| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rita Marreiros, Andreas Müller-Schiffmann, Verian Bader, Suganya Selvarajah, Debendranath Dey, Vishwanath R Lingappa, Carsten Kort. Viral capsid assembly as a model for protein aggregation diseases: Active processes catalyzed by cellular assembly machines comprising novel drug targets. Virus research. vol 207. 2016-05-02. PMID:25451064. |
examples for substrates are amyloid β peptide (aβ) and tau in alzheimer's disease, α-synuclein in parkinson's disease, prions in the prion diseases, disrupted-in-schizophrenia 1 (disc1) in subsets of chronic mental illnesses, and others. |
2016-05-02 |
2023-08-13 |
Not clear |
| Ahmed Abdall. Tau protein as a target for Alzheimer's disease management. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society. vol 23. issue 4. 2016-05-02. PMID:27134542. |
tau protein as a target for alzheimer's disease management. |
2016-05-02 |
2023-08-13 |
Not clear |
| Alberto Rábano, Raquel Cuadros, Paula Merino-Serráis, Izaskun Rodal, Ruth Benavides-Piccione, Elena Gómez, Miguel Medina, Javier DeFelipe, Jesús Avil. Protocols for Monitoring the Development of Tau Pathology in Alzheimer's Disease. Methods in molecular biology (Clifton, N.J.). vol 1303. 2016-04-29. PMID:26235064. |
protocols for monitoring the development of tau pathology in alzheimer's disease. |
2016-04-29 |
2023-08-13 |
Not clear |
| Alberto Rábano, Raquel Cuadros, Paula Merino-Serráis, Izaskun Rodal, Ruth Benavides-Piccione, Elena Gómez, Miguel Medina, Javier DeFelipe, Jesús Avil. Protocols for Monitoring the Development of Tau Pathology in Alzheimer's Disease. Methods in molecular biology (Clifton, N.J.). vol 1303. 2016-04-29. PMID:26235064. |
the microtubule-associated protein tau plays a critical role in the pathogenesis of alzheimer's disease (ad) and several related disorders collectively known as tauopathies. |
2016-04-29 |
2023-08-13 |
Not clear |
| Alberto Rábano, Raquel Cuadros, Paula Merino-Serráis, Izaskun Rodal, Ruth Benavides-Piccione, Elena Gómez, Miguel Medina, Javier DeFelipe, Jesús Avil. Protocols for Monitoring the Development of Tau Pathology in Alzheimer's Disease. Methods in molecular biology (Clifton, N.J.). vol 1303. 2016-04-29. PMID:26235064. |
in the brains of ad patients, tau pathology spreads following a predictable, anatomically defined progression pattern that can be followed by immunohistochemistry looking at brain post-mortem samples from alzheimer patients at different stages of the disease. |
2016-04-29 |
2023-08-13 |
Not clear |
| Alberto Rábano, Raquel Cuadros, Paula Merino-Serráis, Izaskun Rodal, Ruth Benavides-Piccione, Elena Gómez, Miguel Medina, Javier DeFelipe, Jesús Avil. Protocols for Monitoring the Development of Tau Pathology in Alzheimer's Disease. Methods in molecular biology (Clifton, N.J.). vol 1303. 2016-04-29. PMID:26235064. |
here, we describe these three complementary protocols to follow the development of tau pathology in alzheimer's disease. |
2016-04-29 |
2023-08-13 |
Not clear |
| Amandine Grimm, Karen Schmitt, Anne Ecker. Advanced Mitochondrial Respiration Assay for Evaluation of Mitochondrial Dysfunction in Alzheimer's Disease. Methods in molecular biology (Clifton, N.J.). vol 1303. 2016-04-29. PMID:26235066. |
alzheimer's disease (ad) is characterized by the presence of amyloid plaques (aggregates of amyloid-β [aβ]) and neurofibrillary tangles (aggregates of tau) in the brain, but the underlying mechanisms of the disease are still partially unclear. |
2016-04-29 |
2023-08-13 |
mouse |
| Nathalie G Saurat, Frederick J Livesey, Steven Moor. Cortical Differentiation of Human Pluripotent Cells for In Vitro Modeling of Alzheimer's Disease. Methods in molecular biology (Clifton, N.J.). vol 1303. 2016-04-29. PMID:26235073. |
