| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Russell Palm, Jaewon Chang, Jeffrey Blair, Yoelvis Garcia-Mesa, Hyoung-Gon Lee, Rudy J Castellani, Mark A Smith, Xiongwei Zhu, Gemma Casadesu. Down-regulation of serum gonadotropins but not estrogen replacement improves cognition in aged-ovariectomized 3xTg AD female mice. Journal of neurochemistry. vol 130. issue 1. 2014-08-28. PMID:24601954. |
in the aged triple transgenic alzheimer's disease (ad) mouse model (3xad-tg), estrogen replacement after ovariectomy does not improve cognitive function, increases phosphorylated tau levels and decreases inhibition of gsk3 beta. |
2014-08-28 |
2023-08-12 |
mouse |
| Stéphanie Chasseigneaux, Christine Clamagirand, Léa Huguet, Lucie Gorisse-Hussonnois, Christiane Rose, Bernadette Allinquan. Cytoplasmic SET induces tau hyperphosphorylation through a decrease of methylated phosphatase 2A. BMC neuroscience. vol 15. 2014-08-27. PMID:24981783. |
the neuronal cytoplasmic localization of set, an inhibitor of the phosphatase 2a (pp2a), results in tau hyperphosphorylation in the brains of alzheimer patients through mechanisms that are still not well defined. |
2014-08-27 |
2023-08-13 |
Not clear |
| Fabio Lo Monte, Thomas Kramer, Jiamin Gu, Martin Brodrecht, Johannes Pilakowski, Ana Fuertes, Juan Manuel Dominguez, Batya Plotkin, Hagit Eldar-Finkelman, Boris Schmid. Structure-based optimization of oxadiazole-based GSK-3 inhibitors. European journal of medicinal chemistry. vol 61. 2014-08-26. PMID:22749643. |
decreases β-amyloid production and reduces tau hyperphosphorylation, which are both associated with alzheimer's disease (ad). |
2014-08-26 |
2023-08-12 |
zebrafish |
| Nobuyuki Okamura, Shozo Furumoto, Michelle T Fodero-Tavoletti, Rachel S Mulligan, Ryuichi Harada, Paul Yates, Svetlana Pejoska, Yukitsuka Kudo, Colin L Masters, Kazuhiko Yanai, Christopher C Rowe, Victor L Villemagn. Non-invasive assessment of Alzheimer's disease neurofibrillary pathology using 18F-THK5105 PET. Brain : a journal of neurology. vol 137. issue Pt 6. 2014-08-26. PMID:24681664. |
non-invasive imaging of tau pathology in the living brain would be useful for accurately diagnosing alzheimer's disease, tracking disease progression, and evaluating the treatment efficacy of disease-specific therapeutics. |
2014-08-26 |
2023-08-12 |
human |
| Nobuyuki Okamura, Shozo Furumoto, Michelle T Fodero-Tavoletti, Rachel S Mulligan, Ryuichi Harada, Paul Yates, Svetlana Pejoska, Yukitsuka Kudo, Colin L Masters, Kazuhiko Yanai, Christopher C Rowe, Victor L Villemagn. Non-invasive assessment of Alzheimer's disease neurofibrillary pathology using 18F-THK5105 PET. Brain : a journal of neurology. vol 137. issue Pt 6. 2014-08-26. PMID:24681664. |
this technique would be applicable to the longitudinal evaluation of tau deposition and allow a better understanding of the pathophysiology of alzheimer's disease. |
2014-08-26 |
2023-08-12 |
human |
| Alberto Rábano, Raquel Cuadros, Miguel Calero, Félix Hernández, Jesús Avil. Specific profile of tau isoforms in argyrophylic grain disease. Journal of experimental neuroscience. vol 7. 2014-08-26. PMID:25157208. |
pick's disease is included in the 3r group (predominance of 3r isoforms), whereas tau pathology of alzheimer's disease represents and intermediate group (3 or 4 repeats [3r plus 4r, respectively] isoforms). |
2014-08-26 |
2023-08-13 |
Not clear |
