All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
A Miyashita, H Hatsuta, M Kikuchi, A Nakaya, Y Saito, T Tsukie, N Hara, S Ogishima, N Kitamura, K Akazawa, A Kakita, H Takahashi, S Murayama, Y Ihara, T Ikeuchi, R Kuwan. Genes associated with the progression of neurofibrillary tangles in Alzheimer's disease. Translational psychiatry. vol 4. 2016-01-15. PMID:26126179. the spreading of neurofibrillary tangles (nfts), intraneuronal aggregates of highly phosphorylated microtubule-associated protein tau, across the human brain is correlated with the cognitive severity of alzheimer's disease (ad). 2016-01-15 2023-08-13 human
Keerthanaa Balasubramanian Shanthi, Sreeram Krishnan, P Ran. A systematic review and meta-analysis of plasma amyloid 1-42 and tau as biomarkers for Alzheimer's disease. SAGE open medicine. vol 3. 2016-01-15. PMID:26770797. a systematic review and meta-analysis of plasma amyloid 1-42 and tau as biomarkers for alzheimer's disease. 2016-01-15 2023-08-13 Not clear
Keerthanaa Balasubramanian Shanthi, Sreeram Krishnan, P Ran. A systematic review and meta-analysis of plasma amyloid 1-42 and tau as biomarkers for Alzheimer's disease. SAGE open medicine. vol 3. 2016-01-15. PMID:26770797. amyloid 1-42 (aβ42) and tau in cerebrospinal fluid are currently used as markers for diagnosis of alzheimer's disease. 2016-01-15 2023-08-13 Not clear
Keerthanaa Balasubramanian Shanthi, Sreeram Krishnan, P Ran. A systematic review and meta-analysis of plasma amyloid 1-42 and tau as biomarkers for Alzheimer's disease. SAGE open medicine. vol 3. 2016-01-15. PMID:26770797. a meta-analysis was performed to statistically validate the use of plasma aβ42 and tau as biomarkers for alzheimer's disease. 2016-01-15 2023-08-13 Not clear
Roger Pamphlett, Stephen Kum Je. Different Populations of Human Locus Ceruleus Neurons Contain Heavy Metals or Hyperphosphorylated Tau: Implications for Amyloid-β and Tau Pathology in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 45. issue 2. 2016-01-14. PMID:25547633. different populations of human locus ceruleus neurons contain heavy metals or hyperphosphorylated tau: implications for amyloid-β and tau pathology in alzheimer's disease. 2016-01-14 2023-08-13 human
Xiaochuan Wang, Julie Blanchard, Yunn Chyn Tung, Inge Grundke-Iqbal, Khalid Iqba. Inhibition of Protein Phosphatase-2A (PP2A) by I1PP2A Leads to Hyperphosphorylation of Tau, Neurodegeneration, and Cognitive Impairment in Rats. Journal of Alzheimer's disease : JAD. vol 45. issue 2. 2016-01-14. PMID:25589718. protein phosphatase-2a (pp2a) deficiency is a cause of the abnormal hyperphosphorylation of tau, which composes neurofibrillary tangles (nfts) in alzheimer's disease (ad) brain. 2016-01-14 2023-08-13 rat
Katerina Papanikolopoulou, Efthimios M C Skoulaki. Temporally distinct phosphorylations differentiate Tau-dependent learning deficits and premature mortality in Drosophila. Human molecular genetics. vol 24. issue 7. 2016-01-13. PMID:25524708. abnormally phosphorylated tau protein, the major component of neurofibrillary tangles, is critical in the pathogenesis of alzheimer's disease and related tauopathies. 2016-01-13 2023-08-13 mouse
Amy M Pooler, Manuela Polydoro, Eduardo A Maury, Samantha B Nicholls, Snigdha M Reddy, Susanne Wegmann, Christopher William, Lubna Saqran, Ozge Cagsal-Getkin, Rose Pitstick, David R Beier, George A Carlson, Tara L Spires-Jones, Bradley T Hyma. Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer's disease. Acta neuropathologica communications. vol 3. 2016-01-13. PMID:25853174. amyloid accelerates tau propagation and toxicity in a model of early alzheimer's disease. 2016-01-13 2023-08-13 human
