| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Benjamin Combs, Nicholas M Kanaa. Exposure of the Amino Terminus of Tau Is a Pathological Event in Multiple Tauopathies. The American journal of pathology. vol 187. issue 6. 2017-08-08. PMID:28413156. |
conformational display of pad is an early marker of pathological tau in alzheimer disease (ad), but its role in other tauopathies has yet to be firmly established. |
2017-08-08 |
2023-08-13 |
human |
| Hans Zempel, Frank J A Dennissen, Yatender Kumar, Julia Luedtke, Jacek Biernat, Eva-Maria Mandelkow, Eckhard Mandelko. Axodendritic sorting and pathological missorting of Tau are isoform-specific and determined by axon initial segment architecture. The Journal of biological chemistry. vol 292. issue 29. 2017-08-08. PMID:28536263. |
subcellular mislocalization of the microtubule-associated protein tau is a hallmark of alzheimer disease (ad) and other tauopathies. |
2017-08-08 |
2023-08-13 |
human |
| Nobuyuki Okamura, Ryuichi Harada, Katsutoshi Furukawa, Shozo Furumoto, Tetsuro Tago, Kazuhiko Yanai, Hiroyuki Arai, Yukitsuka Kud. Advances in the development of tau PET radiotracers and their clinical applications. Ageing research reviews. vol 30. 2017-08-07. PMID:26802556. |
recent clinical studies using these tracers have demonstrated significant tracer retention in sites susceptible to tau deposition in alzheimer's disease, as well as correlations with the disease severity and cognitive impairment in cases with dementia. |
2017-08-07 |
2023-08-13 |
human |
| Reham Atteya, Mohamed E Ashour, Elsayed E Ibrahim, Mohamed A Farag, Sherif F El-Khamis. Chemical screening identifies the β-Carboline alkaloid harmine to be synergistically lethal with doxorubicin. Mechanisms of ageing and development. vol 161. issue Pt A. 2017-08-07. PMID:27282658. |
we identify the dyrk1a kinase inhibitor harmine, which phosphorylates tau that is deregulated in alzheimer's disease, as a potentiator of cell death induced by non-toxic doses of doxorubicin. |
2017-08-07 |
2023-08-13 |
Not clear |
| Vicent Bonet-Costa, Laura Corrales-Diaz Pomatto, Kelvin J A Davie. The Proteasome and Oxidative Stress in Alzheimer's Disease. Antioxidants & redox signaling. vol 25. issue 16. 2017-08-07. PMID:27392670. |
a major hallmark of alzheimer's disease pathology is the accumulation of amyloid-β (aβ) aggregates (an early marker of alzheimer's disease), and neurofibrillary tangles, comprising the hyper-phosphorylated microtubule-associated protein tau. |
2017-08-07 |
2023-08-13 |
Not clear |
| Vicent Bonet-Costa, Laura Corrales-Diaz Pomatto, Kelvin J A Davie. The Proteasome and Oxidative Stress in Alzheimer's Disease. Antioxidants & redox signaling. vol 25. issue 16. 2017-08-07. PMID:27392670. |
recent studies have indicated that both protein oxidation and excessive phosphorylation may limit proteasomal processing of aβ and tau in alzheimer's disease. |
2017-08-07 |
2023-08-13 |
Not clear |
| Pu Wang, Zhan-You Wan. Metal ions influx is a double edged sword for the pathogenesis of Alzheimer's disease. Ageing research reviews. vol 35. 2017-08-07. PMID:27829171. |
alzheimer's disease (ad) is a common form of dementia in aged people, which is defined by two pathological characteristics: β-amyloid protein (aβ) deposition and tau hyperphosphorylation. |
2017-08-07 |
2023-08-13 |
Not clear |
| Yvette C Wong, Dimitri Krain. α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies. Nature medicine. vol 23. issue 2. 2017-08-07. PMID:28170377. |
furthermore, α-synuclein contributes to the fibrilization of amyloid-b and tau, two key proteins in alzheimer's disease, which suggests a central role for α-synuclein toxicity in neurodegeneration. |
2017-08-07 |
2023-08-13 |
Not clear |
| Lilia Rodriguez, Nguyen-Vi Mohamed, Alexandre Desjardins, Roger Lippé, Edward A Fon, Nicole Lecler. Rab7A regulates tau secretion. Journal of neurochemistry. vol 141. issue 4. 2017-08-07. PMID:28222213. |
the axonal microtubule-associated protein tau, involved in alzheimer's disease (ad), can be found in the extracellular space where it could be taken up by neurons, an event that is believed to contribute to the propagation of tau pathology in the brain. |
2017-08-07 |
2023-08-13 |
human |
| Erik A Williams, Declan McGuone, Matthew P Frosch, Bradley T Hyman, Nora Laver, Anat Stemmer-Rachamimo. Absence of Alzheimer Disease Neuropathologic Changes in Eyes of Subjects With Alzheimer Disease. Journal of neuropathology and experimental neurology. vol 76. issue 5. 2017-08-07. PMID:28379416. |
