| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D Felsky, P Szeszko, L Yu, W G Honer, P L De Jager, J A Schneider, A K Malhotra, T Lencz, T Ikuta, J Pipitone, M M Chakravarty, N J Lobaugh, B H Mulsant, B G Pollock, J L Kennedy, D A Bennett, A N Voinesko. The SORL1 gene and convergent neural risk for Alzheimer's disease across the human lifespan. Molecular psychiatry. vol 19. issue 10. 2015-08-06. PMID:24166411. |
four independent samples were analyzed to determine effects of sorl1 genetic risk variants across the lifespan at multiple phenotypic levels: (1) microstructural integrity of white matter using diffusion tensor imaging in two healthy control samples (n=118, age 18-86; n=68, age 8-40); (2) gene expression using the braincloud postmortem healthy control sample (n=269, age 0-92) and (3) alzheimer's neuropathology (amyloid plaques and tau tangles) using a postmortem sample of healthy, mild cognitive impairment (mci) and alzheimer's individuals (n=710, age 66-108). |
2015-08-06 |
2023-08-12 |
human |
| Asami Kondo, Koorosh Shahpasand, Rebekah Mannix, Jianhua Qiu, Juliet Moncaster, Chun-Hau Chen, Yandan Yao, Yu-Min Lin, Jane A Driver, Yan Sun, Shuo Wei, Man-Li Luo, Onder Albayram, Pengyu Huang, Alexander Rotenberg, Akihide Ryo, Lee E Goldstein, Alvaro Pascual-Leone, Ann C McKee, William Meehan, Xiao Zhen Zhou, Kun Ping L. Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy. Nature. vol 523. issue 7561. 2015-08-06. PMID:26176913. |
traumatic brain injury (tbi), characterized by acute neurological dysfunction, is one of the best known environmental risk factors for chronic traumatic encephalopathy and alzheimer's disease, the defining pathologic features of which include tauopathy made of phosphorylated tau protein (p-tau). |
2015-08-06 |
2023-08-13 |
mouse |
| YoungDoo Kim, Hyejin Park, Jihoon Nah, Seowon Moon, WonJae Lee, Se-Hoon Hong, Tae-In Kam, Yong-Keun Jun. Essential role of POLDIP2 in Tau aggregation and neurotoxicity via autophagy/proteasome inhibition. Biochemical and biophysical research communications. vol 462. issue 2. 2015-08-04. PMID:25930997. |
in alzheimer's disease and other tauopathy, abnormal tau proteins form intracellular aggregates and tau filaments. |
2015-08-04 |
2023-08-13 |
human |
| Toshiki Uchihar. Pretangles and neurofibrillary changes: similarities and differences between AD and CBD based on molecular and morphological evolution. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 34. issue 6. 2015-08-03. PMID:24612177. |
in alzheimer disease, such tau deposition is considered to represent a premature state prior to fibril formation (ad-pretangles), later to form neurofibrillary tangles and finally ghost tangles. |
2015-08-03 |
2023-08-12 |
Not clear |
| Irene López-González, Margarita Carmona, Laura Arregui, Gabor G Kovacs, Isidre Ferre. αB-crystallin and HSP27 in glial cells in tauopathies. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 34. issue 6. 2015-08-03. PMID:24985029. |
the objective of this work was to assess the expression of αb-crystallin, phosphorylated αb-crystallin at ser59 and hsp27 in glial cells with and without tau deposits in progressive supranuclear palsy, corticobasal degeneration (cbd), argyrophilic grain disease (agd), pick's disease (pid), alzheimer's disease, frontotemporal lobar degeneration associated with mutations in the tau gene (ftld-tau), globular glial tauopathy (ggt) and tauopathy in the elderly. |
2015-08-03 |
2023-08-13 |
Not clear |
| N El Kadmiri, I Slassi, B El Moutawakil, S Nadifi, A Tadevosyan, A Hachem, A Soukr. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and Alzheimer's disease. Pathologie-biologie. vol 62. issue 6. 2015-08-03. PMID:25246025. |
neuroproteomics have revealed high affinity interactions between gapdh and alzheimer's disease-associated proteins, including the β-amyloid, β-amyloid precursor protein and tau. |
2015-08-03 |
2023-08-13 |
Not clear |
