| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elliott J Mufson, Sarah Ward, Lester Binde. Prefibrillar tau oligomers in mild cognitive impairment and Alzheimer's disease. Neuro-degenerative diseases. vol 13. issue 2-3. 2014-09-23. PMID:24029627. |
prefibrillar tau oligomers in mild cognitive impairment and alzheimer's disease. |
2014-09-23 |
2023-08-12 |
Not clear |
| Elliott J Mufson, Sarah Ward, Lester Binde. Prefibrillar tau oligomers in mild cognitive impairment and Alzheimer's disease. Neuro-degenerative diseases. vol 13. issue 2-3. 2014-09-23. PMID:24029627. |
alzheimer's disease (ad) is a progressive neurodegenerative disorder characterized by the accumulation of extracellular amyloid-β peptide and intracellular tau. |
2014-09-23 |
2023-08-12 |
Not clear |
| Einar M Sigurdsso. Tau immunotherapy and imaging. Neuro-degenerative diseases. vol 13. issue 2-3. 2014-09-23. PMID:24029727. |
disappointing findings from recent phase iii trials on amyloid-β (aβ) immunotherapy for alzheimer's disease (ad) have shifted the focus of such treatments to the tau protein. |
2014-09-23 |
2023-08-12 |
mouse |
| Behzad Varamini, Angelos K Sikalidis, Kathryn L Bradfor. Resveratrol increases cerebral glycogen synthase kinase phosphorylation as well as protein levels of drebrin and transthyretin in mice: an exploratory study. International journal of food sciences and nutrition. vol 65. issue 1. 2014-09-22. PMID:24020380. |
alzheimer's disease (ad) is characterized by intraneuronal β-amyloid plaques and hyperphosphorylated tau, leading to neuronal cell death and progressive memory losses. |
2014-09-22 |
2023-08-12 |
mouse |
| Han-Chang Huang, Di Tang, Ke Xu, Zhao-Feng Jian. Curcumin attenuates amyloid-β-induced tau hyperphosphorylation in human neuroblastoma SH-SY5Y cells involving PTEN/Akt/GSK-3β signaling pathway. Journal of receptor and signal transduction research. vol 34. issue 1. 2014-09-19. PMID:24188406. |
accumulated amyloid-β peptide (aβ) and hyperphosphorylated tau proteins are two hallmarks of alzheimer's disease (ad). |
2014-09-19 |
2023-08-12 |
human |
| Changsheng Li, Sufang Liu, Ying Xing, Feng Ta. The role of hippocampal tau protein phosphorylation in isoflurane-induced cognitive dysfunction in transgenic APP695 mice. Anesthesia and analgesia. vol 119. issue 2. 2014-09-11. PMID:24977637. |
in the present study, we tested our hypothesis that enhanced tau protein phosphorylation in hippocampus contributes to isoflurane-induced cognitive dysfunction in a mouse model of alzheimer disease. |
2014-09-11 |
2023-08-13 |
mouse |
| S Mondragón-Rodríguez, G Perry, J Luna-Muñoz, M C Acevedo-Aquino, S William. Phosphorylation of tau protein at sites Ser(396-404) is one of the earliest events in Alzheimer's disease and Down syndrome. Neuropathology and applied neurobiology. vol 40. issue 2. 2014-09-10. PMID:24033439. |
phosphorylation of tau protein at sites ser(396-404) is one of the earliest events in alzheimer's disease and down syndrome. |
2014-09-10 |
2023-08-12 |
Not clear |
| S Mondragón-Rodríguez, G Perry, J Luna-Muñoz, M C Acevedo-Aquino, S William. Phosphorylation of tau protein at sites Ser(396-404) is one of the earliest events in Alzheimer's disease and Down syndrome. Neuropathology and applied neurobiology. vol 40. issue 2. 2014-09-10. PMID:24033439. |
phosphorylation, conformational changes and cleavage of tau protein have been widely suggested to contribute to abnormal tau processing in the pathogenesis of alzheimer's disease, as well as in other tauopathies. |
