Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Annalisa Cavallini, Suzanne Brewerton, Amanda Bell, Samantha Sargent, Sarah Glover, Clare Hardy, Roger Moore, John Calley, Devaki Ramachandran, Michael Poidinger, Eric Karran, Peter Davies, Michael Hutton, Philip Szekeres, Suchira Bos. An unbiased approach to identifying tau kinases that phosphorylate tau at sites associated with Alzheimer disease. The Journal of biological chemistry. vol 288. issue 32. 2013-11-01. PMID:23798682. |
an unbiased approach to identifying tau kinases that phosphorylate tau at sites associated with alzheimer disease. |
2013-11-01 |
2023-08-12 |
human |
Annalisa Cavallini, Suzanne Brewerton, Amanda Bell, Samantha Sargent, Sarah Glover, Clare Hardy, Roger Moore, John Calley, Devaki Ramachandran, Michael Poidinger, Eric Karran, Peter Davies, Michael Hutton, Philip Szekeres, Suchira Bos. An unbiased approach to identifying tau kinases that phosphorylate tau at sites associated with Alzheimer disease. The Journal of biological chemistry. vol 288. issue 32. 2013-11-01. PMID:23798682. |
neurofibrillary tangles, one of the hallmarks of alzheimer disease (ad), are composed of paired helical filaments of abnormally hyperphosphorylated tau. |
2013-11-01 |
2023-08-12 |
human |
Futao Zhou, Shuangrong Chen, Xuechuan Su. [Research progress of abnormal phosphorylation of microtubule-associated tau protein and of the targeted inhibition of the phosphorylation]. Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi. vol 29. issue 4. 2013-10-31. PMID:23016437. |
progressive dementia is described as the first and most prominent symptom of alzheimer's disease (ad), and hyperphosphorylation of microtubule associated tau protein (mapt) plays a key role in neurodegeneration and neuronal dysfunction in ad and other neurodegenerative diseases. |
2013-10-31 |
2023-08-12 |
Not clear |
Hitomi Kurinami, Munehisa Shimamura, Naoyuki Sato, Hironori Nakagami, Ryuichi Morishit. Do angiotensin receptor blockers protect against Alzheimer's disease? Drugs & aging. vol 30. issue 6. 2013-10-31. PMID:23532556. |
because growing evidence suggests that angiotensin ii receptor blockers (arbs) effectively inhibit oxidative stress, amyloid beta protein (aβ) metabolism, and tau phosphorylation in animal brains, arbs are considered to be a potential candidate for the treatment of alzheimer's disease (ad). |
2013-10-31 |
2023-08-12 |
Not clear |
Ethika Tyagi, Tina Fiorelli, Michelle Norden, Jaya Padmanabha. Alpha 1-Antichymotrypsin, an Inflammatory Protein Overexpressed in the Brains of Patients with Alzheimer's Disease, Induces Tau Hyperphosphorylation through c-Jun N-Terminal Kinase Activation. International journal of Alzheimer's disease. vol 2013. 2013-10-31. PMID:24175110. |
alpha 1-antichymotrypsin, an inflammatory protein overexpressed in the brains of patients with alzheimer's disease, induces tau hyperphosphorylation through c-jun n-terminal kinase activation. |
2013-10-31 |
2023-08-12 |
mouse |
Beatriz G Perez-Nievas, Thor D Stein, Hwan-Ching Tai, Oriol Dols-Icardo, Thomas C Scotton, Isabel Barroeta-Espar, Leticia Fernandez-Carballo, Estibaliz Lopez de Munain, Jesus Perez, Marta Marquie, Alberto Serrano-Pozo, Mathew P Frosch, Val Lowe, Joseph E Parisi, Ronald C Petersen, Milos D Ikonomovic, Oscar L López, William Klunk, Bradley T Hyman, Teresa Gómez-Isl. Dissecting phenotypic traits linked to human resilience to Alzheimer's pathology. Brain : a journal of neurology. vol 136. issue Pt 8. 2013-10-30. PMID:23824488. |
we identified distinct phenotypic characteristics in the profile of brain fibrillar and soluble amyloid-β and tau accrual and in the glial response that discriminated demented and non-demented individuals with high loads of alzheimer's pathology. |
