| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Georgy Berezhnoy, Christoph Laske, Christoph Trautwei. Metabolomic profiling of CSF and blood serum elucidates general and sex-specific patterns for mild cognitive impairment and Alzheimer's disease patients. Frontiers in aging neuroscience. vol 15. 2023-09-11. PMID:37693649. |
beta-amyloid (abeta) and tau protein in cerebrospinal fluid (csf) are established diagnostic biomarkers for alzheimer's disease (ad). |
2023-09-11 |
2023-10-07 |
Not clear |
| Kai Chen, Riya Gupta, Alejandro Martín-Ávila, Meng Cui, Zhongcong Xie, Guang Yan. Anesthesia-induced hippocampal-cortical hyperactivity and tau hyperphosphorylation impair remote memory retrieval in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-09-11. PMID:37695022. |
anesthesia-induced hippocampal-cortical hyperactivity and tau hyperphosphorylation impair remote memory retrieval in alzheimer's disease. |
2023-09-11 |
2023-10-07 |
Not clear |
| Agata Tarkowska, Wanda Furmaga-Jabłońska, Jacek Bogucki, Janusz Kocki, Ryszard Plut. Preservation of Biomarkers Associated with Alzheimer's Disease (Amyloid Peptides 1-38, 1-40, 1-42, Tau Protein, Beclin 1) in the Blood of Neonates after Perinatal Asphyxia. International journal of molecular sciences. vol 24. issue 17. 2023-09-09. PMID:37686098. |
preservation of biomarkers associated with alzheimer's disease (amyloid peptides 1-38, 1-40, 1-42, tau protein, beclin 1) in the blood of neonates after perinatal asphyxia. |
2023-09-09 |
2023-10-07 |
Not clear |
| Agata Tarkowska, Wanda Furmaga-Jabłońska, Jacek Bogucki, Janusz Kocki, Ryszard Plut. Preservation of Biomarkers Associated with Alzheimer's Disease (Amyloid Peptides 1-38, 1-40, 1-42, Tau Protein, Beclin 1) in the Blood of Neonates after Perinatal Asphyxia. International journal of molecular sciences. vol 24. issue 17. 2023-09-09. PMID:37686098. |
we decided to evaluate serum biomarkers of neuronal injury characteristic for alzheimer's disease such as amyloid peptides (1-38, 1-40 and 1-42), tau protein and beclin 1, which can predict the progression of brain neurodegeneration in future. |
2023-09-09 |
2023-10-07 |
Not clear |
| b' Anna Mengr, Veronika Strnadov\\xc3\\xa1, \\xc5\\xa0t\\xc4\\x9bp\\xc3\\xa1n Strnad, Vladim\\xc3\\xadr Vrkoslav, Helena Pelantov\\xc3\\xa1, Marek Kuzma, Thomas Comptdaer, Blanka \\xc5\\xbdelezn\\xc3\\xa1, Jaroslav Kune\\xc5\\xa1, Marie-Christine Galas, Andrea Pa\\xc4\\x8desov\\xc3\\xa1, Lenka Malet\\xc3\\xadnsk\\xc3\\xa. Feeding High-Fat Diet Accelerates Development of Peripheral and Central Insulin Resistance and Inflammation and Worsens AD-like Pathology in APP/PS1 Mice. Nutrients. vol 15. issue 17. 2023-09-09. PMID:37686722.' |
alzheimer's disease (ad) is a progressive brain disorder characterized by extracellular amyloid-β (aβ) plaques, intracellular neurofibrillary tangles formed by hyperphosphorylated tau protein and neuroinflammation. |
2023-09-09 |
2023-10-07 |
mouse |
| Yi Che. Two-Photon Fluorescent Probes for Amyloid-β Plaques Imaging In Vivo. Molecules (Basel, Switzerland). vol 28. issue 17. 2023-09-09. PMID:37687013. |
amyloid-β (aβ) peptide deposition, hyperphosphorylated tau proteins, reactive astrocytes, high levels of metal ions, and upregulated monoamine oxidases are considered to be the primary pathological markers of alzheimer's disease (ad). |
2023-09-09 |
2023-10-07 |
Not clear |
| Jee Hyun Yi, Eunbi Cho, Soowon Lee, Kyoung Ja Kwon, Seungheon Lee, Juyong Lee, Changyeol Lee, Chan Young Shin, Dong Hyun Kim, Sang Hee Shi. Aβ dissociation by pectolinarin may counteract against Aβ-induced synaptic dysfunction and memory impairment. Biochemical pharmacology. 2023-09-09. PMID:37689271. |
