| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| X Luo, H Shi, L Hou, X Zhong, X Chen, Y Zhang, D Zheng, Y Tan, G Hu, N Mu, J Chen, Y Fang, H He, Y Nin. Different cerebrospinal fluid levels of Alzheimer-type biomarker Aβ42 between general paresis and asymptomatic neurosyphilis. European journal of neurology. vol 22. issue 5. 2015-12-03. PMID:25707998. |
to explore the amyloid and tau metabolism in neurosyphilis patients in different stages, the levels of alzheimer-type biomarkers in general paresis (gp) and asymptomatic neurosyphilis (ans) patients in comparison to patients with alzheimer's disease (ad) and normal controls (ncs) were investigated. |
2015-12-03 |
2023-08-13 |
Not clear |
| A C Ludolph, J Brettschneide. TDP-43 in amyotrophic lateral sclerosis - is it a prion disease? European journal of neurology. vol 22. issue 5. 2015-12-03. PMID:25846565. |
importantly, many of these proteins such as tau and amyloid-β in alzheimer's disease and α-synuclein in parkinson's show a stereotypical sequential distribution pattern with progressing disease. |
2015-12-03 |
2023-08-13 |
Not clear |
| Nana Jin, Xiaomin Yin, Dian Yu, Maohong Cao, Cheng-Xin Gong, Khalid Iqbal, Fei Ding, Xiaosong Gu, Fei Li. Truncation and activation of GSK-3β by calpain I: a molecular mechanism links to tau hyperphosphorylation in Alzheimer's disease. Scientific reports. vol 5. 2015-12-01. PMID:25641096. |
truncation and activation of gsk-3β by calpain i: a molecular mechanism links to tau hyperphosphorylation in alzheimer's disease. |
2015-12-01 |
2023-08-13 |
mouse |
| Nana Jin, Xiaomin Yin, Dian Yu, Maohong Cao, Cheng-Xin Gong, Khalid Iqbal, Fei Ding, Xiaosong Gu, Fei Li. Truncation and activation of GSK-3β by calpain I: a molecular mechanism links to tau hyperphosphorylation in Alzheimer's disease. Scientific reports. vol 5. 2015-12-01. PMID:25641096. |
abnormal hyperphosphorylation of tau is pivotally involved in the pathogenesis of alzheimer's disease (ad) and related tauopathies. |
2015-12-01 |
2023-08-13 |
mouse |
| Zhi-Yuan Zhang, Chaoyun Li, Caroline Zug, Hermann J Schluesene. Icariin ameliorates neuropathological changes, TGF-β1 accumulation and behavioral deficits in a mouse model of cerebral amyloidosis. PloS one. vol 9. issue 8. 2015-11-30. PMID:25101849. |
therefore, icariin might be applied in treatment of neurodegenerative disorders, including alzheimer's disease (ad), which is neuropathologically characterized by β-amyloid aggregation, hyperphosphorylated tau and neuroinflammation. |
2015-11-30 |
2023-08-13 |
mouse |
| Matthew Wozniak, Tracey Bell, Ádám Dénes, Ruth Falshaw, Ruth Itzhak. Anti-HSV1 activity of brown algal polysaccharides and possible relevance to the treatment of Alzheimer's disease. International journal of biological macromolecules. vol 74. 2015-11-30. PMID:25583021. |
herpes simplex virus type 1 (hsv1) induces the formation of the characteristic abnormal molecules of alzheimer's disease (ad) brains, beta-amyloid, and abnormally phosphorylated, ad-like tau (p-tau). |
2015-11-30 |
2023-08-13 |
Not clear |
| Judith M van der Harg, Leslie Eggels, Silvie R Ruigrok, Jeroen J M Hoozemans, Susanne E la Fleur, Wiep Schepe. Neuroinflammation is not a Prerequisite for Diabetes-induced Tau Phosphorylation. Frontiers in neuroscience. vol 9. 2015-11-30. PMID:26617484. |
abnormal phosphorylation and aggregation of tau is a key hallmark of alzheimer's disease (ad). |
2015-11-30 |
2023-08-13 |
rat |
