| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tobias Skillbäck, Bahman Y Farahmand, Christoffer Rosén, Niklas Mattsson, Katarina Nägga, Lena Kilander, Dorota Religa, Anders Wimo, Bengt Winblad, Jonathan M Schott, Kaj Blennow, Maria Eriksdotter, Henrik Zetterber. Cerebrospinal fluid tau and amyloid-β1-42 in patients with dementia. Brain : a journal of neurology. vol 138. issue Pt 9. 2015-11-16. PMID:26133663. |
in addition, cerebrospinal fluid amyloid-β1-42, total tau, phosphorylated tau and the amyloid-β1-42:phosphorylated tau ratio all correlated with poor cognitive performance in alzheimer's disease, as did cerebrospinal fluid amyloid-β1-42 in parkinson's disease dementia and vascular dementia. |
2015-11-16 |
2023-08-13 |
human |
| Jon B Toledo, Henrik Zetterberg, Argonde C van Harten, Lidia Glodzik, Pablo Martinez-Lage, Luisella Bocchio-Chiavetto, Lorena Rami, Oskar Hansson, Reisa Sperling, Sebastiaan Engelborghs, Ricardo S Osorio, Hugo Vanderstichele, Manu Vandijck, Harald Hampel, Stefan Teipl, Abhay Moghekar, Marilyn Albert, William T Hu, Jose A Monge Argilés, Ana Gorostidi, Charlotte E Teunissen, Peter P De Deyn, Bradley T Hyman, Jose L Molinuevo, Giovanni B Frisoni, Gurutz Linazasoro, Mony J de Leon, Wiesje M van der Flier, Philip Scheltens, Kaj Blennow, Leslie M Shaw, John Q Trojanowsk. Alzheimer's disease cerebrospinal fluid biomarker in cognitively normal subjects. Brain : a journal of neurology. vol 138. issue Pt 9. 2015-11-16. PMID:26220940. |
in a large multicentre sample of cognitively normal subjects, as a function of age, gender and apoe genotype, we studied the frequency of abnormal cerebrospinal fluid levels of alzheimer's disease biomarkers including: total tau, phosphorylated tau and amyloid-β1-42. |
2015-11-16 |
2023-08-13 |
human |
| Jon B Toledo, Henrik Zetterberg, Argonde C van Harten, Lidia Glodzik, Pablo Martinez-Lage, Luisella Bocchio-Chiavetto, Lorena Rami, Oskar Hansson, Reisa Sperling, Sebastiaan Engelborghs, Ricardo S Osorio, Hugo Vanderstichele, Manu Vandijck, Harald Hampel, Stefan Teipl, Abhay Moghekar, Marilyn Albert, William T Hu, Jose A Monge Argilés, Ana Gorostidi, Charlotte E Teunissen, Peter P De Deyn, Bradley T Hyman, Jose L Molinuevo, Giovanni B Frisoni, Gurutz Linazasoro, Mony J de Leon, Wiesje M van der Flier, Philip Scheltens, Kaj Blennow, Leslie M Shaw, John Q Trojanowsk. Alzheimer's disease cerebrospinal fluid biomarker in cognitively normal subjects. Brain : a journal of neurology. vol 138. issue Pt 9. 2015-11-16. PMID:26220940. |
amyloid-β amyloid status (negative or positive) and neurodegeneration status (negative or positive) was established based on the pathological cerebrospinal fluid alzheimer's disease cut-off values for cerebrospinal fluid amyloid-β1-42 and total tau, respectively. |
2015-11-16 |
2023-08-13 |
human |
| Yasser Iturria-Medina, Roberto C Sotero, Paule J Toussaint, Alan C Evan. Epidemic spreading model to characterize misfolded proteins propagation in aging and associated neurodegenerative disorders. PLoS computational biology. vol 10. issue 11. 2015-11-13. PMID:25412207. |
for example, misfolded amyloid-ß (aß) and tau proteins are two neuropathogenic hallmarks of alzheimer's disease. |
2015-11-13 |
2023-08-13 |
human |
| Yasser Iturria-Medina, Roberto C Sotero, Paule J Toussaint, Alan C Evan. Epidemic spreading model to characterize misfolded proteins propagation in aging and associated neurodegenerative disorders. PLoS computational biology. vol 10. issue 11. 2015-11-13. PMID:25412207. |
furthermore, this model strongly supports a) the leading role of aß clearance deficiency and early aß onset age during alzheimer's disease progression, b) that effective anatomical distance from aß outbreak region explains regional aß arrival time and aß deposition likelihood, c) the multi-factorial impact of apoe e4 genotype, gender and educational level on lifetime intra-brain aß propagation, and d) the modulatory impact of aß propagation history on tau proteins concentrations, supporting the hypothesis of an interrelated pathway between aß pathophysiology and tauopathy. |