Katja Hochgräfe, Astrid Sydow, Dorthe Matenia, Daniela Cadinu, Stefanie Könen, Olga Petrova, Marcus Pickhardt, Petra Goll, Fabio Morellini, Eckhard Mandelkow, Eva-Maria Mandelko. Preventive methylene blue treatment preserves cognition in mice expressing full-length pro-aggregant human Tau. Acta neuropathologica communications. vol 3. 2016-01-13. PMID:25958115. neurofibrillary tangles (nft) composed of tau are hallmarks of neurodegeneration in alzheimer disease. 2016-01-13 2023-08-13 mouse
Ying Liu, Jin-Tai Yu, Hui-Fu Wang, Xiao-Ke Hao, Yu-Fen Yang, Teng Jiang, Xi-Chen Zhu, Lei Cao, Dao-Qiang Zhang, Lan Ta. Association between NME8 locus polymorphism and cognitive decline, cerebrospinal fluid and neuroimaging biomarkers in Alzheimer's disease. PloS one. vol 9. issue 12. 2016-01-12. PMID:25486118. therefore, this study assessed the strength of association between the nme8 rs2718058 genotypes and ad-related measures including the cerebrospinal fluid (csf) amyloid beta, tau, p-tau concentrations, neuroimaging biomarkers and cognitive performance, in a large cohort from alzheimer's disease neuroimaging initiative (adni) database. 2016-01-12 2023-08-13 human
Chris Moran, Richard Beare, Thanh G Phan, David G Bruce, Michele L Callisaya, Velandai Srikant. Type 2 diabetes mellitus and biomarkers of neurodegeneration. Neurology. vol 85. issue 13. 2016-01-12. PMID:26333802. our objective was to investigate whether type 2 diabetes mellitus (t2dm) influences neurodegeneration in a manner similar to alzheimer disease (ad), by promoting brain β-amyloid (aβ) or tau. 2016-01-12 2023-08-13 Not clear
Charles Duyckaerts, Heiko Braak, Jean-Pierre Brion, Luc Buée, Kelly Del Tredici, Michel Goedert, Glenda Halliday, Manuela Neumann, Maria Grazia Spillantini, Markus Tolnay, Toshiki Uchihar. PART is part of Alzheimer disease. Acta neuropathologica. vol 129. issue 5. 2016-01-11. PMID:25628035. it has been proposed that tau aggregation confined to entorhinal cortex and hippocampus, with no or only minimal aβ deposition, should be considered as a 'primary age-related tauopathy' (part) that is not integral to the continuum of sporadic alzheimer disease (ad). 2016-01-11 2023-08-13 Not clear
Lauren Walker, Kirsty E McAleese, Alan J Thomas, Mary Johnson, Carmen Martin-Ruiz, Craig Parker, Sean J Colloby, Kurt Jellinger, Johannes Attem. Neuropathologically mixed Alzheimer's and Lewy body disease: burden of pathological protein aggregates differs between clinical phenotypes. Acta neuropathologica. vol 129. issue 5. 2016-01-11. PMID:25758940. we quantitatively measured the amount of hyperphosphorylated microtubule associated tau (hp-τ), amyloid-β protein (aβ) and α-synuclein (α-syn) in cases that were neuropathologically diagnosed as mixed alzheimer's disease (ad) and neocortical lewy body disease (lbd) but clinically presented either as dementia due to ad or lbd, the latter including dementia with lewy bodies (dlb) and parkinson's disease dementia (pdd). 2016-01-11 2023-08-13 human