2013-10-30 |
2023-08-12 |
human |
Beatriz G Perez-Nievas, Thor D Stein, Hwan-Ching Tai, Oriol Dols-Icardo, Thomas C Scotton, Isabel Barroeta-Espar, Leticia Fernandez-Carballo, Estibaliz Lopez de Munain, Jesus Perez, Marta Marquie, Alberto Serrano-Pozo, Mathew P Frosch, Val Lowe, Joseph E Parisi, Ronald C Petersen, Milos D Ikonomovic, Oscar L López, William Klunk, Bradley T Hyman, Teresa Gómez-Isl. Dissecting phenotypic traits linked to human resilience to Alzheimer's pathology. Brain : a journal of neurology. vol 136. issue Pt 8. 2013-10-30. PMID:23824488. |
amyloid-β deposition in the form of fibrillar plaques and intimately related oligomeric amyloid-β assemblies, hyperphosphorylated soluble tau species localized in synapses, and glial activation emerged in this series as likely mediators of neurotoxicity and altered cognition, providing further insight into factors and pathways potentially involved in human susceptibility or resilience to alzheimer's pathological changes. |
2013-10-30 |
2023-08-12 |
human |
Joel Jakobsson, Henrik Zetterberg, Kaj Blennow, Carl Johan Ekman, Anette G M Johansson, Mikael Landé. Altered concentrations of amyloid precursor protein metabolites in the cerebrospinal fluid of patients with bipolar disorder. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 4. 2013-10-29. PMID:23212456. |
the cerebrospinal fluid has previously been used to study neurodegenerative processes in alzheimer's disease, from which changes in three core biomarkers have emerged as indicative of degeneration: amyloid β, total tau, and hyperphosphorylated tau. |
2013-10-29 |
2023-08-12 |
Not clear |
David T Chien, Shadfar Bahri, A Katrin Szardenings, Joseph C Walsh, Fanrong Mu, Min-Ying Su, William R Shankle, Arkadij Elizarov, Hartmuth C Kol. Early clinical PET imaging results with the novel PHF-tau radioligand [F-18]-T807. Journal of Alzheimer's disease : JAD. vol 34. issue 2. 2013-10-29. PMID:23234879. |
aggregates of hyperphosphorylated tau (phf-tau), such as neurofibrillary tangles, are linked to the degree of cognitive impairment in alzheimer's disease. |
2013-10-29 |
2023-08-12 |
human |
Brittany N Dugger, Jose A Hidalgo, Glenn Chiarolanza, Monica Mariner, Jonette Henry-Watson, Lucia I Sue, Thomas G Beac. The distribution of phosphorylated tau in spinal cords of Alzheimer's disease and non-demented individuals. Journal of Alzheimer's disease : JAD. vol 34. issue 2. 2013-10-29. PMID:23246918. |
the distribution of phosphorylated tau in spinal cords of alzheimer's disease and non-demented individuals. |
2013-10-29 |
2023-08-12 |
human |
Brittany N Dugger, Jose A Hidalgo, Glenn Chiarolanza, Monica Mariner, Jonette Henry-Watson, Lucia I Sue, Thomas G Beac. The distribution of phosphorylated tau in spinal cords of Alzheimer's disease and non-demented individuals. Journal of Alzheimer's disease : JAD. vol 34. issue 2. 2013-10-29. PMID:23246918. |
abnormal phosphorylation of the microtubule-associated protein tau develops in selected brain regions in normal aging and becomes widespread throughout the brain in alzheimer's disease (ad). |
2013-10-29 |
2023-08-12 |
human |
Matthew E Seward, Eric Swanson, Andrés Norambuena, Anja Reimann, J Nicholas Cochran, Rong Li, Erik D Roberson, George S Bloo. Amyloid-β signals through tau to drive ectopic neuronal cell cycle re-entry in Alzheimer's disease. Journal of cell science. vol 126. issue Pt 5. 2013-10-29. PMID:23345405. |
amyloid-β signals through tau to drive ectopic neuronal cell cycle re-entry in alzheimer's disease. |
2013-10-29 |
2023-08-12 |
mouse |
