Sherif Rashad, Caroline Kornbrek, Sarah Anne Daley, Peter C Dedon, Brian Nguyen, Weiming Xia, Takashi Saito, Takaomi C Saido, Benjamin Wolozi. β-amyloid accumulation enhances microtubule associated protein tau pathology in an APP Frontiers in neuroscience. vol 18. 2024-04-04. PMID:38572146. |
β-amyloid accumulation enhances microtubule associated protein tau pathology in an app the study of the pathophysiology study of alzheimer's disease (ad) has been hampered by lack animal models that recapitulate the major ad pathologies, including extracellular -amyloid (a) deposition, intracellular aggregation of microtubule associated protein tau (mapt), inflammation and neurodegeneration. |
2024-04-04 |
2024-04-06 |
Not clear |
| Wenqi Qian, Lin Yuan, Weishan Zhuge, Liuqing Gu, Yutian Chen, Qichuan Zhuge, Haoqi Ni, Xinhuang L. Regulating Lars2 in mitochondria: A potential Alzheimer's therapy by inhibiting tau phosphorylation. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2024-04-04. PMID:38575503. |
regulating lars2 in mitochondria: a potential alzheimer's therapy by inhibiting tau phosphorylation. |
2024-04-04 |
2024-04-07 |
mouse |
| Fernando Gonzalez-Ortiz, Bjørn-Eivind Kirsebom, José Contador, Jordan E Tanley, Per Selnes, Berglind Gísladóttir, Lene Pålhaugen, Mathilde Suhr Hemminghyth, Jonas Jarholm, Ragnhild Skogseth, Geir Bråthen, Gøril Grøndtvedt, Atle Bjørnerud, Sandra Tecelao, Knut Waterloo, Dag Aarsland, Aida Fernández-Lebrero, Greta García-Escobar, Irene Navalpotro-Gómez, Michael Turton, Agnes Hesthamar, Przemyslaw R Kac, Johanna Nilsson, Jose Luchsinger, Kathleen M Hayden, Peter Harrison, Albert Puig-Pijoan, Henrik Zetterberg, Timothy M Hughes, Marc Suárez-Calvet, Thomas K Karikari, Tormod Fladby, Kaj Blenno. Plasma brain-derived tau is an amyloid-associated neurodegeneration biomarker in Alzheimer's disease. Nature communications. vol 15. issue 1. 2024-04-04. PMID:38575616. |
plasma brain-derived tau is an amyloid-associated neurodegeneration biomarker in alzheimer's disease. |
2024-04-04 |
2024-04-07 |
human |
| Heather M Terron, Sagar J Parikh, Samer O Abdul-Hay, Tomoko Sahara, Dongcheul Kang, Dennis W Dickson, Paul Saftig, Frank M LaFerla, Shelley Lane, Malcolm A Leissrin. Prominent tauopathy and intracellular β-amyloid accumulation triggered by genetic deletion of cathepsin D: implications for Alzheimer disease pathogenesis. Alzheimer's research & therapy. vol 16. issue 1. 2024-04-04. PMID:38575959. |
cathepsin d (catd) is a lysosomal protease that degrades both the amyloid-β protein (aβ) and the microtubule-associated protein, tau, which accumulate pathognomonically in alzheimer disease (ad), but few studies have examined the role of catd in the development of aβ pathology and tauopathy in vivo. |
2024-04-04 |
2024-04-07 |
Not clear |
| Neha Basheer, Luc Buee, Jean-Pierre Brion, Tomas Smolek, Muhammad Khalid Muhammadi, Jozef Hritz, Tomas Hromadka, Ilse Dewachter, Susanne Wegmann, Isabelle Landrieu, Petr Novak, Amritpal Mudher, Norbert Zilk. Shaping the future of preclinical development of successful disease-modifying drugs against Alzheimer's disease: a systematic review of tau propagation models. Acta neuropathologica communications. vol 12. issue 1. 2024-04-04. PMID:38576010. |
shaping the future of preclinical development of successful disease-modifying drugs against alzheimer's disease: a systematic review of tau propagation models. |
2024-04-04 |
2024-04-07 |
Not clear |
| Neha Basheer, Luc Buee, Jean-Pierre Brion, Tomas Smolek, Muhammad Khalid Muhammadi, Jozef Hritz, Tomas Hromadka, Ilse Dewachter, Susanne Wegmann, Isabelle Landrieu, Petr Novak, Amritpal Mudher, Norbert Zilk. Shaping the future of preclinical development of successful disease-modifying drugs against Alzheimer's disease: a systematic review of tau propagation models. Acta neuropathologica communications. vol 12. issue 1. 2024-04-04. PMID:38576010. |
the transcellular propagation of the aberrantly modified protein tau along the functional brain network is a key hallmark of alzheimer's disease and related tauopathies. |
2024-04-04 |
2024-04-07 |
Not clear |