| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ania L Gheyara, Ravikumar Ponnusamy, Biljana Djukic, Ryan J Craft, Kaitlyn Ho, Weikun Guo, Mariel M Finucane, Pascal E Sanchez, Lennart Muck. Tau reduction prevents disease in a mouse model of Dravet syndrome. Annals of neurology. vol 76. issue 3. 2014-12-10. PMID:25042160. |
reducing levels of the microtubule-associated protein tau has shown promise as a potential treatment strategy for diseases with secondary epileptic features such as alzheimer disease. |
2014-12-10 |
2023-08-13 |
mouse |
| Gyungah Jun, Hirohide Asai, Ella Zeldich, Elodie Drapeau, CiDi Chen, Jaeyoon Chung, Jong-Ho Park, Sehwa Kim, Vahram Haroutunian, Tatiana Foroud, Ryozo Kuwano, Jonathan L Haines, Margaret A Pericak-Vance, Gerard D Schellenberg, Kathryn L Lunetta, Jong-Won Kim, Joseph D Buxbaum, Richard Mayeux, Tsuneya Ikezu, Carmela R Abraham, Lindsay A Farre. PLXNA4 is associated with Alzheimer disease and modulates tau phosphorylation. Annals of neurology. vol 76. issue 3. 2014-12-10. PMID:25043464. |
plxna4 is associated with alzheimer disease and modulates tau phosphorylation. |
2014-12-10 |
2023-08-13 |
Not clear |
| Koji Kasanuki, Eizo Iseki, Daizo Kondo, Hiroshige Fujishiro, Michiko Minegishi, Kiyoshi Sato, Omi Katsuse, Hiroaki Hino, Kenji Kosaka, Heii Ara. Neuropathological investigation of hypocretin expression in brains of dementia with Lewy bodies. Neuroscience letters. vol 569. 2014-12-09. PMID:24704327. |
in the present study, we quantitatively examined hcrt immunoreactivity and α-synuclein and tau pathologies in the lht and locus coeruleus (lc) in dementia with lewy bodies (dlb) (n=15), alzheimer's disease (ad) (n=14), and controls (n=7). |
2014-12-09 |
2023-08-13 |
Not clear |
| Harald Lund, Elin Gustafsson, Anne Svensson, Maria Nilsson, Margareta Berg, Dan Sunnemark, Gabriel von Eule. MARK4 and MARK3 associate with early tau phosphorylation in Alzheimer's disease granulovacuolar degeneration bodies. Acta neuropathologica communications. vol 2. 2014-12-08. PMID:24533944. |
mark4 and mark3 associate with early tau phosphorylation in alzheimer's disease granulovacuolar degeneration bodies. |
2014-12-08 |
2023-08-12 |
Not clear |
| Harald Lund, Elin Gustafsson, Anne Svensson, Maria Nilsson, Margareta Berg, Dan Sunnemark, Gabriel von Eule. MARK4 and MARK3 associate with early tau phosphorylation in Alzheimer's disease granulovacuolar degeneration bodies. Acta neuropathologica communications. vol 2. 2014-12-08. PMID:24533944. |
the progression of alzheimer's disease (ad) is associated with an increase of phosphorylated tau in the brain. |
2014-12-08 |
2023-08-12 |
Not clear |
| b' Antonio Di Meco, Yash B Joshi, Domenico Pratic\\xc3\\xb. Sleep deprivation impairs memory, tau metabolism, and synaptic integrity of a mouse model of Alzheimer\'s disease with plaques and tangles. Neurobiology of aging. vol 35. issue 8. 2014-12-08. PMID:24629673.' |
sleep deprivation impairs memory, tau metabolism, and synaptic integrity of a mouse model of alzheimer's disease with plaques and tangles. |
2014-12-08 |
2023-08-12 |
mouse |
| Elysse M Knight, Isaura V A Martins, Sarah Gümüsgöz, Stuart M Allan, Catherine B Lawrenc. High-fat diet-induced memory impairment in triple-transgenic Alzheimer's disease (3xTgAD) mice is independent of changes in amyloid and tau pathology. Neurobiology of aging. vol 35. issue 8. 2014-12-08. PMID:24630364. |
high-fat diet-induced memory impairment in triple-transgenic alzheimer's disease (3xtgad) mice is independent of changes in amyloid and tau pathology. |
