| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jennifer M Zupancic, Matthew D Smith, Hanna Trzeciakiewicz, Mary E Skinner, Sean P Ferris, Emily K Makowski, Michael J Lucas, Nikki McArthur, Ravi S Kane, Henry L Paulson, Peter M Tessie. Quantitative flow cytometric selection of tau conformational nanobodies specific for pathological aggregates. Frontiers in immunology. vol 14. 2023-08-25. PMID:37622125. |
however, there are few reported nanobodies with both conformational and sequence specificity for amyloid aggregates, especially for large and complex proteins such as the tau protein associated with alzheimer's disease, due to difficulties in selecting nanobodies that bind to complex aggregated proteins. |
2023-08-25 |
2023-09-07 |
mouse |
| Jiyeon Lee, Julie M Dimitry, Jong Hee Song, Minsoo Son, Patrick W Sheehan, Melvin W King, G Travis Tabor, Young Ah Goo, Mitchell A Lazar, Leonard Petrucelli, Erik S Musie. Microglial REV-ERBα regulates inflammation and lipid droplet formation to drive tauopathy in male mice. Nature communications. vol 14. issue 1. 2023-08-25. PMID:37626048. |
alzheimer's disease, the most common age-related neurodegenerative disease, is characterized by tau aggregation and associated with disrupted circadian rhythms and dampened clock gene expression. |
2023-08-25 |
2023-09-07 |
mouse |
| Grzegorz Walkiewicz, Alicja Ronisz, Rita Van Ginderdeuren, Sophie Lemmens, Femke H Bouwman, Jeroen J M Hoozemans, Tjado H J Morrema, Annemieke J Rozemuller, Frederique J Hart de Ruyter, Lies De Groef, Ingeborg Stalmans, Dietmar Rudolf Tha. Primary retinal tauopathy: A tauopathy with a distinct molecular pattern. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-08-24. PMID:37615275. |
phosphorylated tau (p-tau) accumulation, a hallmark of alzheimer's disease (ad), can also be found in the retina. |
2023-08-24 |
2023-09-07 |
Not clear |
| Gayatri Dev. The tauopathies. Handbook of clinical neurology. vol 196. 2023-08-24. PMID:37620072. |
disease-modifying therapies have been the focus of drug development, particularly agents targeting aß and tau pathology in alzheimer's disease, although most of these trials have failed. |
2023-08-24 |
2023-09-07 |
Not clear |
| Francesco Panza, Vincenzo Solfrizzi, Antonio Daniele, Madia Lozupon. Passive tau-based immunotherapy for tauopathies. Handbook of clinical neurology. vol 196. 2023-08-24. PMID:37620094. |
in secondary tauopathies, i.e., alzheimer's disease (ad), tau deposition can be observed, but tau may coexist with another protein, i.e., amyloid-β. |
2023-08-24 |
2023-09-07 |
Not clear |
| Qi Zhang, Chunqiu Fan, Luyao Wang, Taoran Li, Min Wang, Ying Han, Jiehui Jian. Glucose metabolism in posterior cingulate cortex has supplementary value to predict the progression of cognitively unimpaired to dementia due to Alzheimer's disease: an exploratory study of GeroScience. 2023-08-23. PMID:37610594. |
glucose metabolism in posterior cingulate cortex has supplementary value to predict the progression of cognitively unimpaired to dementia due to alzheimer's disease: an exploratory study of amyloid-β (aβ) and tau are important biomarkers to predict the progression of cognitively unimpaired (cu) to dementia due to alzheimer's disease (ad), according to the diagnosis framework from the us national institute on aging and the alzheimer's association (nia-aa). |
2023-08-23 |
2023-09-07 |
human |
