| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Peter Filipcik, Martin Cente, Norbert Zilka, Tomas Smolek, Jozef Hanes, Juraj Kucerak, Alena Opattova, Branislav Kovacech, Michal Nova. Intraneuronal accumulation of misfolded tau protein induces overexpression of Hsp27 in activated astrocytes. Biochimica et biophysica acta. vol 1852. issue 7. 2015-08-27. PMID:25772164. |
accumulation of misfolded forms of microtubule associated, neuronal protein tau causes neurofibrillary degeneration typical of alzheimer's disease and other tauopathies. |
2015-08-27 |
2023-08-13 |
rat |
| María Berrocal, Isaac Corbacho, María Vázquez-Hernández, Jesús Ávila, M Rosario Sepúlveda, Ana M Mat. Inhibition of PMCA activity by tau as a function of aging and Alzheimer's neuropathology. Biochimica et biophysica acta. vol 1852. issue 7. 2015-08-27. PMID:25892185. |
inhibition of pmca activity by tau as a function of aging and alzheimer's neuropathology. |
2015-08-27 |
2023-08-13 |
mouse |
| Marica Mariano, Christian Schmitt, Parisa Miralinaghi, Marco Catto, Rolf W Hartmann, Angelo Carotti, Matthias Enge. First selective dual inhibitors of tau phosphorylation and Beta-amyloid aggregation, two major pathogenic mechanisms in Alzheimer's disease. ACS chemical neuroscience. vol 5. issue 12. 2015-08-25. PMID:25247807. |
first selective dual inhibitors of tau phosphorylation and beta-amyloid aggregation, two major pathogenic mechanisms in alzheimer's disease. |
2015-08-25 |
2023-08-13 |
Not clear |
| María del Carmen Cárdenas-Aguayo, Laura Gómez-Virgilio, Steven DeRosa, Marco Antonio Meraz-Río. The role of tau oligomers in the onset of Alzheimer's disease neuropathology. ACS chemical neuroscience. vol 5. issue 12. 2015-08-25. PMID:25268947. |
the role of tau oligomers in the onset of alzheimer's disease neuropathology. |
2015-08-25 |
2023-08-13 |
Not clear |
| Weijie Xu, Yan Yang, Gang Yuan, Wenjun Zhu, Delin Ma, Shuhong H. Exendin-4, a glucagon-like peptide-1 receptor agonist, reduces Alzheimer disease-associated tau hyperphosphorylation in the hippocampus of rats with type 2 diabetes. Journal of investigative medicine : the official publication of the American Federation for Clinical Research. vol 63. issue 2. 2015-08-25. PMID:25479064. |
exendin-4, a glucagon-like peptide-1 receptor agonist, reduces alzheimer disease-associated tau hyperphosphorylation in the hippocampus of rats with type 2 diabetes. |
2015-08-25 |
2023-08-13 |
rat |
| Zhi Tang, Eniko Ioja, Erika Bereczki, Kjell Hultenby, Chunxia Li, Zhizhong Guan, Bengt Winblad, Jin-Jing Pe. mTor mediates tau localization and secretion: Implication for Alzheimer's disease. Biochimica et biophysica acta. vol 1853. issue 7. 2015-08-25. PMID:25791428. |
mtor mediates tau localization and secretion: implication for alzheimer's disease. |
2015-08-25 |
2023-08-13 |
human |
| Zhi Tang, Eniko Ioja, Erika Bereczki, Kjell Hultenby, Chunxia Li, Zhizhong Guan, Bengt Winblad, Jin-Jing Pe. mTor mediates tau localization and secretion: Implication for Alzheimer's disease. Biochimica et biophysica acta. vol 1853. issue 7. 2015-08-25. PMID:25791428. |
abnormally hyperphosphorylated tau aggregates form paired helical filaments (phfs) in neurofibrillary tangles, a key hallmark of alzheimer's disease (ad) and other tauopathies. |
2015-08-25 |
2023-08-13 |
human |
| Genadiy Fonar, Abraham O Samso. NMR structure of the water soluble Aβ17-34 peptide. Bioscience reports. vol 34. issue 6. 2015-08-24. PMID:25284368. |
alzheimer's disease is characterized by aggregation of two proteins in the brain namely aβ (amyloid β) and tau. |
2015-08-24 |
2023-08-13 |
Not clear |
| Claire Paquet, Julien Dumurgier, Jacques Hugo. Pro-Apoptotic Kinase Levels in Cerebrospinal Fluid as Potential Future Biomarkers in Alzheimer's Disease. Frontiers in neurology. vol 6. 2015-08-24. PMID:26300842. |
alzheimer's disease (ad) is characterized by the accumulation of aβ peptides, hyperphosphorylated tau proteins, and neuronal loss in the brain of affected patients. |
2015-08-24 |
2023-08-13 |
human |
| Ilaria Dal Prà, Anna Chiarini, Li Gui, Balu Chakravarthy, Raffaella Pacchiana, Emanuela Gardenal, James F Whitfield, Ubaldo Armat. Do astrocytes collaborate with neurons in spreading the "infectious" aβ and Tau drivers of Alzheimer's disease? The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 21. issue 1. 2015-08-21. PMID:24740577. |
do astrocytes collaborate with neurons in spreading the "infectious" aβ and tau drivers of alzheimer's disease? |
2015-08-21 |
2023-08-13 |
human |
| Ilaria Dal Prà, Anna Chiarini, Li Gui, Balu Chakravarthy, Raffaella Pacchiana, Emanuela Gardenal, James F Whitfield, Ubaldo Armat. Do astrocytes collaborate with neurons in spreading the "infectious" aβ and Tau drivers of Alzheimer's disease? The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 21. issue 1. 2015-08-21. PMID:24740577. |
