| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Harindranath Kadavath, Romina V Hofele, Jacek Biernat, Satish Kumar, Katharina Tepper, Henning Urlaub, Eckhard Mandelkow, Markus Zweckstette. Tau stabilizes microtubules by binding at the interface between tubulin heterodimers. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 24. 2015-10-19. PMID:26034266. |
an important microtubule-associated protein is the protein tau, because its microtubule interaction is impaired in the course of alzheimer's disease and several other neurodegenerative diseases. |
2015-10-19 |
2023-08-13 |
Not clear |
| Liliana Letra, Isabel Santana, Raquel Seiç. Obesity as a risk factor for Alzheimer's disease: the role of adipocytokines. Metabolic brain disease. vol 29. issue 3. 2015-10-16. PMID:24553879. |
interestingly, extensive research on the central effects of leptin in alzheimer's disease-transgenic mice has demonstrated its capacity to enhance synaptic plasticity and strength, as well as to prevent beta-amyloid deposition and tau phosphorylation. |
2015-10-16 |
2023-08-12 |
mouse |
| Paul D Dinkel, Michael R Holden, Nadira Matin, Martin Margitta. RNA Binds to Tau Fibrils and Sustains Template-Assisted Growth. Biochemistry. vol 54. issue 30. 2015-10-16. PMID:26177386. |
tau fibrils are the main proteinacious components of neurofibrillary lesions in alzheimer disease. |
2015-10-16 |
2023-08-13 |
human |
| A E Lang, D N Riherd Methner, A Ferreir. Neuronal degeneration, synaptic defects, and behavioral abnormalities in tau₄₅₋₂₃₀ transgenic mice. Neuroscience. vol 275. 2015-10-15. PMID:24952329. |
among these mechanisms, abnormal tau phosphorylation has received the most attention because neurofibrillary tangles present in alzheimer's disease (ad) and related disorders known as tauopathies are composed of hyperphosphorylated forms of this microtubule-associated protein. |
2015-10-15 |
2023-08-13 |
mouse |
| W Li, M Jiang, Y Xiao, X Zhang, S Cui, G Huan. Folic acid inhibits tau phosphorylation through regulation of PP2A methylation in SH-SY5Y cells. The journal of nutrition, health & aging. vol 19. issue 2. 2015-10-15. PMID:25651436. |
neurofibrillary tangles (nfts), which are composed of intracellular filamentous aggregates of hyperphosphorylated tau protein, are one of the pathological hallmarks of alzheimer's disease (ad). |
2015-10-15 |
2023-08-13 |
Not clear |
| Moritz M Hettich, Frank Matthes, Devon P Ryan, Nadine Griesche, Susanne Schröder, Stephanie Dorn, Sybille Krauβ, Dan Ehninge. The anti-diabetic drug metformin reduces BACE1 protein level by interfering with the MID1 complex. PloS one. vol 9. issue 7. 2015-10-14. PMID:25025689. |
alzheimer's disease (ad), the most common form of dementia in the elderly, is characterized by two neuropathological hallmarks: senile plaques, which are composed of aβ peptides, and neurofibrillary tangles, which are composed of hyperphosphorylated tau protein. |
2015-10-14 |
2023-08-13 |
mouse |
| Mahdiyeh Behnam, Fatemeh Ghorbani, Jin-Hong Shin, Dae-Seong Kim, Hojung Jang, Narges Nouri, Maryam Sedghi, Mansoor Salehi, Behnaz Ansari, Keivan Basir. Homozygous MAPT R406W mutation causing FTDP phenotype: A unique instance of a unique mutation. Gene. vol 570. issue 1. 2015-10-09. PMID:26086902. |
the mapt gene is responsible for the major cases of ftdp-17, and tau also has a role in alzheimer's disease. |
2015-10-09 |
2023-08-13 |
Not clear |
| Yumiko Motoi, Kohei Shimada, Koichi Ishiguro, Nobutaka Hattor. Lithium and autophagy. ACS chemical neuroscience. vol 5. issue 6. 2015-10-08. PMID:24738557. |
in neurodegenerative diseases, lithium enhances degradation of aggregate-prone proteins, including mutated huntingtin, phosphorylated tau, and α-synuclein, and causes damaged mitochondria to degrade, while in a mouse model of cerebral ischemia and alzheimer's disease autophagy downregulation by lithium is observed. |
2015-10-08 |
2023-08-13 |
mouse |
| Z-B Zhao, L Wu, R Xiong, L-L Wang, B Zhang, C Wang, H Li, L Liang, S-D Che. MicroRNA-922 promotes tau phosphorylation by downregulating ubiquitin carboxy-terminal hydrolase L1 (UCHL1) expression in the pathogenesis of Alzheimer's disease. Neuroscience. vol 275. 2015-10-07. PMID:24950120. |
microrna-922 promotes tau phosphorylation by downregulating ubiquitin carboxy-terminal hydrolase l1 (uchl1) expression in the pathogenesis of alzheimer's disease. |
2015-10-07 |
2023-08-13 |
mouse |
| Jian Li, Wenwen Li, Jun Zho. [Gene therapy and Alzheimer's disease]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 40. issue 4. 2015-10-07. PMID:25931222. |
alzheimer's disease (ad) is a progressive neurodegenerative disease characterized by the presence of extracellular β-amyloid in the senile plaques, intracellular aggregates of abnormal phosphorylation of tau protein in the neurofibrillary tangles, neuronal loss and cerebrovascular amyloidosis. |
