| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Eric Feinstein, Sarah J Benbow, Nichole E LaPointe, Nirav Patel, Srinivasan Ramachandran, Thanh D Do, Michelle R Gaylord, Noelle E Huskey, Nicolette Dressler, Megan Korff, Brady Quon, Kristi Lazar Cantrell, Michael T Bowers, Ratnesh Lal, Stuart C Feinstei. Oligomerization of the microtubule-associated protein tau is mediated by its N-terminal sequences: implications for normal and pathological tau action. Journal of neurochemistry. vol 137. issue 6. 2017-06-01. PMID:26953146. |
the microtubule-associated protein tau is essential for neuronal development and maintenance, but is also central to alzheimer's and related dementias. |
2017-06-01 |
2023-08-13 |
Not clear |
| M Ankarcrona, B Winblad, C Monteiro, C Fearns, E T Powers, J Johansson, G T Westermark, J Presto, B-G Ericzon, J W Kell. Current and future treatment of amyloid diseases. Journal of internal medicine. vol 280. issue 2. 2017-05-31. PMID:27165517. |
alzheimer's disease is a neurodegenerative disorder with extracellular amyloid β-peptide (aβ) fibrils and intracellular tau neurofibrillary tangles as pathological hallmarks. |
2017-05-31 |
2023-08-13 |
human |
| Liang Wang, Tammie L Benzinger, Yi Su, Jon Christensen, Karl Friedrichsen, Patricia Aldea, Jonathan McConathy, Nigel J Cairns, Anne M Fagan, John C Morris, Beau M Ance. Evaluation of Tau Imaging in Staging Alzheimer Disease and Revealing Interactions Between β-Amyloid and Tauopathy. JAMA neurology. vol 73. issue 9. 2017-05-30. PMID:27454922. |
evaluation of tau imaging in staging alzheimer disease and revealing interactions between β-amyloid and tauopathy. |
2017-05-30 |
2023-08-13 |
Not clear |
| Liang Wang, Tammie L Benzinger, Yi Su, Jon Christensen, Karl Friedrichsen, Patricia Aldea, Jonathan McConathy, Nigel J Cairns, Anne M Fagan, John C Morris, Beau M Ance. Evaluation of Tau Imaging in Staging Alzheimer Disease and Revealing Interactions Between β-Amyloid and Tauopathy. JAMA neurology. vol 73. issue 9. 2017-05-30. PMID:27454922. |
in vivo tau imaging may become a diagnostic marker for alzheimer disease (ad) and provides insights into the pathophysiology of ad. |
2017-05-30 |
2023-08-13 |
Not clear |
| Michael S Rafi. Targeting tau protein in Alzheimer's disease. Lancet (London, England). vol 388. issue 10062. 2017-05-30. PMID:27863808. |
targeting tau protein in alzheimer's disease. |
2017-05-30 |
2023-08-13 |
Not clear |
| Chenjie Xia, Sara J Makaretz, Christina Caso, Scott McGinnis, Stephen N Gomperts, Jorge Sepulcre, Teresa Gomez-Isla, Bradley T Hyman, Aaron Schultz, Neil Vasdev, Keith A Johnson, Bradford C Dickerso. Association of In Vivo [18F]AV-1451 Tau PET Imaging Results With Cortical Atrophy and Symptoms in Typical and Atypical Alzheimer Disease. JAMA neurology. vol 74. issue 4. 2017-05-30. PMID:28241163. |
association of in vivo [18f]av-1451 tau pet imaging results with cortical atrophy and symptoms in typical and atypical alzheimer disease. |
2017-05-30 |
2023-08-13 |
Not clear |
| Chenjie Xia, Sara J Makaretz, Christina Caso, Scott McGinnis, Stephen N Gomperts, Jorge Sepulcre, Teresa Gomez-Isla, Bradley T Hyman, Aaron Schultz, Neil Vasdev, Keith A Johnson, Bradford C Dickerso. Association of In Vivo [18F]AV-1451 Tau PET Imaging Results With Cortical Atrophy and Symptoms in Typical and Atypical Alzheimer Disease. JAMA neurology. vol 74. issue 4. 2017-05-30. PMID:28241163. |
previous postmortem studies have long demonstrated that neurofibrillary tangles made of hyperphosphorylated tau proteins are closely associated with alzheimer disease clinical phenotype and neurodegeneration pattern. |
2017-05-30 |
2023-08-13 |
Not clear |
| Jesús Avila, Noemí Pallas, Marta Bolós, C Laura Sayas, Felix Hernande. Intracellular and extracellular microtubule associated protein tau as a therapeutic target in Alzheimer disease and other tauopathies. Expert opinion on therapeutic targets. vol 20. issue 6. 2017-05-29. PMID:26652296. |
intracellular and extracellular microtubule associated protein tau as a therapeutic target in alzheimer disease and other tauopathies. |
2017-05-29 |
2023-08-13 |
Not clear |
