| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T A Pascoal, S Mathotaarachchi, S Mohades, A L Benedet, C-O Chung, M Shin, S Wang, T Beaudry, M S Kang, J-P Soucy, A Labbe, S Gauthier, P Rosa-Net. Amyloid-β and hyperphosphorylated tau synergy drives metabolic decline in preclinical Alzheimer's disease. Molecular psychiatry. vol 22. issue 2. 2017-10-03. PMID:27021814. |
amyloid-β and hyperphosphorylated tau synergy drives metabolic decline in preclinical alzheimer's disease. |
2017-10-03 |
2023-08-13 |
Not clear |
| T A Pascoal, S Mathotaarachchi, S Mohades, A L Benedet, C-O Chung, M Shin, S Wang, T Beaudry, M S Kang, J-P Soucy, A Labbe, S Gauthier, P Rosa-Net. Amyloid-β and hyperphosphorylated tau synergy drives metabolic decline in preclinical Alzheimer's disease. Molecular psychiatry. vol 22. issue 2. 2017-10-03. PMID:27021814. |
this study was designed to test the interaction between amyloid-β and tau proteins as a determinant of metabolic decline in preclinical alzheimer's disease (ad). |
2017-10-03 |
2023-08-13 |
Not clear |
| Xuemei Zhang, Yanxian Lin, Neil A Eschmann, Hongjun Zhou, Jennifer N Rauch, Israel Hernandez, Elmer Guzman, Kenneth S Kosik, Songi Ha. RNA stores tau reversibly in complex coacervates. PLoS biology. vol 15. issue 7. 2017-10-03. PMID:28683104. |
here, we report that tau protein, the primary constituent of alzheimer neurofibrillary tangles, can form liquid droplets and therefore has the necessary biophysical properties to undergo liquid-liquid phase separation (llps) in cells. |
2017-10-03 |
2023-08-13 |
Not clear |
| Udo Rüb, Katharina Stratmann, Helmut Heinsen, Domenico Del Turco, Kay Seidel, Wilfred den Dunnen, Horst-Werner Kor. The Brainstem Tau Cytoskeletal Pathology of Alzheimer's Disease: A Brief Historical Overview and Description of its Anatomical Distribution Pattern, Evolutional Features, Pathogenetic and Clinical Relevance. Current Alzheimer research. vol 13. issue 10. 2017-10-02. PMID:27264543. |
the brainstem tau cytoskeletal pathology of alzheimer's disease: a brief historical overview and description of its anatomical distribution pattern, evolutional features, pathogenetic and clinical relevance. |
2017-10-02 |
2023-08-13 |
human |
| Udo Rüb, Katharina Stratmann, Helmut Heinsen, Domenico Del Turco, Kay Seidel, Wilfred den Dunnen, Horst-Werner Kor. The Brainstem Tau Cytoskeletal Pathology of Alzheimer's Disease: A Brief Historical Overview and Description of its Anatomical Distribution Pattern, Evolutional Features, Pathogenetic and Clinical Relevance. Current Alzheimer research. vol 13. issue 10. 2017-10-02. PMID:27264543. |
in contrast to the cerebral cortex the affection of the brainstem in alzheimer's disease (ad) by the neurofibrillary or tau cytoskeletal pathology was recognized only approximately fourty years ago in initial brainstem studies. |
2017-10-02 |
2023-08-13 |
human |
| Siddhartha Mondragón-Rodríguez, George Perry, Fernando Pena-Ortega, Sylvain William. Tau, Amyloid Beta and Deep Brain Stimulation: Aiming to Restore Cognitive Deficit in Alzheimer's Disease. Current Alzheimer research. vol 14. issue 1. 2017-10-02. PMID:27539594. |
tau, amyloid beta and deep brain stimulation: aiming to restore cognitive deficit in alzheimer's disease. |
2017-10-02 |
2023-08-13 |
Not clear |
| Siddhartha Mondragón-Rodríguez, George Perry, Fernando Pena-Ortega, Sylvain William. Tau, Amyloid Beta and Deep Brain Stimulation: Aiming to Restore Cognitive Deficit in Alzheimer's Disease. Current Alzheimer research. vol 14. issue 1. 2017-10-02. PMID:27539594. |
the last two decades have seen a great advance in the data that supports the two current hypotheses in alzheimer`s disease field, the amyloid beta hypothesis and the tau hypothesis. |