alzheimer disease (ad) is the most common cause of dementia in the elderly, and is characterized by extracellular deposition of β-amyloid and intracellular accumulation of hyperphosphorylated tau protein in the brain. |
2017-08-07 |
2023-08-13 |
human |
| Todd J Cohen, Brian H Constance, Andrew W Hwang, Michael James, Chao-Xing Yua. Intrinsic Tau Acetylation Is Coupled to Auto-Proteolytic Tau Fragmentation. PloS one. vol 11. issue 7. 2017-08-01. PMID:27383765. |
tau proteins are abnormally aggregated in a range of neurodegenerative tauopathies including alzheimer's disease (ad). |
2017-08-01 |
2023-08-13 |
Not clear |
| Alessandra Bitto, Daniela Giuliani, Giovanni Pallio, Natasha Irrera, Eleonora Vandini, Fabrizio Canalini, Davide Zaffe, Alessandra Ottani, Letteria Minutoli, Mariagrazia Rinaldi, Salvatore Guarini, Francesco Squadrito, Domenica Altavill. Effects of COX1-2/5-LOX blockade in Alzheimer transgenic 3xTg-AD mice. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. vol 66. issue 5. 2017-08-01. PMID:28238167. |
alzheimer's disease (ad) is associated with amyloid plaques (aβ) and hyperphosphorylated tau protein tangles in the brain. |
2017-08-01 |
2023-08-13 |
mouse |
| I A Kuznetsov, A V Kuznetso. What mechanisms of tau protein transport could be responsible for the inverted tau concentration gradient in degenerating axons? Mathematical medicine and biology : a journal of the IMA. vol 34. issue 1. 2017-07-31. PMID:27034421. |
in tauopathies, such as alzheimer's disease (ad), microtubule (mt)-associated protein tau detaches from mts and aggregates, eventually forming insoluble neurofibrillary tangles. |
2017-07-31 |
2023-08-13 |
Not clear |
| Xu Yan, Niko-Petteri Nykänen, Cecilia A Brunello, Annakaisa Haapasalo, Mikko Hiltunen, Riikka-Liisa Uronen, Henri J Huttune. FRMD4A-cytohesin signaling modulates the cellular release of tau. Journal of cell science. vol 129. issue 10. 2017-07-31. PMID:27044754. |
one of the defining pathological features of alzheimer's disease is the intraneuronal accumulation of tau (also known as mapt) protein. |
2017-07-31 |
2023-08-13 |
Not clear |
| Xu Yan, Niko-Petteri Nykänen, Cecilia A Brunello, Annakaisa Haapasalo, Mikko Hiltunen, Riikka-Liisa Uronen, Henri J Huttune. FRMD4A-cytohesin signaling modulates the cellular release of tau. Journal of cell science. vol 129. issue 10. 2017-07-31. PMID:27044754. |
tau is also secreted from neurons in response to various stimuli and accumulates in the cerebrospinal fluid of alzheimer's disease patients. |
2017-07-31 |
2023-08-13 |
Not clear |
| Xu Yan, Niko-Petteri Nykänen, Cecilia A Brunello, Annakaisa Haapasalo, Mikko Hiltunen, Riikka-Liisa Uronen, Henri J Huttune. FRMD4A-cytohesin signaling modulates the cellular release of tau. Journal of cell science. vol 129. issue 10. 2017-07-31. PMID:27044754. |
individual silencing of ten common late-onset alzheimer's disease risk genes in hek293t cells expressing the tau reporters suggested that frmd4a is functionally linked to tau secretion. |
2017-07-31 |
2023-08-13 |
Not clear |
| Xu Yan, Niko-Petteri Nykänen, Cecilia A Brunello, Annakaisa Haapasalo, Mikko Hiltunen, Riikka-Liisa Uronen, Henri J Huttune. FRMD4A-cytohesin signaling modulates the cellular release of tau. Journal of cell science. vol 129. issue 10. 2017-07-31. PMID:27044754. |
these results suggest that frmd4a, a genetic risk factor for late-onset alzheimer's disease, regulates tau secretion by activating cytohesin-arf6 signaling. |
2017-07-31 |
2023-08-13 |
Not clear |
| Xu Yan, Niko-Petteri Nykänen, Cecilia A Brunello, Annakaisa Haapasalo, Mikko Hiltunen, Riikka-Liisa Uronen, Henri J Huttune. FRMD4A-cytohesin signaling modulates the cellular release of tau. Journal of cell science. vol 129. issue 10. 2017-07-31. PMID:27044754. |
we conclude that genetic risk factors of alzheimer's disease might modulate disease progression by altering tau secretion. |
2017-07-31 |
2023-08-13 |
Not clear |
| Xiaohui Zhao, Linda A Kotilinek, Benjamin Smith, Chris Hlynialuk, Kathleen Zahs, Martin Ramsden, James Cleary, Karen H Ash. Caspase-2 cleavage of tau reversibly impairs memory. Nature medicine. vol 22. issue 11. 2017-07-31. PMID:27723722. |
in alzheimer's disease (ad) and other tauopathies, the tau protein forms fibrils, which are believed to be neurotoxic. |
2017-07-31 |
2023-08-13 |
mouse |
| Ghiam Yamin, David B Teplo. Pittsburgh Compound-B (PiB) binds amyloid β-protein protofibrils. Journal of neurochemistry. vol 140. issue 2. 2017-07-28. PMID:27943341. |
the neuropathology of alzheimer's disease (ad) includes amyloid plaque formation by the amyloid β-protein (aβ) and intracellular paired helical filament formation by tau protein. |
2017-07-28 |
2023-08-13 |
Not clear |