2014-12-08 |
2023-08-12 |
mouse |
| M Florencia Iulita, Simon Allard, Luise Richter, Lisa-Marie Munter, Adriana Ducatenzeiler, Christoph Weise, Sonia Do Carmo, William L Klein, Gerhard Multhaup, A Claudio Cuell. Intracellular Aβ pathology and early cognitive impairments in a transgenic rat overexpressing human amyloid precursor protein: a multidimensional study. Acta neuropathologica communications. vol 2. 2014-12-08. PMID:24903713. |
numerous studies have implicated the abnormal accumulation of intraneuronal amyloid-β (aβ) as an important contributor to alzheimer's disease (ad) pathology, capable of triggering neuroinflammation, tau hyperphosphorylation and cognitive deficits. |
2014-12-08 |
2023-08-13 |
human |
| Jon B Toledo, Ané Korff, Leslie M Shaw, John Q Trojanowski, Jing Zhan. Low levels of cerebrospinal fluid complement 3 and factor H predict faster cognitive decline in mild cognitive impairment. Alzheimer's research & therapy. vol 6. issue 3. 2014-12-05. PMID:25478014. |
alzheimer's disease (ad) is characterized by the deposition of tau and amyloid in the brain. |
2014-12-05 |
2023-08-13 |
Not clear |
| Eva Kontsekova, Norbert Zilka, Branislav Kovacech, Petr Novak, Michal Nova. First-in-man tau vaccine targeting structural determinants essential for pathological tau-tau interaction reduces tau oligomerisation and neurofibrillary degeneration in an Alzheimer's disease model. Alzheimer's research & therapy. vol 6. issue 4. 2014-12-05. PMID:25478017. |
first-in-man tau vaccine targeting structural determinants essential for pathological tau-tau interaction reduces tau oligomerisation and neurofibrillary degeneration in an alzheimer's disease model. |
2014-12-05 |
2023-08-13 |
Not clear |
| Eva Kontsekova, Norbert Zilka, Branislav Kovacech, Petr Novak, Michal Nova. First-in-man tau vaccine targeting structural determinants essential for pathological tau-tau interaction reduces tau oligomerisation and neurofibrillary degeneration in an Alzheimer's disease model. Alzheimer's research & therapy. vol 6. issue 4. 2014-12-05. PMID:25478017. |
we have identified structural determinants on tau protein that are essential for pathological tau-tau interaction in alzheimer's disease (ad). |
2014-12-05 |
2023-08-13 |
Not clear |
| Eva Kontsekova, Norbert Zilka, Branislav Kovacech, Rostislav Skrabana, Michal Nova. Identification of structural determinants on tau protein essential for its pathological function: novel therapeutic target for tau immunotherapy in Alzheimer's disease. Alzheimer's research & therapy. vol 6. issue 4. 2014-12-05. PMID:25478018. |
identification of structural determinants on tau protein essential for its pathological function: novel therapeutic target for tau immunotherapy in alzheimer's disease. |
2014-12-05 |
2023-08-13 |
Not clear |
| Eva Kontsekova, Norbert Zilka, Branislav Kovacech, Rostislav Skrabana, Michal Nova. Identification of structural determinants on tau protein essential for its pathological function: novel therapeutic target for tau immunotherapy in Alzheimer's disease. Alzheimer's research & therapy. vol 6. issue 4. 2014-12-05. PMID:25478018. |
pathologically modified tau protein is the main feature of alzheimer's disease (ad) and related tauopathies. |
2014-12-05 |
2023-08-13 |
Not clear |
| Tomohiro Onishi, Yoshio Matsumoto, Masahiko Hattori, Yuka Obayashi, Kimie Nakamura, Takashi Yano, Takashi Horiguchi, Hiroki Iwashit. Early-onset cognitive deficits and axonal transport dysfunction in P301S mutant tau transgenic mice. Neuroscience research. vol 80. 2014-12-04. PMID:24406748. |
