| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elisa Isopi, Alberto Granzotto, Carlo Corona, Manuela Bomba, Domenico Ciavardelli, Michele Curcio, Lorella M T Canzoniero, Riccardo Navarra, Rossano Lattanzio, Mauro Piantelli, Stefano L Sens. Pyruvate prevents the development of age-dependent cognitive deficits in a mouse model of Alzheimer's disease without reducing amyloid and tau pathology. Neurobiology of disease. vol 81. 2016-08-22. PMID:25434488. |
pyruvate prevents the development of age-dependent cognitive deficits in a mouse model of alzheimer's disease without reducing amyloid and tau pathology. |
2016-08-22 |
2023-08-13 |
mouse |
| Peng Lei, Scott Ayton, Ambili Thoppuvalappil Appukuttan, Irene Volitakis, Paul A Adlard, David I Finkelstein, Ashley I Bus. Clioquinol rescues Parkinsonism and dementia phenotypes of the tau knockout mouse. Neurobiology of disease. vol 81. 2016-08-22. PMID:25796563. |
iron accumulation and tau protein deposition are pathological features of alzheimer's (ad) and parkinson's diseases (pd). |
2016-08-22 |
2023-08-13 |
mouse |
| Wei Jiang, Tao Luo, Sheng Li, Yue Zhou, Xiu-Yin Shen, Feng He, Jie Xu, Hua-Qiao Wan. Quercetin Protects against Okadaic Acid-Induced Injury via MAPK and PI3K/Akt/GSK3β Signaling Pathways in HT22 Hippocampal Neurons. PloS one. vol 11. issue 4. 2016-08-22. PMID:27050422. |
increasing evidence shows that oxidative stress and the hyperphosphorylation of tau protein play essential roles in the progression of alzheimer's disease (ad). |
2016-08-22 |
2023-08-13 |
mouse |
| Michael J Yetman, Stephanie W Fowler, Joanna L Jankowsk. Humanized Tau Mice with Regionalized Amyloid Exhibit Behavioral Deficits but No Pathological Interaction. PloS one. vol 11. issue 4. 2016-08-22. PMID:27070146. |
alzheimer's disease (ad) researchers have struggled for decades to draw a causal link between extracellular aβ aggregation and intraneuronal accumulation of microtubule-associated protein tau. |
2016-08-22 |
2023-08-13 |
mouse |
| Erik S Musiek, David D Xiong, Tirth Patel, Yo Sasaki, Yinong Wang, Adam Q Bauer, Risham Singh, Samantha L Finn, Joseph P Culver, Jeffrey Milbrandt, David M Holtzma. Nmnat1 protects neuronal function without altering phospho-tau pathology in a mouse model of tauopathy. Annals of clinical and translational neurology. vol 3. issue 6. 2016-08-22. PMID:27547771. |
hyperphosphorylation and aggregation of the microtubule-associated protein tau are associated with neurodegeneration in alzheimer's disease and other disorders. |
2016-08-22 |
2023-08-13 |
mouse |
| Janet van Eersel, Claire H Stevens, Magdalena Przybyla, Amadeus Gladbach, Kristie Stefanoska, Chesed Kai-Xin Chan, Wei-Yi Ong, John R Hodges, Greg T Sutherland, Jillian J Kril, Dorothee Abramowski, Matthias Staufenbiel, Glenda M Halliday, Lars M Ittne. Early-onset axonal pathology in a novel P301S-Tau transgenic mouse model of frontotemporal lobar degeneration. Neuropathology and applied neurobiology. vol 41. issue 7. 2016-08-18. PMID:25763777. |
tau becomes hyperphosphorylated in alzheimer's disease (ad) and frontotemporal lobar degeneration (ftld-tau), resulting in functional deficits of neurones, neurofibrillary tangle (nft) formation and eventually dementia. |
2016-08-18 |
2023-08-13 |
mouse |
| Elizabeth E Spangenberg, Rafael J Lee, Allison R Najafi, Rachel A Rice, Monica R P Elmore, Mathew Blurton-Jones, Brian L West, Kim N Gree. Eliminating microglia in Alzheimer's mice prevents neuronal loss without modulating amyloid-β pathology. Brain : a journal of neurology. vol 139. issue Pt 4. 2016-08-18. PMID:26921617. |