| Katryna Cisek, Grace L Cooper, Carol J Huseby, Jeff Kure. Structure and mechanism of action of tau aggregation inhibitors. Current Alzheimer research. vol 11. issue 10. 2015-08-03. PMID:25387336. |
although direct inhibition of tau aggregation has shown promise as a potential treatment strategy for depressing neurofibrillary lesion formation in alzheimer's disease, the mechanism of action of these compounds has been unclear. |
2015-08-03 |
2023-08-13 |
Not clear |
| Wei-Yi Ong, Tahira Farooqui, Hwee-Ling Koh, Akhlaq A Farooqui, Eng-Ang Lin. Protective effects of ginseng on neurological disorders. Frontiers in aging neuroscience. vol 7. 2015-08-03. PMID:26236231. |
the molecular mechanisms of the neuroprotective effects of ginseng in alzheimer's disease (ad) including β-amyloid (aβ) formation, tau hyperphosphorylation and oxidative stress, major depression, stroke, parkinson's disease and multiple sclerosis are presented. |
2015-08-03 |
2023-08-13 |
Not clear |
| . Correction: Tau overexpression impacts a neuroinflammation gene expression network perturbed in Alzheimer's disease. PloS one. vol 10. issue 3. 2015-07-31. PMID:25812032. |
correction: tau overexpression impacts a neuroinflammation gene expression network perturbed in alzheimer's disease. |
2015-07-31 |
2023-08-13 |
Not clear |
| Flora H Duits, Charlotte E Teunissen, Femke H Bouwman, Pieter-Jelle Visser, Niklas Mattsson, Henrik Zetterberg, Kaj Blennow, Oskar Hansson, Lennart Minthon, Niels Andreasen, Jan Marcusson, Anders Wallin, Marcel Olde Rikkert, Magda Tsolaki, Lucilla Parnetti, Sanna-Kaisa Herukka, Harald Hampel, Mony J De Leon, Johannes Schröder, Dag Aarsland, Marinus A Blankenstein, Philip Scheltens, Wiesje M van der Flie. The cerebrospinal fluid "Alzheimer profile": easily said, but what does it mean? Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 10. issue 6. 2015-07-30. PMID:24721526. |
we aimed to identify the most useful definition of the "cerebrospinal fluid alzheimer profile," based on amyloid-ß1-42 (aβ42), total tau, and phosphorylated tau (p-tau), for diagnosis and prognosis of alzheimer's disease (ad). |
2015-07-30 |
2023-08-13 |
Not clear |
| Jinfeng Zhao, Dan Wang, Lingmin Li, Wenhui Zhao, Ce Zhan. Protective effects of humanin on okadaic Acid-induced neurotoxicities in cultured cortical neurons. Neurochemical research. vol 39. issue 11. 2015-07-29. PMID:25142935. |
neurofibrillary tangles are pathological hallmarks of alzheimer's disease (ad), which are mostly composed of hyperphosphorylated tau and directly correlate with dementia in ad patients. |
2015-07-29 |
2023-08-13 |
Not clear |
| Eve Peeraer, Astrid Bottelbergs, Kristof Van Kolen, Ilie-Cosmin Stancu, Bruno Vasconcelos, Michel Mahieu, Hilde Duytschaever, Luc Ver Donck, An Torremans, Ellen Sluydts, Nathalie Van Acker, John A Kemp, Marc Mercken, Kurt R Brunden, John Q Trojanowski, Ilse Dewachter, Virginia M Y Lee, Diederik Moechar. Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice. Neurobiology of disease. vol 73. 2015-07-29. PMID:25220759. |
neurofibrillary tangles composed of hyperphosphorylated fibrillized tau are found in numerous tauopathies including alzheimer's disease. |
2015-07-29 |
2023-08-13 |
mouse |
| Eve Peeraer, Astrid Bottelbergs, Kristof Van Kolen, Ilie-Cosmin Stancu, Bruno Vasconcelos, Michel Mahieu, Hilde Duytschaever, Luc Ver Donck, An Torremans, Ellen Sluydts, Nathalie Van Acker, John A Kemp, Marc Mercken, Kurt R Brunden, John Q Trojanowski, Ilse Dewachter, Virginia M Y Lee, Diederik Moechar. Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice. Neurobiology of disease. vol 73. 2015-07-29. PMID:25220759. |
these results further validate the utility of the tau seeding model in studying disease transmission, and provide a more complete in vivo tauopathy model with associated neurodegeneration which can be used to investigate the mechanisms involved in tau aggregation and spreading, as well as aid in the search for disease modifying treatments for alzheimer's disease and related tauopathies. |
2015-07-29 |