| Sara Rodrigues, Marta Anglada-Huguet, Katja Hochgräfe, Senthilvelrajan Kaniyappan, Susanne Wegmann, Eva-Maria Mandelko. Spreading of Tau Protein Does Not Depend on Aggregation Propensity. Journal of molecular neuroscience : MN. 2023-08-22. PMID:37606769. |
the stereotypical progression of tau pathology during alzheimer disease has been attributed to trans-neuronal spreading of misfolded tau proteins, followed by prion-like templated aggregation of tau. |
2023-08-22 |
2023-09-07 |
mouse |
| Sara Rodrigues, Marta Anglada-Huguet, Katja Hochgräfe, Senthilvelrajan Kaniyappan, Susanne Wegmann, Eva-Maria Mandelko. Spreading of Tau Protein Does Not Depend on Aggregation Propensity. Journal of molecular neuroscience : MN. 2023-08-22. PMID:37606769. |
to study the progressive propagation of tau proteins in brain regions relevant for alzheimer disease, we used mice expressing near-physiological levels of full-length human tau protein carrying pro-aggregant (tauΔk280, tau |
2023-08-22 |
2023-09-07 |
mouse |
| Sergey Shcherbinin, Amanda Morris, Ixavier A Higgins, Ilke Tunali, Ming Lu, Carmen Deveau, Sudeepti Southekal, Vikas Kotari, Cynthia D Evans, Anupa K Arora, Emily C Collins, Michael Pontecorvo, Mark A Mintun, John R Sim. Tau as a diagnostic instrument in clinical trials to predict amyloid in Alzheimer's disease. Alzheimer's & dementia (New York, N. Y.). vol 9. issue 3. 2023-08-21. PMID:37600216. |
tau as a diagnostic instrument in clinical trials to predict amyloid in alzheimer's disease. |
2023-08-21 |
2023-09-07 |
human |
| Sergey Shcherbinin, Amanda Morris, Ixavier A Higgins, Ilke Tunali, Ming Lu, Carmen Deveau, Sudeepti Southekal, Vikas Kotari, Cynthia D Evans, Anupa K Arora, Emily C Collins, Michael Pontecorvo, Mark A Mintun, John R Sim. Tau as a diagnostic instrument in clinical trials to predict amyloid in Alzheimer's disease. Alzheimer's & dementia (New York, N. Y.). vol 9. issue 3. 2023-08-21. PMID:37600216. |
alzheimer's disease (ad) is characterized by the presence of both amyloid and tau pathology. |
2023-08-21 |
2023-09-07 |
human |
| Caitlin Davies, Jane Tulloch, Ellie Yip, Lydia Currie, Marti Colom-Cadena, Susanne Wegmann, Bradley T Hyman, Lewis Wilkins, Monique Hooley, Makis Tzioras, Tara L Spires-Jone. Apolipoprotein E isoform does not influence trans-synaptic spread of tau pathology in a mouse model. Brain and neuroscience advances. vol 7. 2023-08-21. PMID:37600228. |
a key hallmark of alzheimer's disease (ad) is the accumulation of hyperphosphorylated tau in neurofibrillary tangles. |
2023-08-21 |
2023-09-07 |
mouse |
| Fangyuan Duan, Ting Ju, Chen Song, Mengyao Liu, Yi Xiong, Xue Han, Weihong L. Synergetic effect of β-asarone and cannabidiol against Aβ aggregation Computational and structural biotechnology journal. vol 21. 2023-08-21. PMID:37602231. |
the pathophysiology of alzheimer's disease involves a range of complicated biological processes, including the accumulation of beta-amyloid protein and tau protein. |
2023-08-21 |
2023-09-07 |
Not clear |
| Shun-Fat Lau, Amy K Y Fu, Nancy Y I. Receptor-ligand interaction controls microglial chemotaxis and amelioration of Alzheimer's disease pathology. Journal of neurochemistry. 2023-08-21. PMID:37603311. |
in alzheimer's disease (ad), microglial phagocytic clearance regulates the turnover of neurotoxic damps including amyloid beta (aβ) and hyperphosphorylated tau. |
2023-08-21 |
2023-09-07 |
Not clear |
