| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ken C Walls, Rahasson R Ager, Vitaly Vasilevko, Dave Cheng, Rodrigo Medeiros, Frank M LaFerl. p-Tau immunotherapy reduces soluble and insoluble tau in aged 3xTg-AD mice. Neuroscience letters. vol 575. 2014-12-22. PMID:24887583. |
alzheimer's disease (ad) is a proteinopathy characterized by the accumulation of β-amyloid (aβ) and tau. |
2014-12-22 |
2023-08-13 |
mouse |
| Dezhi Liao, Eric C Miller, Peter J Teravski. Tau acts as a mediator for Alzheimer's disease-related synaptic deficits. The European journal of neuroscience. vol 39. issue 7. 2014-12-18. PMID:24712999. |
tau acts as a mediator for alzheimer's disease-related synaptic deficits. |
2014-12-18 |
2023-08-13 |
Not clear |
| Dezhi Liao, Eric C Miller, Peter J Teravski. Tau acts as a mediator for Alzheimer's disease-related synaptic deficits. The European journal of neuroscience. vol 39. issue 7. 2014-12-18. PMID:24712999. |
the two histopathological hallmarks of alzheimer's disease (ad) are amyloid plaques containing multiple forms of amyloid beta (aβ) and neurofibrillary tangles containing phosphorylated tau proteins. |
2014-12-18 |
2023-08-13 |
Not clear |
| Eric C Miller, Peter J Teravskis, Benjamin W Dummer, Xiaohui Zhao, Richard L Huganir, Dezhi Lia. Tau phosphorylation and tau mislocalization mediate soluble Aβ oligomer-induced AMPA glutamate receptor signaling deficits. The European journal of neuroscience. vol 39. issue 7. 2014-12-18. PMID:24713000. |
here, we show that tau mislocalizes to dendritic spines in cultured hippocampal neurons from appswe alzheimer's disease (ad)-transgenic mice and in cultured rat hippocampal neurons treated with soluble aβ oligomers. |
2014-12-18 |
2023-08-13 |
mouse |
| Ryo Saito, Masayuki Kaneko, Yoshihisa Kitamura, Kazuyuki Takata, Koichi Kawada, Yasunobu Okuma, Yasuyuki Nomur. Effects of oxidative stress on the solubility of HRD1, a ubiquitin ligase implicated in Alzheimer's disease. PloS one. vol 9. issue 5. 2014-12-18. PMID:24788773. |
we here show that hrd1 protein was insolubilized by oxidative stress but not by other alzheimer's disease-related molecules and stressors, such as amyloid β, tau, and endoplasmic reticulum stress. |
2014-12-18 |
2023-08-13 |
Not clear |
| Monique Antoinette David, Mourad Tayeb. Detection of protein aggregates in brain and cerebrospinal fluid derived from multiple sclerosis patients. Frontiers in neurology. vol 5. 2014-12-18. PMID:25520699. |
amyloid β, tau protein, as well as amyloid precursor protein normally associated with alzheimer's disease and parkinson's disease were found in lesions and plaques of multiple sclerosis patients. |
2014-12-18 |
2023-08-13 |
Not clear |
| Ioannis Sotiropoulos, André T Lopes, Vitor Pinto, Sofia Lopes, Sara Carlos, Sara Duarte-Silva, Andreia Neves-Carvalho, Filipa Pinto-Ribeiro, Sara Pinheiro, Rui Fernandes, Armando Almeida, Nuno Sousa, Hugo Leite-Almeid. Selective impact of Tau loss on nociceptive primary afferents and pain sensation. Experimental neurology. vol 261. 2014-12-17. PMID:25079367. |
tau protein hyperphosphorylation and consequent malfunction are hallmarks of alzheimer's disease pathology; importantly, pain perception is diminished in these patients. |
2014-12-17 |
2023-08-13 |
mouse |