| Francine Hehn de Oliveira, Edson Rodrigues Neto, Mariana Kumaira Fonseca, André Silvestre Reitz da Costa, Marcio Aloisio Bezerra Cavalcanti Rockenbach, Renata dos Santos Padilha, Liana Lisboa Fernandez, Arlete Hilbi. Neurodegenerative changes in the brainstem and olfactory bulb in people older than 50 years old: a descriptive study. Arquivos de neuro-psiquiatria. vol 73. issue 7. 2015-11-25. PMID:26200050. |
of the 7 individuals who had a final diagnosis of alzheimer's disease (ad), 6 presented tau deposits in some region of the brainstem. |
2015-11-25 |
2023-08-13 |
Not clear |
| Miranda E Orr, Valentina R Garbarino, Angelica Salinas, Rochelle Buffenstei. Sustained high levels of neuroprotective, high molecular weight, phosphorylated tau in the longest-lived rodent. Neurobiology of aging. vol 36. issue 3. 2015-11-24. PMID:25576082. |
tau phosphorylation, aggregation, and subcellular mislocalization coincide with neurodegeneration in numerous diseases, including alzheimer's disease (ad). |
2015-11-24 |
2023-08-13 |
mouse |
| Yasuyuki Kimura, Masanori Ichise, Hiroshi Ito, Hitoshi Shimada, Yoko Ikoma, Chie Seki, Harumasa Takano, Soichiro Kitamura, Hitoshi Shinotoh, Kazunori Kawamura, Ming-Rong Zhang, Naruhiko Sahara, Tetsuya Suhara, Makoto Higuch. PET Quantification of Tau Pathology in Human Brain with 11C-PBB3. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 56. issue 9. 2015-11-24. PMID:26182966. |
tau accumulation in the brain is a pathologic hallmark of alzheimer disease and other tauopathies. |
2015-11-24 |
2023-08-13 |
human |
| Yingjun Zhao, I-Chu Tseng, Charles J Heyser, Edward Rockenstein, Michael Mante, Anthony Adame, Qiuyang Zheng, Timothy Huang, Xin Wang, Pharhad E Arslan, Paramita Chakrabarty, Chengbiao Wu, Guojun Bu, William C Mobley, Yun-Wu Zhang, Peter St George-Hyslop, Eliezer Masliah, Paul Fraser, Huaxi X. Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis. Neuron. vol 87. issue 5. 2015-11-23. PMID:26335643. |
increased appoptosin and caspase-3-cleaved tau were also observed in brain samples of patients with alzheimer's disease and frontotemporal dementia with tau inclusions. |
2015-11-23 |
2023-08-13 |
mouse |
| Rebecca B Weinberg, Elliott J Mufson, Scott E Count. Evidence for a neuroprotective microRNA pathway in amnestic mild cognitive impairment. Frontiers in neuroscience. vol 9. 2015-11-23. PMID:26594146. |
micrornas (mirnas) that regulate mrna stability have been linked to amyloid production, tau phosphorylation, and inflammation in alzheimer's disease (ad). |
2015-11-23 |
2023-08-13 |
human |
| Kristen E Funk, Hilda Mirbaha, Hong Jiang, David M Holtzman, Marc I Diamon. Distinct Therapeutic Mechanisms of Tau Antibodies: Promoting Microglial Clearance Versus Blocking Neuronal Uptake. The Journal of biological chemistry. vol 290. issue 35. 2015-11-20. PMID:26126828. |
tauopathies are neurodegenerative diseases characterized by accumulation of tau amyloids, and include alzheimer disease and certain frontotemporal dementias. |
2015-11-20 |
2023-08-13 |
mouse |
| Kristen E Funk, Hilda Mirbaha, Hong Jiang, David M Holtzman, Marc I Diamon. Distinct Therapeutic Mechanisms of Tau Antibodies: Promoting Microglial Clearance Versus Blocking Neuronal Uptake. The Journal of biological chemistry. vol 290. issue 35. 2015-11-20. PMID:26126828. |
surprisingly, hj9.3 promoted uptake of fibrils composed of the tau repeat domain or alzheimer disease-derived tau aggregates, but failed to influence full-length recombinant tau fibrils. |