we also describe biochemical and imaging based methods to analyse key app and tau phenotypes in neurons generated from pluripotent stem cells from individuals with either monogenic familial alzheimer's disease or down's syndrome. |
2016-04-29 |
2023-08-13 |
human |
| Wera Roth, David Hecker, Eugenio Fav. Systems Biology Approaches to the Study of Biological Networks Underlying Alzheimer's Disease: Role of miRNAs. Methods in molecular biology (Clifton, N.J.). vol 1303. 2016-04-29. PMID:26235078. |
along these lines, recent data pinpoint distinct mirnas and mirna networks being linked to app splicing, processing and aβ pathology (lukiw et al., front genet 3:327, 2013), and furthermore, to the regulation of tau and its cellular subnetworks (lau et al., embo mol med 5:1613, 2013), altogether underlying the onset and propagation of alzheimer's disease. |
2016-04-29 |
2023-08-13 |
human |
| Adriele Silva Alves de Oliveira, Fernando Enrique Santiago, Laiz Furlan Balioni, Merari de Fatima Ramires Ferrari, Maria Camila Almeida, Daniel Carneiro Carrettier. BAG2 expression dictates a functional intracellular switch between the p38-dependent effects of nicotine on tau phosphorylation levels via the α7 nicotinic receptor. Experimental neurology. vol 275 Pt 1. 2016-04-29. PMID:26496817. |
the histopathological hallmarks present in alzheimer's disease (ad) brain are plaques of aβ peptide, neurofibrillary tangles of hyperphosphorylated tau protein, and a reduction in nicotinic acetylcholine receptor (nachr) levels. |
2016-04-29 |
2023-08-13 |
rat |
| Malte Butzlaff, Shabab B Hannan, Peter Karsten, Sarah Lenz, Josephine Ng, Hannes Voßfeldt, Katja Prüßing, Ralf Pflanz, Jörg B Schulz, Tobias Rasse, Aaron Voig. Impaired retrograde transport by the Dynein/Dynactin complex contributes to Tau-induced toxicity. Human molecular genetics. vol 24. issue 13. 2016-04-28. PMID:25794683. |
these filamentous tau inclusions are present in a group of neurodegenerative diseases known as tauopathies, including alzheimer's disease (ad). |
2016-04-28 |
2023-08-13 |
human |
| Sarah N Fontaine, Mackenzie D Martin, Elias Akoury, Victoria A Assimon, Sergiy Borysov, Bryce A Nordhues, Jonathan J Sabbagh, Matt Cockman, Jason E Gestwicki, Markus Zweckstetter, Chad A Dicke. The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics. Human molecular genetics. vol 24. issue 14. 2016-04-28. PMID:25882706. |
the pathological accumulation of abnormally hyperphosphorylated and aggregated tau, a neuronal microtubule (mt)-associated protein that functions to maintain mt stability, is implicated in a number of hereditary and sporadic neurodegenerative diseases including frontotemporal dementia and alzheimer's disease. |
2016-04-28 |
2023-08-13 |
human |
| Yann Fichou, Giorgio Schirò, François-Xavier Gallat, Cedric Laguri, Martine Moulin, Jérôme Combet, Michaela Zamponi, Michael Härtlein, Catherine Picart, Estelle Mossou, Hugues Lortat-Jacob, Jacques-Philippe Colletier, Douglas J Tobias, Martin Wei. Hydration water mobility is enhanced around tau amyloid fibers. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 20. 2016-04-28. PMID:25918405. |
the paired helical filaments (phf) formed by the intrinsically disordered human protein tau are one of the pathological hallmarks of alzheimer disease. |
2016-04-28 |
2023-08-13 |
human |
| Yann Fichou, Giorgio Schirò, François-Xavier Gallat, Cedric Laguri, Martine Moulin, Jérôme Combet, Michaela Zamponi, Michael Härtlein, Catherine Picart, Estelle Mossou, Hugues Lortat-Jacob, Jacques-Philippe Colletier, Douglas J Tobias, Martin Wei. Hydration water mobility is enhanced around tau amyloid fibers. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 20. 2016-04-28. PMID:25918405. |
