Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Jason D Ulrich, David M Holtzma. TREM2 Function in Alzheimer's Disease and Neurodegeneration. ACS chemical neuroscience. vol 7. issue 4. 2017-01-06. PMID:26854967. |
alzheimer's disease (ad), the most common cause of dementia in the elderly, is a complex neurodegenerative disease marked by the appearance of amyloid-β (aβ) plaques and hyperphosphorylated tau tangles. |
2017-01-06 |
2023-08-13 |
mouse |
Mario Merlini, Debora Wanner, Roger M Nitsc. Tau pathology-dependent remodelling of cerebral arteries precedes Alzheimer's disease-related microvascular cerebral amyloid angiopathy. Acta neuropathologica. vol 131. issue 5. 2017-01-06. PMID:26988843. |
tau pathology-dependent remodelling of cerebral arteries precedes alzheimer's disease-related microvascular cerebral amyloid angiopathy. |
2017-01-06 |
2023-08-13 |
human |
Marianna Karina Gorsky, Sylvie Burnouf, Jacqueline Dols, Eckhard Mandelkow, Linda Partridg. Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo. Scientific reports. vol 6. 2017-01-04. PMID:26940749. |
dysfunction and accumulation of the microtubule-associated human tau (htau) protein into intraneuronal aggregates is observed in many neurodegenerative disorders including alzheimer's disease (ad). |
2017-01-04 |
2023-08-13 |
human |
Lenka Hromadkova, Rudolf Kupcik, Barbora Jankovicova, Tomas Rousar, Daniela Ripova, Zuzana Bilkov. Difficulties associated with the structural analysis of proteins susceptible to form aggregates: The case of Tau protein as a biomarker of Alzheimer's disease. Journal of separation science. vol 39. issue 4. 2017-01-03. PMID:26644024. |
difficulties associated with the structural analysis of proteins susceptible to form aggregates: the case of tau protein as a biomarker of alzheimer's disease. |
2017-01-03 |
2023-08-13 |
Not clear |
Lenka Hromadkova, Rudolf Kupcik, Barbora Jankovicova, Tomas Rousar, Daniela Ripova, Zuzana Bilkov. Difficulties associated with the structural analysis of proteins susceptible to form aggregates: The case of Tau protein as a biomarker of Alzheimer's disease. Journal of separation science. vol 39. issue 4. 2017-01-03. PMID:26644024. |
this work is focused on epitope analysis of tau protein, which contains two vqixxk aggregation motifs regarded as crucial elements in the formation of paired helical filaments, the main pathological characteristics of alzheimer's disease. |
2017-01-03 |
2023-08-13 |
Not clear |
Nicolas R Barthélemy, Audrey Gabelle, Christophe Hirtz, François Fenaille, Nicolas Sergeant, Susanna Schraen-Maschke, Jérôme Vialaret, Luc Buée, Christophe Junot, François Becher, Sylvain Lehman. Differential Mass Spectrometry Profiles of Tau Protein in the Cerebrospinal Fluid of Patients with Alzheimer's Disease, Progressive Supranuclear Palsy, and Dementia with Lewy Bodies. Journal of Alzheimer's disease : JAD. vol 51. issue 4. 2016-12-29. PMID:26923020. |
differential mass spectrometry profiles of tau protein in the cerebrospinal fluid of patients with alzheimer's disease, progressive supranuclear palsy, and dementia with lewy bodies. |
2016-12-29 |
2023-08-13 |
Not clear |
Nicolas R Barthélemy, Audrey Gabelle, Christophe Hirtz, François Fenaille, Nicolas Sergeant, Susanna Schraen-Maschke, Jérôme Vialaret, Luc Buée, Christophe Junot, François Becher, Sylvain Lehman. Differential Mass Spectrometry Profiles of Tau Protein in the Cerebrospinal Fluid of Patients with Alzheimer's Disease, Progressive Supranuclear Palsy, and Dementia with Lewy Bodies. Journal of Alzheimer's disease : JAD. vol 51. issue 4. 2016-12-29. PMID:26923020. |