2014-09-10 |
2023-08-12 |
Not clear |
| Ryuichi Harada, Nobuyuki Okamura, Shozo Furumoto, Takeo Yoshikawa, Hiroyuki Arai, Kazuhiko Yanai, Yukitsuka Kud. Use of a benzimidazole derivative BF-188 in fluorescence multispectral imaging for selective visualization of tau protein fibrils in the Alzheimer's disease brain. Molecular imaging and biology. vol 16. issue 1. 2014-09-09. PMID:23868612. |
use of a benzimidazole derivative bf-188 in fluorescence multispectral imaging for selective visualization of tau protein fibrils in the alzheimer's disease brain. |
2014-09-09 |
2023-08-12 |
Not clear |
| Ryuichi Harada, Nobuyuki Okamura, Shozo Furumoto, Takeo Yoshikawa, Hiroyuki Arai, Kazuhiko Yanai, Yukitsuka Kud. Use of a benzimidazole derivative BF-188 in fluorescence multispectral imaging for selective visualization of tau protein fibrils in the Alzheimer's disease brain. Molecular imaging and biology. vol 16. issue 1. 2014-09-09. PMID:23868612. |
selective visualization of amyloid-β and tau protein deposits will help to understand the pathophysiology of alzheimer's disease (ad). |
2014-09-09 |
2023-08-12 |
Not clear |
| Mala V Rao, Mary Kate McBrayer, Jabbar Campbell, Asok Kumar, Audrey Hashim, Henry Sershen, Philip H Stavrides, Masuo Ohno, Michael Hutton, Ralph A Nixo. Specific calpain inhibition by calpastatin prevents tauopathy and neurodegeneration and restores normal lifespan in tau P301L mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 28. 2014-09-09. PMID:25009256. |
tau pathogenicity in alzheimer's disease and other tauopathies is thought to involve the generation of hyperphosphorylated, truncated, and oligomeric tau species with enhanced neurotoxicity, although the generative mechanisms and the implications for disease therapy are not well understood. |
2014-09-09 |
2023-08-13 |
mouse |
| Jean-Marie Sontag, Brandi Wasek, Goce Taleski, Josephine Smith, Erland Arning, Estelle Sontag, Teodoro Bottiglier. Altered protein phosphatase 2A methylation and Tau phosphorylation in the young and aged brain of methylenetetrahydrofolate reductase (MTHFR) deficient mice. Frontiers in aging neuroscience. vol 6. 2014-09-09. PMID:25202269. |
in turn, the down regulation of pp2a/bα was associated with enhanced phosphorylation of tau, a neuropathological hallmark of alzheimer's disease (ad). |
2014-09-09 |
2023-08-13 |
mouse |
| Xifei Yang, Chun'e He, Jie Li, Hongbin Chen, Quan Ma, Xiaojing Sui, Shengli Tian, Ming Ying, Qian Zhang, Yougen Luo, Zhixiong Zhuang, Jianjun Li. Uptake of silica nanoparticles: neurotoxicity and Alzheimer-like pathology in human SK-N-SH and mouse neuro2a neuroblastoma cells. Toxicology letters. vol 229. issue 1. 2014-09-08. PMID:24831964. |
additionally, increased deposit of intracellular β-amyloid 1-42 (aβ(1-42)) and enhanced phosphorylation of tau at ser262 and ser396, two specific pathological hallmarks of alzheimer's disease (ad), were observed in both cell lines with sinps treatment. |
2014-09-08 |
2023-08-13 |
mouse |
| Noriyuki Matsukaw. [The involvement of hippocampal cholinergic neurostimulating peptide and its precursor in Alzheimer pathogenesis]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 34. issue 3. 2014-09-08. PMID:25076779. |
crmp-2 is one of microtubule-associated proteins such as tau protein, and its phosphorylated form increased in the hippocampus of alzheimer brains. |
2014-09-08 |
