| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cristina Di Primio, Paola Quaranta, Marianna Mignanelli, Giacomo Siano, Matteo Bimbati, Arianna Scarlatti, Carmen Rita Piazza, Piero Giorgio Spezia, Paola Perrera, Fulvio Basolo, Anello Marcello Poma, Mario Costa, Mauro Pistello, Antonino Cattane. Severe acute respiratory syndrome coronavirus 2 infection leads to Tau pathological signature in neurons. PNAS nexus. vol 2. issue 9. 2023-09-21. PMID:37731949. |
upon infection, tau is phosphorylated at several pathological epitopes associated with alzheimer's disease and other tauopathies. |
2023-09-21 |
2023-10-07 |
mouse |
| Nina Rostgaard, Pia Holm Jul, Mats Garmer, Christiane Volbrach. Increasing O-GlcNAcylation Attenuates tau Hyperphosphorylation and Behavioral Impairment in rTg4510 Tauopathy Mice. Journal of integrative neuroscience. vol 22. issue 5. 2023-09-21. PMID:37735138. |
tauopathies such as alzheimer's disease (ad) are characterized by abnormal hyperphosphorylation of the microtubule-associated protein tau (mapt) aggregating into neurofibrillary tangles (nfts). |
2023-09-21 |
2023-10-07 |
mouse |
| Zhuchi Tu, Sen Yan, Bofeng Han, Caijuan Li, Weien Liang, Yingqi Lin, Yongyan Ding, Huiyi Wei, Lu Wang, Hao Xu, Jianmeng Ye, Bang Li, Shihua Li, Xiao-Jiang L. Tauopathy promotes spinal cord-dependent production of toxic amyloid-beta in transgenic monkeys. Signal transduction and targeted therapy. vol 8. issue 1. 2023-09-21. PMID:37735155. |
tauopathy, characterized by the hyperphosphorylation and accumulation of the microtubule-associated protein tau, and the accumulation of aβ oligomers, constitute the major pathological hallmarks of alzheimer's disease. |
2023-09-21 |
2023-10-07 |
mouse |
| Muhammad Imran Khan, Eun Sun Jeong, Muhammad Zubair Khan, Jin Hyuk Shin, Jong Deog Ki. Stem cells-derived exosomes alleviate neurodegeneration and Alzheimer's pathogenesis by ameliorating neuroinflamation, and regulating the associated molecular pathways. Scientific reports. vol 13. issue 1. 2023-09-21. PMID:37735227. |
amyloid beta (aβ) aggregation and tau hyper phosphorylation (p-tau) are key molecular factors in alzheimer's disease (ad). |
2023-09-21 |
2023-10-07 |
human |
| Erandis D Torres-Sánchez, Genaro G Ortiz, Emmanuel Reyes-Uribe, Juan H Torres-Jasso, Joel Salazar-Flore. Effect of pesticides on phosphorylation of tau protein, and its influence on Alzheimer's disease. World journal of clinical cases. vol 11. issue 24. 2023-09-20. PMID:37727721. |
effect of pesticides on phosphorylation of tau protein, and its influence on alzheimer's disease. |
2023-09-20 |
2023-10-07 |
human |
| Bhuvanachandra Bhoopal, Krishna Kumar Gollapelli, Naresh Damuka, Mack Miller, Ivan Krizan, Avinash Bansode, Thomas Register, Brett M Frye, Jeongchul Kim, Akiva Mintz, Miranda Orr, Suzanne Craft, Christopher Whitlow, Samuel N Lockhart, Carol Shively, Kiran Kumar Solingapuram Sa. Preliminary PET Imaging of Microtubule-Based PET Radioligand [ ACS chemical neuroscience. 2023-09-19. PMID:37724996. |
preliminary pet imaging of microtubule-based pet radioligand [ the microtubule (mt) instability observed in alzheimer's disease (ad) is commonly attributed to hyperphosphorylation of the mt-associated protein, tau. |
2023-09-19 |
2023-10-07 |
Not clear |
| Bhavarth P Dave, Yesha B Shah, Kunal G Maheshwari, Kaif A Mansuri, Bhadrawati S Prajapati, Humzah I Postwala, Mehul R Chorawal. Pathophysiological Aspects and Therapeutic Armamentarium of Alzheimer's Disease: Recent Trends and Future Development. Cellular and molecular neurobiology. 2023-09-19. PMID:37725199. |
