All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Sarah M Ward, Diana S Himmelstein, Yan Ren, Yifan Fu, Xiao-Wen Yu, Kaleigh Roberts, Lester I Binder, Naruhiko Sahar. TOC1: a valuable tool in assessing disease progression in the rTg4510 mouse model of tauopathy. Neurobiology of disease. vol 67. 2015-01-06. PMID:24631720. with the help of other novel antibodies, the use of this antibody will aid in providing a better understanding of tau toxicity within alzheimer's disease and other tauopathies. 2015-01-06 2023-08-12 mouse
Gayathri Ramachandran, Erix A Milán-Garcés, Jayant B Udgaonkar, Mrinalini Purani. Resonance Raman spectroscopic measurements delineate the structural changes that occur during tau fibril formation. Biochemistry. vol 53. issue 41. 2014-12-31. PMID:25284680. the aggregation of the microtubule-associated protein, tau, into amyloid fibrils is a hallmark of neurodegenerative diseases such as the tauopathies and alzheimer's disease. 2014-12-31 2023-08-13 Not clear
Yafeng Xue, Paul T Wan, Per Hillertz, Fritz Schweikart, Yanlong Zhao, Lisa Wissler, Niek Dekke. X-ray structural analysis of tau-tubulin kinase 1 and its interactions with small molecular inhibitors. ChemMedChem. vol 8. issue 11. 2014-12-29. PMID:24039150. hyperphosphorylation of tau protein is the primary cause of tau pathology and neuronal death associated with alzheimer's disease. 2014-12-29 2023-08-12 Not clear
Mari Takalo, Annakaisa Haapasalo, Henna Martiskainen, Kaisa M A Kurkinen, Henna Koivisto, Pasi Miettinen, Vinoth K M Khandelwal, Susanna Kemppainen, Dorota Kaminska, Petra Mäkinen, Ville Leinonen, Jussi Pihlajamäki, Hilkka Soininen, Markku Laakso, Heikki Tanila, Mikko Hiltune. High-fat diet increases tau expression in the brain of T2DM and AD mice independently of peripheral metabolic status. The Journal of nutritional biochemistry. vol 25. issue 6. 2014-12-23. PMID:24746833. to investigate the effects of both genetic and high-fat-induced diabetic phenotype on the expression and exon 10 splicing of tau, we used the alzheimer's disease mouse model (apde9) cross-bred with the type 2 diabetes mouse model over-expressing insulin-like growth factor 2 in the pancreas. 2014-12-23 2023-08-13 mouse
Mari Takalo, Annakaisa Haapasalo, Henna Martiskainen, Kaisa M A Kurkinen, Henna Koivisto, Pasi Miettinen, Vinoth K M Khandelwal, Susanna Kemppainen, Dorota Kaminska, Petra Mäkinen, Ville Leinonen, Jussi Pihlajamäki, Hilkka Soininen, Markku Laakso, Heikki Tanila, Mikko Hiltune. High-fat diet increases tau expression in the brain of T2DM and AD mice independently of peripheral metabolic status. The Journal of nutritional biochemistry. vol 25. issue 6. 2014-12-23. PMID:24746833. our study suggests that the high-fat diet independently of type 2 diabetes or alzheimer's disease background induces the expression and exon 10 inclusion of tau in the brain of female mice. 2014-12-23 2023-08-13 mouse
Franck R Petry, Jérôme Pelletier, Alexis Bretteville, Françoise Morin, Frédéric Calon, Sébastien S Hébert, Robert A Whittington, Emmanuel Plane. Specificity of anti-tau antibodies when analyzing mice models of Alzheimer's disease: problems and solutions. PloS one. vol 9. issue 5. 2014-12-22. PMID:24788298. aggregates of hyperphosphorylated tau protein are found in a group of diseases called tauopathies, which includes alzheimer's disease. 2014-12-22 2023-08-13 mouse
Ken C Walls, Rahasson R Ager, Vitaly Vasilevko, Dave Cheng, Rodrigo Medeiros, Frank M LaFerl. p-Tau immunotherapy reduces soluble and insoluble tau in aged 3xTg-AD mice. Neuroscience letters. vol 575. 2014-12-22. PMID:24887583. alzheimer's disease (ad) is a proteinopathy characterized by the accumulation of β-amyloid (aβ) and tau. 2014-12-22 2023-08-13 mouse
Dezhi Liao, Eric C Miller, Peter J Teravski. Tau acts as a mediator for Alzheimer's disease-related synaptic deficits. The European journal of neuroscience. vol 39. issue 7. 2014-12-18. PMID:24712999. tau acts as a mediator for alzheimer's disease-related synaptic deficits. 2014-12-18 2023-08-13 Not clear
Dezhi Liao, Eric C Miller, Peter J Teravski. Tau acts as a mediator for Alzheimer's disease-related synaptic deficits. The European journal of neuroscience. vol 39. issue 7. 2014-12-18. PMID:24712999. the two histopathological hallmarks of alzheimer's disease (ad) are amyloid plaques containing multiple forms of amyloid beta (aβ) and neurofibrillary tangles containing phosphorylated tau proteins. 2014-12-18 2023-08-13 Not clear
Eric C Miller, Peter J Teravskis, Benjamin W Dummer, Xiaohui Zhao, Richard L Huganir, Dezhi Lia. Tau phosphorylation and tau mislocalization mediate soluble Aβ oligomer-induced AMPA glutamate receptor signaling deficits. The European journal of neuroscience. vol 39. issue 7. 2014-12-18. PMID:24713000. here, we show that tau mislocalizes to dendritic spines in cultured hippocampal neurons from appswe alzheimer's disease (ad)-transgenic mice and in cultured rat hippocampal neurons treated with soluble aβ oligomers. 2014-12-18 2023-08-13 mouse
