All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Juliana B Hoppe, Christianne G Salbego, Helena Cimarost. SUMOylation: Novel Neuroprotective Approach for Alzheimer's Disease? Aging and disease. vol 6. issue 5. 2015-10-01. PMID:26425387. alzheimer's disease (ad) is a progressive neurodegenerative disease characterized in the brain by the formation of amyloid-beta (aβ)-containing plaques and neurofibrillary tangles containing the microtubule-associated protein tau. 2015-10-01 2023-08-13 Not clear
Cristina Angeloni, Laura Zambonin, Silvana Hreli. Role of methylglyoxal in Alzheimer's disease. BioMed research international. vol 2014. 2015-09-30. PMID:24734229. the major hallmarks of alzheimer's disease are extracellular aggregation of amyloid β peptides and, the presence of intracellular neurofibrillary tangles formed by precipitation/aggregation of hyperphosphorylated tau protein. 2015-09-30 2023-08-13 Not clear
Makoto Higuch. [Cognitive Function and Calcium. Molecular neuroimaging and calcium]. Clinical calcium. vol 25. issue 2. 2015-09-30. PMID:25634049. neurodegenerative dementias exemplified by alzheimer's disease are neuropathologically characterized by deposition of protein aggregates such as amyloid β peptide (aβ), tau protein. 2015-09-30 2023-08-13 Not clear
Yee Lian Chew, Jürgen Götz, Hannah R Nichola. Neuronal protein with tau-like repeats (PTL-1) regulates intestinal SKN-1 nuclear accumulation in response to oxidative stress. Aging cell. vol 14. issue 1. 2015-09-28. PMID:25399685. oxidative stress is a central pathomechanism in alzheimer's disease (ad) and other diseases with tau pathology. 2015-09-28 2023-08-13 Not clear
Jessica Bright, Sami Hussain, Vu Dang, Sarah Wright, Bonnie Cooper, Tony Byun, Carla Ramos, Andrew Singh, Graham Parry, Nancy Stagliano, Irene Griswold-Prenne. Human secreted tau increases amyloid-beta production. Neurobiology of aging. vol 36. issue 2. 2015-09-28. PMID:25442111. the interaction of amyloid-beta (aβ) and tau in the pathogenesis of alzheimer's disease is a subject of intense inquiry, with the bulk of evidence indicating that changes in tau are downstream of aβ. 2015-09-28 2023-08-13 mouse
Jessica Bright, Sami Hussain, Vu Dang, Sarah Wright, Bonnie Cooper, Tony Byun, Carla Ramos, Andrew Singh, Graham Parry, Nancy Stagliano, Irene Griswold-Prenne. Human secreted tau increases amyloid-beta production. Neurobiology of aging. vol 36. issue 2. 2015-09-28. PMID:25442111. to determine if the observed changes in aβ levels were because of intracellular or extracellular secreted tau (etau for extracellular tau), we affinity purified secreted tau from alzheimer's disease patient-derived cortical neuron conditioned media and analyzed it by liquid chromatography-mass spectrometry. 2015-09-28 2023-08-13 mouse
Cristina Tintori, Giuseppina La Sala, Giulia Vignaroli, Lorenzo Botta, Anna Lucia Fallacara, Federico Falchi, Marco Radi, Claudio Zamperini, Elena Dreassi, Lucia Dello Iacono, Donata Orioli, Giuseppe Biamonti, Mirko Garbelli, Andrea Lossani, Francesca Gasparrini, Tiziano Tuccinardi, Ilaria Laurenzana, Adriano Angelucci, Giovanni Maga, Silvia Schenone, Chiara Brullo, Francesca Musumeci, Andrea Desogus, Emmanuele Crespan, Maurizio Bott. Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors. Journal of medicinal chemistry. vol 58. issue 11. 2015-09-28. PMID:25923950. both compounds were found able to inhibit the phosphorylation of the protein tau in an alzheimer's model cell line and showed antiproliferative activities against different cancer cell lines. 2015-09-28 2023-08-13 human
