| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Toshiki Uchihara, Kentaro Endo, Hiromi Kondo, Sachi Okabayashi, Nobuhiro Shimozawa, Yasuhiro Yasutomi, Eijiro Adachi, Nobuyuki Kimur. Tau pathology in aged cynomolgus monkeys is progressive supranuclear palsy/corticobasal degeneration- but not Alzheimer disease-like -Ultrastructural mapping of tau by EDX. Acta neuropathologica communications. vol 4. issue 1. 2017-10-24. PMID:27842611. |
concomitant deposition of amyloid -beta protein (aβ) and neuronal tau as neurofibrillary tangles in the human brain is a hallmark of alzheimer disease (ad). |
2017-10-24 |
2023-08-13 |
human |
| Ibrahim Kaya, Dimitri Brinet, Wojciech Michno, Stina Syvänen, Dag Sehlin, Henrik Zetterberg, Kaj Blennow, Jörg Hanriede. Delineating Amyloid Plaque Associated Neuronal Sphingolipids in Transgenic Alzheimer's Disease Mice (tgArcSwe) Using MALDI Imaging Mass Spectrometry. ACS chemical neuroscience. vol 8. issue 2. 2017-10-24. PMID:27984697. |
the major pathological hallmarks of alzheimer's disease (ad) are the progressive aggregation and accumulation of beta-amyloid (aβ) and hyperphosphorylated tau protein into neurotoxic deposits. |
2017-10-24 |
2023-08-13 |
mouse |
| Sarah Westwood, Emanuela Leoni, Abdul Hye, Steven Lynham, Mizanur R Khondoker, Nicholas J Ashton, Steven J Kiddle, Alison L Baird, Ricardo Sainz-Fuertes, Rufina Leung, John Graf, Cristina Tan Hehir, David Baker, Cristina Cereda, Chantal Bazenet, Malcolm Ward, Madhav Thambisetty, Simon Loveston. Blood-Based Biomarker Candidates of Cerebral Amyloid Using PiB PET in Non-Demented Elderly. Journal of Alzheimer's disease : JAD. vol 52. issue 2. 2017-10-23. PMID:27031486. |
increasingly, clinical trials for alzheimer's disease (ad) are being conducted earlier in the disease phase and with biomarker confirmation using in vivo amyloid pet imaging or csf tau and aβ measures to quantify pathology. |
2017-10-23 |
2023-08-13 |
human |
| Jeffrey L Dage, Alexandra M V Wennberg, David C Airey, Clinton E Hagen, David S Knopman, Mary M Machulda, Rosebud O Roberts, Clifford R Jack, Ronald C Petersen, Michelle M Mielk. Levels of tau protein in plasma are associated with neurodegeneration and cognitive function in a population-based elderly cohort. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 12. issue 12. 2017-10-23. PMID:27436677. |
we examined associations between plasma tau levels and alzheimer's disease (ad)-related magnetic resonance imaging (mri) and positron emission tomography (pet) neuroimaging measures among nondemented individuals. |
2017-10-23 |
2023-08-13 |
Not clear |
| Idir Malki, François-Xavier Cantrelle, Yoann Sottejeau, Guy Lippens, Jean-Charles Lambert, Isabelle Landrie. Regulation of the interaction between the neuronal BIN1 isoform 1 and Tau proteins - role of the SH3 domain. The FEBS journal. vol 284. issue 19. 2017-10-20. PMID:28755476. |
bridging integrator 1 (bin1) gene is a genetic determinant of alzheimer's disease (ad) and has been reported to modulate alzheimer's pathogenesis through pathway(s) involving tau. |
2017-10-20 |
2023-08-13 |
Not clear |
| Keith A Josephs, Dennis W Dickson, Nirubol Tosakulwong, Stephen D Weigand, Melissa E Murray, Leonard Petrucelli, Amanda M Liesinger, Matthew L Senjem, Anthony J Spychalla, David S Knopman, Joseph E Parisi, Ronald C Petersen, Clifford R Jack, Jennifer L Whitwel. Rates of hippocampal atrophy and presence of post-mortem TDP-43 in patients with Alzheimer's disease: a longitudinal retrospective study. The Lancet. Neurology. vol 16. issue 11. 2017-10-20. PMID:28919059. |
post-mortem studies have not identified an association between β-amyloid or tau and rates of hippocampal atrophy in patients with alzheimer's disease. |
2017-10-20 |
2023-08-13 |