Ryo Saito, Masayuki Kaneko, Yoshihisa Kitamura, Kazuyuki Takata, Koichi Kawada, Yasunobu Okuma, Yasuyuki Nomur. Effects of oxidative stress on the solubility of HRD1, a ubiquitin ligase implicated in Alzheimer's disease. PloS one. vol 9. issue 5. 2014-12-18. PMID:24788773. we here show that hrd1 protein was insolubilized by oxidative stress but not by other alzheimer's disease-related molecules and stressors, such as amyloid β, tau, and endoplasmic reticulum stress. 2014-12-18 2023-08-13 Not clear
Monique Antoinette David, Mourad Tayeb. Detection of protein aggregates in brain and cerebrospinal fluid derived from multiple sclerosis patients. Frontiers in neurology. vol 5. 2014-12-18. PMID:25520699. amyloid β, tau protein, as well as amyloid precursor protein normally associated with alzheimer's disease and parkinson's disease were found in lesions and plaques of multiple sclerosis patients. 2014-12-18 2023-08-13 Not clear
Ioannis Sotiropoulos, André T Lopes, Vitor Pinto, Sofia Lopes, Sara Carlos, Sara Duarte-Silva, Andreia Neves-Carvalho, Filipa Pinto-Ribeiro, Sara Pinheiro, Rui Fernandes, Armando Almeida, Nuno Sousa, Hugo Leite-Almeid. Selective impact of Tau loss on nociceptive primary afferents and pain sensation. Experimental neurology. vol 261. 2014-12-17. PMID:25079367. tau protein hyperphosphorylation and consequent malfunction are hallmarks of alzheimer's disease pathology; importantly, pain perception is diminished in these patients. 2014-12-17 2023-08-13 mouse
Mohammad Arif, Jianshe Wei, Qi Zhang, Fei Liu, Gustavo Basurto-Islas, Inge Grundke-Iqbal, Khalid Iqba. Cytoplasmic retention of protein phosphatase 2A inhibitor 2 (I2PP2A) induces Alzheimer-like abnormal hyperphosphorylation of Tau. The Journal of biological chemistry. vol 289. issue 40. 2014-12-17. PMID:25128526. abnormal hyperphosphorylation of tau leads to the formation of neurofibrillary tangles, a hallmark of alzheimer disease (ad), and related tauopathies. 2014-12-17 2023-08-13 Not clear
M Degerman Gunnarsson, L Lannfelt, M Ingelsson, H Basun, L Kilande. High tau levels in cerebrospinal fluid predict rapid decline and increased dementia mortality in Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 37. issue 3-4. 2014-12-16. PMID:24157938. high tau levels in cerebrospinal fluid predict rapid decline and increased dementia mortality in alzheimer's disease. 2014-12-16 2023-08-12 Not clear
M Degerman Gunnarsson, L Lannfelt, M Ingelsson, H Basun, L Kilande. High tau levels in cerebrospinal fluid predict rapid decline and increased dementia mortality in Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 37. issue 3-4. 2014-12-16. PMID:24157938. cerebrospinal fluid (csf) amyloid β42 (aβ42), total tau (t-tau) and phosphorylated tau (p-tau) are useful as predictors of conversion from mild cognitive impairment (mci) to alzheimer's disease (ad) dementia. 2014-12-16 2023-08-12 Not clear
Jing Lu, Ting Li, RongQiao He, Perry F Bartlett, Jürgen Göt. Visualizing the microtubule-associated protein tau in the nucleus. Science China. Life sciences. vol 57. issue 4. 2014-12-16. PMID:24643416. when human tau is over-expressed, it can be immunohistochemically localized to axons and the somatodendritic domain, modeling what is found in neurodegenerative diseases such as alzheimer's disease. 2014-12-16 2023-08-12 mouse
Clara S R Grüning, Ewa A Mirecka, Antonia N Klein, Eckhard Mandelkow, Dieter Willbold, Stephen F Marino, Matthias Stoldt, Wolfgang Hoye. Alternative conformations of the Tau repeat domain in complex with an engineered binding protein. The Journal of biological chemistry. vol 289. issue 33. 2014-12-16. PMID:24966331. the aggregation of tau into paired helical filaments is involved in the pathogenesis of several neurodegenerative diseases, including alzheimer disease. 2014-12-16 2023-08-13 human
Sungsu Lim, Md Mamunul Haque, Dohee Kim, Dong Jin Kim, Yun Kyung Ki. Cell-based Models To Investigate Tau Aggregation. Computational and structural biotechnology journal. vol 12. issue 20-21. 2014-12-16. PMID:25505502. accumulation of abnormal tau aggregates in neuron is an important pathological signature in multiple neurodegenerative disorders including alzheimer's disease. 2014-12-16 2023-08-13 Not clear
Shu Yang, Qihai Gong, Qin Wu, Fei Li, Yuanfu Lu, Jingshan Sh. Alkaloids enriched extract from Dendrobium nobile Lindl. attenuates tau protein hyperphosphorylation and apoptosis induced by lipopolysaccharide in rat brain. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 21. issue 5. 2014-12-15. PMID:24268296. neurofibrillary tangles, one of the characteristic pathological features of alzheimer's disease (ad), are composed of paired helical filaments mainly with hyperphosphorylated tau protein. 2014-12-15 2023-08-12 rat