| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jesús Avila, Diana Simón, Miguel Díaz-Hernández, Jesús Pintor, Félix Hernánde. Sources of extracellular tau and its signaling. Journal of Alzheimer's disease : JAD. vol 40 Suppl 1. 2015-01-16. PMID:24531154. |
however, extracellular tau could also damage neurons and since neuronal death is widespread in alzheimer's disease, mainly among cholinergic neurons, these cells may represent a possible source of extracellular tau. |
2015-01-16 |
2023-08-12 |
Not clear |
| C L Sayas, Jesús Ávil. Crosstalk between axonal classical microtubule-associated proteins and end binding proteins during axon extension: possible implications in neurodegeneration. Journal of Alzheimer's disease : JAD. vol 40 Suppl 1. 2015-01-16. PMID:24531158. |
furthermore, we discuss the potential implications of the dysregulation of the interplay between tau and ebs in neurodegenerative disorders such as alzheimer's disease. |
2015-01-16 |
2023-08-12 |
Not clear |
| Diane P Hanger, Dawn H W Lau, Emma C Phillips, Marie K Bondulich, Tong Guo, Benjamin W Woodward, Amy M Pooler, Wendy Nobl. Intracellular and extracellular roles for tau in neurodegenerative disease. Journal of Alzheimer's disease : JAD. vol 40 Suppl 1. 2015-01-16. PMID:24595196. |
this function of tau is influenced by tau phosphorylation state, which is significantly increased in alzheimer's disease and related tauopathies. |
2015-01-16 |
2023-08-12 |
Not clear |
| Diana L Castillo-Carranza, Julia E Gerson, Urmi Sengupta, Marcos J Guerrero-Muñoz, Cristian A Lasagna-Reeves, Rakez Kaye. Specific targeting of tau oligomers in Htau mice prevents cognitive impairment and tau toxicity following injection with brain-derived tau oligomeric seeds. Journal of Alzheimer's disease : JAD. vol 40 Suppl 1. 2015-01-16. PMID:24603946. |
the most common neurodegenerative disease, alzheimer's disease, is a tauopathy, characterized by the presence of aggregated tau, namely in the form of neurofibrillary tangles. |
2015-01-16 |
2023-08-12 |
mouse |
| Diana L Castillo-Carranza, Julia E Gerson, Urmi Sengupta, Marcos J Guerrero-Muñoz, Cristian A Lasagna-Reeves, Rakez Kaye. Specific targeting of tau oligomers in Htau mice prevents cognitive impairment and tau toxicity following injection with brain-derived tau oligomeric seeds. Journal of Alzheimer's disease : JAD. vol 40 Suppl 1. 2015-01-16. PMID:24603946. |
historically, neurofibrillary tangles have been considered the main tau species of interest in alzheimer's disease; however, we and others have shown that tau oligomers may be the most toxic form and the species responsible for the spread of pathology. |
2015-01-16 |
2023-08-12 |
mouse |
| Sudad Saman, Norman C Y Lee, Itoro Inoyo, Jun Jin, Zhihan Li, Thomas Doyle, Ann C McKee, Garth F Hal. Proteins recruited to exosomes by tau overexpression implicate novel cellular mechanisms linking tau secretion with Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 40 Suppl 1. 2015-01-16. PMID:24718102. |
proteins recruited to exosomes by tau overexpression implicate novel cellular mechanisms linking tau secretion with alzheimer's disease. |
2015-01-16 |
2023-08-13 |
human |
| Sudad Saman, Norman C Y Lee, Itoro Inoyo, Jun Jin, Zhihan Li, Thomas Doyle, Ann C McKee, Garth F Hal. Proteins recruited to exosomes by tau overexpression implicate novel cellular mechanisms linking tau secretion with Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 40 Suppl 1. 2015-01-16. PMID:24718102. |