in some of them, and specifically in alzheimer's disease (ad), hyperphosphorylated forms of tau aggregate into neurofibrillary tangles. |
2016-12-29 |
2023-08-13 |
Not clear |
Elias Akoury, Marco D Mukrasch, Jacek Biernat, Katharina Tepper, Valery Ozenne, Eckhard Mandelkow, Martin Blackledge, Markus Zweckstette. Remodeling of the conformational ensemble of the repeat domain of tau by an aggregation enhancer. Protein science : a publication of the Protein Society. vol 25. issue 5. 2016-12-28. PMID:26940799. |
misfolding of the microtubule-associated protein tau is a hallmark of alzheimer disease and several other neurodegenerative disorders. |
2016-12-28 |
2023-08-13 |
Not clear |
Teng Jiang, Ying-Dong Zhang, Jun-Shan Zhou, Xi-Chen Zhu, You-Yong Tian, Hong-Dong Zhao, Huan Lu, Qing Gao, Lan Tan, Jin-Tai Y. Angiotensin-(1-7) is Reduced and Inversely Correlates with Tau Hyperphosphorylation in Animal Models of Alzheimer's Disease. Molecular neurobiology. vol 53. issue 4. 2016-12-26. PMID:26044748. |
angiotensin-(1-7) is reduced and inversely correlates with tau hyperphosphorylation in animal models of alzheimer's disease. |
2016-12-26 |
2023-08-13 |
mouse |
Wenhui Fan, Yan Long, Yujie Lai, Xuefeng Wang, Guojun Chen, Binglin Zh. NPAS4 Facilitates the Autophagic Clearance of Endogenous Tau in Rat Cortical Neurons. Journal of molecular neuroscience : MN. vol 58. issue 4. 2016-12-26. PMID:26635026. |
however, hyperphosphorylated tau is involved in the pathogenesis of alzheimer's disease (ad) and other tauopathies. |
2016-12-26 |
2023-08-13 |
rat |
M Fá, D Puzzo, R Piacentini, A Staniszewski, H Zhang, M A Baltrons, D D Li Puma, I Chatterjee, J Li, F Saeed, H L Berman, C Ripoli, W Gulisano, J Gonzalez, H Tian, J A Costa, P Lopez, E Davidowitz, W H Yu, V Haroutunian, L M Brown, A Palmeri, E M Sigurdsson, K E Duff, A F Teich, L S Honig, M Sierks, J G Moe, L D'Adamio, C Grassi, N M Kanaan, P E Fraser, O Aranci. Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory. Scientific reports. vol 6. 2016-12-26. PMID:26786552. |
non-fibrillar soluble oligomeric forms of amyloid-β peptide (oaβ) and tau proteins are likely to play a major role in alzheimer's disease (ad). |
2016-12-26 |
2023-08-13 |
mouse |
Waltraud Mair, Jan Muntel, Katharina Tepper, Shaojun Tang, Jacek Biernat, William W Seeley, Kenneth S Kosik, Eckhard Mandelkow, Hanno Steen, Judith A Stee. FLEXITau: Quantifying Post-translational Modifications of Tau Protein in Vitro and in Human Disease. Analytical chemistry. vol 88. issue 7. 2016-12-26. PMID:26877193. |
tauopathies, including alzheimer's disease (ad), are associated with the aggregation of modified microtubule associated protein tau. |
2016-12-26 |
2023-08-13 |
human |
Teng Jiang, Lan Tan, Qing Gao, Huan Lu, Xi-Chen Zhu, Jun-Shan Zhou, Ying-Dong Zhan. Plasma Angiotensin-(1-7) is a Potential Biomarker for Alzheimer's Disease. Current neurovascular research. vol 13. issue 2. 2016-12-26. PMID:26907614. |
brain angiotensin-(1-7) (ang-(1-7)) concentration has been shown to be reduced and inversely correlated with tau pathology in a mouse model of alzheimer's disease (ad). |
2016-12-26 |
2023-08-13 |
mouse |
