| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xu Yan, Niko-Petteri Nykänen, Cecilia A Brunello, Annakaisa Haapasalo, Mikko Hiltunen, Riikka-Liisa Uronen, Henri J Huttune. FRMD4A-cytohesin signaling modulates the cellular release of tau. Journal of cell science. vol 129. issue 10. 2017-07-31. PMID:27044754. |
tau is also secreted from neurons in response to various stimuli and accumulates in the cerebrospinal fluid of alzheimer's disease patients. |
2017-07-31 |
2023-08-13 |
Not clear |
| Xu Yan, Niko-Petteri Nykänen, Cecilia A Brunello, Annakaisa Haapasalo, Mikko Hiltunen, Riikka-Liisa Uronen, Henri J Huttune. FRMD4A-cytohesin signaling modulates the cellular release of tau. Journal of cell science. vol 129. issue 10. 2017-07-31. PMID:27044754. |
individual silencing of ten common late-onset alzheimer's disease risk genes in hek293t cells expressing the tau reporters suggested that frmd4a is functionally linked to tau secretion. |
2017-07-31 |
2023-08-13 |
Not clear |
| Xu Yan, Niko-Petteri Nykänen, Cecilia A Brunello, Annakaisa Haapasalo, Mikko Hiltunen, Riikka-Liisa Uronen, Henri J Huttune. FRMD4A-cytohesin signaling modulates the cellular release of tau. Journal of cell science. vol 129. issue 10. 2017-07-31. PMID:27044754. |
these results suggest that frmd4a, a genetic risk factor for late-onset alzheimer's disease, regulates tau secretion by activating cytohesin-arf6 signaling. |
2017-07-31 |
2023-08-13 |
Not clear |
| Xu Yan, Niko-Petteri Nykänen, Cecilia A Brunello, Annakaisa Haapasalo, Mikko Hiltunen, Riikka-Liisa Uronen, Henri J Huttune. FRMD4A-cytohesin signaling modulates the cellular release of tau. Journal of cell science. vol 129. issue 10. 2017-07-31. PMID:27044754. |
we conclude that genetic risk factors of alzheimer's disease might modulate disease progression by altering tau secretion. |
2017-07-31 |
2023-08-13 |
Not clear |
| Xiaohui Zhao, Linda A Kotilinek, Benjamin Smith, Chris Hlynialuk, Kathleen Zahs, Martin Ramsden, James Cleary, Karen H Ash. Caspase-2 cleavage of tau reversibly impairs memory. Nature medicine. vol 22. issue 11. 2017-07-31. PMID:27723722. |
in alzheimer's disease (ad) and other tauopathies, the tau protein forms fibrils, which are believed to be neurotoxic. |
2017-07-31 |
2023-08-13 |
mouse |
| Ghiam Yamin, David B Teplo. Pittsburgh Compound-B (PiB) binds amyloid β-protein protofibrils. Journal of neurochemistry. vol 140. issue 2. 2017-07-28. PMID:27943341. |
the neuropathology of alzheimer's disease (ad) includes amyloid plaque formation by the amyloid β-protein (aβ) and intracellular paired helical filament formation by tau protein. |
2017-07-28 |
2023-08-13 |
Not clear |
| Tong Li, Hemant K Paude. 14-3-3ζ Mediates Tau Aggregation in Human Neuroblastoma M17 Cells. PloS one. vol 11. issue 8. 2017-07-27. PMID:27548710. |
microtubule-associated protein tau is the major component of paired helical filaments (phfs) associated with the neuropathology of alzheimer's disease (ad). |
2017-07-27 |
2023-08-13 |
human |
| Philippine Camilla Geiszler, Matthew Richard Barron, Marie-Christine Pardo. Impaired burrowing is the most prominent behavioral deficit of aging htau mice. Neuroscience. vol 329. 2017-07-26. PMID:27167086. |
htau mice are deficient of murine tau but express all six human tau isoforms, leading to gradual tau misprocessing and aggregation in brain areas relevant to alzheimer's disease. |
2017-07-26 |
2023-08-13 |
mouse |