alzheimer's disease (ad) is a degenerative brain disorder characterised by various neurological symptoms, including memory impairment and mood disorders, associated with the abnormal accumulation of amyloid b(aβ) and tau proteins in the brain. |
2023-09-09 |
2023-10-07 |
Not clear |
| Vinay Banka, Andrew Kelleher, Dag Sehlin, Greta Hultqvist, Einar M Sigurdsson, Stina Syvänen, Yu-Shin Din. Development of brain-penetrable antibody radioligands for Frontiers in nuclear medicine (Lausanne, Switzerland). vol 3. 2023-09-08. PMID:37680310. |
development of brain-penetrable antibody radioligands for alzheimer's disease (ad) is characterized by the misfolding and aggregation of two major proteins: amyloid-beta (aβ) and tau. |
2023-09-08 |
2023-10-07 |
Not clear |
| Atamjit Singh, Karanvir Singh, Jashandeep Kaur, Ramanpreet Kaur, Aman Sharma, Jasleen Kaur, Uttam Kaur, Renu Chadha, Preet Mohinder Singh Bed. Pathogenesis of Alzheimer's Disease and Diversity of 1,2,3-Triazole Scaffold in Drug Development: Design Strategies, Structural Insights, and Therapeutic Potential. ACS chemical neuroscience. 2023-09-08. PMID:37683129. |
the review will provide (a) precise insight of various established targets of alzheimer's disease including cholinergic, amyloid, tau, monoamine oxidases, glutamate, calcium, and reactive oxygen species hypothesis and (b) design hypothesis, structure-activity relationships, and pharmacological outcomes of 1,2,3-triazole containing multifunctional anti-alzheimer's agents. |
2023-09-08 |
2023-10-07 |
Not clear |
| Daniel C Shippy, Tyler K Ullan. Lipid metabolism transcriptomics of murine microglia in Alzheimer's disease and neuroinflammation. Scientific reports. vol 13. issue 1. 2023-09-08. PMID:37684405. |
alzheimer's disease (ad) is a neurodegenerative disorder characterized by the accumulation of amyloid-β (aβ) plaques followed by intracellular neurofibrillary tangles (nfts) composed of hyperphosphorylated tau. |
2023-09-08 |
2023-10-07 |
mouse |
| Sheng Chen, Anuradhika Puri, Braxton Bell, Joseph Fritsche, Hector Palacios, Maurie Balch, Macy Sprunger, Matthew Howard, Jessica Patterson, Gary Patti, Albert Davis, Meredith Jackre. HtrA1 prevents and reverses α-synuclein aggregation, rendering it non-toxic and seeding incompetent. Research square. 2023-09-07. PMID:37674720. |
htra1 is a pdz serine protease that degrades fibrillar tau, which is associated with alzheimer disease (ad). |
2023-09-07 |
2023-10-07 |
Not clear |
| Mihyun Lim Waugh, Lauren Wolf, James Turner, Lauren Phillips, Shannon Servoss, Melissa Mos. Modulating the RAGE-Induced Inflammatory Response: Peptoids as RAGE Antagonists. Chembiochem : a European journal of chemical biology. 2023-09-07. PMID:37679300. |
while the primary pathology of alzheimer's disease (ad) is defined by brain deposition of amyloid-β (aβ) plaques and tau neurofibrillary tangles, chronic inflammation has emerged as an important factor in ad etiology. upregulated cell surface expression of the receptor for advanced glycation end-products (rage), a key receptor of innate immune response, is reported in ad. in parallel, rage ligands, including aβ aggregates, hmgb1, and s100b, are elevated in ad brain. activation of rage by these ligands triggers release of inflammatory cytokines and upregulates cell surface rage. |
2023-09-07 |
2023-10-07 |
Not clear |
| Yongqi Huang, Jitao Wen, Lisa-Marie Ramirez, Eymen Gümüşdil, Pravin Pokhrel, Viet H Man, Haiqiong Ye, Yue Han, Yunfei Liu, Ping Li, Zhengding Su, Junmei Wang, Hanbin Mao, Markus Zweckstetter, Sarah Perrett, Si Wu, Meng Ga. Methylene blue accelerates liquid-to-gel transition of tau condensates impacting tau function and pathology. Nature communications. vol 14. issue 1. 2023-09-06. PMID:37673952. |
preventing tau aggregation is a potential therapeutic strategy in alzheimer's disease and other tauopathies. |
2023-09-06 |
2023-10-07 |
Not clear |