| Ly Thi Huong Luu Le, Jeeyoung Lee, Dongjoon Im, Sunha Park, Kyoung-Doo Hwang, Jung Hoon Lee, Yanxialei Jiang, Yong-Seok Lee, Young Ho Suh, Hugh I Kim, Min Jae Le. Self-Aggregating Tau Fragments Recapitulate Pathologic Phenotypes and Neurotoxicity of Alzheimer's Disease in Mice. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2023-08-18. PMID:37594721. |
self-aggregating tau fragments recapitulate pathologic phenotypes and neurotoxicity of alzheimer's disease in mice. |
2023-08-18 |
2023-09-07 |
mouse |
| Ly Thi Huong Luu Le, Jeeyoung Lee, Dongjoon Im, Sunha Park, Kyoung-Doo Hwang, Jung Hoon Lee, Yanxialei Jiang, Yong-Seok Lee, Young Ho Suh, Hugh I Kim, Min Jae Le. Self-Aggregating Tau Fragments Recapitulate Pathologic Phenotypes and Neurotoxicity of Alzheimer's Disease in Mice. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2023-08-18. PMID:37594721. |
in tauopathy conditions, such as alzheimer's disease (ad), highly soluble and natively unfolded tau polymerizes into an insoluble filament; however, the mechanistic details of this process remain unclear. |
2023-08-18 |
2023-09-07 |
mouse |
| Bess Fros. Alzheimer's disease and related tauopathies: disorders of disrupted neuronal identity. Trends in neurosciences. 2023-08-17. PMID:37591720. |
in alzheimer's disease (ad) and related tauopathies, evidence suggests that pathogenic forms of tau drive neurodegeneration via neuronal cell cycle re-entry. |
2023-08-17 |
2023-09-07 |
human |
| Yu Zou, Bote Qi, Jingwang Tan, Lulu Guan, Qingwen Zhang, Yunxiang Sun, Fengjuan Huan. Deciphering the Inhibitory Mechanism of Naphthoquinone-Dopamine on the Aggregation of Tau Core Fragments PHF6* and PHF6. ACS chemical neuroscience. 2023-08-16. PMID:37585669. |
the formation of neurofibrillary tangles by abnormal aggregation of tau protein is considered to be an important pathological characteristic of tauopathies, including alzheimer's disease and chronic traumatic encephalopathy. |
2023-08-16 |
2023-09-07 |
Not clear |
| Xin Wang, Erin E Sundermann, Rachel F Buckley, Emilie T Reas, Linda K McEvoy, Sarah J Bank. Sex Differences in the Associations of Obesity with Tau, Amyloid PET, and Cognitive Outcomes in Preclinical Alzheimer's Disease: Cross-Sectional A4 Study. Journal of Alzheimer's disease : JAD. 2023-08-14. PMID:37574737. |
sex differences in the associations of obesity with tau, amyloid pet, and cognitive outcomes in preclinical alzheimer's disease: cross-sectional a4 study. |
2023-08-14 |
2023-08-16 |
Not clear |
| Yao Zhu, Yan Wu, Xinyi Lv, Jiaonan Wu, Chunzi Shen, Qiqiang Tang, Guoping Wan. The relationship between APOE genotype, CSF Tau and cognition across the Alzheimer's disease spectrum, moderation and mediation role of insula network connectivity. CNS neuroscience & therapeutics. 2023-08-14. PMID:37577852. |
the relationship between apoe genotype, csf tau and cognition across the alzheimer's disease spectrum, moderation and mediation role of insula network connectivity. |
2023-08-14 |
2023-08-16 |
Not clear |
| Yao Zhu, Yan Wu, Xinyi Lv, Jiaonan Wu, Chunzi Shen, Qiqiang Tang, Guoping Wan. The relationship between APOE genotype, CSF Tau and cognition across the Alzheimer's disease spectrum, moderation and mediation role of insula network connectivity. CNS neuroscience & therapeutics. 2023-08-14. PMID:37577852. |
to investigate whether insula network connectivity modulates the relationship between apolipoprotein e (apoe) ε4 genotype, cerebrospinal fluid (csf) biomarkers (aβ, tau, and ptau) and cognition across alzheimer's disease (ad) spectrum. |
2023-08-14 |
2023-08-16 |
Not clear |