| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hanne Struyfs, José L Molinuevo, Jean-Jacques Martin, Peter Paul De Deyn, Sebastiaan Engelborgh. Validation of the AD-CSF-index in autopsy-confirmed Alzheimer's disease patients and healthy controls. Journal of Alzheimer's disease : JAD. vol 41. issue 3. 2015-09-18. PMID:24705548. |
the cerebrospinal fluid (csf) biomarkers amyloid-β peptide of 42 amino acids (aβ1-42), total tau-protein (t-tau), and tau phosphorylated at threonine 181 (p-tau181p) are used to diagnose alzheimer's disease (ad). |
2015-09-18 |
2023-08-13 |
Not clear |
| Carlos A Saura, Arnaldo Parra-Damas, Lilian Enriquez-Barret. Gene expression parallels synaptic excitability and plasticity changes in Alzheimer's disease. Frontiers in cellular neuroscience. vol 9. 2015-09-18. PMID:26379494. |
alzheimer's disease (ad) is a neurodegenerative disorder characterized by abnormal accumulation of β-amyloid and tau and synapse dysfunction in memory-related neural circuits. |
2015-09-18 |
2023-08-13 |
mouse |
| Edoardo Micotti, Alessandra Paladini, Claudia Balducci, Daniele Tolomeo, Angelisa Frasca, Moira Marizzoni, Marta Filibian, Anna Caroli, Giovanni Valbusa, Sophie Dix, Mike O'Neill, Laurence Ozmen, Christian Czech, Jill C Richardson, Giovanni B Frisoni, Gianluigi Forlon. Striatum and entorhinal cortex atrophy in AD mouse models: MRI comprehensive analysis. Neurobiology of aging. vol 36. issue 2. 2015-09-17. PMID:25433456. |
alzheimer's disease is experimentally modeled in transgenic (tg) mice overexpressing mutated forms of the human amyloid precursor protein either alone or combined with mutated presenilins and tau. |
2015-09-17 |
2023-08-13 |
mouse |
| Anastasia Noël, Isabelle Poitras, Jacinthe Julien, Franck R Petry, Françoise Morin, Jean Charron, Emmanuel Plane. ERK (MAPK) does not phosphorylate tau under physiological conditions in vivo or in vitro. Neurobiology of aging. vol 36. issue 2. 2015-09-17. PMID:25491074. |
alzheimer's disease is characterized by the deposition of intracellular aggregates of hyperphosphorylated tau protein. |
2015-09-17 |
2023-08-13 |
mouse |
| Federica Prati, Angela De Simone, Paola Bisignano, Andrea Armirotti, Maria Summa, Daniela Pizzirani, Rita Scarpelli, Daniel I Perez, Vincenza Andrisano, Ana Perez-Castillo, Barbara Monti, Francesca Massenzio, Letizia Polito, Marco Racchi, Angelo D Favia, Giovanni Bottegoni, Ana Martinez, Maria Laura Bolognesi, Andrea Cavall. Multitarget drug discovery for Alzheimer's disease: triazinones as BACE-1 and GSK-3β inhibitors. Angewandte Chemie (International ed. in English). vol 54. issue 5. 2015-09-17. PMID:25504761. |
cumulative evidence strongly supports that the amyloid and tau hypotheses are not mutually exclusive, but concomitantly contribute to neurodegeneration in alzheimer's disease (ad). |
2015-09-17 |
2023-08-13 |
mouse |
| F Clavaguera, J Hench, M Goedert, M Tolna. Invited review: Prion-like transmission and spreading of tau pathology. Neuropathology and applied neurobiology. vol 41. issue 1. 2015-09-15. PMID:25399729. |
in the most prevalent tauopathy, alzheimer's disease, tau pathology progresses in a stereotypical manner with the first lesions appearing in the locus coeruleus and the entorhinal cortex from where they appear to spread to the hippocampus and neocortex. |
2015-09-15 |
2023-08-13 |
Not clear |
