| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Genevieve L Stein-O'Brien, Ryan Palaganas, Ernest M Meyer, Javier Redding-Ochoa, Olga Pletnikova, Haidan Guo, William R Bell, Juan C Troncoso, Richard L Huganir, Meaghan Morri. Transcriptional Signatures of Hippocampal Tau Pathology in Primary Age-Related Tauopathy and Alzheimer's Disease. medRxiv : the preprint server for health sciences. 2023-09-25. PMID:37745408. |
tau pathology in primary age-related tauopathy (part) and in alzheimer's disease (ad) has a similar biochemical structure and anatomic distribution, which is distinct from tau pathology in other diseases. |
2023-09-25 |
2023-10-07 |
Not clear |
| Feng Han, JiaQie Lee, Xi Chen, Jacob Ziontz, Tyler Ward, Susan M Landau, Suzanne L Baker, Theresa M Harrison, William J Jagus. Global brain activity and its coupling with cerebrospinal fluid flow is related to tau pathology. bioRxiv : the preprint server for biology. 2023-09-25. PMID:37745434. |
amyloid-β (aβ) and tau deposition constitute alzheimer's disease (ad) neuropathology. |
2023-09-25 |
2023-10-07 |
human |
| Benjamin C Creekmore, Kathryn Kixmoeller, Ben E Black, Edward B Lee, Yi-Wei Chan. Native ultrastructure of fresh human brain vitrified directly from autopsy revealed by cryo-electron tomography with cryo-plasma focused ion beam milling. bioRxiv : the preprint server for biology. 2023-09-25. PMID:37745569. |
lamellae generated in alzheimer's disease brain tissue and imaged by cryo-et reveal intact subcellular structures including components of autophagy and potential tau fibrils. |
2023-09-25 |
2023-10-07 |
human |
| Eva Lepinay, Francesca Cicchett. Tau: a biomarker of Huntington's disease. Molecular psychiatry. 2023-09-25. PMID:37749233. |
we have herein reviewed the literature pertaining to the association between tau levels and cognitive states, zooming in on alzheimer's disease, parkinson's disease and traumatic brain injury in which imaging, cerebrospinal fluid, and blood samples have been interrogated or used to unveil a strong association between tau and cognition. |
2023-09-25 |
2023-10-07 |
Not clear |
| Tiffany E Chow, Christina R Veziris, Nidhi Mundada, Alexis I Martinez-Arroyo, Joel H Kramer, Bruce L Miller, Howard J Rosen, Maria Luisa Gorno-Tempini, Katherine P Rankin, William W Seeley, Gil D Rabinovici, Renaud La Joie, Virginia E Stur. Medial Temporal Lobe Tau Aggregation Relates to Divergent Cognitive and Emotional Empathy Abilities in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2023-09-24. PMID:37742643. |
medial temporal lobe tau aggregation relates to divergent cognitive and emotional empathy abilities in alzheimer's disease. |
2023-09-24 |
2023-10-07 |
Not clear |
| Tiffany E Chow, Christina R Veziris, Nidhi Mundada, Alexis I Martinez-Arroyo, Joel H Kramer, Bruce L Miller, Howard J Rosen, Maria Luisa Gorno-Tempini, Katherine P Rankin, William W Seeley, Gil D Rabinovici, Renaud La Joie, Virginia E Stur. Medial Temporal Lobe Tau Aggregation Relates to Divergent Cognitive and Emotional Empathy Abilities in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2023-09-24. PMID:37742643. |
in alzheimer's disease (ad), the gradual accumulation of amyloid-β (aβ) and tau proteins may underlie alterations in empathy. |
2023-09-24 |
2023-10-07 |
Not clear |
| Lavanya Jain, Maria Khrestian, Shane Formica, Elizabeth D Tuason, Jagan A Pillai, Stephen Rao, Odinachi Oguh, Carol F Lippa, Oscar L Lopez, Sarah B Berman, Debby W Tsuang, Cyrus P Zabetian, David J Irwin, Douglas R Galasko, Irene Litvan, Karen S Marder, Lawrence S Honig, Jori E Fleisher, James E Galvin, Andrea C Bozoki, Angela S Taylor, Marwan N Sabbagh, James B Leverenz, Lynn M Bekri. ATN cerebrospinal fluid biomarkers in dementia with Lewy bodies: Initial results from the United States Dementia with Lewy Bodies Consortium. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-09-23. PMID:37740924. |