| b' Jian-Guo Li, Jin Chu, Carlos Barrero, Salim Merali, Domenico Pratic\\xc3\\xb. Homocysteine exacerbates \\xce\\xb2-amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tangles. Annals of neurology. vol 75. issue 6. 2014-08-25. PMID:24644038.' |
homocysteine exacerbates β-amyloid pathology, tau pathology, and cognitive deficit in a mouse model of alzheimer disease with plaques and tangles. |
2014-08-25 |
2023-08-12 |
mouse |
| b' Jin Chu, Jin-Guo Li, Domenico Pratic\\xc3\\xb. Zileuton improves memory deficits, amyloid and tau pathology in a mouse model of Alzheimer\'s disease with plaques and tangles. PloS one. vol 8. issue 8. 2014-08-21. PMID:23951061.' |
zileuton improves memory deficits, amyloid and tau pathology in a mouse model of alzheimer's disease with plaques and tangles. |
2014-08-21 |
2023-08-12 |
mouse |
| Xiu-Qi Bao, Ning Li, Tao Wang, Xiang-Chen Kong, Wen-Jiao Tai, Hua Sun, Dan Zhan. FLZ alleviates the memory deficits in transgenic mouse model of Alzheimer's disease via decreasing beta-amyloid production and tau hyperphosphorylation. PloS one. vol 8. issue 11. 2014-08-20. PMID:24223757. |
flz alleviates the memory deficits in transgenic mouse model of alzheimer's disease via decreasing beta-amyloid production and tau hyperphosphorylation. |
2014-08-20 |
2023-08-12 |
mouse |
| Xiu-Qi Bao, Ning Li, Tao Wang, Xiang-Chen Kong, Wen-Jiao Tai, Hua Sun, Dan Zhan. FLZ alleviates the memory deficits in transgenic mouse model of Alzheimer's disease via decreasing beta-amyloid production and tau hyperphosphorylation. PloS one. vol 8. issue 11. 2014-08-20. PMID:24223757. |
alzheimer's disease (ad) is the most common cause of dementia worldwide and mainly characterized by the aggregated β-amyloid (aβ) and hyperphosphorylated tau. |
2014-08-20 |
2023-08-12 |
mouse |
| Hye Rin Lee, Hwa Kyoung Shin, So Youn Park, Hye Young Kim, Won Suk Lee, Byung Yong Rhim, Ki Whan Hong, Chi Dae Ki. Attenuation of β-amyloid-induced tauopathy via activation of CK2α/SIRT1: targeting for cilostazol. Journal of neuroscience research. vol 92. issue 2. 2014-08-18. PMID:24254769. |
β-amyloid (aβ) deposits and hyperphosphorylated tau aggregates are the chief hallmarks in the alzheimer's disease (ad) brains, but the strategies for controlling these pathological events remain elusive. |
2014-08-18 |
2023-08-12 |
human |
| Kerstin T S Wirz, Stella Keitel, Dick F Swaab, Joost Verhaagen, Koen Bosser. Early molecular changes in Alzheimer disease: can we catch the disease in its presymptomatic phase? Journal of Alzheimer's disease : JAD. vol 38. issue 4. 2014-08-17. PMID:24072070. |
alzheimer disease (ad) is the most common form of dementia and characterized by deposition of amyloid-β (aβ) plaques, neurofibrillary tangles consisting of hyperphosphorylated tau, atrophy, and progressive neurodegeneration. |
2014-08-17 |
2023-08-12 |
Not clear |
| Amy R Nelson, Krystyna Kolasa, Lori L McMaho. Noradrenergic sympathetic sprouting and cholinergic reinnervation maintains non-amyloidogenic processing of AβPP. Journal of Alzheimer's disease : JAD. vol 38. issue 4. 2014-08-17. PMID:24081376. |
alzheimer's disease (ad) is characterized by amyloid-β (aβ) plaques, hyperphosphorylated tau neurofibrillary tangles, and cholinergic dysfunction. |
2014-08-17 |
2023-08-12 |
human |
| Jamie Toombs, Ross W Paterson, Jonathan M Schott, Henrik Zetterber. Amyloid-beta 42 adsorption following serial tube transfer. Alzheimer's research & therapy. vol 6. issue 1. 2014-08-12. PMID:24472496. |