| Chiho Ishida, Katsuji Kobayashi, Tatsuru Kitamura, Hiroshi Ujike, Kazuo Iwasa, Masahito Yamad. Frontotemporal dementia with parkinsonism linked to chromosome 17 with the MAPT R406W mutation presenting with a broad distribution of abundant senile plaques. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 35. issue 1. 2015-09-14. PMID:25377499. |
this patient showed alzheimer's disease (ad)-like clinical manifestations from the age of 59, with reduced β-amyloid1-42 (aβ42 ) and elevated total and phosphorylated tau levels in the cerebrospinal fluid. |
2015-09-14 |
2023-08-13 |
Not clear |
| Qin Chen, Yi-Qing Chen, Hai-Yan Ye, Jain-Qi Yu, Qi-Quan Shi, Yan Huan. [The mechanism of tenuigenin for eliminating waste product accumulation in cerebral neurons of Alzheimer's disease rats via ubiquitin-proteasome pathway]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. vol 35. issue 3. 2015-09-13. PMID:25951639. |
to explore the scavenging action of tenuigenin (ten) on intracerebral amyloid β protein (aβ) aggregation and the abnormal phosphorylated tau protein and its mechanism in alzheimer's disease (ad) rats' brain. |
2015-09-13 |
2023-08-13 |
rat |
| Xiao-Ling Liu, Ji-Ying Hu, Meng-Yun Hu, Yi Zhang, Zheng-Yuan Hong, Xiao-Qing Cheng, Jie Chen, Dai-Wen Pang, Yi Lian. Sequence-dependent abnormal aggregation of human Tau fragment in an inducible cell model. Biochimica et biophysica acta. vol 1852. issue 8. 2015-09-11. PMID:25912737. |
a pathological hallmark of alzheimer disease (ad) is the accumulation of misfolded hyperphosphorylated microtubule-associated protein tau within neurons, forming neurofibrillary tangles and leading to synaptic dysfunction and neuronal death. |
2015-09-11 |
2023-08-13 |
human |
| Hilda Mirbaha, Brandon B Holmes, David W Sanders, Jan Bieschke, Marc I Diamon. Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation. The Journal of biological chemistry. vol 290. issue 24. 2015-09-10. PMID:25887395. |
we studied recombinant tau repeat domain (rd) and tau assemblies purified from alzheimer disease (ad) brain composed largely of full-length tau. |
2015-09-10 |
2023-08-13 |
Not clear |
| Nana Jin, Xiaomin Yin, Jianlan Gu, Xinhua Zhang, Jianhua Shi, Wei Qian, Yuhua Ji, Maohong Cao, Xiaosong Gu, Fei Ding, Khalid Iqbal, Cheng-Xin Gong, Fei Li. Truncation and Activation of Dual Specificity Tyrosine Phosphorylation-regulated Kinase 1A by Calpain I: A MOLECULAR MECHANISM LINKED TO TAU PATHOLOGY IN ALZHEIMER DISEASE. The Journal of biological chemistry. vol 290. issue 24. 2015-09-10. PMID:25918155. |
truncation and activation of dual specificity tyrosine phosphorylation-regulated kinase 1a by calpain i: a molecular mechanism linked to tau pathology in alzheimer disease. |
2015-09-10 |
2023-08-13 |
mouse |
| Nana Jin, Xiaomin Yin, Jianlan Gu, Xinhua Zhang, Jianhua Shi, Wei Qian, Yuhua Ji, Maohong Cao, Xiaosong Gu, Fei Ding, Khalid Iqbal, Cheng-Xin Gong, Fei Li. Truncation and Activation of Dual Specificity Tyrosine Phosphorylation-regulated Kinase 1A by Calpain I: A MOLECULAR MECHANISM LINKED TO TAU PATHOLOGY IN ALZHEIMER DISEASE. The Journal of biological chemistry. vol 290. issue 24. 2015-09-10. PMID:25918155. |
hyperphosphorylation and dysregulation of exon 10 splicing of tau are pivotally involved in pathogenesis of alzheimer disease (ad) and/or other tauopathies. |
2015-09-10 |
2023-08-13 |
mouse |
| William B Pratt, Jason E Gestwicki, Yoichi Osawa, Andrew P Lieberma. Targeting Hsp90/Hsp70-based protein quality control for treatment of adult onset neurodegenerative diseases. Annual review of pharmacology and toxicology. vol 55. 2015-09-09. PMID:25292434. |