2015-11-13 |
2023-08-13 |
human |
| Arghya Barman, Donald Hamelber. Loss of intramolecular electrostatic interactions and limited conformational ensemble may promote self-association of cis-tau peptide. Proteins. vol 83. issue 3. 2015-11-13. PMID:25524218. |
in the brain of alzheimer's disease patients, the formation of intra-cellular neurofibrillary tangles deposition is a result of self-aggregation of hyper-phosphorylated tau protein. |
2015-11-13 |
2023-08-13 |
Not clear |
| Yee Lian Chew, Xiaochen Fan, Jürgen Götz, Hannah R Nichola. Regulation of age-related structural integrity in neurons by protein with tau-like repeats (PTL-1) is cell autonomous. Scientific reports. vol 4. 2015-11-12. PMID:24898126. |
accumulation of tau is a pathological hallmark of neurodegenerative diseases such as alzheimer's disease. |
2015-11-12 |
2023-08-13 |
caenorhabditis_elegans |
| Sivaraman Purushothuman, Jonathan Ston. The reaction of cerebral cortex to a nearby lesion: damage, survival, self-protection. Brain research. vol 1601. 2015-11-12. PMID:25591482. |
a needlestick injury to cerebral cortex causes immediate damage along the track of the needle (haemorrhage, cell death) and sequelae (the formation of amyloid-positive plaques, extracellular deposits of hyperphosphorylated tau protein, microglial proliferation, astrogliosis) that are long lasting, and mimic the neuropathology associated with alzheimer's disease. |
2015-11-12 |
2023-08-13 |
rat |
| Huilai Tian, Eliot Davidowitz, Patricia Lopez, Ping He, Philip Schulz, James Moe, Michael R Sierk. Isolation and characterization of antibody fragments selective for toxic oligomeric tau. Neurobiology of aging. vol 36. issue 3. 2015-11-12. PMID:25616912. |
oligomeric tau species are important in the onset and progression of alzheimer's disease (ad), as they are neurotoxic and can propagate tau-tangle pathology. |
2015-11-12 |
2023-08-13 |
mouse |
| Alexandra J Mably, Daniel Kanmert, Jessica M Mc Donald, Wen Liu, Barbara J Caldarone, Cynthia A Lemere, Brian O'Nuallain, Kenneth S Kosik, Dominic M Wals. Tau immunization: a cautionary tale? Neurobiology of aging. vol 36. issue 3. 2015-11-12. PMID:25619661. |
the amyloid β (aβ)-protein and microtubule-associated protein, tau, are the major components of the amyloid plaques and neurofibrillary tangles that typify alzheimer's disease (ad) pathology. |
2015-11-12 |
2023-08-13 |
mouse |
| D Porquet, P Andrés-Benito, C Griñán-Ferré, A Camins, I Ferrer, A M Canudas, J Del Valle, Mercè Pallà. Amyloid and tau pathology of familial Alzheimer's disease APP/PS1 mouse model in a senescence phenotype background (SAMP8). Age (Dordrecht, Netherlands). vol 37. issue 1. 2015-11-12. PMID:25663420. |
amyloid and tau pathology of familial alzheimer's disease app/ps1 mouse model in a senescence phenotype background (samp8). |
2015-11-12 |
2023-08-13 |
mouse |
| Naoyuki Sato, Ryuichi Morishit. The roles of lipid and glucose metabolism in modulation of β-amyloid, tau, and neurodegeneration in the pathogenesis of Alzheimer disease. Frontiers in aging neuroscience. vol 7. 2015-11-11. PMID:26557086. |
the roles of lipid and glucose metabolism in modulation of β-amyloid, tau, and neurodegeneration in the pathogenesis of alzheimer disease. |
2015-11-11 |
2023-08-13 |
Not clear |
| Yuan Zhou, Ikuo Hayashi, Jacky Wong, Katherine Tugusheva, John J Renger, Celina Zerbinatt. Intracellular clusterin interacts with brain isoforms of the bridging integrator 1 and with the microtubule-associated protein Tau in Alzheimer's disease. PloS one. vol 9. issue 7. 2015-11-10. PMID:25051234. |