| Mohammad Arif, Jianshe Wei, Qi Zhang, Fei Liu, Gustavo Basurto-Islas, Inge Grundke-Iqbal, Khalid Iqba. Cytoplasmic retention of protein phosphatase 2A inhibitor 2 (I2PP2A) induces Alzheimer-like abnormal hyperphosphorylation of Tau. The Journal of biological chemistry. vol 289. issue 40. 2014-12-17. PMID:25128526. |
abnormal hyperphosphorylation of tau leads to the formation of neurofibrillary tangles, a hallmark of alzheimer disease (ad), and related tauopathies. |
2014-12-17 |
2023-08-13 |
Not clear |
| M Degerman Gunnarsson, L Lannfelt, M Ingelsson, H Basun, L Kilande. High tau levels in cerebrospinal fluid predict rapid decline and increased dementia mortality in Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 37. issue 3-4. 2014-12-16. PMID:24157938. |
high tau levels in cerebrospinal fluid predict rapid decline and increased dementia mortality in alzheimer's disease. |
2014-12-16 |
2023-08-12 |
Not clear |
| M Degerman Gunnarsson, L Lannfelt, M Ingelsson, H Basun, L Kilande. High tau levels in cerebrospinal fluid predict rapid decline and increased dementia mortality in Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 37. issue 3-4. 2014-12-16. PMID:24157938. |
cerebrospinal fluid (csf) amyloid β42 (aβ42), total tau (t-tau) and phosphorylated tau (p-tau) are useful as predictors of conversion from mild cognitive impairment (mci) to alzheimer's disease (ad) dementia. |
2014-12-16 |
2023-08-12 |
Not clear |
| Jing Lu, Ting Li, RongQiao He, Perry F Bartlett, Jürgen Göt. Visualizing the microtubule-associated protein tau in the nucleus. Science China. Life sciences. vol 57. issue 4. 2014-12-16. PMID:24643416. |
when human tau is over-expressed, it can be immunohistochemically localized to axons and the somatodendritic domain, modeling what is found in neurodegenerative diseases such as alzheimer's disease. |
2014-12-16 |
2023-08-12 |
mouse |
| Clara S R Grüning, Ewa A Mirecka, Antonia N Klein, Eckhard Mandelkow, Dieter Willbold, Stephen F Marino, Matthias Stoldt, Wolfgang Hoye. Alternative conformations of the Tau repeat domain in complex with an engineered binding protein. The Journal of biological chemistry. vol 289. issue 33. 2014-12-16. PMID:24966331. |
the aggregation of tau into paired helical filaments is involved in the pathogenesis of several neurodegenerative diseases, including alzheimer disease. |
2014-12-16 |
2023-08-13 |
human |
| Sungsu Lim, Md Mamunul Haque, Dohee Kim, Dong Jin Kim, Yun Kyung Ki. Cell-based Models To Investigate Tau Aggregation. Computational and structural biotechnology journal. vol 12. issue 20-21. 2014-12-16. PMID:25505502. |
accumulation of abnormal tau aggregates in neuron is an important pathological signature in multiple neurodegenerative disorders including alzheimer's disease. |
2014-12-16 |
2023-08-13 |
Not clear |
| Shu Yang, Qihai Gong, Qin Wu, Fei Li, Yuanfu Lu, Jingshan Sh. Alkaloids enriched extract from Dendrobium nobile Lindl. attenuates tau protein hyperphosphorylation and apoptosis induced by lipopolysaccharide in rat brain. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 21. issue 5. 2014-12-15. PMID:24268296. |
neurofibrillary tangles, one of the characteristic pathological features of alzheimer's disease (ad), are composed of paired helical filaments mainly with hyperphosphorylated tau protein. |
2014-12-15 |
2023-08-12 |
rat |
