| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| O Picazo, J Espinosa-Raya, A Briones-Aranda, M Cerbó. Ovariectomy increases the age-induced hyperphosphorylation of Tau at hippocampal CA1. Cognitive processing. vol 17. issue 4. 2017-02-01. PMID:27271684. |
one of the main hallmarks of alzheimer's disease includes the neurofibrillary tangles formation produced by hyperphosphorylation of the tau protein, whose expression is putatively regulated by the ovarian hormones estradiol and progesterone. |
2017-02-01 |
2023-08-13 |
rat |
| Francisco M Torres-Cruz, Fanny Rodríguez-Cruz, Jaime Escobar-Herrera, Norma Barragán-Andrade, Gustavo Basurto-Islas, Daniela Ripova, Jesús Ávila, Francisco Garcia-Sierr. Expression of Tau Produces Aberrant Plasma Membrane Blebbing in Glial Cells Through RhoA-ROCK-Dependent F-Actin Remodeling. Journal of Alzheimer's disease : JAD. vol 52. issue 2. 2017-01-30. PMID:27003208. |
abnormal aggregation of tau in glial cells has been reported in alzheimer's disease (ad) and other tauopathies; however, the pathological significance of these aggregates remains unsolved to date. |
2017-01-30 |
2023-08-13 |
Not clear |
| Mélanie H Thomas, Sandra Pelleieux, Nicolas Vitale, Jean Luc Olivie. Dietary arachidonic acid as a risk factor for age-associated neurodegenerative diseases: Potential mechanisms. Biochimie. vol 130. 2017-01-30. PMID:27473185. |
in a second part, a brief overview of the role of the two main agents of alzheimer's disease, tau protein and aβ peptide is given, followed by the examination of the relationship between arachidonic acid and the disease. |
2017-01-30 |
2023-08-13 |
Not clear |
| Yuma Sonoda, Ikuo Tooyama, Hideyuki Mukai, Kiyoshi Maeda, Haruhiko Akiyama, Toshio Kawamat. S6 kinase phosphorylated at T229 is involved in tau and actin pathologies in Alzheimer's disease. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 36. issue 4. 2017-01-27. PMID:26582459. |
s6 kinase phosphorylated at t229 is involved in tau and actin pathologies in alzheimer's disease. |
2017-01-27 |
2023-08-13 |
human |
| Yuma Sonoda, Ikuo Tooyama, Hideyuki Mukai, Kiyoshi Maeda, Haruhiko Akiyama, Toshio Kawamat. S6 kinase phosphorylated at T229 is involved in tau and actin pathologies in Alzheimer's disease. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 36. issue 4. 2017-01-27. PMID:26582459. |
the 70-kda ribosomal protein s6 kinase (s6k), a serine/threonine kinase that modulates the phosphorylation of the 40s ribosomal protein s6, regulates cell cycle progression and is known as a tau kinase in alzheimer's disease (ad). |
2017-01-27 |
2023-08-13 |
human |
| Shun Nagamine, Tsuneo Yamazaki, Kouki Makioka, Yukio Fujita, Masaki Ikeda, Masamitsu Takatama, Koichi Okamoto, Hideaki Yokoo, Yoshio Iked. Hypersialylation is a common feature of neurofibrillary tangles and granulovacuolar degenerations in Alzheimer's disease and tauopathy brains. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 36. issue 4. 2017-01-27. PMID:26685795. |
here, we report the novel findings that two phosphorylated tau (p-tau)-containing structures associated with alzheimer's disease (ad), that is, neurofibrillary tangles (nfts) and granulovacuolar degenerations (gvds), were hypersialylated. |
2017-01-27 |
2023-08-13 |
Not clear |
| Liang Xu, Jie Zheng, Martin Margittai, Ruth Nussinov, Buyong M. How Does Hyperphopsphorylation Promote Tau Aggregation and Modulate Filament Structure and Stability? ACS chemical neuroscience. vol 7. issue 5. 2017-01-27. PMID:26854860. |