Johanna C Gandy, Miguel Melendez-Ferro, Gautam N Bijur, Fred Van Leuven, Joy K Roche, Benoit Lechat, Herman Devijver, David Demedts, Emma Perez-Costas, Rosalinda C Robert. Glycogen synthase kinase-3β (GSK3β) expression in a mouse model of Alzheimer's disease: a light and electron microscopy study. Synapse (New York, N.Y.). vol 67. issue 6. 2013-10-29. PMID:23390016. |
glycogen synthase kinase-3β (gsk3β) activity has been previously linked to alzheimer's disease (ad) by its phosphorylation of tau and activation by amyloid. |
2013-10-29 |
2023-08-12 |
mouse |
Florence Clavaguera, Isabelle Lavenir, Ben Falcon, Stephan Frank, Michel Goedert, Markus Tolna. "Prion-like" templated misfolding in tauopathies. Brain pathology (Zurich, Switzerland). vol 23. issue 3. 2013-10-28. PMID:23587140. |
in alzheimer's disease, tau pathology develops in a stereotypical manner, with the first lesions appearing in the locus coeruleus and entorhinal cortex, from where they appear to spread to the hippocampus and neocortex. |
2013-10-28 |
2023-08-12 |
Not clear |
Thomas Arendt, Torsten Bullman. Neuronal plasticity in hibernation and the proposed role of the microtubule-associated protein tau as a "master switch" regulating synaptic gain in neuronal networks. American journal of physiology. Regulatory, integrative and comparative physiology. vol 305. issue 5. 2013-10-28. PMID:23824962. |
this mechanism of reversible protein phosphorylation also affects the microtubule-associated protein tau, thereby generating a condition that in the adult human brain is associated with aggregation of tau protein to paired helical filaments (phfs), as observed in alzheimer's disease. |
2013-10-28 |
2023-08-12 |
human |
Katja Hochgräfe, Astrid Sydow, Eva-Maria Mandelko. Regulatable transgenic mouse models of Alzheimer disease: onset, reversibility and spreading of Tau pathology. The FEBS journal. vol 280. issue 18. 2013-10-25. PMID:23517246. |
regulatable transgenic mouse models of alzheimer disease: onset, reversibility and spreading of tau pathology. |
2013-10-25 |
2023-08-12 |
mouse |
Katja Hochgräfe, Astrid Sydow, Eva-Maria Mandelko. Regulatable transgenic mouse models of Alzheimer disease: onset, reversibility and spreading of Tau pathology. The FEBS journal. vol 280. issue 18. 2013-10-25. PMID:23517246. |
accumulation of amyloidogenic proteins such as tau is a hallmark of neurodegenerative diseases including alzheimer disease and fronto-temporal dementias. |
2013-10-25 |
2023-08-12 |
mouse |
Eva Bentmann, Christian Haass, Dorothee Dorman. Stress granules in neurodegeneration--lessons learnt from TAR DNA binding protein of 43 kDa and fused in sarcoma. The FEBS journal. vol 280. issue 18. 2013-10-25. PMID:23587065. |
tau inclusions in alzheimer's disease) show a co-localization with t cell internal antigen-1 as well. |
2013-10-25 |
2023-08-12 |
Not clear |
Huilai Tian, Eliot Davidowitz, Patricia Lopez, Sharareh Emadi, James Moe, Michael Sierk. Trimeric tau is toxic to human neuronal cells at low nanomolar concentrations. International journal of cell biology. vol 2013. 2013-10-25. PMID:24159335. |
in alzheimer's disease (ad), tau aggregates into fibrils and higher order neurofibrillary tangles, a key histopathological feature of ad. |
2013-10-25 |
2023-08-12 |
human |
David J Irwin, Todd J Cohen, Murray Grossman, Steven E Arnold, Elisabeth McCarty-Wood, Vivianna M Van Deerlin, Virginia M-Y Lee, John Q Trojanowsk. Acetylated tau neuropathology in sporadic and hereditary tauopathies. The American journal of pathology. vol 183. issue 2. 2013-10-24. PMID:23885714. |
we have recently shown acetylation of tau at lysine residue 280 (ac-k280) to be a disease-specific modification in alzheimer disease (ad), corticobasal degeneration, and progressive supranuclear palsy, likely representing a major regulatory tau modification. |
2013-10-24 |
2023-08-12 |
Not clear |