the national institute on aging - alzheimer's association (nia-aa) atn research framework proposes to use biomarkers for amyloid (a), tau (t), and neurodegeneration (n) to stage individuals with ad pathological features and track changes longitudinally. |
2023-09-23 |
2023-10-07 |
Not clear |
| Salvatore P Mangiafico, Qing-Zhang Tuo, Xiao-Lan Li, Yu Liu, Christian Haralambous, Xu-Long Ding, Scott Ayton, Qing Wang, D Ross Laybutt, Jeng Yie Chan, Xiang Zhang, Cameron Kos, Helen E Thomas, Thomas Loudovaris, Chieh-Hsin Yang, Christos N Joannides, Benjamin J Lamont, Lunzhi Dai, Hai-Huai He, Biao Dong, Sofianos Andrikopoulos, Ashley I Bush, Peng Le. Tau suppresses microtubule-regulated pancreatic insulin secretion. Molecular psychiatry. 2023-09-22. PMID:37735502. |
tau protein is implicated in the pathogenesis of alzheimer's disease (ad) and other tauopathies, but its physiological function is in debate. |
2023-09-22 |
2023-10-07 |
mouse |
| Wyatt C Powell, Ruiheng Jing, Maciej A Walcza. Chemical Synthesis of Microtubule-Associated Protein Tau. Journal of the American Chemical Society. 2023-09-22. PMID:37737824. |
numerous studies have demonstrated that in diseases such as alzheimer's disease (ad), tau undergoes extensive remodeling. |
2023-09-22 |
2023-10-07 |
Not clear |
| Pijush Chakraborty, Gwladys Rivière, Alina Hebestreit, Alain Ibáñez de Opakua, Ina M Vorberg, Loren B Andreas, Markus Zweckstette. Acetylation discriminates disease-specific tau deposition. Nature communications. vol 14. issue 1. 2023-09-22. PMID:37739953. |
pathogenic aggregation of the protein tau is a hallmark of alzheimer's disease and several other tauopathies. |
2023-09-22 |
2023-10-07 |
Not clear |
| Nidhi S Mundada, Julio C Rojas, Lawren Vandevrede, Elisabeth H Thijssen, Leonardo Iaccarino, Obiora C Okoye, Ranjani Shankar, David N Soleimani-Meigooni, Argentina L Lago, Bruce L Miller, Charlotte E Teunissen, Hillary Heuer, Howie J Rosen, Jeffrey L Dage, William J Jagust, Gil D Rabinovici, Adam L Boxer, Renaud La Joi. Head-to-head comparison between plasma p-tau217 and flortaucipir-PET in amyloid-positive patients with cognitive impairment. Alzheimer's research & therapy. vol 15. issue 1. 2023-09-22. PMID:37740209. |
plasma phosphorylated tau (p-tau) has emerged as a promising biomarker for alzheimer's disease (ad). |
2023-09-22 |
2023-10-07 |
Not clear |
| Michelle M Coleman, Cierra M Keith, Kirk Wilhelmsen, Rashi I Mehta, Camila Vieira Ligo Teixeira, Mark Miller, Melanie Ward, Ramiro Osvaldo Navia, William T McCuddy, Pierre-François D'Haese, Marc W Hau. Surface-based correlates of cognition along the Alzheimer's continuum in a memory clinic population. Frontiers in neurology. vol 14. 2023-09-21. PMID:37731852. |
composite cognitive measures in large-scale studies with biomarker data for amyloid and tau have been widely used to characterize alzheimer's disease (ad). |
2023-09-21 |
2023-10-07 |
Not clear |
| Cristina Di Primio, Paola Quaranta, Marianna Mignanelli, Giacomo Siano, Matteo Bimbati, Arianna Scarlatti, Carmen Rita Piazza, Piero Giorgio Spezia, Paola Perrera, Fulvio Basolo, Anello Marcello Poma, Mario Costa, Mauro Pistello, Antonino Cattane. Severe acute respiratory syndrome coronavirus 2 infection leads to Tau pathological signature in neurons. PNAS nexus. vol 2. issue 9. 2023-09-21. PMID:37731949. |
upon infection, tau is phosphorylated at several pathological epitopes associated with alzheimer's disease and other tauopathies. |
2023-09-21 |
2023-10-07 |
mouse |
