| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Takeshi Kanno, Ayako Tsuchiya, Tomoyuki Nishizak. Hyperphosphorylation of Tau at Ser396 occurs in the much earlier stage than appearance of learning and memory disorders in 5XFAD mice. Behavioural brain research. vol 274. 2015-05-26. PMID:25172181. |
the present study investigated the relation of age-dependent spatial learning/memory impairment and tau phosphorylation in 5xfad mice, a model of alzheimer's disease. |
2015-05-26 |
2023-08-13 |
mouse |
| Young Ju Lee, Ji Eun Kim, Moon Hwa Kwak, Jun Go, Seung Yun Yang, Hyeog Soong Kwon, Byoung Chul Kim, Joo Man Kim, Dae Youn Hwan. Selenium treatment significantly inhibits tumor necrosis factor-α-induced cell death and tau hyperphosphorylation in neuroblastoma cells. Molecular medicine reports. vol 10. issue 4. 2015-05-22. PMID:25109896. |
the hyperphosphorylation of the protein tau disrupts its normal function on regulating axonal transport and leads to the accumulation of neurofibrillary tangles (nft), which are involved in the pathogenesis of alzheimer's disease (ad). |
2015-05-22 |
2023-08-13 |
Not clear |
| Liang Wang, Tammie L Benzinger, Jason Hassenstab, Tyler Blazey, Christopher Owen, Jingxia Liu, Anne M Fagan, John C Morris, Beau M Ance. Spatially distinct atrophy is linked to β-amyloid and tau in preclinical Alzheimer disease. Neurology. vol 84. issue 12. 2015-05-22. PMID:25716355. |
spatially distinct atrophy is linked to β-amyloid and tau in preclinical alzheimer disease. |
2015-05-22 |
2023-08-13 |
Not clear |
| Rozalyn A Simon, Hamid Shirani, K O Andreas Aslund, Marcus Bäck, Vahram Haroutunian, Sam Gandy, K Peter R Nilsso. Pentameric thiophene-based ligands that spectrally discriminate amyloid-β and tau aggregates display distinct solvatochromism and viscosity-induced spectral shifts. Chemistry (Weinheim an der Bergstrasse, Germany). vol 20. issue 39. 2015-05-20. PMID:25111601. |
in this regard, luminescent conjugated oligothiophenes (lcos) have proven useful for spectral discrimination of amyloid-beta (aβ) and tau neurofibrillary tangles (nfts), two of the pathological hallmarks associated with alzheimer's disease. |
2015-05-20 |
2023-08-13 |
Not clear |
| Thanh D Do, Nicholas J Economou, Ali Chamas, Steven K Buratto, Joan-Emma Shea, Michael T Bower. Interactions between amyloid-β and Tau fragments promote aberrant aggregates: implications for amyloid toxicity. The journal of physical chemistry. B. vol 118. issue 38. 2015-05-20. PMID:25153942. |
we have investigated at the oligomeric level interactions between aβ(25-35) and tau(273-284), two important fragments of the amyloid-β and tau proteins, implicated in alzheimer's disease. |
2015-05-20 |
2023-08-13 |
Not clear |
| Huan Lu, Xi-Chen Zhu, Teng Jiang, Jin-Tai Yu, Lan Ta. Body fluid biomarkers in Alzheimer's disease. Annals of translational medicine. vol 3. issue 5. 2015-05-20. PMID:25992369. |
a heterogeneous and slowly progressive disease with extracellular amyloid-β (aβ) deposits and intracellular hyperphosphorylated tau protein aggregates, alzheimer's disease (ad) is already a hard nut to crack, featured with cognitive decline and memory lapse. |
2015-05-20 |
2023-08-13 |
Not clear |
| M Del Campo, C R Oliveira, W Scheper, R Zwart, C Korth, A Müller-Schiffmann, G Kostallas, H Biverstal, J Presto, J Johansson, J J Hoozemans, C F Pereira, C E Teunisse. BRI2 ectodomain affects Aβ42 fibrillation and tau truncation in human neuroblastoma cells. Cellular and molecular life sciences : CMLS. vol 72. issue 8. 2015-05-18. PMID:25336154. |
alzheimer's disease (ad) is pathologically characterized by the presence of misfolded proteins such as amyloid beta (aβ) in senile plaques, and hyperphosphorylated tau and truncated tau in neurofibrillary tangles (nft). |
2015-05-18 |
2023-08-13 |
human |
| Qun Wang, Jia-Yu Zhang, Shi-Jie Liu, Hong-Lian L. Overactivated mitogen-activated protein kinase by anisomycin induces tau hyperphosphorylation. Sheng li xue bao : [Acta physiologica Sinica]. vol 60. issue 4. 2015-05-16. PMID:18690390. |
one of the pathological feathers of alzheimer's disease (ad) is neurofibrillary tangles (nfts), which consist of paired helical filaments (phfs) formed by hyperphosphorylated microtubule-associated protein tau. |
2015-05-16 |
2023-08-12 |
mouse |
| I A Kuznetsov, A V Kuznetso. What tau distribution maximizes fast axonal transport toward the axonal synapse? Mathematical biosciences. vol 253. 2015-05-15. PMID:24747683. |
this theoretical research is aimed at investigating the question of why tau protein concentration exhibits a proximal-distal increase in healthy axons and a proximal-distal decrease in degenerating axons in alzheimer's disease. |
2015-05-15 |
2023-08-13 |
Not clear |
| Chun-Wei Chang, Wen-Chuin Hsu, Alan Pittman, Yih-Ru Wu, John Hardy, Hon-Chung Fun. Structural study of the microtubule-associated protein tau locus of Alzheimer's disease in Taiwan. Biomedical journal. vol 37. issue 3. 2015-05-15. PMID:24923570. |
