| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cory M Nadel, Kristin Wucherer, Abby Oehler, Aye C Thwin, Koli Basu, Matthew D Callahan, Daniel R Southworth, Daniel A Mordes, Charles S Craik, Jason E Gestwick. Phosphorylation of a Cleaved Tau Proteoform at a Single Residue Inhibits Binding to the E3 Ubiquitin Ligase, CHIP. bioRxiv : the preprint server for biology. 2023-08-30. PMID:37645969. |
microtubule-associated protein tau (mapt/tau) accumulates in a family of neurodegenerative diseases, including alzheimer's disease (ad). |
2023-08-30 |
2023-09-07 |
Not clear |
| Michiel Bertsch, Bruno Franchi, Maria Carla Tesi, Veronica Tor. The role of A[Formula: see text] and Tau proteins in Alzheimer's disease: a mathematical model on graphs. Journal of mathematical biology. vol 87. issue 3. 2023-08-30. PMID:37646953. |
the role of a[formula: see text] and tau proteins in alzheimer's disease: a mathematical model on graphs. |
2023-08-30 |
2023-09-07 |
human |
| Michiel Bertsch, Bruno Franchi, Maria Carla Tesi, Veronica Tor. The role of A[Formula: see text] and Tau proteins in Alzheimer's disease: a mathematical model on graphs. Journal of mathematical biology. vol 87. issue 3. 2023-08-30. PMID:37646953. |
toxic proteins such as [formula: see text] amyloid and tau play in fact a crucial role in the development of alzheimer's disease and, separately, have been targets of medical treatments. |
2023-08-30 |
2023-09-07 |
human |
| Xin Wang, Erin E Sundermann, Rachel F Buckley, Sarah J Bank. Sex differences in the association between tau PET and cognitive performance in a non-Hispanic White cohort with preclinical AD. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-08-29. PMID:37641484. |
we investigated how the associations between tau and cognitive measures differ by sex in the preclinical alzheimer's disease (ad) stage. |
2023-08-29 |
2023-09-07 |
Not clear |
| Camilla A Molobekova, Elena M Kondaurova, Tatiana V Ilchibaeva, Alexander Ya Rodnyy, Natalia A Stefanova, Nataliya G Kolosova, Vladimir S Naumenk. Amisulpride decreases tau protein hyperphosphorylation in the brain of OXYS rats. Current Alzheimer research. 2023-08-29. PMID:37641989. |
in this study, oxys rats of three ages (1, 3, and 6 months), a proven model of alzheimer's disease (ad), at various stages of disease progression were used to thoroughly study the effects of amisulpride on behavior and tau protein phosphorylation. |
2023-08-29 |
2023-09-07 |
rat |
| Cecilia Monteiro, Balazs Toth, Flavia Brunstein, Ashwini Bobbala, Seema Datta, Ryan Ceniceros, Sandra Sanabria Bohorquez, Veronica Anania, Kristin Wildsmith, Stephen Schauer, Julie Lee, Michael Dolton, Vidya Ramakrishnan, Daniel Abramzon, Edmond Ten. A Randomized Phase II Study of the Safety and Efficacy of Semorinemab in Participants with Mild-to-Moderate Alzheimer's Disease (Lauriet). Neurology. 2023-08-29. PMID:37643887. |
accumulation of tau pathology in alzheimer's disease (ad) correlates with cognitive decline. |
2023-08-29 |
2023-09-07 |
human |
| William P Flavin, Helia Hosseini, Jeffrey W Ruberti, H Pirouz Kavehpour, Christopher C Giza, Mayumi L Prin. Traumatic brain injury and the pathways to cerebral tau accumulation. Frontiers in neurology. vol 14. 2023-08-28. PMID:37638180. |
there are many pathways involved in phosphorylating tau including diabetes, stroke, alzheimer's disease (ad), brain injury, aging, and drug use. |
2023-08-28 |
2023-09-07 |
Not clear |
| Nathalie Moussa, Ninar Dayou. Exploring the role of COX-2 in Alzheimer's disease: Potential therapeutic implications of COX-2 inhibitors. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society. vol 31. issue 9. 2023-08-28. PMID:37638222. |
in addition to cox-2 enzymes role in inflammation, the formation of amyloid plaques and neurofibrillary tangles in the brain, the review emphasizes that coxs-2 have a crucial role in normal synaptic activity and plasticity, and have a relationship with acetylcholine, tau protein, and beta-amyloid (aβ) which are the main causes of alzheimer's disease. |
2023-08-28 |
2023-09-07 |
Not clear |
| Nathalie Moussa, Ninar Dayou. Exploring the role of COX-2 in Alzheimer's disease: Potential therapeutic implications of COX-2 inhibitors. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society. vol 31. issue 9. 2023-08-28. PMID:37638222. |
furthermore, the review points out that cox-2 enzymes have a relationship with kinase enzymes, including cyclin dependent kinase 5 (cdk5) and glycogen synthase kinase 3β (gsk3β), which are known to play a role in tau phosphorylation and are strongly associated with alzheimer's disease. |
2023-08-28 |
2023-09-07 |
Not clear |
| Ruizhi Wang, Kun Ping Lu, Xiao Zhen Zho. Function and regulation of cis P-tau in the pathogenesis and treatment of conventional and nonconventional tauopathies. Journal of neurochemistry. 2023-08-28. PMID:37638382. |