2023-08-13 |
mouse |
| Anne Eckert, Rebecca Nisbet, Amandine Grimm, Jürgen Göt. March separate, strike together--role of phosphorylated TAU in mitochondrial dysfunction in Alzheimer's disease. Biochimica et biophysica acta. vol 1842. issue 8. 2014-09-03. PMID:24051203. |
march separate, strike together--role of phosphorylated tau in mitochondrial dysfunction in alzheimer's disease. |
2014-09-03 |
2023-08-12 |
human |
| Céline Héraud, Doris Goufak, Kunie Ando, Karelle Leroy, Valérie Suain, Zehra Yilmaz, Robert De Decker, Michèle Authelet, Vincent Laporte, Jean-Noël Octave, Jean-Pierre Brio. Increased misfolding and truncation of tau in APP/PS1/tau transgenic mice compared to mutant tau mice. Neurobiology of disease. vol 62. 2014-09-03. PMID:24076100. |
insoluble tau in 5xfad×tg30 mice compared to insoluble tau in tg30 mice showed increased phosphorylation, enhanced misfolding and truncation changes mimicking more closely the post-translational changes characteristic of phf-tau in alzheimer's disease. |
2014-09-03 |
2023-08-12 |
mouse |
| David Baglietto-Vargas, Masashi Kitazawa, Elaine J Le, Tatiana Estrada-Hernandez, Carlos J Rodriguez-Ortiz, Rodrigo Medeiros, Kim N Green, Frank M LaFerl. Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition. Neurobiology of disease. vol 62. 2014-09-03. PMID:24176788. |
these findings provide better understanding about the role of endogenous tau to alzheimer's disease (ad) pathology and for developing new ad models. |
2014-09-03 |
2023-08-12 |
mouse |
| André Kleinridders, Heather A Ferris, Weikang Cai, C Ronald Kah. Insulin action in brain regulates systemic metabolism and brain function. Diabetes. vol 63. issue 7. 2014-09-03. PMID:24931034. |
in addition, insulin signaling modulates phosphorylation of tau protein, an early component in the development of alzheimer disease. |
2014-09-03 |
2023-08-13 |
Not clear |
| Carol A Colton, Joan G Wilson, Angela Everhart, Donna M Wilcock, Jukka Puoliväli, Taneli Heikkinen, Juho Oksman, Olli Jääskeläinen, Kimmo Lehtimäki, Teemu Laitinen, Nina Vartiainen, Michael P Vite. mNos2 deletion and human NOS2 replacement in Alzheimer disease models. Journal of neuropathology and experimental neurology. vol 73. issue 8. 2014-09-02. PMID:25003233. |
using the appswdi(+)/(+)mnos2(-/-) (cvn-ad) mouse strain, we show a sequence of pathologic events leading to neurodegeneration,which include pathologically hyperphosphorylated tau in the perforant pathway at 6 weeks of age progressing to insoluble tau, early appearance of β-amyloid peptides in perivascular deposits around blood vessels in brain regions known to be vulnerable to alzheimer disease, and progression to damage and overt loss in select vulnerable neuronal populations in these regions. |
2014-09-02 |
2023-08-13 |
mouse |
| Yat Fung Shea, Leung-Wing Chu, Lin Zhou, Wing-Man Li, Oi Yee Lin, May N Y Chan, Aimin Xu, Rachel Wong, Tip Yin Ho, Kin Wah Liu, Joyce Ha, T W Daniel, You-Qiang Song, Karen S La. Cerebrospinal fluid biomarkers of Alzheimer's disease in Chinese patients: a pilot study. American journal of Alzheimer's disease and other dementias. vol 28. issue 8. 2014-08-31. PMID:24085246. |
in view of the paucity of data on cerebrospinal fluid (csf) biomarkers in chinese patients, we evaluated the validity of tau, phosphorylated tau 181 (p-tau-181), amyloid β 42 (aβ42), and aβ40 proteins in chinese patients with alzheimer's disease (ad). |
2014-08-31 |
2023-08-12 |
Not clear |