alzheimer's disease (ad) and frontotemporal lobar degeneration (ftld) are neurodegenerative "tauopathies" characterized by hyperphosphorylated tau accumulation and neurofibrillary tangles. |
2014-12-04 |
2023-08-12 |
mouse |
| Danielle L Graham, Audrey J Gray, John A Joyce, Dongzi Yu, Jill O'Moore, George A Carlson, Mark S Shearman, Tammy L Dellovade, Heike Herin. Increased O-GlcNAcylation reduces pathological tau without affecting its normal phosphorylation in a mouse model of tauopathy. Neuropharmacology. vol 79. 2014-12-03. PMID:24326295. |
neurofibrillary tangles (nft), mainly consisting of fibrillar aggregates of hyperphosphorylated tau, are a defining pathological feature of alzheimer's disease and other tauopathies. |
2014-12-03 |
2023-08-12 |
mouse |
| Jose Vicente Sanchez-Mut, Ester Aso, Holger Heyn, Tadashi Matsuda, Christoph Bock, Isidre Ferrer, Manel Estelle. Promoter hypermethylation of the phosphatase DUSP22 mediates PKA-dependent TAU phosphorylation and CREB activation in Alzheimer's disease. Hippocampus. vol 24. issue 4. 2014-12-03. PMID:24436131. |
promoter hypermethylation of the phosphatase dusp22 mediates pka-dependent tau phosphorylation and creb activation in alzheimer's disease. |
2014-12-03 |
2023-08-12 |
human |
| Tomohiro Umeda, Satomi Maekawa, Tetsuya Kimura, Akihiko Takashima, Takami Tomiyama, Hiroshi Mor. Neurofibrillary tangle formation by introducing wild-type human tau into APP transgenic mice. Acta neuropathologica. vol 127. issue 5. 2014-12-03. PMID:24531886. |
senile plaques comprised of aβ aggregates and neurofibrillary tangles (nfts) composed of hyperphosphorylated tau filaments are the hallmarks of alzheimer's disease (ad). |
2014-12-03 |
2023-08-12 |
mouse |
| Zeshan Ahmed, Jane Cooper, Tracey K Murray, Katya Garn, Emily McNaughton, Hannah Clarke, Samira Parhizkar, Mark A Ward, Annalisa Cavallini, Samuel Jackson, Suchira Bose, Florence Clavaguera, Markus Tolnay, Isabelle Lavenir, Michel Goedert, Michael L Hutton, Michael J O'Neil. A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity. Acta neuropathologica. vol 127. issue 5. 2014-12-03. PMID:24531916. |
intracellular inclusions composed of hyperphosphorylated filamentous tau are a hallmark of alzheimer's disease, progressive supranuclear palsy, pick's disease and other sporadic neurodegenerative tauopathies. |
2014-12-03 |
2023-08-12 |
mouse |
| Zeshan Ahmed, Jane Cooper, Tracey K Murray, Katya Garn, Emily McNaughton, Hannah Clarke, Samira Parhizkar, Mark A Ward, Annalisa Cavallini, Samuel Jackson, Suchira Bose, Florence Clavaguera, Markus Tolnay, Isabelle Lavenir, Michel Goedert, Michael L Hutton, Michael J O'Neil. A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity. Acta neuropathologica. vol 127. issue 5. 2014-12-03. PMID:24531916. |
this process is referred to as 'tau propagation' and may explain the stereotypic progression of tau pathology in the brains of alzheimer's disease patients. |
2014-12-03 |
2023-08-12 |
mouse |
| Wei Qian, Fei Li. Regulation of alternative splicing of tau exon 10. Neuroscience bulletin. vol 30. issue 2. 2014-12-03. PMID:24627328. |
the neuronal microtubule-associated protein tau is abnormally hyperphosphorylated and aggregated into neurofibrillary tangles in the brains of individuals with alzheimer's disease and related neurodegenerative disorders. |
2014-12-03 |
2023-08-12 |
human |