| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zsófia Majláth, József Toldi, László Vécse. The potential role of kynurenines in Alzheimer's disease: pathomechanism and therapeutic possibilities by influencing the glutamate receptors. Journal of neural transmission (Vienna, Austria : 1996). vol 121. issue 8. 2015-05-12. PMID:24346138. |
the pathomechanism of alzheimer's disease (ad) is associated with characteristic neuropathological features such as extracellular amyloid-β and intracellular tau deposition. |
2015-05-12 |
2023-08-12 |
Not clear |
| Debomoy K Lahiri, Balmiki Ra. Intravenous immunoglobulin treatment preserves and protects primary rat hippocampal neurons and primary human brain cultures against oxidative insults. Current Alzheimer research. vol 11. issue 7. 2015-05-12. PMID:25115544. |
alzheimer's disease (ad) is characterized by deleterious accumulation of amyloid-β (aβ) peptide into senile plaque, neurofibrillary tangles formed from hyperphosphorylated tau protein, and loss of cholinergic synapses in the cerebral cortex. |
2015-05-12 |
2023-08-13 |
human |
| Lakshman Puli, Heikki Tanila, Norman Relki. Intravenous immunoglobulins for Alzheimer's disease. Current Alzheimer research. vol 11. issue 7. 2015-05-12. PMID:25115546. |
alzheimer's disease (ad) is a chronic neurodegenerative disease associated with intracerebral accumulation of aggregated amyloid-beta (aβ) and tau proteins, as well as neuroinflammation. |
2015-05-12 |
2023-08-13 |
mouse |
| Jian-Zhi Wang, Xinya Gao, Zhi-Hao Wan. The physiology and pathology of microtubule-associated protein tau. Essays in biochemistry. vol 56. 2015-05-12. PMID:25131590. |
since tau gene mutations and abnormal post-translational modifications have been detected in over 20 neurodegenerative disorders, namely the tauopathies, tau has gained widespread attention as a target protein in alzheimer's disease and other neurodegenerative disorders. |
2015-05-12 |
2023-08-13 |
human |
| Scott E Counts, Sylvia E Perez, Bin He, Elliott J Mufso. Intravenous immunoglobulin reduces tau pathology and preserves neuroplastic gene expression in the 3xTg mouse model of Alzheimer's disease. Current Alzheimer research. vol 11. issue 7. 2015-05-12. PMID:25156574. |
intravenous immunoglobulin reduces tau pathology and preserves neuroplastic gene expression in the 3xtg mouse model of alzheimer's disease. |
2015-05-12 |
2023-08-13 |
mouse |
| Michael A Brister, Anil K Pandey, Agata A Bielska, Neal J Zondl. OGlcNAcylation and phosphorylation have opposing structural effects in tau: phosphothreonine induces particular conformational order. Journal of the American Chemical Society. vol 136. issue 10. 2015-05-11. PMID:24559475. |
in the microtubule-associated protein tau, hyperphosphorylation is associated with protein misfolding and aggregation as the neurofibrillary tangles of alzheimer's disease, whereas oglcnacylation stabilizes the soluble form of tau. |
2015-05-11 |
2023-08-12 |
Not clear |
| Pierre Lau, Carlo Sala Frigerio, Bart De Stroope. Variance in the identification of microRNAs deregulated in Alzheimer's disease and possible role of lincRNAs in the pathology: the need of larger datasets. Ageing research reviews. vol 17. 2015-05-11. PMID:24607832. |
in the past decade, tremendous efforts have been put mainly into identifying micrornas that are changed in alzheimer's disease, with the goal to provide biomarkers of the disease and to better characterize molecular pathways that are deregulated concomitantly to the formation of tau and amyloid aggregates. |
2015-05-11 |
2023-08-12 |
Not clear |