| Abbas M Walji, Eric D Hostetler, Harold Selnick, Zhizhen Zeng, Patricia Miller, Idriss Bennacef, Cristian Salinas, Brett Connolly, Liza Gantert, Marie Holahan, Stacey O'Malley, Mona Purcell, Kerry Riffel, Jing Li, Jaume Balsells, Julie A OBrien, Stacey Melquist, Aileen Soriano, Xiaoping Zhang, Aimie Ogawa, Serena Xu, Elizabeth Joshi, Joseph Della Rocca, Fred J Hess, Joel Schachter, David Hesk, David Schenk, Arie Struyk, Kerim Babaoglu, Talakad G Lohith, Yaode Wang, Kun Yang, Jianmin Fu, Jeffrey L Evelhoch, Paul J Colema. Discovery of 6-(Fluoro-(18)F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([(18)F]-MK-6240): A Positron Emission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs). Journal of medicinal chemistry. vol 59. issue 10. 2017-05-29. PMID:27088900. |
neurofibrillary tangles (nfts) made up of aggregated tau protein have been identified as the pathologic hallmark of several neurodegenerative diseases including alzheimer's disease. |
2017-05-29 |
2023-08-13 |
Not clear |
| Kanae Ando, Mikiko Oka, Yosuke Ohtake, Motoki Hayashishita, Sawako Shimizu, Shin-Ichi Hisanaga, Koichi M Iijim. Tau phosphorylation at Alzheimer's disease-related Ser356 contributes to tau stabilization when PAR-1/MARK activity is elevated. Biochemical and biophysical research communications. vol 478. issue 2. 2017-05-29. PMID:27520376. |
tau phosphorylation at alzheimer's disease-related ser356 contributes to tau stabilization when par-1/mark activity is elevated. |
2017-05-29 |
2023-08-13 |
human |
| Kanae Ando, Mikiko Oka, Yosuke Ohtake, Motoki Hayashishita, Sawako Shimizu, Shin-Ichi Hisanaga, Koichi M Iijim. Tau phosphorylation at Alzheimer's disease-related Ser356 contributes to tau stabilization when PAR-1/MARK activity is elevated. Biochemical and biophysical research communications. vol 478. issue 2. 2017-05-29. PMID:27520376. |
abnormal phosphorylation of the microtubule-associated protein tau is observed in many neurodegenerative diseases, including alzheimer's disease (ad). |
2017-05-29 |
2023-08-13 |
human |
| Kun Ping Lu, Asami Kondo, Onder Albayram, Megan K Herbert, Hekun Liu, Xiao Zhen Zho. Potential of the Antibody Against cis-Phosphorylated Tau in the Early Diagnosis, Treatment, and Prevention of Alzheimer Disease and Brain Injury. JAMA neurology. vol 73. issue 11. 2017-05-29. PMID:27654282. |
potential of the antibody against cis-phosphorylated tau in the early diagnosis, treatment, and prevention of alzheimer disease and brain injury. |
2017-05-29 |
2023-08-13 |
mouse |
| Petr Novak, Reinhold Schmidt, Eva Kontsekova, Norbert Zilka, Branislav Kovacech, Rostislav Skrabana, Zuzana Vince-Kazmerova, Stanislav Katina, Lubica Fialova, Michal Prcina, Vojtech Parrak, Peter Dal-Bianco, Martin Brunner, Wolfgang Staffen, Michael Rainer, Matej Ondrus, Stefan Ropele, Miroslav Smisek, Roman Sivak, Bengt Winblad, Michal Nova. Safety and immunogenicity of the tau vaccine AADvac1 in patients with Alzheimer's disease: a randomised, double-blind, placebo-controlled, phase 1 trial. The Lancet. Neurology. vol 16. issue 2. 2017-05-29. PMID:27955995. |
safety and immunogenicity of the tau vaccine aadvac1 in patients with alzheimer's disease: a randomised, double-blind, placebo-controlled, phase 1 trial. |
2017-05-29 |
2023-08-13 |
Not clear |
| Petr Novak, Reinhold Schmidt, Eva Kontsekova, Norbert Zilka, Branislav Kovacech, Rostislav Skrabana, Zuzana Vince-Kazmerova, Stanislav Katina, Lubica Fialova, Michal Prcina, Vojtech Parrak, Peter Dal-Bianco, Martin Brunner, Wolfgang Staffen, Michael Rainer, Matej Ondrus, Stefan Ropele, Miroslav Smisek, Roman Sivak, Bengt Winblad, Michal Nova. Safety and immunogenicity of the tau vaccine AADvac1 in patients with Alzheimer's disease: a randomised, double-blind, placebo-controlled, phase 1 trial. The Lancet. Neurology. vol 16. issue 2. 2017-05-29. PMID:27955995. |
neurofibrillary pathology composed of tau protein is a main correlate of cognitive impairment in patients with alzheimer's disease. |
2017-05-29 |
2023-08-13 |
Not clear |