Roy O Weller, Cheryl A Hawkes, Roxana O Carare, John Hard. Does the difference between PART and Alzheimer's disease lie in the age-related changes in cerebral arteries that trigger the accumulation of Aβ and propagation of tau? Acta neuropathologica. vol 129. issue 5. 2016-01-11. PMID:25814152. does the difference between part and alzheimer's disease lie in the age-related changes in cerebral arteries that trigger the accumulation of aβ and propagation of tau? 2016-01-11 2023-08-13 Not clear
Yun-Chieh Tasi, Ting-Yu Chin, Ying-Ju Chen, Chun-Chih Huang, Shou-Lun Lee, Tzong-Yuan W. Potential natural products for Alzheimer's disease: targeted search using the internal ribosome entry site of tau and amyloid-β precursor protein. International journal of molecular sciences. vol 16. issue 4. 2016-01-11. PMID:25903151. potential natural products for alzheimer's disease: targeted search using the internal ribosome entry site of tau and amyloid-β precursor protein. 2016-01-11 2023-08-13 mouse
Yun-Chieh Tasi, Ting-Yu Chin, Ying-Ju Chen, Chun-Chih Huang, Shou-Lun Lee, Tzong-Yuan W. Potential natural products for Alzheimer's disease: targeted search using the internal ribosome entry site of tau and amyloid-β precursor protein. International journal of molecular sciences. vol 16. issue 4. 2016-01-11. PMID:25903151. overexpression of the amyloid precursor protein (app) and the hyperphosphorylation of the tau protein are vital in the understanding of the cause of alzheimer's disease (ad). 2016-01-11 2023-08-13 mouse
De-Lin Ma, Fu-Qiong Chen, Wei-Jie Xu, Wen-Zhu Yue, Gang Yuan, Yan Yan. Early intervention with glucagon-like peptide 1 analog liraglutide prevents tau hyperphosphorylation in diabetic db/db mice. Journal of neurochemistry. vol 135. issue 2. 2016-01-11. PMID:26183127. neurofibrillary tangles, which consist of hyperphosphorylated tau and misfolded microtubules, is one of the neuropathological hallmarks of alzheimer's disease. 2016-01-11 2023-08-13 mouse
Ce Xie, Yoshiyuki Soeda, Yuki Shinzaki, Yasuko In, Koji Tomoo, Yasuo Ihara, Tomohiro Miyasak. Identification of key amino acids responsible for the distinct aggregation properties of microtubule-associated protein 2 and tau. Journal of neurochemistry. vol 135. issue 1. 2016-01-08. PMID:26134402. so far, it is largely unknown why tau but not map2 is selectively involved in the filamentous inclusions (neurofibrillary tangles, nft) formation in tauopathies, including alzheimer's disease. 2016-01-08 2023-08-13 Not clear
Pritika J Narayan, Claire Lill, Richard Faull, Maurice A Curtis, Mike Draguno. Increased acetyl and total histone levels in post-mortem Alzheimer's disease brain. Neurobiology of disease. vol 74. 2016-01-06. PMID:25484284. using immunolabelling, histone markers correlated significantly with the level of glial fibrillary acidic protein and hla-dp, -dq and -dr immunopositive cells and with the pathological hallmarks of alzheimer's disease (hyperphosphorylated tau load and β-amyloid plaques). 2016-01-06 2023-08-13 human
Angela Tam, Christian Dansereau, AmanPreet Badhwar, Pierre Orban, Sylvie Belleville, Howard Chertkow, Alain Dagher, Alexandru Hanganu, Oury Monchi, Pedro Rosa-Neto, Amir Shmuel, Seqian Wang, John Breitner, Pierre Belle. Common Effects of Amnestic Mild Cognitive Impairment on Resting-State Connectivity Across Four Independent Studies. Frontiers in aging neuroscience. vol 7. 2016-01-06. PMID:26733866. if our findings can be replicated and associated with other established biomarkers of alzheimer's disease (e.g., amyloid and tau quantification), then these functional connections may be promising candidate biomarkers for alzheimer's disease. 2016-01-06 2023-08-13 human