tau proteins are hyperphosphorylated at common sites in their n- and c-terminal domains in at least three neurodegenerative diseases, parkinson, dementia with lewy bodies, and alzheimer's, suggesting specific pathology but general mechanism. |
2017-01-27 |
2023-08-13 |
human |
| Hui-Fu Wang, Yu Wan, Xiao-Ke Hao, Lei Cao, Xi-Chen Zhu, Teng Jiang, Meng-Shan Tan, Lin Tan, Dao-Qiang Zhang, Lan Tan, Jin-Tai Y. Bridging Integrator 1 (BIN1) Genotypes Mediate Alzheimer's Disease Risk by Altering Neuronal Degeneration. Journal of Alzheimer's disease : JAD. vol 52. issue 1. 2017-01-27. PMID:27003210. |
bridging integrator 1 (bin1) has been identified as one of the most associated loci for alzheimer's disease (ad), and recently was reported to modulate tau pathology to mediate ad in vitro. |
2017-01-27 |
2023-08-13 |
Not clear |
| Kenneth Hensley, Petri Kursul. Collapsin Response Mediator Protein-2 (CRMP2) is a Plausible Etiological Factor and Potential Therapeutic Target in Alzheimer's Disease: Comparison and Contrast with Microtubule-Associated Protein Tau. Journal of Alzheimer's disease : JAD. vol 53. issue 1. 2017-01-27. PMID:27079722. |
collapsin response mediator protein-2 (crmp2) is a plausible etiological factor and potential therapeutic target in alzheimer's disease: comparison and contrast with microtubule-associated protein tau. |
2017-01-27 |
2023-08-13 |
Not clear |
| Kenneth Hensley, Petri Kursul. Collapsin Response Mediator Protein-2 (CRMP2) is a Plausible Etiological Factor and Potential Therapeutic Target in Alzheimer's Disease: Comparison and Contrast with Microtubule-Associated Protein Tau. Journal of Alzheimer's disease : JAD. vol 53. issue 1. 2017-01-27. PMID:27079722. |
alzheimer's disease (ad) has long been viewed as a pathology that must be caused either by aberrant amyloid-β protein precursor (aβpp) processing, dysfunctional tau protein processing, or a combination of these two factors. |
2017-01-27 |
2023-08-13 |
Not clear |
| Ezra C Holsto. The Electrophysiological Phenomenon of Alzheimer's Disease: A Psychopathology Theory. Issues in mental health nursing. vol 36. issue 8. 2017-01-23. PMID:26379134. |
the current understanding of alzheimer's disease (ad) is based on the aβ and tau pathology and the resulting neuropathological changes, which are associated with manifested clinical symptoms. |
2017-01-23 |
2023-08-13 |
Not clear |
| Jianhui Liu, Zixuan Liu, Yonglan Zhang, Fei Yi. Leptin signaling plays a critical role in the geniposide-induced decrease of tau phosphorylation. Acta biochimica et biophysica Sinica. vol 47. issue 12. 2017-01-23. PMID:26496899. |
all these results indicate that geniposide may regulate tau phosphorylation through leptin signaling, and geniposide may be a promising therapeutic compound for the treatment of alzheimer's disease in the future. |
2017-01-23 |
2023-08-13 |
mouse |
| Bo-Wen Zheng, Li Yang, Xue-Ling Dai, Zhao-Feng Jiang, Han-Chang Huan. Roles of O-GlcNAcylation on amyloid-β precursor protein processing, tau phosphorylation, and hippocampal synapses dysfunction in Alzheimer's disease. Neurological research. vol 38. issue 2. 2017-01-13. PMID:27078700. |
roles of o-glcnacylation on amyloid-β precursor protein processing, tau phosphorylation, and hippocampal synapses dysfunction in alzheimer's disease. |
2017-01-13 |
2023-08-13 |
Not clear |
| Bo-Wen Zheng, Li Yang, Xue-Ling Dai, Zhao-Feng Jiang, Han-Chang Huan. Roles of O-GlcNAcylation on amyloid-β precursor protein processing, tau phosphorylation, and hippocampal synapses dysfunction in Alzheimer's disease. Neurological research. vol 38. issue 2. 2017-01-13. PMID:27078700. |