2017-10-02 |
2023-08-13 |
Not clear |
| Keran Ma, JoAnne McLauri. α-Melanocyte Stimulating Hormone as a Potential Therapy for Alzheimer`s Disease. Current Alzheimer research. vol 14. issue 1. 2017-10-02. PMID:27539595. |
alzheimer's disease (ad) is characterized by accumulation and aggregation of beta-amyloid peptide, neurofibrillary tangles of hyperphosphorylated tau, neuroinflammation, synaptic degeneration and eventual neuronal cell loss. |
2017-10-02 |
2023-08-13 |
Not clear |
| Jianlan Gu, Feng Wu, Wen Xu, Jianhua Shi, Wen Hu, Nana Jin, Wei Qian, Xinglong Wang, Khalid Iqbal, Cheng-Xin Gong, Fei Li. TDP-43 suppresses tau expression via promoting its mRNA instability. Nucleic acids research. vol 45. issue 10. 2017-10-02. PMID:28335005. |
in the brains of individuals with alzheimer's disease (ad) and chronic traumatic encephalopathy, tau pathology is accompanied usually by intracellular aggregation of transactive response dna-binding protein 43 (tdp-43). |
2017-10-02 |
2023-08-13 |
mouse |
| Jeremy D Baker, Lindsey B Shelton, Dali Zheng, Filippo Favretto, Bryce A Nordhues, April Darling, Leia E Sullivan, Zheying Sun, Parth K Solanki, Mackenzie D Martin, Amirthaa Suntharalingam, Jonathan J Sabbagh, Stefan Becker, Eckhard Mandelkow, Vladimir N Uversky, Markus Zweckstetter, Chad A Dickey, John Koren, Laura J Blai. Human cyclophilin 40 unravels neurotoxic amyloids. PLoS biology. vol 15. issue 6. 2017-10-02. PMID:28654636. |
the aberrant accumulation of the microtubule associating protein tau (mapt, tau) into toxic oligomers and amyloid deposits is a primary pathology in tauopathies, the most common of which is alzheimer's disease (ad). |
2017-10-02 |
2023-08-13 |
mouse |
| Chin Hong Tan, Bradley T Hyman, Jacinth J X Tan, Christopher P Hess, William P Dillon, Gerard D Schellenberg, Lilah M Besser, Walter A Kukull, Karolina Kauppi, Linda K McEvoy, Ole A Andreassen, Anders M Dale, Chun Chieh Fan, Rahul S Desika. Polygenic hazard scores in preclinical Alzheimer disease. Annals of neurology. vol 82. issue 3. 2017-10-02. PMID:28940650. |
phs predicted longitudinal clinical decline among older individuals with moderate to high consortium to establish a registry for alzheimer's disease (amyloid) and braak (tau) scores at autopsy, even among apoe ɛ4 noncarriers. |
2017-10-02 |
2023-08-13 |
Not clear |
| Aurélie Joly-Amado, Karisa S Serraneau, Milene Brownlow, Caralina Marín de Evsikova, John R Speakman, Marcia N Gordon, Dave Morga. Metabolic changes over the course of aging in a mouse model of tau deposition. Neurobiology of aging. vol 44. 2017-09-28. PMID:27318134. |
these diverse changes in metabolism in a mouse model of tau deposition are discussed in the context of known changes in energy metabolism in alzheimer's disease. |
2017-09-28 |
2023-08-13 |
mouse |
| Emilie Dorard, Lucie Gorisse-Hussonnois, Chantal Guihenneuc-Jouyaux, Christelle Albac, Marie-Claude Potier, Bernadette Allinquan. Increases of SET level and translocation are correlated with tau hyperphosphorylation at ser202/thr205 in CA1 of Ts65Dn mice. Neurobiology of aging. vol 46. 2017-09-28. PMID:27460148. |
here, we show that in ca1 of 3-month-old ts65dn mice modeling ds, set level is increased, and set is translocated to the cytoplasm and associated with tau hyperphosphorylations at ser202/thr205 and with amyloid precursor protein caspase cleaved as observed in alzheimer disease brains. |
2017-09-28 |
2023-08-13 |
mouse |