2015-11-20 |
2023-08-13 |
mouse |
| Kristen E Funk, Hilda Mirbaha, Hong Jiang, David M Holtzman, Marc I Diamon. Distinct Therapeutic Mechanisms of Tau Antibodies: Promoting Microglial Clearance Versus Blocking Neuronal Uptake. The Journal of biological chemistry. vol 290. issue 35. 2015-11-20. PMID:26126828. |
no antibody inhibited uptake of full-length recombinant fibrils into primary neurons, but hj9.3 blocked neuronal uptake of tau repeat domain fibrils and alzheimer disease-derived tau. |
2015-11-20 |
2023-08-13 |
mouse |
| Pooja Joshi, Luisa Benussi, Roberto Furlan, Roberta Ghidoni, Claudia Verderi. Extracellular vesicles in Alzheimer's disease: friends or foes? Focus on aβ-vesicle interaction. International journal of molecular sciences. vol 16. issue 3. 2015-11-17. PMID:25741766. |
the intercellular transfer of amyloid-β (aβ) and tau proteins has received increasing attention in alzheimer's disease (ad). |
2015-11-17 |
2023-08-13 |
Not clear |
| Felipe Dias Leal, Camilo Henrique da Silva Lima, Ricardo Bicca de Alencastro, Helena Carla Castro, Carlos Rangel Rodrigues, Magaly Girão Albuquerqu. Hologram QSAR models of a series of 6-arylquinazolin-4-amine inhibitors of a new Alzheimer's disease target: dual specificity tyrosine-phosphorylation-regulated kinase-1A enzyme. International journal of molecular sciences. vol 16. issue 3. 2015-11-17. PMID:25756379. |
dual specificity tyrosine-phosphorylation-regulated kinase-1a (dyrk1a) is an enzyme directly involved in alzheimer's disease, since its increased expression leads to β-amyloidosis, tau protein aggregation, and subsequent formation of neurofibrillary tangles. |
2015-11-17 |
2023-08-13 |
Not clear |
| Tobias Skillbäck, Bahman Y Farahmand, Christoffer Rosén, Niklas Mattsson, Katarina Nägga, Lena Kilander, Dorota Religa, Anders Wimo, Bengt Winblad, Jonathan M Schott, Kaj Blennow, Maria Eriksdotter, Henrik Zetterber. Cerebrospinal fluid tau and amyloid-β1-42 in patients with dementia. Brain : a journal of neurology. vol 138. issue Pt 9. 2015-11-16. PMID:26133663. |
progressive cognitive decline in combination with a cerebrospinal fluid biomarker pattern of low levels of amyloid-β1-42 and high levels of total tau and phosphorylated tau is typical of alzheimer's disease. |
2015-11-16 |
2023-08-13 |
human |
| Tobias Skillbäck, Bahman Y Farahmand, Christoffer Rosén, Niklas Mattsson, Katarina Nägga, Lena Kilander, Dorota Religa, Anders Wimo, Bengt Winblad, Jonathan M Schott, Kaj Blennow, Maria Eriksdotter, Henrik Zetterber. Cerebrospinal fluid tau and amyloid-β1-42 in patients with dementia. Brain : a journal of neurology. vol 138. issue Pt 9. 2015-11-16. PMID:26133663. |
the highest levels of total tau and phosphorylated tau and the lowest levels of amyloid-β1-42 and amyloid-β1-42:phosphorylated tau ratios were found in alzheimer's disease. |
2015-11-16 |
2023-08-13 |
human |
| Tobias Skillbäck, Bahman Y Farahmand, Christoffer Rosén, Niklas Mattsson, Katarina Nägga, Lena Kilander, Dorota Religa, Anders Wimo, Bengt Winblad, Jonathan M Schott, Kaj Blennow, Maria Eriksdotter, Henrik Zetterber. Cerebrospinal fluid tau and amyloid-β1-42 in patients with dementia. Brain : a journal of neurology. vol 138. issue Pt 9. 2015-11-16. PMID:26133663. |
low amyloid-β1-42, high total tau and high phosphorylated tau correlated with low mini-mental state examination scores in alzheimer's disease. |
2015-11-16 |
2023-08-13 |
human |