Not clear |
| Laurent Lunven, Hugues Bonnet, Samir Yahiaoui, Wei Yi, Laurène Da Costa, Marine Peuchmaur, Ahcène Boumendjel, Sabine Chieric. Disruption of Fibers from the Tau Model AcPHF6 by Naturally Occurring Aurones and Synthetic Analogues. ACS chemical neuroscience. vol 7. issue 7. 2017-10-19. PMID:27225823. |
the formation of tau aggregates is strongly linked to the neurodegenerative process in tauopathies such as alzheimer's disease (ad). |
2017-10-19 |
2023-08-13 |
Not clear |
| Mathilde Wauters, Ruddy Wattiez, Laurence Ri. Internalization of the Extracellular Full-Length Tau Inside Neuro2A and Cortical Cells Is Enhanced by Phosphorylation. Biomolecules. vol 6. issue 3. 2017-10-18. PMID:27548242. |
this suggests that hyperphosphorylated tau protein could spread between neurons in pathological conditions such as alzheimer's disease. |
2017-10-18 |
2023-08-13 |
Not clear |
| Mahmoud L Soliman, Jonathan D Geiger, Xuesong Che. Caffeine Blocks HIV-1 Tat-Induced Amyloid Beta Production and Tau Phosphorylation. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 12. issue 1. 2017-10-18. PMID:27629410. |
the increased life expectancy of people living with hiv-1 who are taking effective anti-retroviral therapeutics is now accompanied by increased alzheimer's disease (ad)-like neurocognitive problems and neuropathological features such as increased levels of amyloid beta (aβ) and phosphorylated tau proteins. |
2017-10-18 |
2023-08-13 |
Not clear |
| P Dourlen, F J Fernandez-Gomez, C Dupont, B Grenier-Boley, C Bellenguez, H Obriot, R Caillierez, Y Sottejeau, J Chapuis, A Bretteville, F Abdelfettah, C Delay, N Malmanche, H Soininen, M Hiltunen, M-C Galas, P Amouyel, N Sergeant, L Buée, J-C Lambert, B Dermau. Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology. Molecular psychiatry. vol 22. issue 6. 2017-10-17. PMID:27113998. |
functional screening of alzheimer risk loci identifies ptk2b as an in vivo modulator and early marker of tau pathology. |
2017-10-17 |
2023-08-13 |
mouse |
| Kuo-Hsuan Chang, Chih-Hsin Lin, Hsuan-Chiang Chen, Hsin-Yu Huang, Shu-Ling Chen, Te-Hsien Lin, Chintakunta Ramesh, Chin-Chang Huang, Hon-Chung Fung, Yih-Ru Wu, Hei-Jen Huang, Guey-Jen Lee-Chen, Hsiu Mei Hsieh-Li, Ching-Fa Ya. The Potential of Indole/Indolylquinoline Compounds in Tau Misfolding Reduction by Enhancement of HSPB1. CNS neuroscience & therapeutics. vol 23. issue 1. 2017-10-17. PMID:27424519. |
neurofibrillary tangles formed from tau misfolding have long been considered one of the pathological hallmarks of alzheimer's disease (ad). |
2017-10-17 |
2023-08-13 |
Not clear |
| Maud Gratuze, Jacinthe Julien, Françoise Morin, Frédéric Calon, Sébastien S Hébert, André Marette, Emmanuel Plane. High-fat, high-sugar, and high-cholesterol consumption does not impact tau pathogenesis in a mouse model of Alzheimer's disease-like tau pathology. Neurobiology of aging. vol 47. 2017-10-17. PMID:27565300. |
high-fat, high-sugar, and high-cholesterol consumption does not impact tau pathogenesis in a mouse model of alzheimer's disease-like tau pathology. |
2017-10-17 |
2023-08-13 |
mouse |
| Maud Gratuze, Jacinthe Julien, Françoise Morin, Frédéric Calon, Sébastien S Hébert, André Marette, Emmanuel Plane. High-fat, high-sugar, and high-cholesterol consumption does not impact tau pathogenesis in a mouse model of Alzheimer's disease-like tau pathology. Neurobiology of aging. vol 47. 2017-10-17. PMID:27565300. |
aggregates of hyperphosphorylated tau protein are a pathological hallmark of alzheimer's disease (ad). |
2017-10-17 |
2023-08-13 |
mouse |
| Chun-Ling Dai, Yunn Chyn Tung, Fei Liu, Cheng-Xin Gong, Khalid Iqba. Tau passive immunization inhibits not only tau but also Aβ pathology. Alzheimer's research & therapy. vol 9. issue 1. 2017-10-17. PMID:28073379. |