| Rosie Freer, Pietro Sormanni, Giulia Vecchi, Prajwal Ciryam, Christopher M Dobson, Michele Vendruscol. A protein homeostasis signature in healthy brains recapitulates tissue vulnerability to Alzheimer's disease. Science advances. vol 2. issue 8. 2017-07-26. PMID:27532054. |
in alzheimer's disease, aggregates of aβ and tau in amyloid plaques and neurofibrillary tangles spread progressively across brain tissues following a characteristic pattern, implying a tissue-specific vulnerability to the disease. |
2017-07-26 |
2023-08-13 |
Not clear |
| Hongjun Fu, Gustavo A Rodriguez, Mathieu Herman, Sheina Emrani, Eden Nahmani, Geoffrey Barrett, Helen Y Figueroa, Eliana Goldberg, S Abid Hussaini, Karen E Duf. Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer's Disease. Neuron. vol 93. issue 3. 2017-07-26. PMID:28111080. |
tau pathology induces excitatory neuron loss, grid cell dysfunction, and spatial memory deficits reminiscent of early alzheimer's disease. |
2017-07-26 |
2023-08-13 |
mouse |
| Shashank Shekhar, Rahul Kumar, Nitish Rai, Vijay Kumar, Kusum Singh, Ashish Datt Upadhyay, Manjari Tripathi, Sadanand Dwivedi, Aparajit B Dey, Sharmistha De. Estimation of Tau and Phosphorylated Tau181 in Serum of Alzheimer's Disease and Mild Cognitive Impairment Patients. PloS one. vol 11. issue 7. 2017-07-24. PMID:27459603. |
estimation of tau and phosphorylated tau181 in serum of alzheimer's disease and mild cognitive impairment patients. |
2017-07-24 |
2023-08-13 |
Not clear |
| Shashank Shekhar, Rahul Kumar, Nitish Rai, Vijay Kumar, Kusum Singh, Ashish Datt Upadhyay, Manjari Tripathi, Sadanand Dwivedi, Aparajit B Dey, Sharmistha De. Estimation of Tau and Phosphorylated Tau181 in Serum of Alzheimer's Disease and Mild Cognitive Impairment Patients. PloS one. vol 11. issue 7. 2017-07-24. PMID:27459603. |
the elevated level of cerebrospinal fluid (csf) tau and phosphorylated tau181 (p-tau181) proteins are well established hallmarks of alzheimer's disease (ad). |
2017-07-24 |
2023-08-13 |
Not clear |
| Ting Yang, Shaomin Li, Huixin Xu, Dominic M Walsh, Dennis J Selko. Large Soluble Oligomers of Amyloid β-Protein from Alzheimer Brain Are Far Less Neuroactive Than the Smaller Oligomers to Which They Dissociate. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 1. 2017-07-24. PMID:28053038. |
soluble oligomers of amyloid β-protein (oaβ) isolated from the brains of alzheimer's disease (ad) patients have been shown experimentally (in the absence of amyloid plaques) to impair hippocampal synaptic plasticity, decrease synapses, induce tau hyperphosphorylation and neuritic dystrophy, activate microglial inflammation, and impair memory in normal adult rodents. |
2017-07-24 |
2023-08-13 |
mouse |
| Gabor G Kovacs, John L Robinson, Sharon X Xie, Edward B Lee, Murray Grossman, David A Wolk, David J Irwin, Dan Weintraub, Christopher F Kim, Theresa Schuck, Ahmed Yousef, Stephanie T Wagner, Eunran Suh, Vivianna M Van Deerlin, Virginia M-Y Lee, John Q Trojanowsk. Evaluating the Patterns of Aging-Related Tau Astrogliopathy Unravels Novel Insights Into Brain Aging and Neurodegenerative Diseases. Journal of neuropathology and experimental neurology. vol 76. issue 4. 2017-07-24. PMID:28340083. |
we found that (i) the amygdala is a hotspot for all artag types; (ii) age at death, male sex, and presence of primary frontotemporal lobar degeneration (ftld) tauopathy are significantly associated with artag; (iii) age at death, greater degree of brain atrophy, ventricular enlargement, and alzheimer disease (ad)-related variables are associated with subpial, white matter, and perivascular artag types; (iv) ad-related variables are associated particularly with lobar white matter artag; and (v) gray matter artag in primary ftld-tauopathies appears in areas without neuronal tau pathology. |
