All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Catherine M Cowan, Amrit Mudhe. Are tau aggregates toxic or protective in tauopathies? Frontiers in neurology. vol 4. 2013-08-21. PMID:23964266. aggregation of highly phosphorylated tau into aggregated forms such as filaments and neurofibrillary tangles is one of the defining pathological hallmarks of alzheimer's disease and other tauopathies. 2013-08-21 2023-08-12 human
Kerstin Morcinek, Christoph Köhler, Jürgen Götz, Hannsjörg Schröde. Pattern of tau hyperphosphorylation and neurotransmitter markers in the brainstem of senescent tau filament forming transgenic mice. Brain research. vol 1497. 2013-08-20. PMID:23261664. to address the question whether tau filament forming mice expressing mutated human tau mirror histopathological changes observed in alzheimer brainstem, the degree and distribution of neurofibrillary lesions as well as the pattern of cholinergic and monoaminergic neurons were investigated. 2013-08-20 2023-08-12 mouse
Kerstin Morcinek, Christoph Köhler, Jürgen Götz, Hannsjörg Schröde. Pattern of tau hyperphosphorylation and neurotransmitter markers in the brainstem of senescent tau filament forming transgenic mice. Brain research. vol 1497. 2013-08-20. PMID:23261664. although numerous brainstem nuclei in our model expressed human tau protein, the development of neurofibrillary tangles, neuropil threads and ghost tangles was rare and likewise its distribution differed largely from alzheimer's disease pattern. 2013-08-20 2023-08-12 mouse
Bruno Bulic, Marcus Pickhardt, Eckhard Mandelko. Progress and developments in tau aggregation inhibitors for Alzheimer disease. Journal of medicinal chemistry. vol 56. issue 11. 2013-08-20. PMID:23484434. progress and developments in tau aggregation inhibitors for alzheimer disease. 2013-08-20 2023-08-12 Not clear
M S M Wai, P Luan, Y Jiang, W M Chan, T Y M Tsui, H C Tang, W P Lam, M Fan, D T Ye. Long term ketamine and ketamine plus alcohol toxicity - what can we learn from animal models? Mini reviews in medicinal chemistry. vol 13. issue 2. 2013-08-19. PMID:22512581. our laboratory has documented initially that ketamine can induce the formation of hyperphosphorlated tau (hypertau), which is a hallmark of alzheimer's disease (ad), in the cerebral cortex of both mice and monkeys as well as apoptosis in neurons in these species. 2013-08-19 2023-08-12 mouse
Justin M Nussbaum, Matthew E Seward, George S Bloo. Alzheimer disease: a tale of two prions. Prion. vol 7. issue 1. 2013-08-19. PMID:22965142. alzheimer disease (ad) has traditionally been thought to involve the misfolding and aggregation of two different factors that contribute in parallel to pathogenesis: amyloid-β (aβ) peptides, which represent proteolytic fragments of the transmembrane amyloid precursor protein, and tau, which normally functions as a neuronally enriched, microtubule-associated protein that predominantly accumulates in axons. 2013-08-19 2023-08-12 Not clear
Antonella Caccamo, Andrea Magrì, David X Medina, Elena V Wisely, Manuel F López-Aranda, Alcino J Silva, Salvatore Odd. mTOR regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies. Aging cell. vol 12. issue 3. 2013-08-14. PMID:23425014. mtor regulates tau phosphorylation and degradation: implications for alzheimer's disease and other tauopathies. 2013-08-14 2023-08-12 mouse
Antonella Caccamo, Andrea Magrì, David X Medina, Elena V Wisely, Manuel F López-Aranda, Alcino J Silva, Salvatore Odd. mTOR regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies. Aging cell. vol 12. issue 3. 2013-08-14. PMID:23425014. accumulation of tau is a critical event in several neurodegenerative disorders, collectively known as tauopathies, which include alzheimer's disease and frontotemporal dementia. 2013-08-14 2023-08-12 mouse
Qiu-Yan Liu, Jin-Tai Yu, Dan Miao, Xiao-Ying Ma, Hui-Fu Wang, Wei Wang, Lan Ta. An exploratory study on STX6, MOBP, MAPT, and EIF2AK3 and late-onset Alzheimer's disease. Neurobiology of aging. vol 34. issue 5. 2013-08-13. PMID:23116876. both alzheimer's disease (ad) and progressive supranuclear palsy (psp) are a class of neurodegenerative diseases associated with the pathologic aggregation of tau protein in the human brain. 2013-08-13 2023-08-12 human
Lars Messing, Jochen Martin Decker, Maria Joseph, Eckhard Mandelkow, Eva-Maria Mandelko. Cascade of tau toxicity in inducible hippocampal brain slices and prevention by aggregation inhibitors. Neurobiology of aging. vol 34. issue 5. 2013-08-13. PMID:23158765. mislocalization and aggregation of the axonal protein tau are hallmarks of alzheimer's disease and other tauopathies. 2013-08-13 2023-08-12 mouse
Urszula Wasik, Gabriela Schneider, Anna Mietelska-Porowska, Marcin Mazurkiewicz, Hanna Fabczak, Serge Weis, Claudia Zabke, Charles R Harrington, Anna Filipek, Grazyna Niewiadomsk. Calcyclin binding protein and Siah-1 interacting protein in Alzheimer's disease pathology: neuronal localization and possible function. Neurobiology of aging. vol 34. issue 5. 2013-08-13. PMID:23260124. we have used brain tissue from alzheimer's disease (ad) patients and from transgenic mice modeling 2 different pathologies characteristic for ad: amyloid and tau. 2013-08-13 2023-08-12 mouse