alzheimer's disease (ad) is the primary cause of dementia and is characterized by the death of brain cells due to the accumulation of insoluble amyloid plaques, hyperphosphorylation of tau protein, and the formation of neurofibrillary tangles within the cells. |
2023-09-19 |
2023-10-07 |
Not clear |
| Ju Hee Kang, Magdalena Korecka, Edward B Lee, Katheryn A Q Cousins, Thomas F Tropea, Alice A Chen-Plotkin, David J Irwin, David Wolk, Magdalena Brylska, Yang Wan, Leslie M Sha. Alzheimer Disease Biomarkers: Moving from CSF to Plasma for Reliable Detection of Amyloid and tau Pathology. Clinical chemistry. 2023-09-19. PMID:37725909. |
alzheimer disease biomarkers: moving from csf to plasma for reliable detection of amyloid and tau pathology. |
2023-09-19 |
2023-10-07 |
Not clear |
| Shanshan Wang, Suzhi Liu, Shaofa Ke, Wenjun Zhou, Tengwei Pa. APOEɛ4 Status and Plasma p-tau181 Levels May Influence Memory and Executive Function Decline in Older Adults Without Dementia. Journal of Alzheimer's disease : JAD. 2023-09-18. PMID:37718807. |
elevated tau phosphorylation has been linked to the apolipoprotein e (apoe) ɛ4 allele, which is considered one of the most significant genes related to alzheimer's disease (ad). |
2023-09-18 |
2023-10-07 |
Not clear |
| Jun Chang, Yujiao Li, Xiaoqian Shan, Xi Chen, Xuhe Yan, Jianwei Liu, Lan Zha. Neural stem cells promote neuroplasticity: a promising therapeutic strategy for the treatment of Alzheimer's disease. Neural regeneration research. vol 19. issue 3. 2023-09-18. PMID:37721293. |
due to their significant ability to self-renew, differentiate, and migrate, neural stem cells play an essential role in reversing synaptic and neuronal damage, reducing the pathology of alzheimer's disease, including amyloid-β, tau protein, and neuroinflammation, and secreting neurotrophic factors and growth factors that are related to plasticity. |
2023-09-18 |
2023-10-07 |
Not clear |
| Emma M Coomans, Danielle van Westen, Alexa Pichet Binette, Olof Strandberg, Nicola Spotorno, Geidy E Serrano, Thomas G Beach, Sebastian Palmqvist, Erik Stomrud, Rik Ossenkoppele, Oskar Hansso. Interactions between vascular burden and amyloid-β pathology on trajectories of tau accumulation. Brain : a journal of neurology. 2023-09-18. PMID:37721482. |
to conclude, we demonstrated that cerebrovascular pathology - in the presence of amyloid-β pathology - modifies tau accumulation in early stages of alzheimer's disease. |
2023-09-18 |
2023-10-07 |
human |
| Emma M Coomans, Danielle van Westen, Alexa Pichet Binette, Olof Strandberg, Nicola Spotorno, Geidy E Serrano, Thomas G Beach, Sebastian Palmqvist, Erik Stomrud, Rik Ossenkoppele, Oskar Hansso. Interactions between vascular burden and amyloid-β pathology on trajectories of tau accumulation. Brain : a journal of neurology. 2023-09-18. PMID:37721482. |
this opens the possibility that interventions targeting microbleeds may attenuate the rate of tau accumulation in alzheimer's disease. |
2023-09-18 |
2023-10-07 |
human |
| Lenka Hromadkova, Chae Kim, Tracy Haldiman, Lihua Peng, Xiongwei Zhu, Mark Cohen, Rohan de Silva, Jiri G Safa. Evolving prion-like tau conformers differentially alter postsynaptic proteins in neurons inoculated with distinct isolates of Alzheimer's disease tau. Cell & bioscience. vol 13. issue 1. 2023-09-18. PMID:37723591. |
evolving prion-like tau conformers differentially alter postsynaptic proteins in neurons inoculated with distinct isolates of alzheimer's disease tau. |
2023-09-18 |
2023-10-07 |
Not clear |
| Lenka Hromadkova, Chae Kim, Tracy Haldiman, Lihua Peng, Xiongwei Zhu, Mark Cohen, Rohan de Silva, Jiri G Safa. Evolving prion-like tau conformers differentially alter postsynaptic proteins in neurons inoculated with distinct isolates of Alzheimer's disease tau. Cell & bioscience. vol 13. issue 1. 2023-09-18. PMID:37723591. |