alzheimer disease (ad), a central nervous system degenerative disease, is characterized by abnormal deposition of amyloid-β peptide (aβ), neurofibrillary tangles formed by hyperphosphorylated tau and synaptic loss. |
2017-01-13 |
2023-08-13 |
Not clear |
| Jason D Ulrich, David M Holtzma. TREM2 Function in Alzheimer's Disease and Neurodegeneration. ACS chemical neuroscience. vol 7. issue 4. 2017-01-06. PMID:26854967. |
alzheimer's disease (ad), the most common cause of dementia in the elderly, is a complex neurodegenerative disease marked by the appearance of amyloid-β (aβ) plaques and hyperphosphorylated tau tangles. |
2017-01-06 |
2023-08-13 |
mouse |
| Mario Merlini, Debora Wanner, Roger M Nitsc. Tau pathology-dependent remodelling of cerebral arteries precedes Alzheimer's disease-related microvascular cerebral amyloid angiopathy. Acta neuropathologica. vol 131. issue 5. 2017-01-06. PMID:26988843. |
tau pathology-dependent remodelling of cerebral arteries precedes alzheimer's disease-related microvascular cerebral amyloid angiopathy. |
2017-01-06 |
2023-08-13 |
human |
| Marianna Karina Gorsky, Sylvie Burnouf, Jacqueline Dols, Eckhard Mandelkow, Linda Partridg. Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo. Scientific reports. vol 6. 2017-01-04. PMID:26940749. |
dysfunction and accumulation of the microtubule-associated human tau (htau) protein into intraneuronal aggregates is observed in many neurodegenerative disorders including alzheimer's disease (ad). |
2017-01-04 |
2023-08-13 |
human |
| Lenka Hromadkova, Rudolf Kupcik, Barbora Jankovicova, Tomas Rousar, Daniela Ripova, Zuzana Bilkov. Difficulties associated with the structural analysis of proteins susceptible to form aggregates: The case of Tau protein as a biomarker of Alzheimer's disease. Journal of separation science. vol 39. issue 4. 2017-01-03. PMID:26644024. |
difficulties associated with the structural analysis of proteins susceptible to form aggregates: the case of tau protein as a biomarker of alzheimer's disease. |
2017-01-03 |
2023-08-13 |
Not clear |
| Lenka Hromadkova, Rudolf Kupcik, Barbora Jankovicova, Tomas Rousar, Daniela Ripova, Zuzana Bilkov. Difficulties associated with the structural analysis of proteins susceptible to form aggregates: The case of Tau protein as a biomarker of Alzheimer's disease. Journal of separation science. vol 39. issue 4. 2017-01-03. PMID:26644024. |
this work is focused on epitope analysis of tau protein, which contains two vqixxk aggregation motifs regarded as crucial elements in the formation of paired helical filaments, the main pathological characteristics of alzheimer's disease. |
2017-01-03 |
2023-08-13 |
Not clear |
| Nicolas R Barthélemy, Audrey Gabelle, Christophe Hirtz, François Fenaille, Nicolas Sergeant, Susanna Schraen-Maschke, Jérôme Vialaret, Luc Buée, Christophe Junot, François Becher, Sylvain Lehman. Differential Mass Spectrometry Profiles of Tau Protein in the Cerebrospinal Fluid of Patients with Alzheimer's Disease, Progressive Supranuclear Palsy, and Dementia with Lewy Bodies. Journal of Alzheimer's disease : JAD. vol 51. issue 4. 2016-12-29. PMID:26923020. |
differential mass spectrometry profiles of tau protein in the cerebrospinal fluid of patients with alzheimer's disease, progressive supranuclear palsy, and dementia with lewy bodies. |
2016-12-29 |
2023-08-13 |
Not clear |