| Jeremy Koppel, Valerie Vingtdeux, Philippe Marambaud, Cristina d'Abramo, Heidy Jimenez, Mark Stauber, Rachel Friedman, Peter Davie. CB2 receptor deficiency increases amyloid pathology and alters tau processing in a transgenic mouse model of Alzheimer's disease. Molecular medicine (Cambridge, Mass.). vol 20. 2015-05-11. PMID:24722782. |
cb2 receptor deficiency increases amyloid pathology and alters tau processing in a transgenic mouse model of alzheimer's disease. |
2015-05-11 |
2023-08-13 |
mouse |
| Giuseppina Amadoro, Veronica Corsetti, Giulia Maria Sancesario, Adele Lubrano, Gaia Melchiorri, Sergio Bernardini, Pietro Calissano, Giuseppe Sancesari. Cerebrospinal fluid levels of a 20-22 kDa NH2 fragment of human tau provide a novel neuronal injury biomarker in Alzheimer's disease and other dementias. Journal of Alzheimer's disease : JAD. vol 42. issue 1. 2015-05-11. PMID:24851856. |
cerebrospinal fluid levels of a 20-22 kda nh2 fragment of human tau provide a novel neuronal injury biomarker in alzheimer's disease and other dementias. |
2015-05-11 |
2023-08-13 |
human |
| Giuseppina Amadoro, Veronica Corsetti, Giulia Maria Sancesario, Adele Lubrano, Gaia Melchiorri, Sergio Bernardini, Pietro Calissano, Giuseppe Sancesari. Cerebrospinal fluid levels of a 20-22 kDa NH2 fragment of human tau provide a novel neuronal injury biomarker in Alzheimer's disease and other dementias. Journal of Alzheimer's disease : JAD. vol 42. issue 1. 2015-05-11. PMID:24851856. |
truncation at n-terminal domain of tau protein is early associated with neurofibrillary pathology in several human tauopathies, including alzheimer's disease (ad). |
2015-05-11 |
2023-08-13 |
human |
| Maria V Fawaz, Allen F Brooks, Melissa E Rodnick, Garrett M Carpenter, Xia Shao, Timothy J Desmond, Phillip Sherman, Carole A Quesada, Brian G Hockley, Michael R Kilbourn, Roger L Albin, Kirk A Frey, Peter J H Scot. High affinity radiopharmaceuticals based upon lansoprazole for PET imaging of aggregated tau in Alzheimer's disease and progressive supranuclear palsy: synthesis, preclinical evaluation, and lead selection. ACS chemical neuroscience. vol 5. issue 8. 2015-05-11. PMID:24896980. |
high affinity radiopharmaceuticals based upon lansoprazole for pet imaging of aggregated tau in alzheimer's disease and progressive supranuclear palsy: synthesis, preclinical evaluation, and lead selection. |
2015-05-11 |
2023-08-13 |
human |
| Francesco Angelucci, Francesca Gelfo, Marco Fiore, Nicoletta Croce, Aleksander A Mathé, Sergio Bernardini, Carlo Caltagiron. The effect of neuropeptide Y on cell survival and neurotrophin expression in in-vitro models of Alzheimer's disease. Canadian journal of physiology and pharmacology. vol 92. issue 8. 2015-05-11. PMID:25026432. |
alzheimer's disease (ad) is a disorder characterized by the accumulation of abnormally folded protein fragments in neurons, i.e., β-amyloid (aβ) and tau protein, leading to cell death. |
2015-05-11 |
2023-08-13 |
Not clear |
| Joëlle Rosseels, Jeff Van den Brande, Marie Violet, Dirk Jacobs, Pierre Grognet, Juan Lopez, Isabelle Huvent, Marina Caldara, Erwin Swinnen, Anthony Papegaey, Raphaëlle Caillierez, Valerie Buée-Scherrer, Sebastiaan Engelborghs, Guy Lippens, Morvane Colin, Luc Buée, Marie-Christine Galas, Eugeen Vanmechelen, Joris Winderick. Tau monoclonal antibody generation based on humanized yeast models: impact on Tau oligomerization and diagnostics. The Journal of biological chemistry. vol 290. issue 7. 2015-05-08. PMID:25540200. |
a link between tau phosphorylation and aggregation has been shown in different models for alzheimer disease, including yeast. |
2015-05-08 |
2023-08-13 |
mouse |