critical target proteins that unfold and aggregate in these diseases, such as the polyglutamine androgen receptor in spinal and bulbar muscular atrophy, huntingtin in huntington's disease, α-synuclein in parkinson's disease, and tau in alzheimer's disease, are client proteins of heat shock protein 90 (hsp90), and their turnover is regulated by the protein quality control function of the hsp90/hsp70-based chaperone machinery. |
2015-09-09 |
2023-08-13 |
Not clear |
| Jayanthi Repalli, Daniel Meruel. Screening strategies to identify HSP70 modulators to treat Alzheimer's disease. Drug design, development and therapy. vol 9. 2015-09-09. PMID:25609918. |
in patients with alzheimer's disease, beta amyloids and tau proteins form plaques/oligomers and oligomers/tangles that affect the ability of neurons to function properly. |
2015-09-09 |
2023-08-13 |
Not clear |
| J M van der Harg, A Nölle, R Zwart, A S Boerema, E S van Haastert, A M Strijkstra, J Jm Hoozemans, W Schepe. The unfolded protein response mediates reversible tau phosphorylation induced by metabolic stress. Cell death & disease. vol 5. 2015-09-08. PMID:25165879. |
the unfolded protein response (upr) is activated in neurodegenerative tauopathies such as alzheimer's disease (ad) in close connection with early stages of tau pathology. |
2015-09-08 |
2023-08-13 |
Not clear |
| Monique Richter, Agneta Mewes, Manuela Fritsch, Ute Krügel, Ralf Hoffmann, David Singe. Doubly Phosphorylated Peptide Vaccines to Protect Transgenic P301S Mice against Alzheimer's Disease Like Tau Aggregation. Vaccines. vol 2. issue 3. 2015-09-08. PMID:26344748. |
doubly phosphorylated peptide vaccines to protect transgenic p301s mice against alzheimer's disease like tau aggregation. |
2015-09-08 |
2023-08-13 |
mouse |
| N Maritza Dowling, Sterling C Johnson, Carey E Gleason, William J Jagus. The mediational effects of FDG hypometabolism on the association between cerebrospinal fluid biomarkers and neurocognitive function. NeuroImage. vol 105. 2015-09-03. PMID:25450107. |
positive cerebrospinal fluid (csf) biomarkers of tau and amyloid beta42 suggest possible active underlying alzheimer's disease (ad) including neurometabolic dysfunction and neurodegeneration leading to eventual cognitive decline. |
2015-09-03 |
2023-08-13 |
Not clear |
| Michel Goeder. NEURODEGENERATION. Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled Aβ, tau, and α-synuclein. Science (New York, N.Y.). vol 349. issue 6248. 2015-09-03. PMID:26250687. |
alzheimer's and parkinson's diseases: the prion concept in relation to assembled aβ, tau, and α-synuclein. |
2015-09-03 |
2023-08-13 |
Not clear |
| Michel Goeder. NEURODEGENERATION. Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled Aβ, tau, and α-synuclein. Science (New York, N.Y.). vol 349. issue 6248. 2015-09-03. PMID:26250687. |
the pathological assembly of aβ, tau, and α-synuclein is at the heart of alzheimer's and parkinson's diseases. |
2015-09-03 |
2023-08-13 |
Not clear |
| Michel Goeder. NEURODEGENERATION. Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled Aβ, tau, and α-synuclein. Science (New York, N.Y.). vol 349. issue 6248. 2015-09-03. PMID:26250687. |
extracellular deposits of aβ and intraneuronal tau inclusions define alzheimer's disease, whereas intracellular inclusions of α-synuclein make up the lewy pathology of parkinson's disease. |
2015-09-03 |
2023-08-13 |
Not clear |