Yoshiaki Omura, Abdallah Nihrane, Dominic Lu, Marilyn K Jones, Yasuhiro Shimotsuura, Motomu Ohk. Simple New Method of Detecting Lies By Identifying Invisible Unique Physiological Reflex Response Appearing Often Less Than 10-15 Seconds on the Specific Parts of Face of Lying Person; Quick Screening of Potential Murderers & Problematic Persons. Acupuncture & electro-therapeutics research. vol 40. issue 2. 2015-09-28. PMID:26369253. at least one abnormal pupil with bdort of (-)8-(-)12 & marked reduction in acetylcholine and abnormal increase in any of 3 alzheimer's disease associated factors apolipoprotein (apo) e4, β-amyloid (1-42), tau protein, viral and bacterial infections were detected in both pupils and forehead of murderers and people who often have problems with others. 2015-09-28 2023-08-13 Not clear
Sang-Je Park, Young-Hyun Kim, Gyu-Hwi Nam, Se-Hee Choe, Sang-Rae Lee, Sun-Uk Kim, Ji-Su Kim, Bo-Woong Sim, Bong-Seok Song, Kang-Jin Jeong, Youngjeon Lee, Young Il Park, Kyoung-Min Lee, Jae-Won Huh, Kyu-Tae Chan. Quantitative expression analysis of APP pathway and tau phosphorylation-related genes in the ICV STZ-induced non-human primate model of sporadic Alzheimer's disease. International journal of molecular sciences. vol 16. issue 2. 2015-09-25. PMID:25622254. quantitative expression analysis of app pathway and tau phosphorylation-related genes in the icv stz-induced non-human primate model of sporadic alzheimer's disease. 2015-09-25 2023-08-13 monkey
Sang-Je Park, Young-Hyun Kim, Gyu-Hwi Nam, Se-Hee Choe, Sang-Rae Lee, Sun-Uk Kim, Ji-Su Kim, Bo-Woong Sim, Bong-Seok Song, Kang-Jin Jeong, Youngjeon Lee, Young Il Park, Kyoung-Min Lee, Jae-Won Huh, Kyu-Tae Chan. Quantitative expression analysis of APP pathway and tau phosphorylation-related genes in the ICV STZ-induced non-human primate model of sporadic Alzheimer's disease. International journal of molecular sciences. vol 16. issue 2. 2015-09-25. PMID:25622254. the accumulation and aggregation of misfolded proteins in the brain, such as amyloid-β (aβ) and hyperphosphorylated tau, is a neuropathological hallmark of alzheimer's disease (ad). 2015-09-25 2023-08-13 monkey
Lixin Song, Sherry X Lu, Xuesong Ouyang, Jerry Melchor, Julie Lee, Giuseppe Terracina, Xiaohai Wang, Lynn Hyde, J Fred Hess, Eric M Parker, Lili Zhan. Analysis of tau post-translational modifications in rTg4510 mice, a model of tau pathology. Molecular neurodegeneration. vol 10. 2015-09-25. PMID:25881209. microtubule associated protein tau is the major component of the neurofibrillary tangles (nfts) found in the brains of patients with alzheimer's disease and several other neurodegenerative diseases. 2015-09-25 2023-08-13 mouse
Daniel Sevlever, Fanggeng Zou, Li Ma, Sebastian Carrasquillo, Michael G Crump, Oliver J Culley, Talisha A Hunter, Gina D Bisceglio, Linda Younkin, Mariet Allen, Minerva M Carrasquillo, Sigrid B Sando, Jan O Aasly, Dennis W Dickson, Neill R Graff-Radford, Ronald C Petersen, Ferenc Deák, Olivia Belbi. Genetically-controlled Vesicle-Associated Membrane Protein 1 expression may contribute to Alzheimer's pathophysiology and susceptibility. Molecular neurodegeneration. vol 10. 2015-09-25. PMID:25881291. alzheimer's disease is a neurodegenerative disorder in which extracellular deposition of β-amyloid (aβ) oligomers causes synaptic injury resulting in early memory loss, altered homeostasis, accumulation of hyperphosphorylated tau and cell death. 2015-09-25 2023-08-13 Not clear
Georg M Kerbler, Jürgen Fripp, Christopher C Rowe, Victor L Villemagne, Olivier Salvado, Stephen Rose, Elizabeth J Coulso. Basal forebrain atrophy correlates with amyloid β burden in Alzheimer's disease. NeuroImage. Clinical. vol 7. 2015-09-24. PMID:25610772. the brains of patients suffering from alzheimer's disease (ad) have three classical pathological hallmarks: amyloid-beta (aβ) plaques, tau tangles, and neurodegeneration, including that of cholinergic neurons of the basal forebrain. 2015-09-24 2023-08-13 human