| Joëlle Rosseels, Jeff Van den Brande, Marie Violet, Dirk Jacobs, Pierre Grognet, Juan Lopez, Isabelle Huvent, Marina Caldara, Erwin Swinnen, Anthony Papegaey, Raphaëlle Caillierez, Valerie Buée-Scherrer, Sebastiaan Engelborghs, Guy Lippens, Morvane Colin, Luc Buée, Marie-Christine Galas, Eugeen Vanmechelen, Joris Winderick. Tau monoclonal antibody generation based on humanized yeast models: impact on Tau oligomerization and diagnostics. The Journal of biological chemistry. vol 290. issue 7. 2015-05-08. PMID:25540200. |
in hippocampal homogenates from thy-tau22 mice and cortex homogenates obtained from alzheimer patients, adx215 consistently stained specific low order tau oligomers in diseased brain, which in size correspond to tau dimers. |
2015-05-08 |
2023-08-13 |
mouse |
| Joëlle Rosseels, Jeff Van den Brande, Marie Violet, Dirk Jacobs, Pierre Grognet, Juan Lopez, Isabelle Huvent, Marina Caldara, Erwin Swinnen, Anthony Papegaey, Raphaëlle Caillierez, Valerie Buée-Scherrer, Sebastiaan Engelborghs, Guy Lippens, Morvane Colin, Luc Buée, Marie-Christine Galas, Eugeen Vanmechelen, Joris Winderick. Tau monoclonal antibody generation based on humanized yeast models: impact on Tau oligomerization and diagnostics. The Journal of biological chemistry. vol 290. issue 7. 2015-05-08. PMID:25540200. |
when used to assess tau levels in human cerebrospinal fluid, the antibodies permitted us to discriminate patients with alzheimer disease or other dementia like vascular dementia, indicative that these antibodies hold promising diagnostic potential. |
2015-05-08 |
2023-08-13 |
mouse |
| Zachary A Levine, Luca Larini, Nichole E LaPointe, Stuart C Feinstein, Joan-Emma She. Regulation and aggregation of intrinsically disordered peptides. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 9. 2015-05-08. PMID:25691742. |
however, dysfunctions in tau can lead to tau oligomerization, fibril formation, and neurodegenerative disease, including alzheimer's disease. |
2015-05-08 |
2023-08-13 |
Not clear |
| Balasubramaniam Annamalai, Je-Seong Won, Seungho Choi, Inderjit Singh, Avtar K Sing. Role of S-nitrosoglutathione mediated mechanisms in tau hyper-phosphorylation. Biochemical and biophysical research communications. vol 458. issue 1. 2015-05-06. PMID:25640839. |
hyperphosphorylation and polymerization of microtubule-associated protein tau into paired helical filaments (phfs) is one of the hallmarks of alzheimer's disease (ad). |
2015-05-06 |
2023-08-13 |
mouse |
| Sunhyo Kim, Daehoon Lee, Jae Chun Song, Sun-Jung Cho, Sang-Moon Yun, Young Ho Koh, Jihyun Song, Gail V W Johnson, Chulman J. NDP52 associates with phosphorylated tau in brains of an Alzheimer disease mouse model. Biochemical and biophysical research communications. vol 454. issue 1. 2015-05-01. PMID:25450380. |
ndp52 associates with phosphorylated tau in brains of an alzheimer disease mouse model. |
2015-05-01 |
2023-08-13 |
mouse |
| Brandon B Holmes, Jennifer L Furman, Thomas E Mahan, Tritia R Yamasaki, Hilda Mirbaha, William C Eades, Larisa Belaygorod, Nigel J Cairns, David M Holtzman, Marc I Diamon. Proteopathic tau seeding predicts tauopathy in vivo. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 41. 2015-04-30. PMID:25261551. |
in tauopathies such as alzheimer's disease, this model predicts that tau seeds propagate pathology through the brain via cell-cell transfer in neural networks. |
2015-04-30 |
2023-08-13 |
mouse |
| Xiong Wang, Lu Tan, Yanjun Lu, Jing Peng, Yaowu Zhu, Yadong Zhang, Ziyong Su. MicroRNA-138 promotes tau phosphorylation by targeting retinoic acid receptor alpha. FEBS letters. vol 589. issue 6. 2015-04-29. PMID:25680531. |
alzheimer's disease (ad) is a progressive neurodegenerative dementia characterized by aβ deposition and neurofibrillary tangles (nfts) composed of hyperphosphorylated tau. |
2015-04-29 |
2023-08-13 |
Not clear |