although accumulation of misfolded tau species has been shown to predict cognitive decline in patients with alzheimer's disease (ad) and other tauopathies but with the remarkable diversity of clinical manifestations, neuropathology profiles, and time courses of disease progression remaining unexplained by current genetic data. |
2023-09-18 |
2023-10-07 |
Not clear |
| Giulia Giacomucci, Salvatore Mazzeo, Chiara Crucitti, Assunta Ingannato, Silvia Bagnoli, Sonia Padiglioni, Giulia Galdo, Filippo Emiliani, Daniele Frigerio, Valentina Moschini, Carmen Morinelli, Sandro Sorbi, Valentina Bessi, Benedetta Nacmia. Plasma p-tau181 as a promising non-invasive biomarker of Alzheimer's Disease pathology in Subjective Cognitive Decline and Mild Cognitive Impairment. Journal of the neurological sciences. vol 453. 2023-09-16. PMID:37716237. |
the aim of this study is to investigate the role of plasma phosphorylated tau (p-tau) 181 as a potential biomarker for alzheimer's disease (ad) pathology in the early stages of the disease, as a valuable marker for tauopathy. |
2023-09-16 |
2023-10-07 |
Not clear |
| Biao Cai, Nan Shao, Ting Ye, Peng Zhou, Wenwen Si, Hang Song, Guangyun Wang, Junping Ko. Phosphorylation of MAP 1A regulates Hyperphosphorylation of Tau in Alzheimer's Disease Model. Neuropathology and applied neurobiology. 2023-09-14. PMID:37705167. |
phosphorylation of map 1a regulates hyperphosphorylation of tau in alzheimer's disease model. |
2023-09-14 |
2023-10-07 |
Not clear |
| Biao Cai, Nan Shao, Ting Ye, Peng Zhou, Wenwen Si, Hang Song, Guangyun Wang, Junping Ko. Phosphorylation of MAP 1A regulates Hyperphosphorylation of Tau in Alzheimer's Disease Model. Neuropathology and applied neurobiology. 2023-09-14. PMID:37705167. |
hyperphosphorylation of tau is one of the important pathological features of alzheimer's disease (ad). |
2023-09-14 |
2023-10-07 |
Not clear |
| Xinyi Zhao, Wen Zeng, Hong Xu, Zihan Sun, Yingxin Hu, Beibei Peng, Jennifer D McBride, Jiangtao Duan, Juan Deng, Bin Zhang, Soo-Jung Kim, Bryan Zoll, Takashi Saito, Hiroki Sasaguri, Takaomi C Saido, Carlo Ballatore, Haishan Yao, Zhaoyin Wang, John Q Trojanowski, Kurt R Brunden, Virginia M-Y Lee, Zhuohao H. A microtubule stabilizer ameliorates protein pathogenesis and neurodegeneration in mouse models of repetitive traumatic brain injury. Science translational medicine. vol 15. issue 713. 2023-09-13. PMID:37703352. |
tau pathogenesis is a hallmark of many neurodegenerative diseases, including alzheimer's disease (ad). |
2023-09-13 |
2023-10-07 |
mouse |
| Christopher G Schwarz, Walter K Kremers, Stephen D Weigand, Carl M Prakaashana, Matthew L Senjem, Scott A Przybelski, Val J Lowe, Jeffrey L Gunter, Kejal Kantarci, Prashanthi Vemuri, Jonathan Graff-Radford, Ronald C Petersen, David S Knopman, Clifford R Jac. Effects of de-facing software mri_reface on utility of imaging biomarkers used in Alzheimer's disease research. NeuroImage. Clinical. vol 40. 2023-09-13. PMID:37703605. |
in this work, we focused on brain imaging measures of amyloid (a), tau (t), neurodegeneration (n), and vascular (v) measures used in alzheimer's disease (ad) research. |
2023-09-13 |
2023-10-07 |
human |
| Kevin Rose, Tyler Jepson, Sankalp Shukla, Alex Maya-Romero, Martin Kampmann, Ke Xu, James H Hurle. Tau fibrils induce nanoscale membrane damage and nucleate cytosolic tau at lysosomes. bioRxiv : the preprint server for biology. 2023-09-11. PMID:37693477. |
the prion-like spread of protein aggregates is a leading hypothesis for the propagation of neurofibrillary lesions in the brain, including the spread of tau inclusions associated with alzheimer's disease. |
2023-09-11 |
2023-10-07 |
Not clear |