in addition to amyloid-β plaque and tau neurofibrillary tangle deposition, neuroinflammation is considered a key feature of alzheimer's disease pathology. |
2016-08-18 |
2023-08-13 |
mouse |
| Magdalena Gąssowska, Irena Baranowska-Bosiacka, Joanna Moczydłowska, Maciej Tarnowski, Anna Pilutin, Izabela Gutowska, Lidia Strużyńska, Dariusz Chlubek, Agata Adamczy. Perinatal exposure to lead (Pb) promotes Tau phosphorylation in the rat brain in a GSK-3β and CDK5 dependent manner: Relevance to neurological disorders. Toxicology. vol 347-349. 2016-08-18. PMID:27012722. |
hyperphosphorylation of tau is involved in the pathomechanism of neurological disorders such as alzheimer's, parkinson's diseases as well as autism. |
2016-08-18 |
2023-08-13 |
rat |
| Qian Zhang, Huimin Zhao, Wei Liu, Zhou Zhang, Hui Qin, Fang Luo, Song Len. Developmental perfluorooctane sulfonate exposure results in tau hyperphosphorylation and β-amyloid aggregation in adults rats: Incidence for link to Alzheimer's disease. Toxicology. vol 347-349. 2016-08-18. PMID:27018931. |
developmental perfluorooctane sulfonate exposure results in tau hyperphosphorylation and β-amyloid aggregation in adults rats: incidence for link to alzheimer's disease. |
2016-08-18 |
2023-08-13 |
rat |
| Qian Zhang, Huimin Zhao, Wei Liu, Zhou Zhang, Hui Qin, Fang Luo, Song Len. Developmental perfluorooctane sulfonate exposure results in tau hyperphosphorylation and β-amyloid aggregation in adults rats: Incidence for link to Alzheimer's disease. Toxicology. vol 347-349. 2016-08-18. PMID:27018931. |
two pathological hallmarks of alzheimer's disease (ad), tau hyperphosphorylation and β-amyloid (aβ) aggregation, were examined. |
2016-08-18 |
2023-08-13 |
rat |
| Tetsuro Tago, Shozo Furumoto, Nobuyuki Okamura, Ryuichi Harada, Hajime Adachi, Yoichi Ishikawa, Kazuhiko Yanai, Ren Iwata, Yukitsuka Kud. Structure-Activity Relationship of 2-Arylquinolines as PET Imaging Tracers for Tau Pathology in Alzheimer Disease. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 57. issue 4. 2016-08-16. PMID:26697966. |
structure-activity relationship of 2-arylquinolines as pet imaging tracers for tau pathology in alzheimer disease. |
2016-08-16 |
2023-08-13 |
Not clear |
| Tetsuro Tago, Shozo Furumoto, Nobuyuki Okamura, Ryuichi Harada, Hajime Adachi, Yoichi Ishikawa, Kazuhiko Yanai, Ren Iwata, Yukitsuka Kud. Structure-Activity Relationship of 2-Arylquinolines as PET Imaging Tracers for Tau Pathology in Alzheimer Disease. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 57. issue 4. 2016-08-16. PMID:26697966. |
abnormal deposition of amyloid-β and hyperphosphorylated tau protein in the brain are the pathologic hallmark of alzheimer disease (ad). |
2016-08-16 |
2023-08-13 |
Not clear |
| My Jonasson, Anders Wall, Konstantinos Chiotis, Laure Saint-Aubert, Helena Wilking, Margareta Sprycha, Beatrice Borg, Alf Thibblin, Jonas Eriksson, Jens Sörensen, Gunnar Antoni, Agneta Nordberg, Mark Lubberin. Tracer Kinetic Analysis of (S)-¹⁸F-THK5117 as a PET Tracer for Assessing Tau Pathology. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 57. issue 4. 2016-08-16. PMID:26795290. |
because a correlation between tau pathology and the clinical symptoms of alzheimer disease (ad) has been hypothesized, there is increasing interest in developing pet tracers that bind specifically to tau protein. |
2016-08-16 |
2023-08-13 |
Not clear |
