All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Kiwamu Watanabe, Kengo Uemura, Megumi Asada, Masato Maesako, Haruhiko Akiyama, Shun Shimohama, Ryosuke Takahashi, Ayae Kinoshit. The participation of insulin-like growth factor-binding protein 3 released by astrocytes in the pathology of Alzheimer's disease. Molecular brain. vol 8. issue 1. 2016-07-06. PMID:26637371. alzheimer's disease (ad) is characterized by senile plaques, extracellular deposits composed primarily of amyloid-beta (aβ), and neurofibrillary tangles, which are abnormal intracellular inclusions containing hyperphosphorylated tau. 2016-07-06 2023-08-13 Not clear
Iacopo Gesmundo, Tania Villanova, Eleonora Gargantini, Emanuela Arvat, Ezio Ghigo, Riccarda Granat. The Mineralocorticoid Agonist Fludrocortisone Promotes Survival and Proliferation of Adult Hippocampal Progenitors. Frontiers in endocrinology. vol 7. 2016-07-06. PMID:27379018. finally, fludro blocked aβ1-42-induced hyperphosphorylation of tau protein, which is a main feature of alzheimer's disease. 2016-07-06 2023-08-13 rat
Song-In Kim, Hee Jae Lee, Sung-Soo Kim, Yong-Soo Kwon, Wanjoo Chu. Sequestration of sorcin by aberrant forms of tau results in the defective calcium homeostasis. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 20. issue 4. 2016-07-06. PMID:27382355. neurofi brillary tangles (nfts) of microtubule-associated protein tau are a pathological hallmark of alzheimer's disease (ad). 2016-07-06 2023-08-13 Not clear
Barbara Plagg, Daniela Ehrlich, Kathrin M Kniewallner, Josef Marksteiner, Christian Humpe. Increased Acetylation of Histone H4 at Lysine 12 (H4K12) in Monocytes of Transgenic Alzheimer's Mice and in Human Patients. Current Alzheimer research. vol 12. issue 8. 2016-07-01. PMID:26159193. alzheimer's disease (ad) is a neurodegenerative disorder characterized by amyloid-β (aβ) plaque formation, tau pathology, neurodegeneration and inflammatory processes. 2016-07-01 2023-08-13 mouse
William I Zhang, Gregory Antonios, Alberto Rabano, Thomas A Bayer, Anja Schneider, Silvio O Rizzol. Super-Resolution Microscopy of Cerebrospinal Fluid Biomarkers as a Tool for Alzheimer's Disease Diagnostics. Journal of Alzheimer's disease : JAD. vol 46. issue 4. 2016-06-30. PMID:25881910. alzheimer's disease (ad) is neuropathologically characterized by aggregates of amyloid-β peptides (aβ) and tau proteins. 2016-06-30 2023-08-13 Not clear
Tapan K Khan, Daniel L Alko. Alzheimer's Disease Cerebrospinal Fluid and Neuroimaging Biomarkers: Diagnostic Accuracy and Relationship to Drug Efficacy. Journal of Alzheimer's disease : JAD. vol 46. issue 4. 2016-06-30. PMID:26402622. widely researched alzheimer's disease (ad) biomarkers include in vivo brain imaging with pet and mri, imaging of amyloid plaques, and biochemical assays of aβ 1 - 42, total tau, and phosphorylated tau (p-tau-181) in cerebrospinal fluid (csf). 2016-06-30 2023-08-13 Not clear
Eduardo Rigon Zimmer, Antoine Leuzy, Serge Gauthier, Pedro Rosa-Net. Developments in Tau PET Imaging. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. vol 41. issue 5. 2016-06-29. PMID:25424608. abstract the presence of neurofibrillary tangles in the brain is a hallmark feature of several neurodegenerative diseases termed "tauopathies," including alzheimer's disease (ad) and the tau molecular subgroup of frontotemporal lobar degeneration (ftld-tau). 2016-06-29 2023-08-13 Not clear
Thomas Arendt, Martina K Brückner, Andreas Lösch. Regional mosaic genomic heterogeneity in the elderly and in Alzheimer's disease as a correlate of neuronal vulnerability. Acta neuropathologica. vol 130. issue 4. 2016-06-28. PMID:26298468. alzheimer's disease (ad) is a neurodegenerative disorder characterized by fibrillary aggregates of aβ peptide and tau protein. 2016-06-28 2023-08-13 human
Mark A Colijn, George T Grossber. Amyloid and Tau Biomarkers in Subjective Cognitive Impairment. Journal of Alzheimer's disease : JAD. vol 47. issue 1. 2016-06-28. PMID:26402749. not surprisingly, we found that amyloid and tau biomarker profiles become increasingly abnormal from sci, to mci, to alzheimer's disease. 2016-06-28 2023-08-13 Not clear
Behrooz Moosavi, Bibimaryam Mousavi, Ian G Macreadi. Yeast Model of Amyloid-β and Tau Aggregation in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 47. issue 1. 2016-06-28. PMID:26402750. yeast model of amyloid-β and tau aggregation in alzheimer's disease. 2016-06-28 2023-08-13 Not clear
Behrooz Moosavi, Bibimaryam Mousavi, Ian G Macreadi. Yeast Model of Amyloid-β and Tau Aggregation in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 47. issue 1. 2016-06-28. PMID:26402750. the amyloid-β peptide (aβ) and the phosphorylated protein tau have been widely implicated in alzheimer's disease and are the focus of most research. 2016-06-28 2023-08-13 Not clear