| Geri Meduri, Kevin Guillemeau, Omar Dounane, Véronique Sazdovitch, Charles Duyckaerts, Béatrice Chambraud, Etienne Emile Baulieu, Julien Giustinian. Caspase-cleaved Tau-D(421) is colocalized with the immunophilin FKBP52 in the autophagy-endolysosomal system of Alzheimer's disease neurons. Neurobiology of aging. vol 46. 2017-09-28. PMID:27479154. |
pathologic modifications of the tau protein leading to neurofibrillary tangle (nft) formation are a common feature of a wide range of neurodegenerative diseases known as tauopathies, which include alzheimer's disease (ad). |
2017-09-28 |
2023-08-13 |
Not clear |
| E Magnin, J Dumurgier, E Bouaziz-Amar, S Bombois, D Wallon, A Gabelle, S Lehmann, F Blanc, O Bousiges, D Hannequin, B Jung, C Miguet-Alfonsi, M Quillard, F Pasquier, K Peoc'h, J-L Laplanche, J Hugon, C Paque. [Alzheimer's disease cerebro-spinal fluid biomarkers: A clinical research tool sometimes useful in daily clinical practice of memory clinics for the diagnosis of complex cases]. La Revue de medecine interne. vol 38. issue 4. 2017-09-28. PMID:27890382. |
cerebro-spinal fluid (csf) biomarkers (total tau protein, threonine 181 phosphorylated tau protein and amyloid aβ1-42 peptide) are associated with cerebral neuropathological lesions observed in alzheimer's disease (neuronal death, neurofibrillary tangle with abnormal tau deposits and amyloid plaque). |
2017-09-28 |
2023-08-13 |
human |
| Jeffrey A Zahratka, Yvonne Shao, McKenzie Shaw, Kaitlin Todd, Shane V Formica, Maria Khrestian, Thomas Montine, James B Leverenz, Lynn M Bekri. Regulatory region genetic variation is associated with FYN expression in Alzheimer's disease. Neurobiology of aging. vol 51. 2017-09-28. PMID:28033507. |
neurofibrillary tangles (nfts), composed of hyperphosphorylated tau, are a key pathologic feature of alzheimer's disease (ad). |
2017-09-28 |
2023-08-13 |
Not clear |
| Yang Wang, Tatiana Veremeyko, Andus Hon-Kit Wong, Rachid El Fatimy, Zhiyun Wei, Wei Cai, Anna M Krichevsk. Downregulation of miR-132/212 impairs S-nitrosylation balance and induces tau phosphorylation in Alzheimer's disease. Neurobiology of aging. vol 51. 2017-09-28. PMID:28089352. |
downregulation of mir-132/212 impairs s-nitrosylation balance and induces tau phosphorylation in alzheimer's disease. |
2017-09-28 |
2023-08-13 |
human |
| Yang Wang, Tatiana Veremeyko, Andus Hon-Kit Wong, Rachid El Fatimy, Zhiyun Wei, Wei Cai, Anna M Krichevsk. Downregulation of miR-132/212 impairs S-nitrosylation balance and induces tau phosphorylation in Alzheimer's disease. Neurobiology of aging. vol 51. 2017-09-28. PMID:28089352. |
microrna-132 is markedly downregulated in alzheimer's disease (ad) and related tauopathies, and its levels are closely associated with tau pathology in ad. |
2017-09-28 |
2023-08-13 |
human |
| Yari Carlomagno, Dah-Eun Chloe Chung, Mei Yue, Monica Castanedes-Casey, Benjamin J Madden, Judy Dunmore, Jimei Tong, Michael DeTure, Dennis W Dickson, Leonard Petrucelli, Casey Coo. An acetylation-phosphorylation switch that regulates tau aggregation propensity and function. The Journal of biological chemistry. vol 292. issue 37. 2017-09-27. PMID:28760828. |
the aberrant accumulation of tau protein is a pathological hallmark of a class of neurodegenerative diseases known as tauopathies, including alzheimer's disease and related dementias. |
2017-09-27 |
2023-08-13 |
Not clear |
| Jason G Kilian, Heng-Wei Hsu, Kenneth Mata, Fred W Wolf, Masashi Kitazaw. Astrocyte transport of glutamate and neuronal activity reciprocally modulate tau pathology in Drosophila. Neuroscience. vol 348. 2017-09-26. PMID:28215745. |
abnormal buildup of the microtubule associated protein tau is a major pathological hallmark of alzheimer's disease (ad) and various tauopathies. |
2017-09-26 |
2023-08-13 |
mouse |