| Nina Rostgaard, Pia Holm Jul, Mats Garmer, Christiane Volbrach. Increasing O-GlcNAcylation Attenuates tau Hyperphosphorylation and Behavioral Impairment in rTg4510 Tauopathy Mice. Journal of integrative neuroscience. vol 22. issue 5. 2023-09-21. PMID:37735138. |
tauopathies such as alzheimer's disease (ad) are characterized by abnormal hyperphosphorylation of the microtubule-associated protein tau (mapt) aggregating into neurofibrillary tangles (nfts). |
2023-09-21 |
2023-10-07 |
mouse |
| Zhuchi Tu, Sen Yan, Bofeng Han, Caijuan Li, Weien Liang, Yingqi Lin, Yongyan Ding, Huiyi Wei, Lu Wang, Hao Xu, Jianmeng Ye, Bang Li, Shihua Li, Xiao-Jiang L. Tauopathy promotes spinal cord-dependent production of toxic amyloid-beta in transgenic monkeys. Signal transduction and targeted therapy. vol 8. issue 1. 2023-09-21. PMID:37735155. |
tauopathy, characterized by the hyperphosphorylation and accumulation of the microtubule-associated protein tau, and the accumulation of aβ oligomers, constitute the major pathological hallmarks of alzheimer's disease. |
2023-09-21 |
2023-10-07 |
mouse |
| Muhammad Imran Khan, Eun Sun Jeong, Muhammad Zubair Khan, Jin Hyuk Shin, Jong Deog Ki. Stem cells-derived exosomes alleviate neurodegeneration and Alzheimer's pathogenesis by ameliorating neuroinflamation, and regulating the associated molecular pathways. Scientific reports. vol 13. issue 1. 2023-09-21. PMID:37735227. |
amyloid beta (aβ) aggregation and tau hyper phosphorylation (p-tau) are key molecular factors in alzheimer's disease (ad). |
2023-09-21 |
2023-10-07 |
human |
| Erandis D Torres-Sánchez, Genaro G Ortiz, Emmanuel Reyes-Uribe, Juan H Torres-Jasso, Joel Salazar-Flore. Effect of pesticides on phosphorylation of tau protein, and its influence on Alzheimer's disease. World journal of clinical cases. vol 11. issue 24. 2023-09-20. PMID:37727721. |
effect of pesticides on phosphorylation of tau protein, and its influence on alzheimer's disease. |
2023-09-20 |
2023-10-07 |
human |
| Bhuvanachandra Bhoopal, Krishna Kumar Gollapelli, Naresh Damuka, Mack Miller, Ivan Krizan, Avinash Bansode, Thomas Register, Brett M Frye, Jeongchul Kim, Akiva Mintz, Miranda Orr, Suzanne Craft, Christopher Whitlow, Samuel N Lockhart, Carol Shively, Kiran Kumar Solingapuram Sa. Preliminary PET Imaging of Microtubule-Based PET Radioligand [ ACS chemical neuroscience. 2023-09-19. PMID:37724996. |
preliminary pet imaging of microtubule-based pet radioligand [ the microtubule (mt) instability observed in alzheimer's disease (ad) is commonly attributed to hyperphosphorylation of the mt-associated protein, tau. |
2023-09-19 |
2023-10-07 |
Not clear |
| Bhavarth P Dave, Yesha B Shah, Kunal G Maheshwari, Kaif A Mansuri, Bhadrawati S Prajapati, Humzah I Postwala, Mehul R Chorawal. Pathophysiological Aspects and Therapeutic Armamentarium of Alzheimer's Disease: Recent Trends and Future Development. Cellular and molecular neurobiology. 2023-09-19. PMID:37725199. |
alzheimer's disease (ad) is the primary cause of dementia and is characterized by the death of brain cells due to the accumulation of insoluble amyloid plaques, hyperphosphorylation of tau protein, and the formation of neurofibrillary tangles within the cells. |
2023-09-19 |
2023-10-07 |
Not clear |
| Ju Hee Kang, Magdalena Korecka, Edward B Lee, Katheryn A Q Cousins, Thomas F Tropea, Alice A Chen-Plotkin, David J Irwin, David Wolk, Magdalena Brylska, Yang Wan, Leslie M Sha. Alzheimer Disease Biomarkers: Moving from CSF to Plasma for Reliable Detection of Amyloid and tau Pathology. Clinical chemistry. 2023-09-19. PMID:37725909. |
alzheimer disease biomarkers: moving from csf to plasma for reliable detection of amyloid and tau pathology. |
2023-09-19 |
2023-10-07 |
Not clear |