tau misprocessing to form aggregates and other toxic species has emerged as a major feature in our developing understanding of the etiology and pathogenesis of alzheimer's disease (ad). |
2015-01-16 |
2023-08-13 |
human |
| Markus Storbeck, Kristina Hupperich, John Antonydas Gaspar, Kesavan Meganathan, Lilian Martínez Carrera, Radu Wirth, Agapios Sachinidis, Brunhilde Wirt. Neuronal-specific deficiency of the splicing factor Tra2b causes apoptosis in neurogenic areas of the developing mouse brain. PloS one. vol 9. issue 2. 2015-01-10. PMID:24586484. |
tra2b has been shown to be involved in splicing processes of nasp (nuclear autoantigenic sperm protein), mapt (microtubule associated protein tau) and smn (survival motor neuron), and is therefore implicated in spermatogenesis and neurological diseases like alzheimer's disease, dementia, parkinson's disease and spinal muscular atrophy. |
2015-01-10 |
2023-08-12 |
mouse |
| Sarah M Ward, Diana S Himmelstein, Yan Ren, Yifan Fu, Xiao-Wen Yu, Kaleigh Roberts, Lester I Binder, Naruhiko Sahar. TOC1: a valuable tool in assessing disease progression in the rTg4510 mouse model of tauopathy. Neurobiology of disease. vol 67. 2015-01-06. PMID:24631720. |
with the help of other novel antibodies, the use of this antibody will aid in providing a better understanding of tau toxicity within alzheimer's disease and other tauopathies. |
2015-01-06 |
2023-08-12 |
mouse |
| Gayathri Ramachandran, Erix A Milán-Garcés, Jayant B Udgaonkar, Mrinalini Purani. Resonance Raman spectroscopic measurements delineate the structural changes that occur during tau fibril formation. Biochemistry. vol 53. issue 41. 2014-12-31. PMID:25284680. |
the aggregation of the microtubule-associated protein, tau, into amyloid fibrils is a hallmark of neurodegenerative diseases such as the tauopathies and alzheimer's disease. |
2014-12-31 |
2023-08-13 |
Not clear |
| Yafeng Xue, Paul T Wan, Per Hillertz, Fritz Schweikart, Yanlong Zhao, Lisa Wissler, Niek Dekke. X-ray structural analysis of tau-tubulin kinase 1 and its interactions with small molecular inhibitors. ChemMedChem. vol 8. issue 11. 2014-12-29. PMID:24039150. |
hyperphosphorylation of tau protein is the primary cause of tau pathology and neuronal death associated with alzheimer's disease. |
2014-12-29 |
2023-08-12 |
Not clear |
| Mari Takalo, Annakaisa Haapasalo, Henna Martiskainen, Kaisa M A Kurkinen, Henna Koivisto, Pasi Miettinen, Vinoth K M Khandelwal, Susanna Kemppainen, Dorota Kaminska, Petra Mäkinen, Ville Leinonen, Jussi Pihlajamäki, Hilkka Soininen, Markku Laakso, Heikki Tanila, Mikko Hiltune. High-fat diet increases tau expression in the brain of T2DM and AD mice independently of peripheral metabolic status. The Journal of nutritional biochemistry. vol 25. issue 6. 2014-12-23. PMID:24746833. |
to investigate the effects of both genetic and high-fat-induced diabetic phenotype on the expression and exon 10 splicing of tau, we used the alzheimer's disease mouse model (apde9) cross-bred with the type 2 diabetes mouse model over-expressing insulin-like growth factor 2 in the pancreas. |
2014-12-23 |
2023-08-13 |
mouse |
| Mari Takalo, Annakaisa Haapasalo, Henna Martiskainen, Kaisa M A Kurkinen, Henna Koivisto, Pasi Miettinen, Vinoth K M Khandelwal, Susanna Kemppainen, Dorota Kaminska, Petra Mäkinen, Ville Leinonen, Jussi Pihlajamäki, Hilkka Soininen, Markku Laakso, Heikki Tanila, Mikko Hiltune. High-fat diet increases tau expression in the brain of T2DM and AD mice independently of peripheral metabolic status. The Journal of nutritional biochemistry. vol 25. issue 6. 2014-12-23. PMID:24746833. |