accumulation of hyperphosphorylated tau protein is a histopathological hallmark of alzheimer's disease (ad) and related tauopathies. |
2017-10-17 |
2023-08-13 |
mouse |
| Frances C Quevenco, Maria G Preti, Jiri M G van Bergen, Jun Hua, Michael Wyss, Xu Li, Simon J Schreiner, Stefanie C Steininger, Rafael Meyer, Irene B Meier, Adam M Brickman, Sandra E Leh, Anton F Gietl, Alfred Buck, Roger M Nitsch, Klaas P Pruessmann, Peter C M van Zijl, Christoph Hock, Dimitri Van De Ville, Paul G Unschul. Memory performance-related dynamic brain connectivity indicates pathological burden and genetic risk for Alzheimer's disease. Alzheimer's research & therapy. vol 9. issue 1. 2017-10-17. PMID:28359293. |
the incidence of alzheimer's disease (ad) strongly relates to advanced age and progressive deposition of cerebral amyloid-beta (aβ), hyperphosphorylated tau, and iron. |
2017-10-17 |
2023-08-13 |
human |
| R Martínez-Pérez, I Paredes, P M Munarriz, B Paredes, J F Alé. Chronic traumatic encephalopathy: The unknown disease. Neurologia (Barcelona, Spain). vol 32. issue 3. 2017-10-16. PMID:25534950. |
although it shares certain histopathological findings with alzheimer disease, chronic traumatic encephalopathy has a more specific presentation (hyperphosphorylated tau protein deposited as neurofibrillary tangles, associated with neuropil threads and sometimes with beta-amyloid plaques). |
2017-10-16 |
2023-08-13 |
Not clear |
| Felipe G Serrano, Cheril Tapia-Rojas, Francisco J Carvajal, Pedro Cisternas, Elisabet Viayna, Irene Sola, Diego Munoz-Torrero, Nibaldo C Inestros. Rhein-Huprine Derivatives Reduce Cognitive Impairment, Synaptic Failure and Amyloid Pathology in AβPPswe/PS-1 Mice of Different Ages. Current Alzheimer research. vol 13. issue 9. 2017-10-16. PMID:26502813. |
alzheimer's disease (ad) is a neurodegenerative disorder in which the amyloid-β (aβ) peptide plays a key role in synaptic impairment and memory decline associated with neuronal dysfunction and intra-neuronal accumulation of hyperphosphorylated tau protein. |
2017-10-16 |
2023-08-13 |
mouse |
| Marco Magistri, Dmitry Velmeshev, Madina Makhmutova, Prutha Patel, Gregory C Sartor, Claude-Henry Volmar, Claes Wahlestedt, Mohammad Ali Faghih. The BET-Bromodomain Inhibitor JQ1 Reduces Inflammation and Tau Phosphorylation at Ser396 in the Brain of the 3xTg Model of Alzheimer's Disease. Current Alzheimer research. vol 13. issue 9. 2017-10-16. PMID:27117003. |
the bet-bromodomain inhibitor jq1 reduces inflammation and tau phosphorylation at ser396 in the brain of the 3xtg model of alzheimer's disease. |
2017-10-16 |
2023-08-13 |
Not clear |
| Susan Fromholt, Christian Reitano, Hilda Brown, Jada Lewis, David R Borchel. Generation of a new transgenic mouse model for assessment of tau gene silencing therapies. Alzheimer's research & therapy. vol 8. 2017-10-16. PMID:27593210. |
in alzheimer's disease, therapies that silence the expression of tau could be a viable strategy to slow disease progression. |
2017-10-16 |
2023-08-13 |
mouse |
| Andrzej Stanisław Ciepla. Protein folding, misfolding and aggregation: The importance of two-electron stabilizing interactions. PloS one. vol 12. issue 9. 2017-10-16. PMID:28922400. |
carrying no information about side chain-side chain interactions, this function nonetheless identifies basic features of the secondary and tertiary structure, establishes sequence correlates of the metamorphic and ph-driven equilibria, relates binding affinities and folding rate constants to secondary structure preferences, and manifests common patterns of backbone density distribution in amyloidogenic regions of alzheimer's amyloid β and tau, parkinson's α-synuclein and prions. |
2017-10-16 |
2023-08-13 |
Not clear |