Behrooz Moosavi, Bibimaryam Mousavi, Ian G Macreadi. Yeast Model of Amyloid-β and Tau Aggregation in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 47. issue 1. 2016-06-28. PMID:26402750. the use of yeast enables powerful new approaches to understanding how to overcome the effects of aβ and tau, and such advances could lead to new therapies to prevent the progression of alzheimer's disease. 2016-06-28 2023-08-13 Not clear
Craig S Atwood, Richard L Bowe. A Unified Hypothesis of Early- and Late-Onset Alzheimer's Disease Pathogenesis. Journal of Alzheimer's disease : JAD. vol 47. issue 1. 2016-06-28. PMID:26402752. early-onset familial alzheimer's disease (eofad) and late-onset sporadic ad (losad) both follow a similar pathological and biochemical course that includes: neuron and synapse loss and dysfunction, microvascular damage, microgliosis, extracellular amyloid-β deposition, tau phosphorylation, formation of intracellular neurofibrillary tangles, endoreduplication and related cell cycle events in affected brain regions. 2016-06-28 2023-08-13 Not clear
Qianqian Wang, Jianping Jia, Wei Qin, Liyong Wu, Dan Li, Qi Wang, Hanzhi L. A Novel AβPP M722K Mutation Affects Amyloid-β Secretion and Tau Phosphorylation and May Cause Early-Onset Familial Alzheimer's Disease in Chinese Individuals. Journal of Alzheimer's disease : JAD. vol 47. issue 1. 2016-06-28. PMID:26402764. a novel aβpp m722k mutation affects amyloid-β secretion and tau phosphorylation and may cause early-onset familial alzheimer's disease in chinese individuals. 2016-06-28 2023-08-13 Not clear
An Verheyen, Annick Diels, Joyce Dijkmans, Tutu Oyelami, Giulia Meneghello, Liesbeth Mertens, Sofie Versweyveld, Marianne Borgers, Arjan Buist, Pieter Peeters, Miroslav Ci. Using Human iPSC-Derived Neurons to Model TAU Aggregation. PloS one. vol 10. issue 12. 2016-06-28. PMID:26720731. alzheimer's disease and frontotemporal dementia are amongst the most common forms of dementia characterized by the formation and deposition of abnormal tau in the brain. 2016-06-28 2023-08-13 human
Huanliang Liu, Xiaoxia Jin, Xiaomin Yin, Nana Jin, Fei Liu, Wei Qia. PKA-CREB Signaling Suppresses Tau Transcription. Journal of Alzheimer's disease : JAD. vol 46. issue 1. 2016-06-27. PMID:25720403. accumulated and abnormally hyperphosphorylated tau aggregates into neurofibrillary tangles in the brains of patients with alzheimer's disease (ad). 2016-06-27 2023-08-13 human
Sanna-Kaisa Herukka, Jaana Rummukainen, Jouni Ihalainen, Mikael von Und Zu Fraunberg, Anne M Koivisto, Ossi Nerg, Lakshman K Puli, Toni T Seppälä, Henrik Zetterberg, Okko T Pyykkö, Seppo Helisalmi, Heikki Tanila, Irina Alafuzoff, Mikko Hiltunen, Jaakko Rinne, Hilkka Soininen, Juha E Jääskeläinen, Ville Leinone. Amyloid-β and Tau Dynamics in Human Brain Interstitial Fluid in Patients with Suspected Normal Pressure Hydrocephalus. Journal of Alzheimer's disease : JAD. vol 46. issue 1. 2016-06-27. PMID:25720406. amyloid-β (aβ1 - 42), total tau (t-tau), and phosphorylated tau (p-tau181) in the cerebrospinal fluid (csf) are the most promising biomarkers of alzheimer's disease (ad). 2016-06-27 2023-08-13 mouse
Francesco Panza, Davide Seripa, Vincenzo Solfrizzi, Bruno P Imbimbo, Andrea Santamato, Madia Lozupone, Rosa Capozzo, Camilla Prete, Alberto Pilotto, Antonio Greco, Giancarlo Logroscin. Tau aggregation inhibitors: the future of Alzheimer's pharmacotherapy? Expert opinion on pharmacotherapy. vol 17. issue 4. 2016-06-27. PMID:26809554. tau aggregation inhibitors: the future of alzheimer's pharmacotherapy? 2016-06-27 2023-08-13 Not clear
Anthony Fourier, Erik Portelius, Henrik Zetterberg, Kaj Blennow, Isabelle Quadrio, Armand Perret-Liaude. Pre-analytical and analytical factors influencing Alzheimer's disease cerebrospinal fluid biomarker variability. Clinica chimica acta; international journal of clinical chemistry. vol 449. 2016-06-22. PMID:26141614. a panel of cerebrospinal fluid (csf) biomarkers including total tau (t-tau), phosphorylated tau protein at residue 181 (p-tau) and β-amyloid peptides (aβ42 and aβ40), is frequently used as an aid in alzheimer's disease (ad) diagnosis for young patients with cognitive impairment, for predicting prodromal ad in mild cognitive impairment (mci) subjects, for ad discrimination in atypical clinical phenotypes and for inclusion/exclusion and stratification of patients in clinical trials. 2016-06-22 2023-08-13 human
Nicholas M Kanaan, Kristine Cox, Victor E Alvarez, Thor D Stein, Sharra Poncil, Ann C McKe. Characterization of Early Pathological Tau Conformations and Phosphorylation in Chronic Traumatic Encephalopathy. Journal of neuropathology and experimental neurology. vol 75. issue 1. 2016-06-22. PMID:26671985. additionally, phosphorylation at serine 422 in tau occurs early and correlates with cognitive decline in patients with alzheimer disease (ad). 2016-06-22 2023-08-13 Not clear