| Ali Mahzarnia, Michael W Lutz, Alexandra Bade. A Continuous Extension of Gene Set Enrichment Analysis using the Likelihood Ratio Test Statistics Identifies VEGF as a Candidate Pathway for Alzheimer's disease. bioRxiv : the preprint server for biology. 2023-09-04. PMID:37662249. |
alzheimer's disease involves brain pathologies such as amyloid plaque depositions and hyperphosphorylated tau tangles and is accompanied by cognitive decline. |
2023-09-04 |
2023-09-07 |
Not clear |
| Zhentao Yu, Zhuoyu Shi, Tingting Dan, Mustafa Dere, Minjeong Kim, Quefeng Li, Guorong W. Uncovering Diverse Mechanistic Spreading Pathways in Disease Progression of Alzheimer's Disease. Journal of Alzheimer's disease reports. vol 7. issue 1. 2023-09-04. PMID:37662609. |
the at[n] research framework focuses on three major biomarkers in alzheimer's disease (ad): amyloid-β deposition (a), pathologic tau (t), and neurodegeneration [n]. |
2023-09-04 |
2023-09-07 |
Not clear |
| Pablo Martínez-Cañada, Eduardo Perez-Valero, Jesus Minguillon, Francisco Pelayo, Miguel A López-Gordo, Christian Morilla. Combining aperiodic 1/f slopes and brain simulation: An EEG/MEG proxy marker of excitation/inhibition imbalance in Alzheimer's disease. Alzheimer's & dementia (Amsterdam, Netherlands). vol 15. issue 3. 2023-09-04. PMID:37662693. |
accumulation and interaction of amyloid-beta (aβ) and tau proteins during progression of alzheimer's disease (ad) are shown to tilt neuronal circuits away from balanced excitation/inhibition (e/i). |
2023-09-04 |
2023-09-07 |
human |
| Anny Ho, Bidii Ngala, Chiaki Yamada, Christopher Garcia, Carolina Duarte, Juliet Akkaoui, Dumitru Ciolac, Amilia Nusbaum, William Kochen, Daniela Efremova, Stanislav Groppa, Lubov Nathanson, Stephanie Bissel, Adrian Oblak, Melissa A Kacena, Alexandru Movil. IL-34 exacerbates pathogenic features of Alzheimer's disease and calvaria osteolysis in triple transgenic (3x-Tg) female mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 166. 2023-09-04. PMID:37666180. |
hallmark features of alzheimer's disease (ad) include elevated accumulation of aggregated aβ40 and aβ42 peptides, hyperphosphorylated tau (p-tau), and neuroinflammation. |
2023-09-04 |
2023-09-07 |
mouse |
| Jie Ding, Chushu Shen, Zhenguo Wang, Yongfeng Yang, Georges El Fakhri, Jie Lu, Dong Liang, Hairong Zheng, Yun Zhou, Tao Su. Tau-PET abnormality as a biomarker for Alzheimer's disease staging and early detection: a topological perspective. Cerebral cortex (New York, N.Y. : 1991). 2023-09-01. PMID:37653600. |
alzheimer's disease can be detected early through biomarkers such as tau positron emission tomography (pet) imaging, which shows abnormal protein accumulations in the brain. |
2023-09-01 |
2023-09-07 |
human |
| Xiaoyu Tang, Zhipeng Kan, Na Li, Jinbao Huang, Jinsong Zhang, Henry J Thompson, Feng Gao, Yong Shen, Liang Zhang, Zhongwen Xie, Xiaochun Wan, Yijun Wan. Mechanisms underlying large-leaf yellow tea mediated inhibition of cognitive impairment in the 5xFAD model of Alzheimer's disease. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 120. 2023-08-31. PMID:37651754. |
alzheimer's disease (ad) is the most common cause of dementia and is characterized by amyloid-β (aβ) peptides and hyperphosphorylated tau proteins. |
2023-08-31 |
2023-09-07 |
Not clear |
| Hasaeam Cho, Jimin Lee, Hanjoon Nho, Keunmin Lee, Bopil Gim, Juncheol Lee, Jaehee Lee, Kai K Ewert, Youli Li, Stuart C Feinstein, Cyrus R Safinya, Kyeong Sik Jin, Myung Chul Cho. Synchrotron X-ray study of intrinsically disordered and polyampholytic Tau 4RS and 4RL under controlled ionic strength. The European physical journal. E, Soft matter. vol 46. issue 9. 2023-08-31. PMID:37653246. |
aggregated and hyperphosphorylated tau is one of the pathological hallmarks of alzheimer's disease. |
2023-08-31 |
2023-09-07 |
Not clear |