detection of the enhanced hydration water mobility around tau fibers is conjectured to potentially contribute to the early diagnosis of alzheimer patients by diffusion mri. |
2016-04-28 |
2023-08-13 |
human |
| Khalid Iqbal, Fei Liu, Cheng-Xin Gon. Tau and neurodegenerative disease: the story so far. Nature reviews. Neurology. vol 12. issue 1. 2016-04-28. PMID:26635213. |
in the previous year, a paired helical filament (phf) protein had been identified in neurofibrillary tangles in the brains of individuals with alzheimer disease (ad), but it was not until 1986 that the phf protein and tau were discovered to be one and the same. |
2016-04-28 |
2023-08-13 |
Not clear |
| Joannee Zumkehr, Carlos J Rodriguez-Ortiz, David Cheng, Zanett Kieu, Thin Wai, Charlesice Hawkins, Jason Kilian, Siok Lam Lim, Rodrigo Medeiros, Masashi Kitazaw. Ceftriaxone ameliorates tau pathology and cognitive decline via restoration of glial glutamate transporter in a mouse model of Alzheimer's disease. Neurobiology of aging. vol 36. issue 7. 2016-04-26. PMID:25964214. |
ceftriaxone ameliorates tau pathology and cognitive decline via restoration of glial glutamate transporter in a mouse model of alzheimer's disease. |
2016-04-26 |
2023-08-13 |
mouse |
| Dave J Koss, Lianne Robinson, Anna Mietelska-Porowska, Anna Gasiorowska, Kristina Sepčić, Tom Turk, Marcel Jaspars, Grazyna Niewiadomska, Roderick H Scott, Bettina Platt, Gernot Riede. Polymeric alkylpyridinium salts permit intracellular delivery of human Tau in rat hippocampal neurons: requirement of Tau phosphorylation for functional deficits. Cellular and molecular life sciences : CMLS. vol 72. issue 23. 2016-04-25. PMID:26070304. |
patients suffering from tauopathies including frontotemporal dementia (ftd) and alzheimer's disease (ad) present with intra-neuronal aggregation of microtubule-associated protein tau. |
2016-04-25 |
2023-08-13 |
mouse |
| Jeanna M Wheeler, Pamela J McMillan, Michele Hawk, Michiyo Iba, Linda Robinson, George J Xu, Beth A Dombroski, Doori Jeong, Marc A Dichter, Halvor Juul, Elaine Loomis, Murray Raskind, James B Leverenz, John Q Trojanowski, Virginia M Y Lee, Gerard D Schellenberg, Brian C Kraeme. High copy wildtype human 1N4R tau expression promotes early pathological tauopathy accompanied by cognitive deficits without progressive neurofibrillary degeneration. Acta neuropathologica communications. vol 3. 2016-04-21. PMID:26041339. |
accumulation of insoluble conformationally altered hyperphosphorylated tau occurs as part of the pathogenic process in alzheimer's disease (ad) and other tauopathies. |
2016-04-21 |
2023-08-13 |
human |
| Laetitia Lemoine, Laure Saint-Aubert, Amelia Marutle, Gunnar Antoni, Jonas P Eriksson, Bernardino Ghetti, Nobuyuki Okamura, Inger Nennesmo, Per-Göran Gillberg, Agneta Nordber. Visualization of regional tau deposits using (3)H-THK5117 in Alzheimer brain tissue. Acta neuropathologica communications. vol 3. 2016-04-21. PMID:26134112. |
visualization of regional tau deposits using (3)h-thk5117 in alzheimer brain tissue. |
2016-04-21 |
2023-08-13 |
Not clear |
| Laetitia Lemoine, Laure Saint-Aubert, Amelia Marutle, Gunnar Antoni, Jonas P Eriksson, Bernardino Ghetti, Nobuyuki Okamura, Inger Nennesmo, Per-Göran Gillberg, Agneta Nordber. Visualization of regional tau deposits using (3)H-THK5117 in Alzheimer brain tissue. Acta neuropathologica communications. vol 3. 2016-04-21. PMID:26134112. |
the accumulation of neurofibrillary tangles, composed of aggregated hyperphosphorylated tau protein, starts spreading early in specific regions in the course of alzheimer's disease (ad), correlating with the progression of memory dysfunction. |
2016-04-21 |
2023-08-13 |
Not clear |