2023-08-13 |
mouse |
| Keith A Vossel, Jordan C Xu, Vira Fomenko, Takashi Miyamoto, Elsa Suberbielle, Joseph A Knox, Kaitlyn Ho, Daniel H Kim, Gui-Qiu Yu, Lennart Muck. Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β. The Journal of cell biology. vol 209. issue 3. 2015-07-29. PMID:25963821. |
axonal transport deficits in alzheimer's disease (ad) are attributed to amyloid β (aβ) peptides and pathological forms of the microtubule-associated protein tau. |
2015-07-29 |
2023-08-13 |
mouse |
| Charles R Harrington, John M D Storey, Scott Clunas, Kathleen A Harrington, David Horsley, Ahtsham Ishaq, Steven J Kemp, Christopher P Larch, Colin Marshall, Sarah L Nicoll, Janet E Rickard, Michael Simpson, James P Sinclair, Lynda J Storey, Claude M Wischi. Cellular Models of Aggregation-dependent Template-directed Proteolysis to Characterize Tau Aggregation Inhibitors for Treatment of Alzheimer Disease. The Journal of biological chemistry. vol 290. issue 17. 2015-07-28. PMID:25759392. |
cellular models of aggregation-dependent template-directed proteolysis to characterize tau aggregation inhibitors for treatment of alzheimer disease. |
2015-07-28 |
2023-08-13 |
mouse |
| Charles R Harrington, John M D Storey, Scott Clunas, Kathleen A Harrington, David Horsley, Ahtsham Ishaq, Steven J Kemp, Christopher P Larch, Colin Marshall, Sarah L Nicoll, Janet E Rickard, Michael Simpson, James P Sinclair, Lynda J Storey, Claude M Wischi. Cellular Models of Aggregation-dependent Template-directed Proteolysis to Characterize Tau Aggregation Inhibitors for Treatment of Alzheimer Disease. The Journal of biological chemistry. vol 290. issue 17. 2015-07-28. PMID:25759392. |
alzheimer disease (ad) is a degenerative tauopathy characterized by aggregation of tau protein through the repeat domain to form intraneuronal paired helical filaments (phfs). |
2015-07-28 |
2023-08-13 |
mouse |
| Maria João Leitão, Inês Baldeiras, Sanna-Kaisa Herukka, Maria Pikkarainen, Ville Leinonen, Anja Hviid Simonsen, Armand Perret-Liaudet, Anthony Fourier, Isabelle Quadrio, Pedro Mota Veiga, Catarina Resende de Oliveir. Chasing the Effects of Pre-Analytical Confounders - A Multicenter Study on CSF-AD Biomarkers. Frontiers in neurology. vol 6. 2015-07-28. PMID:26217300. |
core cerebrospinal fluid (csf) biomarkers - aβ42, tau, and phosphorylated tau (ptau) - have been recently incorporated in the revised criteria for alzheimer's disease (ad). |
2015-07-28 |
2023-08-13 |
Not clear |
| J Koppel, H Jimenez, M Azose, C D'Abramo, C Acker, J Buthorn, B S Greenwald, J Lewis, M Lesser, Z Liu, P Davie. Pathogenic tau species drive a psychosis-like phenotype in a mouse model of Alzheimer's disease. Behavioural brain research. vol 275. 2015-07-24. PMID:25151619. |
pathogenic tau species drive a psychosis-like phenotype in a mouse model of alzheimer's disease. |
2015-07-24 |
2023-08-13 |
mouse |
| J Koppel, H Jimenez, M Azose, C D'Abramo, C Acker, J Buthorn, B S Greenwald, J Lewis, M Lesser, Z Liu, P Davie. Pathogenic tau species drive a psychosis-like phenotype in a mouse model of Alzheimer's disease. Behavioural brain research. vol 275. 2015-07-24. PMID:25151619. |
psychotic alzheimer's disease (ad+p) is a rapidly progressive variant of ad associated with an increased burden of frontal tau pathology that affects up to 50% of those with ad, and is observed more commonly in females. |
2015-07-24 |
2023-08-13 |
mouse |
| Ethan A Winkler, Abhay P Sagare, Berislav V Zlokovi. The pericyte: a forgotten cell type with important implications for Alzheimer's disease? Brain pathology (Zurich, Switzerland). vol 24. issue 4. 2015-07-23. PMID:24946075. |
pericytes are cells in the blood-brain barrier (bbb) that degenerate in alzheimer's disease (ad), a neurodegenerative disorder characterized by early neurovascular dysfunction, elevation of amyloid β-peptide (aβ), tau pathology and neuronal loss, leading to progressive cognitive decline and dementia. |
2015-07-23 |
2023-08-13 |
Not clear |