Moonhee Lee, Edith McGeer, Patrick L McGee. Activated human microglia stimulate neuroblastoma cells to upregulate production of beta amyloid protein and tau: implications for Alzheimer's disease pathogenesis. Neurobiology of aging. vol 36. issue 1. 2015-09-21. PMID:25169677. activated human microglia stimulate neuroblastoma cells to upregulate production of beta amyloid protein and tau: implications for alzheimer's disease pathogenesis. 2015-09-21 2023-08-13 human
Chandana Buddhala, Meghan C Campbell, Joel S Perlmutter, Paul T Kotzbaue. Correlation between decreased CSF α-synuclein and Aβ₁₋₄₂ in Parkinson disease. Neurobiology of aging. vol 36. issue 1. 2015-09-21. PMID:25212463. in contrast with increased csf tau in alzheimer disease, csf tau did not significantly differ between pd and controls. 2015-09-21 2023-08-13 human
Zhinian Lei, Corey Brizzee, Gail V W Johnso. BAG3 facilitates the clearance of endogenous tau in primary neurons. Neurobiology of aging. vol 36. issue 1. 2015-09-21. PMID:25212465. tau is a microtubule associated protein that is found primarily in neurons, and in pathologic conditions, such as alzheimer's disease (ad) it accumulates and contributes to the disease process. 2015-09-21 2023-08-13 mouse
Jeffrey L Seeburger, Daniel J Holder, Marc Combrinck, Catharine Joachim, Omar Laterza, Michael Tanen, Aimee Dallob, Derek Chappell, Karen Snyder, Mary Flynn, Adam Simon, Vijay Modur, William Z Potter, Gordon Wilcock, Mary J Savage, A David Smit. Cerebrospinal fluid biomarkers distinguish postmortem-confirmed Alzheimer's disease from other dementias and healthy controls in the OPTIMA cohort. Journal of Alzheimer's disease : JAD. vol 44. issue 2. 2015-09-21. PMID:25391385. cerebrospinal fluid (csf) amyloid-β (aβ) and tau have been studied as markers of alzheimer's disease (ad). 2015-09-21 2023-08-13 human
Pedro A Dionísio, Joana D Amaral, Maria F Ribeiro, Adrian C Lo, Rudi D'Hooge, Cecília M P Rodrigue. Amyloid-β pathology is attenuated by tauroursodeoxycholic acid treatment in APP/PS1 mice after disease onset. Neurobiology of aging. vol 36. issue 1. 2015-09-21. PMID:25443293. alzheimer's disease (ad) is a neurodegenerative disorder hallmarked by the accumulation of extracellular amyloid-β (aβ) peptide and intraneuronal hyperphosphorylated tau, as well as chronic neuroinflammation. 2015-09-21 2023-08-13 mouse
Susana Boluda, Michiyo Iba, Bin Zhang, Kevin M Raible, Virginia M-Y Lee, John Q Trojanowsk. Differential induction and spread of tau pathology in young PS19 tau transgenic mice following intracerebral injections of pathological tau from Alzheimer's disease or corticobasal degeneration brains. Acta neuropathologica. vol 129. issue 2. 2015-09-21. PMID:25534024. differential induction and spread of tau pathology in young ps19 tau transgenic mice following intracerebral injections of pathological tau from alzheimer's disease or corticobasal degeneration brains. 2015-09-21 2023-08-13 mouse
Susana Boluda, Michiyo Iba, Bin Zhang, Kevin M Raible, Virginia M-Y Lee, John Q Trojanowsk. Differential induction and spread of tau pathology in young PS19 tau transgenic mice following intracerebral injections of pathological tau from Alzheimer's disease or corticobasal degeneration brains. Acta neuropathologica. vol 129. issue 2. 2015-09-21. PMID:25534024. filamentous tau pathologies are hallmark lesions of several neurodegenerative tauopathies including alzheimer's disease (ad) and corticobasal degeneration (cbd) which show cell type-specific and topographically distinct tau inclusions. 2015-09-21 2023-08-13 mouse