2017-07-24 |
2023-08-13 |
human |
| Samuel N Lockhart, Suzanne L Baker, Nobuyuki Okamura, Katsutoshi Furukawa, Aiko Ishiki, Shozo Furumoto, Manabu Tashiro, Kazuhiko Yanai, Hiroyuki Arai, Yukitsuka Kudo, Ryuichi Harada, Naoki Tomita, Kotaro Hiraoka, Shoichi Watanuki, William J Jagus. Dynamic PET Measures of Tau Accumulation in Cognitively Normal Older Adults and Alzheimer's Disease Patients Measured Using [18F] THK-5351. PloS one. vol 11. issue 6. 2017-07-19. PMID:27355840. |
dynamic pet measures of tau accumulation in cognitively normal older adults and alzheimer's disease patients measured using [18f] thk-5351. |
2017-07-19 |
2023-08-13 |
human |
| Jing Zhao, Isabelle Huvent, Guy Lippens, David Eliezer, Anqiang Zhang, Quanhong Li, Peter Tessier, Robert J Linhardt, Fuming Zhang, Chunyu Wan. Glycan Determinants of Heparin-Tau Interaction. Biophysical journal. vol 112. issue 5. 2017-07-19. PMID:28297651. |
tau aggregates into paired helical filaments within neurons, a pathological hallmark of alzheimer's disease. |
2017-07-19 |
2023-08-13 |
Not clear |
| W J Fesse. Concordance of Several Subcellular Interactions Initiates Alzheimer's Dementia: Their Reversal Requires Combination Treatment. American journal of Alzheimer's disease and other dementias. vol 32. issue 3. 2017-07-19. PMID:28423937. |
the pathogenesis of alzheimer's disease involves multiple pathways that, at the macrolevel, include decreased proliferation plus increased loss affecting neurons, astrocytes, and capillaries and, at the subcellular level, involve several elements: amyloid/amyloid precursor protein, presenilins, the unfolded protein response, the ubiquitin/proteasome system, the wnt/catenin system, the notch signaling system, mitochondria, mitophagy, calcium, and tau. |
2017-07-19 |
2023-08-13 |
Not clear |
| Jorge Sepulcre, Michel J Grothe, Mert Sabuncu, Jasmeer Chhatwal, Aaron P Schultz, Bernard Hanseeuw, Georges El Fakhri, Reisa Sperling, Keith A Johnso. Hierarchical Organization of Tau and Amyloid Deposits in the Cerebral Cortex. JAMA neurology. vol 74. issue 7. 2017-07-19. PMID:28558094. |
abnormal accumulation of tau and amyloid-β (aβ) proteins in the human brain are 2 pathologic hallmarks of alzheimer disease (ad). |
2017-07-19 |
2023-08-13 |
human |
| Adam L Boxer, Jin-Tai Yu, Lawrence I Golbe, Irene Litvan, Anthony E Lang, Günter U Höglinge. Advances in progressive supranuclear palsy: new diagnostic criteria, biomarkers, and therapeutic approaches. The Lancet. Neurology. vol 16. issue 7. 2017-07-19. PMID:28653647. |
since tau pathology is also central to alzheimer's disease and chronic traumatic encephalopathy, a successful tau therapeutic for psp might inform treatment of other neurodegenerative diseases. |
2017-07-19 |
2023-08-13 |
Not clear |
| Jorge Sepulcre, Aaron P Schultz, Mert Sabuncu, Teresa Gomez-Isla, Jasmeer Chhatwal, Alex Becker, Reisa Sperling, Keith A Johnso. In Vivo Tau, Amyloid, and Gray Matter Profiles in the Aging Brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 28. 2017-07-18. PMID:27413148. |
we provide a comparative in vivo examination of the brain network-based distribution of two hallmarks of alzheimer's disease (ad) pathology in cognitively normal individuals: (1) tau, detected with a novel positron emission tomography (pet) tracer known as (18)f-av-1451; and (2) amyloid-β, quantified with (11)c-pib pet. |
2017-07-18 |
2023-08-13 |
human |