structural study of the microtubule-associated protein tau locus of alzheimer's disease in taiwan. |
2015-05-15 |
2023-08-13 |
Not clear |
| Michel Goedert, Ben Falcon, Florence Clavaguera, Markus Tolna. Prion-like mechanisms in the pathogenesis of tauopathies and synucleinopathies. Current neurology and neuroscience reports. vol 14. issue 11. 2015-05-14. PMID:25218483. |
neurodegenerative diseases, including alzheimer's disease and parkinson's disease, are characterized by the abnormal aggregation of a small number of intracellular proteins, with tau and α-synuclein being the most commonly affected. |
2015-05-14 |
2023-08-13 |
Not clear |
| Nobuyuki Okamura, Ryuichi Harada, Shozo Furumoto, Hiroyuki Arai, Kazuhiko Yanai, Yukitsuka Kud. Tau PET imaging in Alzheimer's disease. Current neurology and neuroscience reports. vol 14. issue 11. 2015-05-14. PMID:25239654. |
tau pet imaging in alzheimer's disease. |
2015-05-14 |
2023-08-13 |
Not clear |
| Nobuyuki Okamura, Ryuichi Harada, Shozo Furumoto, Hiroyuki Arai, Kazuhiko Yanai, Yukitsuka Kud. Tau PET imaging in Alzheimer's disease. Current neurology and neuroscience reports. vol 14. issue 11. 2015-05-14. PMID:25239654. |
for use of tau pet as a biomarker of tau pathology in alzheimer's disease, pet tracers should have high affinity to phf-tau and high selectivity for tau over amyloid-β and other protein deposits. |
2015-05-14 |
2023-08-13 |
Not clear |
| Zsófia Majláth, József Toldi, László Vécse. The potential role of kynurenines in Alzheimer's disease: pathomechanism and therapeutic possibilities by influencing the glutamate receptors. Journal of neural transmission (Vienna, Austria : 1996). vol 121. issue 8. 2015-05-12. PMID:24346138. |
the pathomechanism of alzheimer's disease (ad) is associated with characteristic neuropathological features such as extracellular amyloid-β and intracellular tau deposition. |
2015-05-12 |
2023-08-12 |
Not clear |
| Debomoy K Lahiri, Balmiki Ra. Intravenous immunoglobulin treatment preserves and protects primary rat hippocampal neurons and primary human brain cultures against oxidative insults. Current Alzheimer research. vol 11. issue 7. 2015-05-12. PMID:25115544. |
alzheimer's disease (ad) is characterized by deleterious accumulation of amyloid-β (aβ) peptide into senile plaque, neurofibrillary tangles formed from hyperphosphorylated tau protein, and loss of cholinergic synapses in the cerebral cortex. |
2015-05-12 |
2023-08-13 |
human |
| Lakshman Puli, Heikki Tanila, Norman Relki. Intravenous immunoglobulins for Alzheimer's disease. Current Alzheimer research. vol 11. issue 7. 2015-05-12. PMID:25115546. |
alzheimer's disease (ad) is a chronic neurodegenerative disease associated with intracerebral accumulation of aggregated amyloid-beta (aβ) and tau proteins, as well as neuroinflammation. |
2015-05-12 |
2023-08-13 |
mouse |
| Jian-Zhi Wang, Xinya Gao, Zhi-Hao Wan. The physiology and pathology of microtubule-associated protein tau. Essays in biochemistry. vol 56. 2015-05-12. PMID:25131590. |
since tau gene mutations and abnormal post-translational modifications have been detected in over 20 neurodegenerative disorders, namely the tauopathies, tau has gained widespread attention as a target protein in alzheimer's disease and other neurodegenerative disorders. |
2015-05-12 |
2023-08-13 |
human |
| Scott E Counts, Sylvia E Perez, Bin He, Elliott J Mufso. Intravenous immunoglobulin reduces tau pathology and preserves neuroplastic gene expression in the 3xTg mouse model of Alzheimer's disease. Current Alzheimer research. vol 11. issue 7. 2015-05-12. PMID:25156574. |
intravenous immunoglobulin reduces tau pathology and preserves neuroplastic gene expression in the 3xtg mouse model of alzheimer's disease. |
2015-05-12 |
2023-08-13 |
mouse |
| Michael A Brister, Anil K Pandey, Agata A Bielska, Neal J Zondl. OGlcNAcylation and phosphorylation have opposing structural effects in tau: phosphothreonine induces particular conformational order. Journal of the American Chemical Society. vol 136. issue 10. 2015-05-11. PMID:24559475. |
in the microtubule-associated protein tau, hyperphosphorylation is associated with protein misfolding and aggregation as the neurofibrillary tangles of alzheimer's disease, whereas oglcnacylation stabilizes the soluble form of tau. |
2015-05-11 |
2023-08-12 |
Not clear |
| Pierre Lau, Carlo Sala Frigerio, Bart De Stroope. Variance in the identification of microRNAs deregulated in Alzheimer's disease and possible role of lincRNAs in the pathology: the need of larger datasets. Ageing research reviews. vol 17. 2015-05-11. PMID:24607832. |
in the past decade, tremendous efforts have been put mainly into identifying micrornas that are changed in alzheimer's disease, with the goal to provide biomarkers of the disease and to better characterize molecular pathways that are deregulated concomitantly to the formation of tau and amyloid aggregates. |
2015-05-11 |
2023-08-12 |
Not clear |