| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Diego Iacono, Susan M Resnick, Richard O'Brien, Alan B Zonderman, Yang An, Olga Pletnikova, Gay Rudow, Barbara Crain, Juan C Troncos. Mild cognitive impairment and asymptomatic Alzheimer disease subjects: equivalent β-amyloid and tau loads with divergent cognitive outcomes. Journal of neuropathology and experimental neurology. vol 73. issue 4. 2014-05-12. PMID:24607960. |
mild cognitive impairment and asymptomatic alzheimer disease subjects: equivalent β-amyloid and tau loads with divergent cognitive outcomes. |
2014-05-12 |
2023-08-12 |
human |
| Diana L Castillo-Carranza, Urmi Sengupta, Marcos J Guerrero-Muñoz, Cristian A Lasagna-Reeves, Julia E Gerson, Gurpreet Singh, D Mark Estes, Alan D T Barrett, Kelly T Dineley, George R Jackson, Rakez Kaye. Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 12. 2014-05-08. PMID:24647946. |
recent findings suggest that tau oligomers, which form before neurofibrillary tangles (nfts), are the true neurotoxic tau entities in neurodegenerative tauopathies, including alzheimer's disease (ad). |
2014-05-08 |
2023-08-12 |
mouse |
| Li-Rong Xu, Xiao-Ling Liu, Jie Chen, Yi Lian. Protein disulfide isomerase interacts with tau protein and inhibits its fibrillization. PloS one. vol 8. issue 10. 2014-04-29. PMID:24098548. |
tau protein is implicated in the pathogenesis of neurodegenerative disorders such as tauopathies including alzheimer disease, and tau fibrillization is thought to be related to neuronal toxicity. |
2014-04-29 |
2023-08-12 |
Not clear |
| Li-Rong Xu, Xiao-Ling Liu, Jie Chen, Yi Lian. Protein disulfide isomerase interacts with tau protein and inhibits its fibrillization. PloS one. vol 8. issue 10. 2014-04-29. PMID:24098548. |
physiological inhibitors of tau fibrillization hold promise for developing new strategies for treatment of alzheimer disease. |
2014-04-29 |
2023-08-12 |
Not clear |
| Li-Rong Xu, Xiao-Ling Liu, Jie Chen, Yi Lian. Protein disulfide isomerase interacts with tau protein and inhibits its fibrillization. PloS one. vol 8. issue 10. 2014-04-29. PMID:24098548. |
because protein disulfide isomerase (pdi) is both an enzyme and a chaperone, and implicated in neuroprotection against alzheimer disease, we want to know whether pdi can prevent tau fibrillization. |
2014-04-29 |
2023-08-12 |
Not clear |
| J Pozueta, R Lefort, M L Shelansk. Synaptic changes in Alzheimer's disease and its models. Neuroscience. vol 251. 2014-04-23. PMID:22687952. |
alzheimer's disease (ad) is a highly prevalent neurodegenerative disorder characterized by a progressive loss of cognition and the presence of two hallmark lesions, senile plaques (sp) and neurofibrillary tangles (nft), which result from the accumulation and deposition of the β-amyloid peptide (aβ) and the aggregation of hyperphosphorylated tau protein, respectively. |
2014-04-23 |
2023-08-12 |
Not clear |
| Ana M García-Cabrero, Rosa Guerrero-López, Beatriz G Giráldez, María Llorens-Martín, Jesús Avila, José M Serratosa, Marina P Sánche. Hyperexcitability and epileptic seizures in a model of frontotemporal dementia. Neurobiology of disease. vol 58. 2014-04-23. PMID:23774255. |
abnormal forms of hyperphosphorylated tau accumulate in alzheimer disease and other tauopathies. |
2014-04-23 |
2023-08-12 |
mouse |
| Un Young Yu, Byong Chul Yoo, Jung-Hyuck Ah. Regulatory B Subunits of Protein Phosphatase 2A Are Involved in Site-specific Regulation of Tau Protein Phosphorylation. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 18. issue 2. 2014-04-23. PMID:24757378. |
hyperphosphorylated isoforms of tau are major components of neurofibrillary tangles, which are histopathological hallmarks of alzheimer's disease. |
2014-04-23 |
2023-08-13 |
Not clear |
| Yu-Jing Tan, Dexin Sui, Wei-Han Wang, Min-Hao Kuo, Gavin E Reid, Merlin L Bruenin. Phosphopeptide enrichment with TiO2-modified membranes and investigation of tau protein phosphorylation. Analytical chemistry. vol 85. issue 12. 2014-04-22. PMID:23638980. |
the combination of membrane enrichment with tandem mass spectrometry reveals seven phosphorylation sites from in vivo phosphorylated tau (p-tau) protein, which is associated with alzheimer's disease. |
2014-04-22 |
2023-08-12 |
Not clear |
| Qing Yan Liu, Marilyn N Vera Chang, Joy X Lei, Roger Koukiekolo, Brandon Smith, Dongling Zhang, Othman Ghrib. Identification of microRNAs involved in Alzheimer's progression using a rabbit model of the disease. American journal of neurodegenerative disease. vol 3. issue 1. 2014-04-22. PMID:24754001. |
alzheimer's disease (ad) is the most common neurodegenerative disorder characterized by the presence of extracellular plaques of β-amyloid peptides and intracellular tangles of hyperphosphorylated tau proteins in the brain. |
2014-04-22 |
2023-08-13 |