cerebrospinal fluid (csf) amyloid-beta 38 (aβ38), 40 (aβ40), 42 (aβ42) and total tau (t-tau) are finding increasing utility as biomarkers of alzheimer's disease (ad). |
2014-08-12 |
2023-08-12 |
Not clear |
| Bradley T Hyma. Tau propagation, different tau phenotypes, and prion-like properties of tau. Neuron. vol 82. issue 6. 2014-08-12. PMID:24945760. |
(2014) demonstrate in this issue of neuron that the natively unfolded protein tau can propagate indefinitely in distinct stable strains, therefore supporting the general idea that tau has prion-like properties, with implications for alzheimer's disease and other tauopathies. |
2014-08-12 |
2023-08-13 |
Not clear |
| Tetsuya Kimura, Daniel J Whitcomb, Jihoon Jo, Philip Regan, Thomas Piers, Seonghoo Heo, Christopher Brown, Tsutomu Hashikawa, Miyuki Murayama, Heon Seok, Ioannis Sotiropoulos, Eunjoon Kim, Graham L Collingridge, Akihiko Takashima, Kwangwook Ch. Microtubule-associated protein tau is essential for long-term depression in the hippocampus. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 369. issue 1633. 2014-08-11. PMID:24298146. |
the microtubule-associated protein tau is a principal component of neurofibrillary tangles, and has been identified as a key molecule in alzheimer's disease and other tauopathies. |
2014-08-11 |
2023-08-12 |
mouse |
| Jeremy Koppel, Valerie Vingtdeux, Philippe Marambaud, Cristina d'Abramo, Heidy Jimenez, Mark Stauber, Rachel Friedman, Peter Davie. CB₂ receptor deficiency increases amyloid pathology and alters tau processing in a transgenic mouse model of Alzheimer's disease. Molecular medicine (Cambridge, Mass.). vol 19. 2014-08-08. PMID:24408112. |
cb₂ receptor deficiency increases amyloid pathology and alters tau processing in a transgenic mouse model of alzheimer's disease. |
2014-08-08 |
2023-08-12 |
mouse |
| Casey Cook, Yari Carlomagno, Tania F Gendron, Judy Dunmore, Kristyn Scheffel, Caroline Stetler, Mary Davis, Dennis Dickson, Matthew Jarpe, Michael DeTure, Leonard Petrucell. Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance. Human molecular genetics. vol 23. issue 1. 2014-08-04. PMID:23962722. |
the accumulation of hyperphosphorylated tau in neurofibrillary tangles (nfts) is a neuropathological hallmark of tauopathies, including alzheimer's disease (ad) and chronic traumatic encephalopathy, but effective therapies directly targeting the tau protein are currently lacking. |
2014-08-04 |
2023-08-12 |
mouse |
| Xiaoxiao Luo, Liu Yang, Xin Chen, Shiyong L. Tau hyperphosphorylation: a downstream effector of isoflurane-induced neuroinflammation in aged rodents. Medical hypotheses. vol 82. issue 1. 2014-08-04. PMID:24290657. |
in alzheimer's disease (ad) models, proinflammatory cytokines can induce tau hyperphosphorylation which is associated with synaptic abnormality and further cognitive impairment. |
2014-08-04 |
2023-08-12 |
Not clear |
| Jere E Meredith, Sethu Sankaranarayanan, Valerie Guss, Anthony J Lanzetti, Flora Berisha, Robert J Neely, J Randall Slemmon, Erik Portelius, Henrik Zetterberg, Kaj Blennow, Holly Soares, Michael Ahlijanian, Charles F Albrigh. Characterization of novel CSF Tau and ptau biomarkers for Alzheimer's disease. PloS one. vol 8. issue 10. 2014-08-02. PMID:24116116. |
characterization of novel csf tau and ptau biomarkers for alzheimer's disease. |
2014-08-02 |
2023-08-12 |
Not clear |