2015-10-07 |
2023-08-13 |
Not clear |
| Sepideh Parsi, Pascal Y Smith, Claudia Goupil, Véronique Dorval, Sébastien S Héber. Preclinical Evaluation of miR-15/107 Family Members as Multifactorial Drug Targets for Alzheimer's Disease. Molecular therapy. Nucleic acids. vol 4. 2015-10-07. PMID:26440600. |
alzheimer's disease (ad) is a multifactorial, fatal neurodegenerative disorder characterized by the abnormal accumulation of aβ and tau deposits in the brain. |
2015-10-07 |
2023-08-13 |
mouse |
| Daniel S Weitzner, Elizabeth B Engler-Chiurazzi, Linda A Kotilinek, Karen Hsiao Ashe, Miranda Nicole Ree. Morris Water Maze Test: Optimization for Mouse Strain and Testing Environment. Journal of visualized experiments : JoVE. issue 100. 2015-10-06. PMID:26132096. |
this is a frequently used background strain to study the age-dependent effects of mutant p301l tau (rtg(taup301l)4510 mice) on the memory deficits associated with alzheimer's disease. |
2015-10-06 |
2023-08-13 |
mouse |
| Stefania Rigacc. Olive Oil Phenols as Promising Multi-targeting Agents Against Alzheimer's Disease. Advances in experimental medicine and biology. vol 863. 2015-10-02. PMID:26092624. |
in the meantime, studies conducted both in vivo and in vitro have started to reveal the great potential of the phenolic component of extra virgin olive oil (mainly oleuropein aglycone and oleocanthal) in counteracting amyloid aggregation and toxicity, with a particular emphasis on the pathways involved in the onset and progression of alzheimer's disease: amyloid precursor protein processing, amyloid-beta (aβ) peptide and tau aggregation, autophagy impairment, neuroinflammation. |
2015-10-02 |
2023-08-13 |
Not clear |
| Chulman Jo, Soner Gundemir, Susanne Pritchard, Youngnam N Jin, Irfan Rahman, Gail V W Johnso. Nrf2 reduces levels of phosphorylated tau protein by inducing autophagy adaptor protein NDP52. Nature communications. vol 5. 2015-10-01. PMID:24667209. |
moreover, ndp52 associates with phosphorylated tau from brain cortical samples of alzheimer disease cases, and the amount of phosphorylated tau in sarkosyl-insoluble fractions is inversely proportional to that of ndp52. |
2015-10-01 |
2023-08-12 |
mouse |
| Jason S Cheng, Ryan Craft, Gui-Qiu Yu, Kaitlyn Ho, Xin Wang, Geetha Mohan, Sergey Mangnitsky, Ravikumar Ponnusamy, Lennart Muck. Tau reduction diminishes spatial learning and memory deficits after mild repetitive traumatic brain injury in mice. PloS one. vol 9. issue 12. 2015-10-01. PMID:25551452. |
because reduction of the microtubule-associated protein tau has beneficial effects in mouse models of alzheimer's disease and epilepsy, we wanted to determine whether this strategy can also improve the outcome of mild traumatic brain injury (tbi). |
2015-10-01 |
2023-08-13 |
mouse |
| Di Xia, Chuanzhou Li, Jürgen Göt. Pseudophosphorylation of Tau at distinct epitopes or the presence of the P301L mutation targets the microtubule-associated protein Tau to dendritic spines. Biochimica et biophysica acta. vol 1852. issue 5. 2015-10-01. PMID:25558816. |
alzheimer's disease is characterized by the accumulation of amyloid-β (aβ) and tau in the brain. |
2015-10-01 |
2023-08-13 |
Not clear |
| Juliana B Hoppe, Christianne G Salbego, Helena Cimarost. SUMOylation: Novel Neuroprotective Approach for Alzheimer's Disease? Aging and disease. vol 6. issue 5. 2015-10-01. PMID:26425387. |
alzheimer's disease (ad) is a progressive neurodegenerative disease characterized in the brain by the formation of amyloid-beta (aβ)-containing plaques and neurofibrillary tangles containing the microtubule-associated protein tau. |
2015-10-01 |
2023-08-13 |
Not clear |
| Cristina Angeloni, Laura Zambonin, Silvana Hreli. Role of methylglyoxal in Alzheimer's disease. BioMed research international. vol 2014. 2015-09-30. PMID:24734229. |
the major hallmarks of alzheimer's disease are extracellular aggregation of amyloid β peptides and, the presence of intracellular neurofibrillary tangles formed by precipitation/aggregation of hyperphosphorylated tau protein. |
2015-09-30 |
2023-08-13 |
Not clear |
| Makoto Higuch. [Cognitive Function and Calcium. Molecular neuroimaging and calcium]. Clinical calcium. vol 25. issue 2. 2015-09-30. PMID:25634049. |
neurodegenerative dementias exemplified by alzheimer's disease are neuropathologically characterized by deposition of protein aggregates such as amyloid β peptide (aβ), tau protein. |
2015-09-30 |
2023-08-13 |
Not clear |
| Yee Lian Chew, Jürgen Götz, Hannah R Nichola. Neuronal protein with tau-like repeats (PTL-1) regulates intestinal SKN-1 nuclear accumulation in response to oxidative stress. Aging cell. vol 14. issue 1. 2015-09-28. PMID:25399685. |
oxidative stress is a central pathomechanism in alzheimer's disease (ad) and other diseases with tau pathology. |
2015-09-28 |
2023-08-13 |
Not clear |