Elisa Dassie, Melissa R Andrews, Jean-Charles Bensadoun, Matthias Cacquevel, Bernard L Schneider, Patrick Aebischer, Fred S Wouters, Jill C Richardson, Ishrut Hussain, David R Howlett, Maria Grazia Spillantini, James W Fawcet. Focal expression of adeno-associated viral-mutant tau induces widespread impairment in an APP mouse model. Neurobiology of aging. vol 34. issue 5. 2013-08-13. PMID:23273572. therefore, tastpm mice injected with mutant tau displayed many of the main features characteristic of human alzheimer's disease patients and might be used as a model to test new drugs to ameliorate clinical features of alzheimer's disease. 2013-08-13 2023-08-12 mouse
Todd J Cohen, Dave Friedmann, Andrew W Hwang, Ronen Marmorstein, Virginia M Y Le. The microtubule-associated tau protein has intrinsic acetyltransferase activity. Nature structural & molecular biology. vol 20. issue 6. 2013-08-12. PMID:23624859. tau proteins are the building blocks of neurofibrillary tangles (nfts) found in a range of neurodegenerative tauopathies, including alzheimer's disease. 2013-08-12 2023-08-12 Not clear
Kazutomi Kanemar. [Immunotherapy targeting misfolded proteins in neurodegenerative disease]. Brain and nerve = Shinkei kenkyu no shinpo. vol 65. issue 4. 2013-08-07. PMID:23568995. the major components of pathological aggregates have been characterized in various neurodegenerative diseases; for example, amyloid β-protein and phosphorylated tau in alzheimer's disease, α-synuclein in parkinson's disease, sod1 or tdp-43 in amyotrophic lateral sclerosis, and huntingtin in huntington's disease. 2013-08-07 2023-08-12 Not clear
Yancy Ferrer-Acosta, Eva N Rodríguez-Cruz, François Orange, Hector De Jesús-Cortés, Bismark Madera, Jaime Vaquer-Alicea, Juan Ballester, Maxime J-F Guinel, George S Bloom, Irving E Veg. EFhd2 is a novel amyloid protein associated with pathological tau in Alzheimer's disease. Journal of neurochemistry. vol 125. issue 6. 2013-08-06. PMID:23331044. efhd2 is a novel amyloid protein associated with pathological tau in alzheimer's disease. 2013-08-06 2023-08-12 mouse
Zhi Tang, Erika Bereczki, Haiyan Zhang, Shan Wang, Chunxia Li, Xinying Ji, Rui M Branca, Janne Lehtiö, Zhizhong Guan, Peter Filipcik, Shaohua Xu, Bengt Winblad, Jin-Jing Pe. Mammalian target of rapamycin (mTor) mediates tau protein dyshomeostasis: implication for Alzheimer disease. The Journal of biological chemistry. vol 288. issue 22. 2013-08-06. PMID:23585566. mammalian target of rapamycin (mtor) mediates tau protein dyshomeostasis: implication for alzheimer disease. 2013-08-06 2023-08-12 Not clear
Zhi Tang, Erika Bereczki, Haiyan Zhang, Shan Wang, Chunxia Li, Xinying Ji, Rui M Branca, Janne Lehtiö, Zhizhong Guan, Peter Filipcik, Shaohua Xu, Bengt Winblad, Jin-Jing Pe. Mammalian target of rapamycin (mTor) mediates tau protein dyshomeostasis: implication for Alzheimer disease. The Journal of biological chemistry. vol 288. issue 22. 2013-08-06. PMID:23585566. previous evidence from post-mortem alzheimer disease (ad) brains and drug (especially rapamycin)-oriented in vitro and in vivo models implicated an aberrant accumulation of the mammalian target of rapamycin (mtor) in tangle-bearing neurons in ad brains and its role in the formation of abnormally hyperphosphorylated tau. 2013-08-06 2023-08-12 Not clear
Florence Clavaguera, Hiroyasu Akatsu, Graham Fraser, R Anthony Crowther, Stephan Frank, Jürgen Hench, Alphonse Probst, David T Winkler, Julia Reichwald, Matthias Staufenbiel, Bernardino Ghetti, Michel Goedert, Markus Tolna. Brain homogenates from human tauopathies induce tau inclusions in mouse brain. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 23. 2013-08-06. PMID:23690619. filamentous inclusions made of hyperphosphorylated tau are characteristic of numerous human neurodegenerative diseases, including alzheimer's disease, tangle-only dementia, pick disease, argyrophilic grain disease (agd), progressive supranuclear palsy, and corticobasal degeneration. 2013-08-06 2023-08-12 mouse
Florence Clavaguera, Hiroyasu Akatsu, Graham Fraser, R Anthony Crowther, Stephan Frank, Jürgen Hench, Alphonse Probst, David T Winkler, Julia Reichwald, Matthias Staufenbiel, Bernardino Ghetti, Michel Goedert, Markus Tolna. Brain homogenates from human tauopathies induce tau inclusions in mouse brain. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 23. 2013-08-06. PMID:23690619. in alzheimer's disease and agd, it has been shown that filamentous tau appears to spread in a stereotypic manner as the disease progresses. 2013-08-06 2023-08-12 mouse
Salvatore Odd. The role of mTOR signaling in Alzheimer disease. Frontiers in bioscience (Scholar edition). vol 4. 2013-08-05. PMID:22202101. the buildup of abeta and tau is believed to directly cause or contribute to the progressive cognitive deficits characteristic of alzheimer disease. 2013-08-05 2023-08-12 Not clear