| Jane Kovalevich, Anne-Sophie Cornec, Yuemang Yao, Michael James, Alexander Crowe, Virginia M-Y Lee, John Q Trojanowski, Amos B Smith, Carlo Ballatore, Kurt R Brunde. Characterization of Brain-Penetrant Pyrimidine-Containing Molecules with Differential Microtubule-Stabilizing Activities Developed as Potential Therapeutic Agents for Alzheimer's Disease and Related Tauopathies. The Journal of pharmacology and experimental therapeutics. vol 357. issue 2. 2016-08-16. PMID:26980057. |
the microtubule (mt)-stabilizing protein tau disengages from mts and forms intracellular inclusions known as neurofibrillary tangles in alzheimer's disease and related tauopathies. |
2016-08-16 |
2023-08-13 |
mouse |
| Gabor G Kovacs, Monika Cs Horvath, Katalin Majtenyi, Mirjam I Lutz, Yasmin L Hurd, Eva Kelle. Heroin abuse exaggerates age-related deposition of hyperphosphorylated tau and p62-positive inclusions. Neurobiology of aging. vol 36. issue 11. 2016-08-15. PMID:26254956. |
the observation of increased hyperphosphorylated tau levels correlating with microglial activation in opiate abusers has been interpreted as predisposition to accelerated alzheimer disease-related changes. |
2016-08-15 |
2023-08-13 |
Not clear |
| Gabor G Kovacs, Monika Cs Horvath, Katalin Majtenyi, Mirjam I Lutz, Yasmin L Hurd, Eva Kelle. Heroin abuse exaggerates age-related deposition of hyperphosphorylated tau and p62-positive inclusions. Neurobiology of aging. vol 36. issue 11. 2016-08-15. PMID:26254956. |
we confirm previous findings that heroin addiction associates with tau hyperphosphorylation in predilection brain areas for aging and alzheimer disease. |
2016-08-15 |
2023-08-13 |
Not clear |
| C R Overk, E Rockenstein, J Florio, Q Cheng, E Maslia. Differential calcium alterations in animal models of neurodegenerative disease: Reversal by FK506. Neuroscience. vol 310. 2016-08-15. PMID:26341908. |
abnormal accumulation of amyloid β (aβ), α-synuclein (α-syn), and microtubule-associated protein tau (tau) have been implicated in neurodegenerative diseases including alzheimer's disease (ad), parkinson's disease (pd), and pick's disease (pid). |
2016-08-15 |
2023-08-13 |
mouse |
| Teng Jiang, Lan Tan, Xi-Chen Zhu, Jun-Shan Zhou, Lei Cao, Meng-Shan Tan, Hui-Fu Wang, Qi Chen, Ying-Dong Zhang, Jin-Tai Y. Silencing of TREM2 exacerbates tau pathology, neurodegenerative changes, and spatial learning deficits in P301S tau transgenic mice. Neurobiology of aging. vol 36. issue 12. 2016-08-15. PMID:26364736. |
tau pathology is a pathological hallmark for several neurodegenerative diseases including alzheimer's disease and frontotemporal dementia. |
2016-08-15 |
2023-08-13 |
mouse |
| Teng Jiang, Lan Tan, Xi-Chen Zhu, Jun-Shan Zhou, Lei Cao, Meng-Shan Tan, Hui-Fu Wang, Qi Chen, Ying-Dong Zhang, Jin-Tai Y. Silencing of TREM2 exacerbates tau pathology, neurodegenerative changes, and spatial learning deficits in P301S tau transgenic mice. Neurobiology of aging. vol 36. issue 12. 2016-08-15. PMID:26364736. |
recently, a correlation between trem2 expression and hyperphosphorylated tau has been revealed in the brain of alzheimer's disease patients, suggesting a potential association between trem2 and tau pathology. |
2016-08-15 |
2023-08-13 |
mouse |
| Bernadeta Michalski, Maria M Corrada, Claudia H Kawas, Margaret Fahnestoc. Brain-derived neurotrophic factor and TrkB expression in the "oldest-old," the 90+ Study: correlation with cognitive status and levels of soluble amyloid-beta. Neurobiology of aging. vol 36. issue 12. 2016-08-15. PMID:26410307. |
decreased brain-derived neurotrophic factor (bdnf) contributes to memory loss in alzheimer's disease (ad), and soluble assemblies of amyloid-beta (aβ) and tau contribute to neurodegeneration. |
2016-08-15 |
2023-08-13 |
human |