conventional tauopathies are a group of disease characterized by tau inclusions in the brains, including alzheimer's disease (ad), pick's disease (pid), progressive supranuclear palsy (psp), corticobasal degeneration (cbd), and certain types of frontotemporal dementia (ftd), among which ad is the most prevalent. |
2023-08-28 |
2023-09-07 |
Not clear |
| George S Bloom, Andrés Norambuen. Dysregulation of mTOR by tau in Alzheimer's disease. Cytoskeleton (Hoboken, N.J.). 2023-08-28. PMID:37638691. |
dysregulation of mtor by tau in alzheimer's disease. |
2023-08-28 |
2023-09-07 |
Not clear |
| George S Bloom, Andrés Norambuen. Dysregulation of mTOR by tau in Alzheimer's disease. Cytoskeleton (Hoboken, N.J.). 2023-08-28. PMID:37638691. |
interest in tau rose by the late 1980's, when it was shown to be the principal subunit of the neurofibrillary tangles (nfts) that accumulate in alzheimer's disease (ad) brain, and achieved new heights by the late 1990's, when numerous tau mutations were found to be highly penetrant for ad-related disorders that also are associated with nfts and came to be known as non-alzheimer's tauopathies. |
2023-08-28 |
2023-09-07 |
Not clear |
| Junhao Li, Amit Kumar, Bengt Långström, Agneta Nordberg, Hans Ågre. Insight into the Binding of First- and Second-Generation PET Tracers to 4R and 3R/4R Tau Protofibrils. ACS chemical neuroscience. 2023-08-28. PMID:37639522. |
similar to alzheimer's disease (ad), the abnormal aggregation of tau fibrils in the central neuronal and glial cells is a major hallmark of psp disease. |
2023-08-28 |
2023-09-07 |
Not clear |
| Giulia Arenare, Riccardo Manca, Paolo Caffarra, Annalena Venneri, On Behalf Of The Alzheimer's Disease Neuroimaging Initiativ. Associations between Neuropsychiatric Symptoms and Alzheimer's Disease Biomarkers in People with Mild Cognitive Impairment. Brain sciences. vol 13. issue 8. 2023-08-26. PMID:37626552. |
this study aimed to investigate the association between nps severity and alzheimer's disease (ad) biomarkers, i.e., amyloid-β (aβ), phosphorylated tau protein (p-tau) and hippocampal volume ratio (hr), to characterise in more detail mci patients with a poor prognosis. |
2023-08-26 |
2023-09-07 |
Not clear |
| Tong Zhang, Nshunge Musheshe, Christina H J T M van der Veen, Helmut W Kessels, Amalia Dolga, Peter De Deyn, Ulrich Eisel, Martina Schmid. The Expression of Epac2 and GluA3 in an Alzheimer's Disease Experimental Model and Postmortem Patient Samples. Biomedicines. vol 11. issue 8. 2023-08-26. PMID:37626593. |
alzheimer's disease (ad) is one of the most prevalent neurodegenerative diseases, characterized by amyloid beta (aβ) and hyperphosphorylated tau accumulation in the brain. |
2023-08-26 |
2023-09-07 |
Not clear |
| Toshiyuki Murai, Satoru Matsud. Metabolic Reprogramming toward Aerobic Glycolysis and the Gut Microbiota Involved in the Brain Amyloid Pathology. Biology. vol 12. issue 8. 2023-08-26. PMID:37626967. |
alzheimer's disease (ad) is characterized by the formation of senile plaques consisting of fibrillated amyloid-β (aβ), dystrophic neurites, and the neurofibrillary tangles of tau. |
2023-08-26 |
2023-09-07 |
human |
| Timothy J Baumgartner, Zahra Haghighijoo, Nana A Goode, Nolan M Dvorak, Parsa Arman, Fernanda Laezz. Voltage-Gated Na Life (Basel, Switzerland). vol 13. issue 8. 2023-08-26. PMID:37629512. |
voltage-gated na alzheimer's disease (ad) is the most common cause of dementia and is classically characterized by two major histopathological abnormalities: extracellular plaques composed of amyloid beta (aβ) and intracellular hyperphosphorylated tau. |
2023-08-26 |
2023-09-07 |
Not clear |
| Esteban Cruz, Rebecca M Nisbet, Jürgen Göt. Break and accelerator-The mechanics of Tau (and amyloid) toxicity. Cytoskeleton (Hoboken, N.J.). 2023-08-26. PMID:37632370. |
aggregates of the microtubule-associated protein tau define more than a dozen primary tauopathies, and together with amyloid-β, the secondary tauopathy alzheimer's disease (ad). |
2023-08-26 |
2023-09-07 |
Not clear |
| Javaria Baig, Neha Sawant, Priyanka Rawat, Arubala P Reddy, P Hemachandra Reddy, Sudhir Kshirsaga. Abnormal interaction of Rlip with mutant APP/Abeta and phosphorylated tau reduces wild-type Rlip levels and disrupt Rlip function in Alzheimer's disease. Biochimica et biophysica acta. Molecular basis of disease. 2023-08-26. PMID:37633469. |
abnormal interaction of rlip with mutant app/abeta and phosphorylated tau reduces wild-type rlip levels and disrupt rlip function in alzheimer's disease. |
2023-08-26 |
2023-09-07 |
Not clear |
| Javaria Baig, Neha Sawant, Priyanka Rawat, Arubala P Reddy, P Hemachandra Reddy, Sudhir Kshirsaga. Abnormal interaction of Rlip with mutant APP/Abeta and phosphorylated tau reduces wild-type Rlip levels and disrupt Rlip function in Alzheimer's disease. Biochimica et biophysica acta. Molecular basis of disease. 2023-08-26. PMID:37633469. |
mutant app and mutant tau interact with the rlip protein which leads to decreased wild-type rlip levels and disrupt rlip function in alzheimer's disease. |
2023-08-26 |
2023-09-07 |
Not clear |