| Se Hoon Choi, Young Hye Kim, Matthias Hebisch, Christopher Sliwinski, Seungkyu Lee, Carla D'Avanzo, Hechao Chen, Basavaraj Hooli, Caroline Asselin, Julien Muffat, Justin B Klee, Can Zhang, Brian J Wainger, Michael Peitz, Dora M Kovacs, Clifford J Woolf, Steven L Wagner, Rudolph E Tanzi, Doo Yeon Ki. A three-dimensional human neural cell culture model of Alzheimer's disease. Nature. vol 515. issue 7526. 2014-12-15. PMID:25307057. |
the amyloid hypothesis of alzheimer's disease posits that the excessive accumulation of amyloid-β peptide leads to neurofibrillary tangles composed of aggregated hyperphosphorylated tau. |
2014-12-15 |
2023-08-13 |
mouse |
| Se Hoon Choi, Young Hye Kim, Matthias Hebisch, Christopher Sliwinski, Seungkyu Lee, Carla D'Avanzo, Hechao Chen, Basavaraj Hooli, Caroline Asselin, Julien Muffat, Justin B Klee, Can Zhang, Brian J Wainger, Michael Peitz, Dora M Kovacs, Clifford J Woolf, Steven L Wagner, Rudolph E Tanzi, Doo Yeon Ki. A three-dimensional human neural cell culture model of Alzheimer's disease. Nature. vol 515. issue 7526. 2014-12-15. PMID:25307057. |
human neurons derived from alzheimer's disease patients have shown elevated levels of toxic amyloid-β species and phosphorylated tau but did not demonstrate amyloid-β plaques or neurofibrillary tangles. |
2014-12-15 |
2023-08-13 |
mouse |
| David Peterson, Caitlin Munger, Jared Crowley, Chris Corcoran, Carlos Cruchaga, Alison M Goate, Maria C Norton, Robert C Green, Ronald G Munger, John C S Breitner, Kathleen A Welsh-Bohmer, Constantine Lyketsos, Joann Tschanz, John S K Kauw. Variants in PPP3R1 and MAPT are associated with more rapid functional decline in Alzheimer's disease: the Cache County Dementia Progression Study. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 10. issue 3. 2014-12-10. PMID:23727081. |
single-nucleotide polymorphisms (snps) located in the gene encoding the regulatory subunit of the protein phosphatase 2b (ppp3r1, rs1868402) and the microtubule-associated protein tau (mapt, rs3785883) gene were recently associated with higher cerebrospinal fluid (csf) tau levels in samples from the knight alzheimer's disease research center at washington university (wu) and alzheimer's disease neuroimaging initiative (adni). |
2014-12-10 |
2023-08-12 |
Not clear |
| Qinxi Guo, Hongmei Li, Allysa L Cole, Ji-Yeun Hur, Yueming Li, Hui Zhen. Modeling Alzheimer's disease in mouse without mutant protein overexpression: cooperative and independent effects of Aβ and tau. PloS one. vol 8. issue 11. 2014-12-10. PMID:24278307. |
modeling alzheimer's disease in mouse without mutant protein overexpression: cooperative and independent effects of aβ and tau. |
2014-12-10 |
2023-08-12 |
mouse |
| Qinxi Guo, Hongmei Li, Allysa L Cole, Ji-Yeun Hur, Yueming Li, Hui Zhen. Modeling Alzheimer's disease in mouse without mutant protein overexpression: cooperative and independent effects of Aβ and tau. PloS one. vol 8. issue 11. 2014-12-10. PMID:24278307. |
alzheimer's disease (ad), the most common cause of dementia in the elderly, has two pathological hallmarks: aβ plaques and aggregation of hyperphosphorylated tau (p-tau). |
2014-12-10 |
2023-08-12 |
mouse |
| Katherine J Kopeikina, Susanne Wegmann, Rose Pitstick, George A Carlson, Brian J Bacskai, Rebecca A Betensky, Bradley T Hyman, Tara L Spires-Jone. Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathy. PloS one. vol 8. issue 11. 2014-12-10. PMID:24278327. |
neurofibrillary tangles (nfts) of tau are one of the defining hallmarks of alzheimer's disease (ad), and are closely associated with neuronal degeneration. |
2014-12-10 |
2023-08-12 |
mouse |