| Petr Novak, Reinhold Schmidt, Eva Kontsekova, Norbert Zilka, Branislav Kovacech, Rostislav Skrabana, Zuzana Vince-Kazmerova, Stanislav Katina, Lubica Fialova, Michal Prcina, Vojtech Parrak, Peter Dal-Bianco, Martin Brunner, Wolfgang Staffen, Michael Rainer, Matej Ondrus, Stefan Ropele, Miroslav Smisek, Roman Sivak, Bengt Winblad, Michal Nova. Safety and immunogenicity of the tau vaccine AADvac1 in patients with Alzheimer's disease: a randomised, double-blind, placebo-controlled, phase 1 trial. The Lancet. Neurology. vol 16. issue 2. 2017-05-29. PMID:27955995. |
immunotherapy targeting pathological tau proteins is therefore a promising strategy for disease-modifying treatment of alzheimer's disease. |
2017-05-29 |
2023-08-13 |
Not clear |
| Aoyan Dong, Jon B Toledo, Nicolas Honnorat, Jimit Doshi, Erdem Varol, Aristeidis Sotiras, David Wolk, John Q Trojanowski, Christos Davatziko. Heterogeneity of neuroanatomical patterns in prodromal Alzheimer's disease: links to cognition, progression and biomarkers. Brain : a journal of neurology. vol 140. issue 3. 2017-05-29. PMID:28003242. |
amyloid and tau deposition) dimensions in alzheimer's disease and its prodromal stages. |
2017-05-29 |
2023-08-13 |
human |
| Michael J Pontecorvo, Michael D Devous, Michael Navitsky, Ming Lu, Stephen Salloway, Frederick W Schaerf, Danna Jennings, Anupa K Arora, Anne McGeehan, Nathaniel C Lim, Hui Xiong, Abhinay D Joshi, Andrew Siderowf, Mark A Mintu. Relationships between flortaucipir PET tau binding and amyloid burden, clinical diagnosis, age and cognition. Brain : a journal of neurology. vol 140. issue 3. 2017-05-29. PMID:28077397. |
the advent of tau-targeted positron emission tomography tracers such as flortaucipir (18f-av-1451, also known as 18f-t807) have made it possible to investigate the sequence of development of tau and amyloid-β in relationship to age, and to the development of cognitive impairment due to alzheimer's disease. |
2017-05-29 |
2023-08-13 |
human |
| Michael J Pontecorvo, Michael D Devous, Michael Navitsky, Ming Lu, Stephen Salloway, Frederick W Schaerf, Danna Jennings, Anupa K Arora, Anne McGeehan, Nathaniel C Lim, Hui Xiong, Abhinay D Joshi, Andrew Siderowf, Mark A Mintu. Relationships between flortaucipir PET tau binding and amyloid burden, clinical diagnosis, age and cognition. Brain : a journal of neurology. vol 140. issue 3. 2017-05-29. PMID:28077397. |
in this study, flortaucipir tau and florbetapir amyloid positron emission tomography were obtained for 217 subjects including 16 young and 58 older cognitively normal subjects, 95 subjects with mild cognitive impairment (mini-mental state examination 24-30) and 48 subjects with clinically-defined possible or probable alzheimer's disease (mini-mental state examination >10). |
2017-05-29 |
2023-08-13 |
human |
| Michael J Pontecorvo, Michael D Devous, Michael Navitsky, Ming Lu, Stephen Salloway, Frederick W Schaerf, Danna Jennings, Anupa K Arora, Anne McGeehan, Nathaniel C Lim, Hui Xiong, Abhinay D Joshi, Andrew Siderowf, Mark A Mintu. Relationships between flortaucipir PET tau binding and amyloid burden, clinical diagnosis, age and cognition. Brain : a journal of neurology. vol 140. issue 3. 2017-05-29. PMID:28077397. |
finally, within the aβ+ group, increasing levels of flortaucipir tau binding were associated with increased cognitive impairment, as assessed by mini-mental state examination and alzheimer's disease assessment scale. |
2017-05-29 |
2023-08-13 |
human |
| Maiko Ono, Naruhiko Sahara, Katsushi Kumata, Bin Ji, Ruiqing Ni, Shunsuke Koga, Dennis W Dickson, John Q Trojanowski, Virginia M-Y Lee, Mari Yoshida, Isao Hozumi, Yasumasa Yoshiyama, John C van Swieten, Agneta Nordberg, Tetsuya Suhara, Ming-Rong Zhang, Makoto Higuch. Distinct binding of PET ligands PBB3 and AV-1451 to tau fibril strains in neurodegenerative tauopathies. Brain : a journal of neurology. vol 140. issue 3. 2017-05-29. PMID:28087578. |
fluorescence microscopy demonstrated intense labelling of non-ghost and ghost tangles with pbb3 and av-1451, while dystrophic neurites were more clearly detected by pbb3 in brains of alzheimer's disease and diffuse neurofibrillary tangles with calcification, characterized by accumulation of all six tau isoforms. |
2017-05-29 |
2023-08-13 |
Not clear |