Ruben Smith, Moa Wibom, Tomas Olsson, Douglas Hägerström, Jonas Jögi, Gil D Rabinovici, Oskar Hansso. Posterior Accumulation of Tau and Concordant Hypometabolism in an Early-Onset Alzheimer's Disease Patient with Presenilin-1 Mutation. Journal of Alzheimer's disease : JAD. vol 51. issue 2. 2016-12-20. PMID:26836192. |
posterior accumulation of tau and concordant hypometabolism in an early-onset alzheimer's disease patient with presenilin-1 mutation. |
2016-12-20 |
2023-08-13 |
Not clear |
Ruben Smith, Moa Wibom, Tomas Olsson, Douglas Hägerström, Jonas Jögi, Gil D Rabinovici, Oskar Hansso. Posterior Accumulation of Tau and Concordant Hypometabolism in an Early-Onset Alzheimer's Disease Patient with Presenilin-1 Mutation. Journal of Alzheimer's disease : JAD. vol 51. issue 2. 2016-12-20. PMID:26836192. |
it is unclear whether the distribution of tau pathology differs between cases with early-onset familial alzheimer's disease (ad) and sporadic ad. |
2016-12-20 |
2023-08-13 |
Not clear |
Xiao-Ping Hong, Tao Chen, Ni-Na Yin, Yong-Ming Han, Fang Yuan, Yan-Jun Duan, Feng Shen, Yan-Hong Zhang, Ze-Bin Che. Puerarin Ameliorates D-Galactose Induced Enhanced Hippocampal Neurogenesis and Tau Hyperphosphorylation in Rat Brain. Journal of Alzheimer's disease : JAD. vol 51. issue 2. 2016-12-20. PMID:26890737. |
enhanced neurogenesis has been reported in the hippocampus of patients with alzheimer's disease (ad), the most common neurodegenerative disorder characterized with amyloid-β (aβ) aggregation, tau hyperphosphorylation, and progressive neuronal loss. |
2016-12-20 |
2023-08-13 |
rat |
Brittany N Dugger, Charisse M Whiteside, Chera L Maarouf, Douglas G Walker, Thomas G Beach, Lucia I Sue, Angelica Garcia, Travis Dunckley, Bessie Meechoovet, Eric M Reiman, Alex E Rohe. The Presence of Select Tau Species in Human Peripheral Tissues and Their Relation to Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 51. issue 2. 2016-12-20. PMID:26890756. |
the presence of select tau species in human peripheral tissues and their relation to alzheimer's disease. |
2016-12-20 |
2023-08-13 |
human |
Brittany N Dugger, Charisse M Whiteside, Chera L Maarouf, Douglas G Walker, Thomas G Beach, Lucia I Sue, Angelica Garcia, Travis Dunckley, Bessie Meechoovet, Eric M Reiman, Alex E Rohe. The Presence of Select Tau Species in Human Peripheral Tissues and Their Relation to Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 51. issue 2. 2016-12-20. PMID:26890756. |
tau becomes excessively phosphorylated in alzheimer's disease (ad) and is widely studied within the brain. |
2016-12-20 |
2023-08-13 |
human |
Chul Hyoung Lyoo, Hanna Cho, Jae Yong Choi, Mi Song Hwang, Sang Kyoon Hong, Yun Joong Kim, Young Hoon Ryu, Myung Sik Le. Tau Accumulation in Primary Motor Cortex of Variant Alzheimer's Disease with Spastic Paraparesis. Journal of Alzheimer's disease : JAD. vol 51. issue 3. 2016-12-19. PMID:26890779. |
tau accumulation in primary motor cortex of variant alzheimer's disease with spastic paraparesis. |
2016-12-19 |
2023-08-13 |
Not clear |
Chul Hyoung Lyoo, Hanna Cho, Jae Yong Choi, Mi Song Hwang, Sang Kyoon Hong, Yun Joong Kim, Young Hoon Ryu, Myung Sik Le. Tau Accumulation in Primary Motor Cortex of Variant Alzheimer's Disease with Spastic Paraparesis. Journal of Alzheimer's disease : JAD. vol 51. issue 3. 2016-12-19. PMID:26890779. |
we studied topographic distribution of tau and amyloid-β in a patient with variant alzheimer's disease with spastic paraparesis (varad) by comparing ad patients. |
2016-12-19 |
2023-08-13 |
Not clear |