intracellular clusterin interacts with brain isoforms of the bridging integrator 1 and with the microtubule-associated protein tau in alzheimer's disease. |
2015-11-10 |
2023-08-13 |
mouse |
| Izaskun Buendia, Javier Egea, Esther Parada, Elisa Navarro, Rafael León, María Isabel Rodríguez-Franco, Manuela G Lópe. The melatonin-N,N-dibenzyl(N-methyl)amine hybrid ITH91/IQM157 affords neuroprotection in an in vitro Alzheimer's model via hemo-oxygenase-1 induction. ACS chemical neuroscience. vol 6. issue 2. 2015-11-10. PMID:25393881. |
we have investigated the protective effects of ith91/iqm157, a hybrid of melatonin and n,n-dibenzyl(n-methyl)amine, in an in vitro model of alzheimer's disease (ad)-like pathology that combines amyloid beta (aβ) and tau hyperphosphorylation induced by okadaic acid (oa), in the human neuroblastoma cell line sh-sy5y. |
2015-11-10 |
2023-08-13 |
human |
| Caterina Branca, Elena V Wisely, Lauren K Hartman, Antonella Caccamo, Salvatore Odd. Administration of a selective β2 adrenergic receptor antagonist exacerbates neuropathology and cognitive deficits in a mouse model of Alzheimer's disease. Neurobiology of aging. vol 35. issue 12. 2015-11-09. PMID:25034342. |
currently, there are no available approaches to cure or slow down the progression of alzheimer's disease (ad), which is characterized by the accumulation of extracellular amyloid-β (aβ) deposits and intraneuronal tangles that comprised hyperphosphorylated tau. |
2015-11-09 |
2023-08-13 |
mouse |
| Christelle Frederick, Kunie Ando, Karelle Leroy, Céline Héraud, Valérie Suain, Luc Buée, Jean-Pierre Brio. Rapamycin ester analog CCI-779/Temsirolimus alleviates tau pathology and improves motor deficit in mutant tau transgenic mice. Journal of Alzheimer's disease : JAD. vol 44. issue 4. 2015-11-09. PMID:25408212. |
neurofibrillary tangles are intracellular inclusions made of tau protein that accumulates in neurons in alzheimer's disease (ad) and in other tauopathies. |
2015-11-09 |
2023-08-13 |
mouse |
| Petronella Kettunen, Susanna Larsson, Sandra Holmgren, Sandra Olsson, Lennart Minthon, Henrik Zetterberg, Kaj Blennow, Staffan Nilsson, Annica Sjölande. Genetic variants of GSK3B are associated with biomarkers for Alzheimer's disease and cognitive function. Journal of Alzheimer's disease : JAD. vol 44. issue 4. 2015-11-09. PMID:25420549. |
hyperphosphorylated tau is one of the hallmarks of alzheimer's disease (ad). |
2015-11-09 |
2023-08-13 |
Not clear |
| Dharmini C Mehta, Jennifer L Short, Sarah N Hilmer, Joseph A Nicolazz. Drug access to the central nervous system in Alzheimer's disease: preclinical and clinical insights. Pharmaceutical research. vol 32. issue 3. 2015-11-03. PMID:25319097. |
alzheimer's disease (ad) is a neurodegenerative disorder, characterized by β-amyloid plaques and hyperphosphorylated tau tangles in the brain. |
2015-11-03 |
2023-08-13 |
Not clear |
| Eun-Bum Kang, Joon-Yong Ch. Effect of treadmill exercise on PI3K/AKT/mTOR, autophagy, and Tau hyperphosphorylation in the cerebral cortex of NSE/htau23 transgenic mice. Journal of exercise nutrition & biochemistry. vol 19. issue 3. 2015-11-03. PMID:26527331. |
neurofibrillary tangles, one of pathological features of alzheimer's disease, are produced by the hyperphosphorylation and aggregation of tau protein. |
2015-11-03 |
2023-08-13 |
mouse |
| Uwe Ueberham, Susanne Rohn, Elke Ueberham, Susanne Wodischeck, Isabel Hilbrich, Max Holzer, Martina K Brückner, Hildegard Gruschka, Thomas Arend. Pin1 promotes degradation of Smad proteins and their interaction with phosphorylated tau in Alzheimer's disease. Neuropathology and applied neurobiology. vol 40. issue 7. 2015-10-30. PMID:24964035. |
pin1 promotes degradation of smad proteins and their interaction with phosphorylated tau in alzheimer's disease. |
2015-10-30 |
2023-08-13 |
Not clear |