evidence has begun emerging for the "contagious" and destructive aβ42 (amyloid-beta42) oligomers and phosphorylated tau oligomers as drivers of sporadic alzheimer's disease (ad), which advances along a pathway starting from the brainstem or entorhinal cortex and leading to cognition-related upper cerebral cortex regions. |
2015-08-21 |
2023-08-13 |
human |
| Kristina Paholikova, Barbara Salingova, Alena Opattova, Rostislav Skrabana, Petra Majerova, Norbert Zilka, Branislav Kovacech, Monika Zilkova, Peter Barath, Michal Nova. N-terminal truncation of microtubule associated protein tau dysregulates its cellular localization. Journal of Alzheimer's disease : JAD. vol 43. issue 3. 2015-08-21. PMID:25147106. |
under pathological conditions, tau undergoes multiple modifications that lead to the formation of insoluble deposits in neurons, resulting in neuronal dysfunction in several neurodegenerative disorders collectively called tauopathies, with alzheimer's disease being the most frequent example. |
2015-08-21 |
2023-08-13 |
human |
| Sarah M Ciupek, Jingheng Cheng, Yousuf O Ali, Hui-Chen Lu, Daoyun J. Progressive functional impairments of hippocampal neurons in a tauopathy mouse model. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 21. 2015-08-20. PMID:26019329. |
the age-dependent progression of tau pathology is a major characteristic of tauopathies, including alzheimer's disease (ad), and plays an important role in the behavioral phenotypes of ad, including memory deficits. |
2015-08-20 |
2023-08-13 |
mouse |
| Kim Henriksen, Inger Byrjalsen, Claus Christiansen, Morten Asser Karsda. Relationship between serum levels of tau fragments and clinical progression of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 43. issue 4. 2015-08-18. PMID:25171717. |
relationship between serum levels of tau fragments and clinical progression of alzheimer's disease. |
2015-08-18 |
2023-08-13 |
Not clear |
| Rasha M Hussein, Reem M Hashem, Laila A Rashe. Evaluation of the amyloid beta-GFP fusion protein as a model of amyloid beta peptides-mediated aggregation: a study of DNAJB6 chaperone. Frontiers in molecular neuroscience. vol 8. 2015-08-18. PMID:26283911. |
alzheimer's disease (ad) is a progressive neurodegenerative disease characterized by the accumulation and aggregation of extracellular amyloid β (aβ) peptides and intracellular aggregation of hyper-phosphorylated tau protein. |
2015-08-18 |
2023-08-13 |
human |
| Bess Frost, Jürgen Götz, Mel B Fean. Connecting the dots between tau dysfunction and neurodegeneration. Trends in cell biology. vol 25. issue 1. 2015-08-17. PMID:25172552. |
identifying the causes of abnormal tau phosphorylation and subsequent aggregation has been the focus of much research, and is currently a major target for the development of therapeutic interventions for tauopathies, including alzheimer's disease (ad). |
2015-08-17 |
2023-08-13 |
Not clear |
| Ting-Ting Chu, Qian-Qian Li, Tian Qiu, Zhan-Yi Sun, Zhi-Wen Hu, Yong-Xiang Chen, Yu-Fen Zhao, Yan-Mei L. Clearance of the intracellular high level of the tau protein directed by an artificial synthetic hydrolase. Molecular bioSystems. vol 10. issue 12. 2015-08-14. PMID:25308803. |
promoting clearance of intracellular excessive tau is a potential therapeutic strategy for treating alzheimer's disease. |
2015-08-14 |
2023-08-13 |
Not clear |
| Juciano Gasparotto, Mario Roberto Senger, Alice Kunzler, Adriana Degrossoli, Salvatore Giovanni de Simone, Rafael Calixto Bortolin, Nauana Somensi, Carolina Saibro Girardi, Celeste da Silva Freitas de Souza, Kátia da Silva Calabrese, Felipe Dal-Pizzol, José Claudio Fonseca Moreira, Floriano Paes Silva, Daniel Pens Gelai. Increased tau phosphorylation and receptor for advanced glycation endproducts (RAGE) in the brain of mice infected with Leishmania amazonensis. Brain, behavior, and immunity. vol 43. 2015-08-07. PMID:25014011. |
the aim of the present work was to investigate if peripheral infection of balb/c mice with leishmania amazonensis affects tau phosphorylation and rage protein content in the brain, which represent biochemical markers of neurodegenerative processes observed in diseases with a pro-inflammatory component, including alzheimer's disease and down syndrome. |
2015-08-07 |
2023-08-13 |
mouse |
| Petra Majerova, Monika Zilkova, Zuzana Kazmerova, Andrej Kovac, Kristina Paholikova, Branislav Kovacech, Norbert Zilka, Michal Nova. Microglia display modest phagocytic capacity for extracellular tau oligomers. Journal of neuroinflammation. vol 11. 2015-08-07. PMID:25217135. |
abnormal misfolded tau protein is a driving force of neurofibrillary degeneration in alzheimer's disease. |
2015-08-07 |
2023-08-13 |
Not clear |
| Nicole Maphis, Guixiang Xu, Olga N Kokiko-Cochran, Shanya Jiang, Astrid Cardona, Richard M Ransohoff, Bruce T Lamb, Kiran Bhaska. Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain. Brain : a journal of neurology. vol 138. issue Pt 6. 2015-08-07. PMID:25833819. |
pathological aggregation of tau is a hallmark of alzheimer's disease and related tauopathies. |
2015-08-07 |
2023-08-13 |
mouse |