our study suggests that the high-fat diet independently of type 2 diabetes or alzheimer's disease background induces the expression and exon 10 inclusion of tau in the brain of female mice. |
2014-12-23 |
2023-08-13 |
mouse |
| Franck R Petry, Jérôme Pelletier, Alexis Bretteville, Françoise Morin, Frédéric Calon, Sébastien S Hébert, Robert A Whittington, Emmanuel Plane. Specificity of anti-tau antibodies when analyzing mice models of Alzheimer's disease: problems and solutions. PloS one. vol 9. issue 5. 2014-12-22. PMID:24788298. |
aggregates of hyperphosphorylated tau protein are found in a group of diseases called tauopathies, which includes alzheimer's disease. |
2014-12-22 |
2023-08-13 |
mouse |
| Ken C Walls, Rahasson R Ager, Vitaly Vasilevko, Dave Cheng, Rodrigo Medeiros, Frank M LaFerl. p-Tau immunotherapy reduces soluble and insoluble tau in aged 3xTg-AD mice. Neuroscience letters. vol 575. 2014-12-22. PMID:24887583. |
alzheimer's disease (ad) is a proteinopathy characterized by the accumulation of β-amyloid (aβ) and tau. |
2014-12-22 |
2023-08-13 |
mouse |
| Dezhi Liao, Eric C Miller, Peter J Teravski. Tau acts as a mediator for Alzheimer's disease-related synaptic deficits. The European journal of neuroscience. vol 39. issue 7. 2014-12-18. PMID:24712999. |
tau acts as a mediator for alzheimer's disease-related synaptic deficits. |
2014-12-18 |
2023-08-13 |
Not clear |
| Dezhi Liao, Eric C Miller, Peter J Teravski. Tau acts as a mediator for Alzheimer's disease-related synaptic deficits. The European journal of neuroscience. vol 39. issue 7. 2014-12-18. PMID:24712999. |
the two histopathological hallmarks of alzheimer's disease (ad) are amyloid plaques containing multiple forms of amyloid beta (aβ) and neurofibrillary tangles containing phosphorylated tau proteins. |
2014-12-18 |
2023-08-13 |
Not clear |
| Eric C Miller, Peter J Teravskis, Benjamin W Dummer, Xiaohui Zhao, Richard L Huganir, Dezhi Lia. Tau phosphorylation and tau mislocalization mediate soluble Aβ oligomer-induced AMPA glutamate receptor signaling deficits. The European journal of neuroscience. vol 39. issue 7. 2014-12-18. PMID:24713000. |
here, we show that tau mislocalizes to dendritic spines in cultured hippocampal neurons from appswe alzheimer's disease (ad)-transgenic mice and in cultured rat hippocampal neurons treated with soluble aβ oligomers. |
2014-12-18 |
2023-08-13 |
mouse |
| Ryo Saito, Masayuki Kaneko, Yoshihisa Kitamura, Kazuyuki Takata, Koichi Kawada, Yasunobu Okuma, Yasuyuki Nomur. Effects of oxidative stress on the solubility of HRD1, a ubiquitin ligase implicated in Alzheimer's disease. PloS one. vol 9. issue 5. 2014-12-18. PMID:24788773. |
we here show that hrd1 protein was insolubilized by oxidative stress but not by other alzheimer's disease-related molecules and stressors, such as amyloid β, tau, and endoplasmic reticulum stress. |
2014-12-18 |
2023-08-13 |
Not clear |
| Monique Antoinette David, Mourad Tayeb. Detection of protein aggregates in brain and cerebrospinal fluid derived from multiple sclerosis patients. Frontiers in neurology. vol 5. 2014-12-18. PMID:25520699. |
amyloid β, tau protein, as well as amyloid precursor protein normally associated with alzheimer's disease and parkinson's disease were found in lesions and plaques of multiple sclerosis patients. |
2014-12-18 |
2023-08-13 |
Not clear |