human |
| Toshihisa Tanaka, Daisuke Mayuyama, Masatoshi Taked. [Alzheimer disease and tau protein]. Rinsho shinkeigaku = Clinical neurology. vol 52. issue 11. 2014-04-21. PMID:23196553. |
[alzheimer disease and tau protein]. |
2014-04-21 |
2023-08-12 |
Not clear |
| Toshihisa Tanaka, Daisuke Mayuyama, Masatoshi Taked. [Alzheimer disease and tau protein]. Rinsho shinkeigaku = Clinical neurology. vol 52. issue 11. 2014-04-21. PMID:23196553. |
to elucidate involvement of tau protein in neurodegenerative processes in alzheimer disease and related disorders, self-assembly process and degradative process of tau protein were examined. |
2014-04-21 |
2023-08-12 |
Not clear |
| Lucilla Parnetti, Lucia Farotti, Paolo Eusebi, Davide Chiasserini, Claudia De Carlo, David Giannandrea, Nicola Salvadori, Viviana Lisetti, Nicola Tambasco, Aroldo Rossi, Nour K Majbour, Omar El-Agnaf, Paolo Calabres. Differential role of CSF alpha-synuclein species, tau, and Aβ42 in Parkinson's Disease. Frontiers in aging neuroscience. vol 6. 2014-04-18. PMID:24744728. |
preliminary evidences show that the combination of csf t-α-syn and classical alzheimer's disease (ad) biomarkers-β-amyloid 1-42 (aβ42), total tau (t-tau), phosphorylated tau (p-tau)-differentiate pd patients from controls, and that reduced levels of aβ42 represent a predictive factor for development of cognitive deterioration in pd. |
2014-04-18 |
2023-08-13 |
Not clear |
| Gucci Jijuan Gu, Harald Lund, Di Wu, Andries Blokzijl, Christina Classon, Gabriel von Euler, Ulf Landegren, Dan Sunnemark, Masood Kamali-Moghadda. Role of individual MARK isoforms in phosphorylation of tau at Ser²⁶² in Alzheimer's disease. Neuromolecular medicine. vol 15. issue 3. 2014-04-15. PMID:23666762. |
role of individual mark isoforms in phosphorylation of tau at ser²⁶² in alzheimer's disease. |
2014-04-15 |
2023-08-12 |
human |
| Gucci Jijuan Gu, Harald Lund, Di Wu, Andries Blokzijl, Christina Classon, Gabriel von Euler, Ulf Landegren, Dan Sunnemark, Masood Kamali-Moghadda. Role of individual MARK isoforms in phosphorylation of tau at Ser²⁶² in Alzheimer's disease. Neuromolecular medicine. vol 15. issue 3. 2014-04-15. PMID:23666762. |
the microtubule-affinity regulating kinase (mark) family consists of four highly conserved members that have been implicated in phosphorylation of tau protein, causing formation of neurofibrillary tangles in alzheimer's disease (ad). |
2014-04-15 |
2023-08-12 |
human |
| Katrine Christa Nordskov Sorensen, Anja Hviid Simonsen, Ulla Bachmann Holmetoft, Steen Gregers Hasselbalch, Niels H H Heegaar. Neprilysin-like activity correlates with CSF-Tau and phospho-tau in patients with Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 37. issue 2. 2014-04-15. PMID:23948879. |
a relation between amyloid-β peptide (aβ) accumulation and neprilysin (nep), an aβ degrading enzyme, has been proposed but studies of nep and the levels of the pathological hallmarks of alzheimer's disease (ad), aβ and tau, in cerebrospinal fluid (csf) are scarce. |
2014-04-15 |
2023-08-12 |
Not clear |
| Inmaculada Cuchillo-Ibáñez, Valeria Balmaceda, Arancha Botella-López, Alberto Rabano, Jesus Avila, Javier Sáez-Valer. Beta-amyloid impairs reelin signaling. PloS one. vol 8. issue 8. 2014-04-15. PMID:23951306. |
reelin is a signaling protein increasingly associated with the pathogenesis of alzheimer's disease that relevantly modulates tau phosphorylation. |
2014-04-15 |
2023-08-12 |
Not clear |
| Yoav Raz, Yifat Mille. Interactions between Aβ and mutated Tau lead to polymorphism and induce aggregation of Aβ-mutated tau oligomeric complexes. PloS one. vol 8. issue 8. 2014-04-15. PMID:23951348. |
experimental studies have shown that in alzheimer's disease aβ peptide forms aggregates both with itself and with wild-type tau. |
2014-04-15 |
2023-08-12 |
Not clear |
| Yongchang Diwu, Jinzhou Tian, Jing Sh. Effect of Xixin decoction on phosphorylation toxicity at specific sites of tau protein in brains of rats with sporadic Alzheimer disease. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. vol 33. issue 6. 2014-04-15. PMID:24660612. |
effect of xixin decoction on phosphorylation toxicity at specific sites of tau protein in brains of rats with sporadic alzheimer disease. |
2014-04-15 |
2023-08-12 |
rat |
| Yongchang Diwu, Jinzhou Tian, Jing Sh. Effect of Xixin decoction on phosphorylation toxicity at specific sites of tau protein in brains of rats with sporadic Alzheimer disease. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. vol 33. issue 6. 2014-04-15. PMID:24660612. |
to explore the mechanism of action of xixin decoction (xxd) for the prevention and treatment of sporadic alzheimer disease (sad) by investigating the effects of xxd on the phosphorylation of thr231 and ser422 sites of tau protein. |
2014-04-15 |
2023-08-12 |
rat |